BR112014015105A2 - inibidores da via de sinalização notch e uso do mesmo no tratamento de cânceres - Google Patents

inibidores da via de sinalização notch e uso do mesmo no tratamento de cânceres

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Publication number
BR112014015105A2
BR112014015105A2 BR112014015105A BR112014015105A BR112014015105A2 BR 112014015105 A2 BR112014015105 A2 BR 112014015105A2 BR 112014015105 A BR112014015105 A BR 112014015105A BR 112014015105 A BR112014015105 A BR 112014015105A BR 112014015105 A2 BR112014015105 A2 BR 112014015105A2
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BR
Brazil
Prior art keywords
signaling pathway
notch signaling
pathway inhibitors
cancer treatment
treatment
Prior art date
Application number
BR112014015105A
Other languages
English (en)
Other versions
BR112014015105A8 (pt
BR112014015105B1 (pt
Inventor
Radtke Freddy
Zhu Jieping
Lehal Rajwinder
Reinmüller Viktoria
Original Assignee
Ecole Polytechnique Fed De Lausanne (Epfl)
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Publication date
Application filed by Ecole Polytechnique Fed De Lausanne (Epfl) filed Critical Ecole Polytechnique Fed De Lausanne (Epfl)
Publication of BR112014015105A2 publication Critical patent/BR112014015105A2/pt
Publication of BR112014015105A8 publication Critical patent/BR112014015105A8/pt
Publication of BR112014015105B1 publication Critical patent/BR112014015105B1/pt

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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4412—Non condensed pyridines; Hydrogenated derivatives thereof having oxo groups directly attached to the heterocyclic ring
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    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/351—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom not condensed with another ring
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    • C07C217/82—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of non-condensed six-membered aromatic rings of the same non-condensed six-membered aromatic ring
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  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
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Abstract

resumo a presente invenção refere-se à utilização de inibidores da via de sinalização notch selecionados a partir do grupo consistindo de 6-(4-terc-butilfenoxi)piridin-3-amina (i3), seus derivados, no tratamento e/ou prevenção de cânceres.
BR112014015105-9A 2011-12-21 2012-12-21 Composição farmacêutica, kit e usos de um composto BR112014015105B1 (pt)

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