MX355632B - Inhibidores de la trayectoria de señalización notch y uso de los mismos en el tratamiento de cánceres. - Google Patents

Inhibidores de la trayectoria de señalización notch y uso de los mismos en el tratamiento de cánceres.

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Publication number
MX355632B
MX355632B MX2014007544A MX2014007544A MX355632B MX 355632 B MX355632 B MX 355632B MX 2014007544 A MX2014007544 A MX 2014007544A MX 2014007544 A MX2014007544 A MX 2014007544A MX 355632 B MX355632 B MX 355632B
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MX
Mexico
Prior art keywords
inhibitors
cancers
signalling pathway
treatment
notch signalling
Prior art date
Application number
MX2014007544A
Other languages
English (en)
Other versions
MX2014007544A (es
Inventor
Radtke Freddy
Lehal Rajwinder
Reinmüller Viktoria
Zhu Jieping
Original Assignee
Ecole Polytechnique Fed Lausanne Epfl
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Publication date
Application filed by Ecole Polytechnique Fed Lausanne Epfl filed Critical Ecole Polytechnique Fed Lausanne Epfl
Publication of MX2014007544A publication Critical patent/MX2014007544A/es
Publication of MX355632B publication Critical patent/MX355632B/es

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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4412—Non condensed pyridines; Hydrogenated derivatives thereof having oxo groups directly attached to the heterocyclic ring
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    • A61K31/09—Ethers or acetals having an ether linkage to aromatic ring nuclear carbon having two or more such linkages
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    • A61K31/136—Amines having aromatic rings, e.g. ketamine, nortriptyline having the amino group directly attached to the aromatic ring, e.g. benzeneamine
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    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
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Abstract

La presente invención se refiere al uso de inhibidores de la trayectoria de señalización Notch seleccionados del grupo que consiste de 6-(4-tert-butilfenoxi)piridin-3-amina (I3), sus derivados, en el tratamiento y/o prevención de cánceres.
MX2014007544A 2011-12-21 2012-12-21 Inhibidores de la trayectoria de señalización notch y uso de los mismos en el tratamiento de cánceres. MX355632B (es)

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EP11010130.0A EP2606884A1 (en) 2011-12-21 2011-12-21 Inhibitors of notch signaling pathway and use thereof in treatment of cancers
PCT/IB2012/057622 WO2013093885A1 (en) 2011-12-21 2012-12-21 Inhibitors of notch signalling pathway and use thereof in treatment of cancers

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HRP20180348T1 (hr) 2018-04-06
EP2606884A1 (en) 2013-06-26
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US20210382038A1 (en) 2021-12-09
RS56907B1 (sr) 2018-05-31
LT2793884T (lt) 2018-02-26
RU2014127753A (ru) 2016-02-10
BR112014015105A8 (pt) 2017-06-27
WO2013093885A1 (en) 2013-06-27
TR201802117T4 (tr) 2018-03-21
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US20140329867A1 (en) 2014-11-06
AU2012356033A1 (en) 2014-08-07
US10054581B1 (en) 2018-08-21
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AU2012356033B2 (en) 2017-08-03
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