CY1118841T1 - Παραγωγα αμινοκυκλοβουτανιου, μεθοδος παρασκευης αυτων και η χρηση αυτων ως φαρμακα - Google Patents
Παραγωγα αμινοκυκλοβουτανιου, μεθοδος παρασκευης αυτων και η χρηση αυτων ως φαρμακαInfo
- Publication number
- CY1118841T1 CY1118841T1 CY20171100409T CY171100409T CY1118841T1 CY 1118841 T1 CY1118841 T1 CY 1118841T1 CY 20171100409 T CY20171100409 T CY 20171100409T CY 171100409 T CY171100409 T CY 171100409T CY 1118841 T1 CY1118841 T1 CY 1118841T1
- Authority
- CY
- Cyprus
- Prior art keywords
- atom
- group
- aminocyclobutani
- medicines
- preparing
- Prior art date
Links
- 239000003814 drug Substances 0.000 title abstract 2
- 229910052731 fluorine Chemical group 0.000 abstract 3
- 125000001153 fluoro group Chemical group F* 0.000 abstract 3
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 3
- 229910052801 chlorine Chemical group 0.000 abstract 2
- 125000001309 chloro group Chemical group Cl* 0.000 abstract 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 2
- 229940127523 NMDA Receptor Antagonists Drugs 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- KZZKOVLJUKWSKX-UHFFFAOYSA-N cyclobutanamine Chemical class NC1CCC1 KZZKOVLJUKWSKX-UHFFFAOYSA-N 0.000 abstract 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C231/00—Preparation of carboxylic acid amides
- C07C231/14—Preparation of carboxylic acid amides by formation of carboxamide groups together with reactions not involving the carboxamide groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
- C07C235/40—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of rings other than six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/24—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
- C07C255/49—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C255/57—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and carboxyl groups, other than cyano groups, bound to the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/04—Systems containing only non-condensed rings with a four-membered ring
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Neurosurgery (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pain & Pain Management (AREA)
- Engineering & Computer Science (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Epidemiology (AREA)
- Psychiatry (AREA)
- Rheumatology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Furan Compounds (AREA)
- Dermatology (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Η παρούσα εφεύρεση έχει ως αντικείμενο παράγωγα αμινοκυκλοβουτανίου, κυρίως ως ανταγωνιστές υποδοχέων NMDA, εφαρμογή αυτών στην θεραπευτική του ανθρώπου και μεθόδους παρασκευής αυτών. Αυτές οι ενώσεις αντιστοιχούν στον γενικό τύπο (1) για τον οποίο: - Χ1 αντιπροσωπεύει άτομο υδρογόνου ή ένα άτομο φθορίου• - Χ2 είναι ένα άτομο υδρογόνου ή ένα άτομο φθορίου ή ένα άτομο χλωρίου• - R1 αντιπροσωπεύει ένα άτομο υδρογόνου ή ένα άτομο φθορίου ή ένα άτομο χλωρίου ή μια μεθύλ ομάδα ή μια μεθόξυ ομάδα ή μια κύανο ομάδα• R2 αντιπροσωπεύει μαζί ή ξεχωριστά μια μεθύλ ομάδα ή μια αιθύλ ομάδα.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR1261621A FR2998892B1 (fr) | 2012-12-04 | 2012-12-04 | Derives d'aminocyclobutane, leur procede de preparation et leur utilisation a titre de medicaments |
| PCT/EP2013/075481 WO2014086825A1 (fr) | 2012-12-04 | 2013-12-04 | Derives d'aminocyclobutane, leur procede de preparation et leur utilisation a titre de medicaments |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CY1118841T1 true CY1118841T1 (el) | 2018-01-10 |
Family
ID=48128432
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CY20171100409T CY1118841T1 (el) | 2012-12-04 | 2017-04-06 | Παραγωγα αμινοκυκλοβουτανιου, μεθοδος παρασκευης αυτων και η χρηση αυτων ως φαρμακα |
Country Status (31)
| Country | Link |
|---|---|
| US (2) | US9469601B2 (el) |
| EP (1) | EP2928861B1 (el) |
| JP (1) | JP6391586B2 (el) |
| KR (1) | KR102221928B1 (el) |
| CN (2) | CN104854083B (el) |
| AR (1) | AR093787A1 (el) |
| AU (1) | AU2013354133B2 (el) |
| BR (1) | BR112015012752B1 (el) |
| CA (1) | CA2893216C (el) |
| CY (1) | CY1118841T1 (el) |
| DK (1) | DK2928861T3 (el) |
| ES (1) | ES2621896T3 (el) |
| FR (1) | FR2998892B1 (el) |
| HK (1) | HK1212968A1 (el) |
| HR (1) | HRP20170564T1 (el) |
| IL (1) | IL239146A (el) |
| LT (1) | LT2928861T (el) |
| MA (1) | MA38229B1 (el) |
| MX (1) | MX364556B (el) |
| MY (1) | MY179886A (el) |
| NZ (1) | NZ709572A (el) |
| PL (1) | PL2928861T3 (el) |
| PT (1) | PT2928861T (el) |
| RS (1) | RS55916B1 (el) |
| RU (1) | RU2655919C2 (el) |
| SA (1) | SA515360518B1 (el) |
| SI (1) | SI2928861T1 (el) |
| TN (1) | TN2015000240A1 (el) |
| TW (1) | TWI603947B (el) |
| UA (1) | UA114017C2 (el) |
| WO (1) | WO2014086825A1 (el) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW202003519A (zh) * | 2018-03-28 | 2020-01-16 | 日商武田藥品工業股份有限公司 | 雜環化合物及其用途 |
| JP2021050161A (ja) | 2019-09-25 | 2021-04-01 | 武田薬品工業株式会社 | 複素環化合物及びその用途 |
| CN114269747B (zh) * | 2019-11-18 | 2023-04-18 | 苏州恩华生物医药科技有限公司 | 一种1’,2’-二氢-3’h-螺[环丁烷1,4’-异喹啉]-3’-酮衍生物及其应用 |
Family Cites Families (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3133924A (en) * | 1960-05-31 | 1964-05-19 | Bristol Myers Co | Amino-substituted cyclobutane carboxamides |
| FR2581059B1 (fr) * | 1985-04-25 | 1988-04-22 | Pf Medicament | Procede de preparation du chlorhydrate de phenyl-1 diethyl amino carbonyl-1 aminomethyl-2 cyclopropane (z) |
| US5621142A (en) * | 1994-02-22 | 1997-04-15 | Asahi Kasei Kogyo Kabushiki Kaisha | Aminoalkylcyclopropane derivatives |
| US6197830B1 (en) | 1995-09-22 | 2001-03-06 | Bruce M. Frome | Method for achieving relief from sympathetically mediated pain |
| ES2241055T3 (es) | 1996-08-23 | 2005-10-16 | Endo Pharmaceuticals Inc | Composicion que contiene un anticonvulsionante para tratar el dolor neuropatico. |
| NZ502671A (en) | 1997-09-08 | 2003-01-31 | Warner Lambert Co | Combination of an analgesic with anti-epileptic properties and a NSAID |
| US6172118B1 (en) | 1998-04-14 | 2001-01-09 | Smithkline Beecham Corporation | Compounds |
| BR9912827A (pt) | 1998-07-16 | 2001-05-02 | Sloan Kettering Inst Cancer | Composições tópicas compreendendo um analgésico opióide e um antagonista de nmda |
| US6362201B1 (en) | 1999-03-02 | 2002-03-26 | Merck & Co., Inc. | 3-cyclopropyl and 3-cyclobutyl pyrrolidine modulators of chemokine receptor activity |
| US7820688B2 (en) | 2001-04-27 | 2010-10-26 | Memorial Sloan-Kettering Cancer Center | Topical anesthetic/opioid formulations and uses thereof |
| AU2003210486B2 (en) | 2002-01-16 | 2007-06-28 | Endo Pharmaceuticals Inc. | Pharmaceutical composition and method for treating disorders of the central nervous system |
| TW200307539A (en) * | 2002-02-01 | 2003-12-16 | Bristol Myers Squibb Co | Cycloalkyl inhibitors of potassium channel function |
| US7687080B2 (en) | 2002-11-25 | 2010-03-30 | Taraxos Inc. | Treatment of neuropathy |
| JP2008528587A (ja) | 2005-01-25 | 2008-07-31 | グラクソ グループ リミテッド | 抗菌剤 |
| CL2008000322A1 (es) | 2007-02-01 | 2008-09-05 | Tibotec Pharm Ltd | Proceso para la preparacion de un compuesto derivado de 2-tiazol-2-il-quinolina; compuestos intermediarios; y proceso de preparacion de dichos compuestos intermediarios. |
| CA2685344A1 (en) * | 2007-04-26 | 2008-11-06 | Auspex Pharmaceuticals, Inc. | Deuterium labelled ketamine |
| US20090061024A1 (en) | 2007-08-27 | 2009-03-05 | Wyeth | Compositions and methods employing nmda antagonists for achieving an anesthetic-sparing effect |
| KR101497747B1 (ko) | 2007-11-28 | 2015-03-04 | 아스텔라스세이야쿠 가부시키가이샤 | 축합 인단 화합물 |
| CN102066345B (zh) | 2008-01-16 | 2013-07-17 | 生物科技研究有限公司 | *唑烷衍生物作为nmda拮抗剂 |
| WO2010036937A1 (en) | 2008-09-27 | 2010-04-01 | Taraxos Inc. | Topical formulations for treatment of neuropathy |
| TW201026667A (en) | 2008-09-30 | 2010-07-16 | Merz Pharma Gmbh & Co Kgaa | Glycine b antagonists |
| FR2943666B1 (fr) | 2009-03-31 | 2011-04-15 | Commissariat Energie Atomique | Metallophore derive de nicotianamine et ses procedes de fabrication |
| FR2944011B1 (fr) * | 2009-04-03 | 2011-05-20 | Pf Medicament | Derives d'aminocyclobutane ou d'aminocyclobutene, leur procede de preparation et leur utilisation a titre de medicaments. |
| EP2427435B1 (en) * | 2009-05-07 | 2017-06-14 | Medifron DBT Inc. | Substituted phenylureas and phenylamides as vanilloid receptor ligands |
| FR2946535B1 (fr) | 2009-06-10 | 2011-09-09 | Neureva | Composition comprenant une molecule favorisant l'interaction neurone-glie, notamment pour prevenir la formation de la cicatrice gliale et induire la regeneration neurale. |
| TWI544923B (zh) | 2009-12-29 | 2016-08-11 | 何應瑞 | 用於治療神經退化性疾病之醫藥組合物 |
-
2012
- 2012-12-04 FR FR1261621A patent/FR2998892B1/fr not_active Expired - Fee Related
-
2013
- 2013-12-03 TW TW102144198A patent/TWI603947B/zh not_active IP Right Cessation
- 2013-12-04 WO PCT/EP2013/075481 patent/WO2014086825A1/fr active Application Filing
- 2013-12-04 CN CN201380063117.8A patent/CN104854083B/zh not_active Expired - Fee Related
- 2013-12-04 MY MYPI2015701784A patent/MY179886A/en unknown
- 2013-12-04 RS RS20170379A patent/RS55916B1/sr unknown
- 2013-12-04 US US14/649,448 patent/US9469601B2/en active Active
- 2013-12-04 PT PT138114020T patent/PT2928861T/pt unknown
- 2013-12-04 KR KR1020157017845A patent/KR102221928B1/ko active IP Right Grant
- 2013-12-04 AR ARP130104484A patent/AR093787A1/es not_active Application Discontinuation
- 2013-12-04 DK DK13811402.0T patent/DK2928861T3/en active
- 2013-12-04 BR BR112015012752-5A patent/BR112015012752B1/pt not_active IP Right Cessation
- 2013-12-04 UA UAA201506431A patent/UA114017C2/uk unknown
- 2013-12-04 MX MX2015006686A patent/MX364556B/es active IP Right Grant
- 2013-12-04 RU RU2015126104A patent/RU2655919C2/ru active
- 2013-12-04 LT LTEP13811402.0T patent/LT2928861T/lt unknown
- 2013-12-04 PL PL13811402T patent/PL2928861T3/pl unknown
- 2013-12-04 AU AU2013354133A patent/AU2013354133B2/en not_active Ceased
- 2013-12-04 MA MA38229A patent/MA38229B1/fr unknown
- 2013-12-04 SI SI201330607A patent/SI2928861T1/sl unknown
- 2013-12-04 JP JP2015545991A patent/JP6391586B2/ja active Active
- 2013-12-04 ES ES13811402.0T patent/ES2621896T3/es active Active
- 2013-12-04 EP EP13811402.0A patent/EP2928861B1/fr active Active
- 2013-12-04 CN CN201710102368.2A patent/CN106957285B/zh not_active Expired - Fee Related
- 2013-12-04 NZ NZ709572A patent/NZ709572A/en not_active IP Right Cessation
- 2013-12-04 CA CA2893216A patent/CA2893216C/fr active Active
-
2015
- 2015-06-02 TN TNP2015000240A patent/TN2015000240A1/fr unknown
- 2015-06-02 IL IL239146A patent/IL239146A/en active IP Right Grant
- 2015-06-03 SA SA515360518A patent/SA515360518B1/ar unknown
-
2016
- 2016-01-29 HK HK16101031.1A patent/HK1212968A1/zh not_active IP Right Cessation
- 2016-09-12 US US15/262,885 patent/US9687459B2/en active Active
-
2017
- 2017-04-06 CY CY20171100409T patent/CY1118841T1/el unknown
- 2017-04-10 HR HRP20170564TT patent/HRP20170564T1/hr unknown
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