MX352085B - Método a base de euglobulina para determinar la actividad biológica de defibrótido. - Google Patents

Método a base de euglobulina para determinar la actividad biológica de defibrótido.

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Publication number
MX352085B
MX352085B MX2014016114A MX2014016114A MX352085B MX 352085 B MX352085 B MX 352085B MX 2014016114 A MX2014016114 A MX 2014016114A MX 2014016114 A MX2014016114 A MX 2014016114A MX 352085 B MX352085 B MX 352085B
Authority
MX
Mexico
Prior art keywords
defibrotide
biological activity
determining
euglobulin
based method
Prior art date
Application number
MX2014016114A
Other languages
English (en)
Other versions
MX2014016114A (es
Inventor
Ignon Terenzio
Kumar Vijay
Islam Khalid
Original Assignee
Gentium S R L
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=46829846&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MX352085(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Gentium S R L filed Critical Gentium S R L
Publication of MX2014016114A publication Critical patent/MX2014016114A/es
Publication of MX352085B publication Critical patent/MX352085B/es

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
    • C12Q1/37—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving peptidase or proteinase
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/711—Natural deoxyribonucleic acids, i.e. containing only 2'-deoxyriboses attached to adenine, guanine, cytosine or thymine and having 3'-5' phosphodiester links
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6435—Plasmin (3.4.21.7), i.e. fibrinolysin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/56—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving blood clotting factors, e.g. involving thrombin, thromboplastin, fibrinogen
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21007—Plasmin (3.4.21.7), i.e. fibrinolysin
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/52—Use of compounds or compositions for colorimetric, spectrophotometric or fluorometric investigation, e.g. use of reagent paper and including single- and multilayer analytical elements
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/86—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood coagulating time or factors, or their receptors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/12—Type of nucleic acid catalytic nucleic acids, e.g. ribozymes
    • C12N2310/127—DNAzymes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/914—Hydrolases (3)
    • G01N2333/948—Hydrolases (3) acting on peptide bonds (3.4)
    • G01N2333/968—Plasmin, i.e. fibrinolysin

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Immunology (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Physics & Mathematics (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Hematology (AREA)
  • Analytical Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • Urology & Nephrology (AREA)
  • Neurosurgery (AREA)
  • Food Science & Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Cell Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Plant Pathology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

La presente invención se refiere a un método in vitro para determinar la actividad biológica del defibrótido, que comprende las etapas de: a) poner en contacto al defibrótido, euglobulina de mamífero y sustrato específico para la plasmina el cual, por la reacción con la plasmina, proporciona un producto medible; y b) medir la cantidad de producto formada en tiempos sucesivos, para determinar de esta manera la actividad biológica del defibrótido.
MX2014016114A 2012-06-22 2012-06-22 Método a base de euglobulina para determinar la actividad biológica de defibrótido. MX352085B (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/IT2012/000193 WO2013190582A1 (en) 2012-06-22 2012-06-22 Euglobulin-based method for determining the biological activity of defibrotide

Publications (2)

Publication Number Publication Date
MX2014016114A MX2014016114A (es) 2015-09-23
MX352085B true MX352085B (es) 2017-11-08

Family

ID=46829846

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2014016114A MX352085B (es) 2012-06-22 2012-06-22 Método a base de euglobulina para determinar la actividad biológica de defibrótido.

Country Status (17)

Country Link
US (6) US9902952B2 (es)
EP (1) EP2864496B2 (es)
JP (1) JP6198821B2 (es)
KR (4) KR102038357B1 (es)
CN (2) CN110079580B (es)
AU (1) AU2012383169B2 (es)
BR (1) BR112014031934B1 (es)
CA (1) CA2874960C (es)
DK (1) DK2864496T4 (es)
ES (1) ES2660969T5 (es)
HK (1) HK1208503A1 (es)
IL (1) IL236132B (es)
IN (1) IN2014DN10584A (es)
MX (1) MX352085B (es)
RU (1) RU2627177C2 (es)
SG (1) SG11201408481UA (es)
WO (1) WO2013190582A1 (es)

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Also Published As

Publication number Publication date
WO2013190582A1 (en) 2013-12-27
US9902952B2 (en) 2018-02-27
KR20190016148A (ko) 2019-02-15
HK1208503A1 (en) 2016-03-04
ES2660969T3 (es) 2018-03-26
US20230357762A1 (en) 2023-11-09
IL236132A0 (en) 2015-01-29
ES2660969T5 (es) 2021-09-03
KR20180098420A (ko) 2018-09-03
US20210363519A1 (en) 2021-11-25
IL236132B (en) 2018-07-31
KR20150044877A (ko) 2015-04-27
RU2014149089A (ru) 2016-08-10
CN110079580B (zh) 2022-12-06
US11085043B2 (en) 2021-08-10
CA2874960A1 (en) 2013-12-27
DK2864496T3 (en) 2018-01-15
MX2014016114A (es) 2015-09-23
US20200208148A1 (en) 2020-07-02
KR101948243B1 (ko) 2019-05-21
CN104619857A (zh) 2015-05-13
JP6198821B2 (ja) 2017-09-20
JP2015521477A (ja) 2015-07-30
AU2012383169A1 (en) 2015-01-15
EP2864496A1 (en) 2015-04-29
RU2627177C2 (ru) 2017-08-03
EP2864496B2 (en) 2020-11-25
US11236328B2 (en) 2022-02-01
BR112014031934B1 (pt) 2021-05-04
US20180334672A1 (en) 2018-11-22
BR112014031934A8 (pt) 2018-01-02
CA2874960C (en) 2021-05-18
US20210388350A1 (en) 2021-12-16
CN110079580A (zh) 2019-08-02
IN2014DN10584A (es) 2015-08-28
BR112014031934A2 (pt) 2017-06-27
KR20190112197A (ko) 2019-10-02
DK2864496T4 (da) 2021-01-04
AU2012383169B2 (en) 2017-12-21
US20150176003A1 (en) 2015-06-25
KR102038357B1 (ko) 2019-10-31
EP2864496B1 (en) 2017-11-29
US11746348B2 (en) 2023-09-05
SG11201408481UA (en) 2015-01-29

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