MX349837B - Composicion de transglutaminasa seca. - Google Patents
Composicion de transglutaminasa seca.Info
- Publication number
- MX349837B MX349837B MX2010011208A MX2010011208A MX349837B MX 349837 B MX349837 B MX 349837B MX 2010011208 A MX2010011208 A MX 2010011208A MX 2010011208 A MX2010011208 A MX 2010011208A MX 349837 B MX349837 B MX 349837B
- Authority
- MX
- Mexico
- Prior art keywords
- composition
- dry
- transglutaminase
- dry transglutaminase
- salt
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/1025—Acyltransferases (2.3)
- C12N9/104—Aminoacyltransferases (2.3.2)
- C12N9/1044—Protein-glutamine gamma-glutamyltransferase (2.3.2.13), i.e. transglutaminase or factor XIII
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/14—Blood; Artificial blood
- A61K35/16—Blood plasma; Blood serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/45—Transferases (2)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/96—Stabilising an enzyme by forming an adduct or a composition; Forming enzyme conjugates
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y203/00—Acyltransferases (2.3)
- C12Y203/02—Aminoacyltransferases (2.3.2)
- C12Y203/02013—Protein-glutamine gamma-glutamyltransferase (2.3.2.13), i.e. transglutaminase or factor XIII
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Zoology (AREA)
- Epidemiology (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Immunology (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Hematology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Microbiology (AREA)
- Cell Biology (AREA)
- General Chemical & Material Sciences (AREA)
- Diabetes (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Developmental Biology & Embryology (AREA)
- Virology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Enzymes And Modification Thereof (AREA)
Abstract
La presente invención se refiere a una composición de transglutaminasa seca, la composición se puede obtener por liofilización o secado por rociado de una composición acuosa que comprende una transglutaminasa, una sal y al menos un componente adicional seleccionado del grupo que consiste de un azúcar, un aminoácido, y un amortiguador, en donde la concentración de la sal en la composición acuosa está en el intervalo de 5 hasta 100 mM. En los aspectos adicionales, la presente invención se refiere a un método de preparación de la composición de transglutaminasa seca, una solución reconstituida, una composición farmacéutica y un método de tratamiento.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP08103642 | 2008-04-21 | ||
| PCT/EP2009/054657 WO2009130181A2 (en) | 2008-04-21 | 2009-04-20 | Dry transglutaminase composition |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MX2010011208A MX2010011208A (es) | 2010-11-12 |
| MX349837B true MX349837B (es) | 2017-08-16 |
Family
ID=40792660
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2010011208A MX349837B (es) | 2008-04-21 | 2009-04-20 | Composicion de transglutaminasa seca. |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US10391062B2 (es) |
| EP (1) | EP2268267B1 (es) |
| JP (1) | JP6244079B2 (es) |
| KR (2) | KR101897534B1 (es) |
| CN (2) | CN102065844A (es) |
| AU (1) | AU2009240026B2 (es) |
| CA (1) | CA2722230C (es) |
| ES (1) | ES2640343T3 (es) |
| MX (1) | MX349837B (es) |
| PL (1) | PL2268267T3 (es) |
| RU (1) | RU2616847C2 (es) |
| WO (1) | WO2009130181A2 (es) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5929760B2 (ja) * | 2010-12-07 | 2016-06-08 | 味の素株式会社 | 安定化酵素組成物及びその製造方法 |
| US20180169117A1 (en) * | 2014-03-20 | 2018-06-21 | Otsuka Pharmaceutical Co., Ltd. | Pharmaceutical formulation comprising a substituted phenyl - (1,3-dihydro-isoindol-2-yl) - methanone |
| CN105462950B (zh) * | 2016-02-16 | 2017-09-26 | 上海青瑞食品科技有限公司 | 一种液体酶制剂及制备方法 |
| CN106337044B (zh) * | 2016-09-30 | 2018-08-31 | 迈克生物股份有限公司 | 凝血酶溶液 |
| SG11201908457WA (en) | 2017-03-15 | 2019-10-30 | Cerecin Inc | Pharmaceutical compositions having high drug loadings of medium chain triglycerides and methods related thereto |
Family Cites Families (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2916711A1 (de) * | 1979-04-25 | 1980-11-06 | Behringwerke Ag | Blutgerinnungsfaktoren und verfahren zu ihrer herstellung |
| JPS56135418A (en) | 1980-03-27 | 1981-10-22 | Green Cross Corp:The | Heat treatment of aqueous solution containing 8 factor of coagulation of blood derived from human |
| US4877608A (en) * | 1987-11-09 | 1989-10-31 | Rorer Pharmaceutical Corporation | Pharmaceutical plasma protein formulations in low ionic strength media |
| US5612456A (en) * | 1988-11-14 | 1997-03-18 | Zymogenetics, Inc. | Factor XIII compositions |
| JP2719166B2 (ja) | 1989-02-02 | 1998-02-25 | 鐘紡株式会社 | 毛髪化粧料組成物 |
| DE3939346A1 (de) | 1989-11-29 | 1991-06-06 | Behringwerke Ag | Arzneimitel zur subkutanen oder intramuskulaeren applikation enthaltend polypeptide |
| JPH03240738A (ja) | 1990-02-20 | 1991-10-28 | Hoechst Japan Ltd | 糖尿病性壊疽治療剤 |
| JP3281368B2 (ja) | 1990-11-30 | 2002-05-13 | 味の素株式会社 | 安定化トランスグルタミナーゼ組成物及び保存法 |
| JP3353383B2 (ja) * | 1992-06-02 | 2002-12-03 | 味の素株式会社 | 酵素製剤及び結着成形食品の製造法 |
| EP0572987B1 (en) | 1992-06-02 | 1999-08-25 | Ajinomoto Co., Inc. | Process for producing bound-formed food |
| US5330974A (en) | 1993-03-01 | 1994-07-19 | Fibratek, Inc. | Therapeutic fibrinogen compositions |
| KR100302935B1 (ko) | 1993-03-30 | 2001-11-30 | 바트 루디거 | 사람혈액응고인자xiii과아프로티닌을포함하는약제학적조성물 |
| AT402788B (de) | 1993-08-03 | 1997-08-25 | Immuno Ag | Virussichere blutgerinnungsfaktor xiii-präparation |
| US5939385A (en) | 1993-08-13 | 1999-08-17 | Zymogenetics, Inc. | Transglutaminase cross-linkable polypeptides and methods relating thereto |
| DE19508192A1 (de) * | 1995-03-09 | 1996-09-12 | Behringwerke Ag | Stabile Transglutaminasepräparate und Verfahren zu ihrer Herstellung |
| JPH08333277A (ja) | 1995-06-05 | 1996-12-17 | Hoechst Japan Ltd | ヒト血液凝固第ｘｉｉｉ因子の安定化された水性液製剤 |
| AUPN801296A0 (en) | 1996-02-12 | 1996-03-07 | Csl Limited | Stabilised growth hormone formulation and method of preparation thereof |
| KR100858830B1 (ko) | 1998-11-18 | 2008-09-17 | 체에스엘 베링 게엠베하 | 조직 접합제용의 안정화된 단백질 제제 |
| JP4200644B2 (ja) | 1999-09-17 | 2008-12-24 | 味の素株式会社 | 食品加工用塩漬剤 |
| ATE300953T1 (de) | 2000-05-10 | 2005-08-15 | Novo Nordisk Healthcare Ag | Verwendung von faktor vii-a und faktor xiii enthaltenden pharmazeutischen verbindungen |
| KR20020092469A (ko) * | 2000-05-10 | 2002-12-11 | 노보 노르디스크 에이/에스 | 인자 ＶＩＩａ 및 인자 ＸＩＩＩ를 포함하는 제약학적조성물 |
| AU2002225994A1 (en) | 2000-11-03 | 2002-05-15 | Zymogenetics Inc. | Use of blood coagulation factor xiii for treating haemophilia |
| JP2003055257A (ja) * | 2001-08-10 | 2003-02-26 | Nihon Pharmaceutical Co Ltd | 安定な血液凝固第ｘｉｉｉ因子製剤 |
| GB0207092D0 (en) * | 2002-03-26 | 2002-05-08 | Sod Conseils Rech Applic | Stable pharmaceutical composition containing factor VIII |
| GB0216001D0 (en) * | 2002-07-10 | 2002-08-21 | Nat Blood Authority | Process and composition |
| JP2004123566A (ja) * | 2002-09-30 | 2004-04-22 | Nihon Pharmaceutical Co Ltd | ヒト血漿由来血液凝固第ｘｉｉｉ因子製剤およびその製造方法 |
| JP2008510476A (ja) * | 2004-08-27 | 2008-04-10 | ノボ ノルディスク ヘルス ケア アクチェンゲゼルシャフト | 生物学的材料からのｘｉｉｉ因子ポリペプチドの精製 |
| JP5074750B2 (ja) * | 2005-12-07 | 2012-11-14 | 一般財団法人化学及血清療法研究所 | シクロデキストリン類を含有する液状フィブリノゲン製剤 |
| US20090311240A1 (en) * | 2008-05-22 | 2009-12-17 | Baxter International Inc. | VEGF165 Delivered by Fibrin Sealant to Reduce Tissue Necrosis |
-
2009
- 2009-04-20 US US12/937,884 patent/US10391062B2/en active Active
- 2009-04-20 KR KR1020167028896A patent/KR101897534B1/ko active IP Right Grant
- 2009-04-20 KR KR1020107025565A patent/KR101710471B1/ko active IP Right Grant
- 2009-04-20 MX MX2010011208A patent/MX349837B/es active IP Right Grant
- 2009-04-20 RU RU2010145064A patent/RU2616847C2/ru active
- 2009-04-20 ES ES09735163.9T patent/ES2640343T3/es active Active
- 2009-04-20 PL PL09735163T patent/PL2268267T3/pl unknown
- 2009-04-20 CN CN2009801241515A patent/CN102065844A/zh active Pending
- 2009-04-20 EP EP09735163.9A patent/EP2268267B1/en active Active
- 2009-04-20 JP JP2011505472A patent/JP6244079B2/ja active Active
- 2009-04-20 WO PCT/EP2009/054657 patent/WO2009130181A2/en active Application Filing
- 2009-04-20 CA CA2722230A patent/CA2722230C/en not_active Expired - Fee Related
- 2009-04-20 CN CN201610285066.9A patent/CN105925545A/zh active Pending
- 2009-04-20 AU AU2009240026A patent/AU2009240026B2/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| AU2009240026B2 (en) | 2014-05-29 |
| US10391062B2 (en) | 2019-08-27 |
| KR101710471B1 (ko) | 2017-02-27 |
| EP2268267A2 (en) | 2011-01-05 |
| JP2011518206A (ja) | 2011-06-23 |
| CA2722230A1 (en) | 2009-10-29 |
| RU2010145064A (ru) | 2012-05-27 |
| KR20110015552A (ko) | 2011-02-16 |
| JP6244079B2 (ja) | 2017-12-06 |
| CA2722230C (en) | 2016-08-23 |
| WO2009130181A3 (en) | 2010-07-15 |
| AU2009240026A1 (en) | 2009-10-29 |
| CN102065844A (zh) | 2011-05-18 |
| RU2616847C2 (ru) | 2017-04-18 |
| CN105925545A (zh) | 2016-09-07 |
| EP2268267B1 (en) | 2017-06-14 |
| KR20160124245A (ko) | 2016-10-26 |
| US20110165140A1 (en) | 2011-07-07 |
| KR101897534B1 (ko) | 2018-09-12 |
| ES2640343T3 (es) | 2017-11-02 |
| MX2010011208A (es) | 2010-11-12 |
| PL2268267T3 (pl) | 2017-12-29 |
| WO2009130181A2 (en) | 2009-10-29 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant or registration |