EA201400567A1 - НОВЫЕ ПРОИЗВОДНЫЕ ЦИКЛОГЕКСИЛАМИНА, ОБЛАДАЮЩИЕ АГОНИСТИЧЕСКОЙ АКТИВНОСТЬЮ ПО ОТНОШЕНИЮ К β2 АДРЕНЕРГИЧЕСКОМУ РЕЦЕПТОРУ И АНТАГОНИСТИЧЕСКОЙ АКТИВНОСТЬЮ ПО ОТНОШЕНИЮ К МУСКАРИНОВОМУ РЕЦЕПТОРУ М3 - Google Patents

НОВЫЕ ПРОИЗВОДНЫЕ ЦИКЛОГЕКСИЛАМИНА, ОБЛАДАЮЩИЕ АГОНИСТИЧЕСКОЙ АКТИВНОСТЬЮ ПО ОТНОШЕНИЮ К β2 АДРЕНЕРГИЧЕСКОМУ РЕЦЕПТОРУ И АНТАГОНИСТИЧЕСКОЙ АКТИВНОСТЬЮ ПО ОТНОШЕНИЮ К МУСКАРИНОВОМУ РЕЦЕПТОРУ М3

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Publication number
EA201400567A1
EA201400567A1 EA201400567A EA201400567A EA201400567A1 EA 201400567 A1 EA201400567 A1 EA 201400567A1 EA 201400567 A EA201400567 A EA 201400567A EA 201400567 A EA201400567 A EA 201400567A EA 201400567 A1 EA201400567 A1 EA 201400567A1
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EA
Eurasian Patent Office
Prior art keywords
respect
receptor
activity
muscarino
cyclogexylamine
Prior art date
Application number
EA201400567A
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English (en)
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EA027443B1 (ru
Inventor
Хосе Аигваде-Бош
Сильвиа Гваль-Ройг
Мария Прат-Кинонес
Карлос Пуиг-Дуран
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Альмираль, С.А.
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=45033908&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EA201400567(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Альмираль, С.А. filed Critical Альмираль, С.А.
Publication of EA201400567A1 publication Critical patent/EA201400567A1/ru
Publication of EA027443B1 publication Critical patent/EA027443B1/ru

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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/538—1,4-Oxazines, e.g. morpholine ortho- or peri-condensed with carbocyclic ring systems
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
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    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

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  • Chemical & Material Sciences (AREA)
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  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

В заявке описаны новые соединения, обладающие двойной активностью: агонистической по отношению к β2 адренергическому рецептору и антагонистической по отношению к мускариновому рецептору М3, содержащие их фармацевтические композиции, способ их получения и их применение для лечения респираторных заболеваний.
EA201400567A 2011-11-11 2012-11-09 ПРОИЗВОДНЫЕ ЦИКЛОГЕКСИЛАМИНА, ОБЛАДАЮЩИЕ АГОНИСТИЧЕСКОЙ АКТИВНОСТЬЮ ПО ОТНОШЕНИЮ К β2 АДРЕНЕРГИЧЕСКОМУ РЕЦЕПТОРУ И АНТАГОНИСТИЧЕСКОЙ АКТИВНОСТЬЮ ПО ОТНОШЕНИЮ К МУСКАРИНОВОМУ РЕЦЕПТОРУ М3 EA027443B1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP11382344.7A EP2592078A1 (en) 2011-11-11 2011-11-11 New cyclohexylamine derivatives having beta2 adrenergic agonist and M3 muscarinic antagonist activities
US201161563907P 2011-11-28 2011-11-28
PCT/EP2012/072309 WO2013068552A1 (en) 2011-11-11 2012-11-09 NEW CYCLOHEXYLAMINE DERIVATIVES HAVING β2 ADRENERGIC AGONIST AND M3 MUSCARINIC ANTAGONIST ACTIVITIES

Publications (2)

Publication Number Publication Date
EA201400567A1 true EA201400567A1 (ru) 2014-10-30
EA027443B1 EA027443B1 (ru) 2017-07-31

Family

ID=45033908

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201400567A EA027443B1 (ru) 2011-11-11 2012-11-09 ПРОИЗВОДНЫЕ ЦИКЛОГЕКСИЛАМИНА, ОБЛАДАЮЩИЕ АГОНИСТИЧЕСКОЙ АКТИВНОСТЬЮ ПО ОТНОШЕНИЮ К β2 АДРЕНЕРГИЧЕСКОМУ РЕЦЕПТОРУ И АНТАГОНИСТИЧЕСКОЙ АКТИВНОСТЬЮ ПО ОТНОШЕНИЮ К МУСКАРИНОВОМУ РЕЦЕПТОРУ М3

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US (4) US9233108B2 (ru)
EP (2) EP2592078A1 (ru)
JP (1) JP6084626B2 (ru)
KR (1) KR101830474B1 (ru)
CN (1) CN103998443B (ru)
AR (1) AR088828A1 (ru)
AU (1) AU2012333986B2 (ru)
BR (1) BR112014010598B1 (ru)
CA (1) CA2849868C (ru)
CL (1) CL2014001018A1 (ru)
CO (1) CO6930369A2 (ru)
CR (1) CR20140181A (ru)
CY (1) CY1117696T1 (ru)
DK (1) DK2776425T3 (ru)
EA (1) EA027443B1 (ru)
EC (1) ECSP14013340A (ru)
ES (1) ES2582472T3 (ru)
HR (1) HRP20161116T1 (ru)
HU (1) HUE029485T2 (ru)
IL (1) IL232477A (ru)
ME (1) ME02489B (ru)
MX (1) MX347280B (ru)
MY (1) MY172806A (ru)
PE (1) PE20141232A1 (ru)
PH (1) PH12014501056A1 (ru)
PL (1) PL2776425T3 (ru)
PT (1) PT2776425T (ru)
RS (1) RS55047B1 (ru)
SG (1) SG11201401979QA (ru)
SI (1) SI2776425T1 (ru)
SM (1) SMT201600252B (ru)
TW (2) TW201319062A (ru)
UY (1) UY34448A (ru)
WO (1) WO2013068552A1 (ru)

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EP2386555A1 (en) 2010-05-13 2011-11-16 Almirall, S.A. New cyclohexylamine derivatives having beta2 adrenergic agonist and m3 muscarinic antagonist activities
EP2592078A1 (en) 2011-11-11 2013-05-15 Almirall, S.A. New cyclohexylamine derivatives having beta2 adrenergic agonist and M3 muscarinic antagonist activities
EA201500651A1 (ru) 2012-12-18 2015-11-30 Альмираль, С.А. НОВЫЕ ПРОИЗВОДНЫЕ ЦИКЛОГЕКСИЛ- И ХИНУКЛИДИНИЛКАРБАМАТА, ОБЛАДАЮЩИЕ АГОНИСТИЧЕСКОЙ АКТИВНОСТЬЮ ПО ОТНОШЕНИЮ К β2 АДРЕНЕРГИЧЕСКОМУ РЕЦЕПТОРУ И АНТАГОНИСТИЧЕСКОЙ АКТИВНОСТЬЮ ПО ОТНОШЕНИЮ К МУСКАРИНОВОМУ РЕЦЕПТОРУ М3
TWI643853B (zh) 2013-02-27 2018-12-11 阿爾米雷爾有限公司 同時具有β2腎上腺素受體促效劑和M3毒蕈鹼受體拮抗劑活性之2-氨基-1-羥乙基-8-羥基喹啉-2(1H)-酮衍生物之鹽類
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