CY1118852T1 - Παραγωγα πυριμιδοοξαζοσινης ως αναστολεις της mtor - Google Patents
Παραγωγα πυριμιδοοξαζοσινης ως αναστολεις της mtorInfo
- Publication number
- CY1118852T1 CY1118852T1 CY20171100270T CY171100270T CY1118852T1 CY 1118852 T1 CY1118852 T1 CY 1118852T1 CY 20171100270 T CY20171100270 T CY 20171100270T CY 171100270 T CY171100270 T CY 171100270T CY 1118852 T1 CY1118852 T1 CY 1118852T1
- Authority
- CY
- Cyprus
- Prior art keywords
- pyrimidoxazoin
- products
- mtor inhibitors
- mtor
- inhibitors
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Diabetes (AREA)
- Biomedical Technology (AREA)
- Immunology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Pain & Pain Management (AREA)
- Pulmonology (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Rheumatology (AREA)
- Child & Adolescent Psychology (AREA)
- Ophthalmology & Optometry (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Η εφεύρεση αφορά σε δικυκλικά ετεροκυκλικά παράγωγα με γενικό τύπο (I), σε μια διαδικασία παρασκευής τους και στη θεραπευτική τους χρήση.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR1250768A FR2986232B1 (fr) | 2012-01-26 | 2012-01-26 | Derives heterocycliques bicycliques, leur preparation et leur application en therapeutique |
| PCT/IB2013/050656 WO2013111106A1 (en) | 2012-01-26 | 2013-01-25 | Pyrimidooxazocine derivatives as mtor - inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CY1118852T1 true CY1118852T1 (el) | 2018-01-10 |
Family
ID=47997597
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CY20171100270T CY1118852T1 (el) | 2012-01-26 | 2017-02-28 | Παραγωγα πυριμιδοοξαζοσινης ως αναστολεις της mtor |
Country Status (26)
| Country | Link |
|---|---|
| US (1) | US9120812B2 (el) |
| EP (1) | EP2807172B1 (el) |
| JP (1) | JP6068508B2 (el) |
| KR (1) | KR20140125389A (el) |
| CN (1) | CN104203958B (el) |
| AR (1) | AR089782A1 (el) |
| AU (1) | AU2013213261B2 (el) |
| BR (1) | BR112014018226A8 (el) |
| CA (1) | CA2862747A1 (el) |
| CY (1) | CY1118852T1 (el) |
| DK (1) | DK2807172T3 (el) |
| ES (1) | ES2617880T3 (el) |
| FR (1) | FR2986232B1 (el) |
| HR (1) | HRP20170288T1 (el) |
| HU (1) | HUE031917T2 (el) |
| IL (1) | IL233774A (el) |
| LT (1) | LT2807172T (el) |
| MX (1) | MX348841B (el) |
| PL (1) | PL2807172T3 (el) |
| PT (1) | PT2807172T (el) |
| RU (1) | RU2627269C2 (el) |
| SG (1) | SG11201404325VA (el) |
| SI (1) | SI2807172T1 (el) |
| TW (1) | TWI572608B (el) |
| UY (1) | UY34594A (el) |
| WO (1) | WO2013111106A1 (el) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2926596C (en) * | 2013-10-16 | 2020-07-14 | Shanghai Yingli Pharmaceutical Co., Ltd | Fused heterocyclic compound, preparation method therefor, pharmaceutical composition, and uses thereof |
| CN107001317B (zh) * | 2014-09-29 | 2019-05-24 | 山东轩竹医药科技有限公司 | 高选择性取代嘧啶类pi3k抑制剂 |
| US10307707B2 (en) * | 2017-05-17 | 2019-06-04 | Thomas P. Daly | 1-amino-2-methyl-2-propanol derivatives |
| WO2020055761A1 (en) | 2018-09-10 | 2020-03-19 | Mirati Therapeutics, Inc. | Combination therapies |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE427310T1 (de) * | 2002-01-18 | 2009-04-15 | Kyorin Seiyaku Kk | Kondensierte bicyclische pyrimidinderivate |
| CN1753897A (zh) * | 2002-11-22 | 2006-03-29 | 日本烟草产业株式会社 | 稠合双环含氮杂环 |
| ES2539478T3 (es) * | 2008-11-11 | 2015-07-01 | Xcovery Holding Company Llc | Inhibidores de PI3K/mTOR cinasa |
| CN102459248A (zh) * | 2009-05-26 | 2012-05-16 | 埃克塞里艾克西斯公司 | 作为PI3K/mTOR抑制剂的苯并氧杂环庚三烯以及它们使用与制造方法 |
| KR20130113950A (ko) * | 2010-05-19 | 2013-10-16 | 엑스커버리 홀딩 컴퍼니 엘엘씨 | Ｍｔｏｒ 선택적 키나아제 억제제 |
-
2012
- 2012-01-26 FR FR1250768A patent/FR2986232B1/fr not_active Expired - Fee Related
-
2013
- 2013-01-23 AR ARP130100196A patent/AR089782A1/es unknown
- 2013-01-25 UY UY0001034594A patent/UY34594A/es not_active Application Discontinuation
- 2013-01-25 PT PT137123311T patent/PT2807172T/pt unknown
- 2013-01-25 LT LTEP13712331.1T patent/LT2807172T/lt unknown
- 2013-01-25 SG SG11201404325VA patent/SG11201404325VA/en unknown
- 2013-01-25 PL PL13712331T patent/PL2807172T3/pl unknown
- 2013-01-25 ES ES13712331.1T patent/ES2617880T3/es active Active
- 2013-01-25 TW TW102102986A patent/TWI572608B/zh not_active IP Right Cessation
- 2013-01-25 SI SI201330547A patent/SI2807172T1/sl unknown
- 2013-01-25 DK DK13712331.1T patent/DK2807172T3/en active
- 2013-01-25 MX MX2014009084A patent/MX348841B/es active IP Right Grant
- 2013-01-25 BR BR112014018226A patent/BR112014018226A8/pt not_active Application Discontinuation
- 2013-01-25 CA CA2862747A patent/CA2862747A1/en not_active Abandoned
- 2013-01-25 US US14/374,838 patent/US9120812B2/en active Active
- 2013-01-25 AU AU2013213261A patent/AU2013213261B2/en not_active Ceased
- 2013-01-25 HU HUE13712331A patent/HUE031917T2/en unknown
- 2013-01-25 KR KR1020147023238A patent/KR20140125389A/ko active IP Right Grant
- 2013-01-25 RU RU2014134640A patent/RU2627269C2/ru not_active IP Right Cessation
- 2013-01-25 EP EP13712331.1A patent/EP2807172B1/en active Active
- 2013-01-25 WO PCT/IB2013/050656 patent/WO2013111106A1/en active Application Filing
- 2013-01-25 JP JP2014553846A patent/JP6068508B2/ja active Active
- 2013-01-25 CN CN201380016539.XA patent/CN104203958B/zh active Active
-
2014
- 2014-07-23 IL IL233774A patent/IL233774A/en active IP Right Grant
-
2017
- 2017-02-21 HR HRP20170288TT patent/HRP20170288T1/hr unknown
- 2017-02-28 CY CY20171100270T patent/CY1118852T1/el unknown
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