LT2807172T - Pirimidooksazocino dariniai kaip mtor slopikliai - Google Patents

Pirimidooksazocino dariniai kaip mtor slopikliai

Info

Publication number
LT2807172T
LT2807172T LTEP13712331.1T LT13712331T LT2807172T LT 2807172 T LT2807172 T LT 2807172T LT 13712331 T LT13712331 T LT 13712331T LT 2807172 T LT2807172 T LT 2807172T
Authority
LT
Lithuania
Prior art keywords
pyrimidooxazocine
mtor
inhibitors
derivatives
pyrimidooxazocine derivatives
Prior art date
Application number
LTEP13712331.1T
Other languages
English (en)
Inventor
Alain Braun
Olivier Crespin
Yann Foricher
Gilbert Marciniak
Nicolas Muzet
Eric Nicolai
Cécile PASCAL
Bertrand Vivet
Fabrice Viviani
Original Assignee
Sanofi
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi filed Critical Sanofi
Publication of LT2807172T publication Critical patent/LT2807172T/lt

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/16Otologicals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/04Anorexiants; Antiobesity agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00Antiparasitic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D519/00Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D498/00Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04Ortho-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Endocrinology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Child & Adolescent Psychology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Emergency Medicine (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Psychiatry (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
LTEP13712331.1T 2012-01-26 2013-01-25 Pirimidooksazocino dariniai kaip mtor slopikliai LT2807172T (lt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR1250768A FR2986232B1 (fr) 2012-01-26 2012-01-26 Derives heterocycliques bicycliques, leur preparation et leur application en therapeutique
PCT/IB2013/050656 WO2013111106A1 (en) 2012-01-26 2013-01-25 Pyrimidooxazocine derivatives as mtor - inhibitors

Publications (1)

Publication Number Publication Date
LT2807172T true LT2807172T (lt) 2017-03-27

Family

ID=47997597

Family Applications (1)

Application Number Title Priority Date Filing Date
LTEP13712331.1T LT2807172T (lt) 2012-01-26 2013-01-25 Pirimidooksazocino dariniai kaip mtor slopikliai

Country Status (26)

Country Link
US (1) US9120812B2 (lt)
EP (1) EP2807172B1 (lt)
JP (1) JP6068508B2 (lt)
KR (1) KR20140125389A (lt)
CN (1) CN104203958B (lt)
AR (1) AR089782A1 (lt)
AU (1) AU2013213261B2 (lt)
BR (1) BR112014018226A8 (lt)
CA (1) CA2862747A1 (lt)
CY (1) CY1118852T1 (lt)
DK (1) DK2807172T3 (lt)
ES (1) ES2617880T3 (lt)
FR (1) FR2986232B1 (lt)
HR (1) HRP20170288T1 (lt)
HU (1) HUE031917T2 (lt)
IL (1) IL233774A (lt)
LT (1) LT2807172T (lt)
MX (1) MX348841B (lt)
PL (1) PL2807172T3 (lt)
PT (1) PT2807172T (lt)
RU (1) RU2627269C2 (lt)
SG (1) SG11201404325VA (lt)
SI (1) SI2807172T1 (lt)
TW (1) TWI572608B (lt)
UY (1) UY34594A (lt)
WO (1) WO2013111106A1 (lt)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SG11201602446VA (en) * 2013-10-16 2016-05-30 Shanghai Yingli Pharm Co Ltd Fused heterocyclic compound, preparation method therefor, pharmaceutical composition, and uses thereof
WO2016050201A1 (zh) * 2014-09-29 2016-04-07 山东轩竹医药科技有限公司 高选择性取代嘧啶类pi3k抑制剂
US10307707B2 (en) * 2017-05-17 2019-06-04 Thomas P. Daly 1-amino-2-methyl-2-propanol derivatives
JP2022500384A (ja) 2018-09-10 2022-01-04 ミラティ セラピューティクス, インコーポレイテッド 組み合わせ療法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003062245A1 (fr) * 2002-01-18 2003-07-31 Kyorin Pharmaceutical Co., Ltd. Derives de pyrimidine fusionnes bicycliques
WO2004047755A2 (en) * 2002-11-22 2004-06-10 Japan Tobacco Inc. Fused bicyclic nitrogen-containing heterocycles
AU2009314544C1 (en) * 2008-11-11 2015-11-12 Xcovery Holding Company Llc PI3K/mTOR kinase inhibitors
WO2010138487A1 (en) * 2009-05-26 2010-12-02 Exelixis, Inc. BENZOXAZEPINES AS INHIBITORS OF PI3K/m TOR AND METHODS OF THEIR USE AND MANUFACTURE
US8912178B2 (en) * 2010-05-19 2014-12-16 Xcovery Holdings Company, LLC mTOR selective kinase inhibitors

Also Published As

Publication number Publication date
BR112014018226A8 (pt) 2017-07-11
AR089782A1 (es) 2014-09-17
CN104203958B (zh) 2017-05-31
HUE031917T2 (en) 2017-08-28
FR2986232A1 (fr) 2013-08-02
EP2807172A1 (en) 2014-12-03
PT2807172T (pt) 2017-03-06
FR2986232B1 (fr) 2014-02-14
IL233774A (en) 2016-06-30
HRP20170288T1 (hr) 2017-04-21
AU2013213261B2 (en) 2017-07-20
KR20140125389A (ko) 2014-10-28
RU2014134640A (ru) 2016-03-27
SI2807172T1 (sl) 2017-03-31
US9120812B2 (en) 2015-09-01
CY1118852T1 (el) 2018-01-10
BR112014018226A2 (lt) 2017-06-20
RU2627269C2 (ru) 2017-08-04
PL2807172T3 (pl) 2017-05-31
UY34594A (es) 2013-09-02
TW201333016A (zh) 2013-08-16
TWI572608B (zh) 2017-03-01
ES2617880T3 (es) 2017-06-20
JP6068508B2 (ja) 2017-01-25
CN104203958A (zh) 2014-12-10
SG11201404325VA (en) 2014-08-28
JP2015504914A (ja) 2015-02-16
EP2807172B1 (en) 2016-11-30
MX2014009084A (es) 2015-02-05
MX348841B (es) 2017-06-30
CA2862747A1 (en) 2013-08-01
WO2013111106A1 (en) 2013-08-01
US20140378433A1 (en) 2014-12-25
DK2807172T3 (en) 2017-03-06
AU2013213261A1 (en) 2014-08-21

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