MX342385B - Inhibidores de la ruta del complemento que se unen a c5 y c5a sin evitar la formación de c5b. - Google Patents

Inhibidores de la ruta del complemento que se unen a c5 y c5a sin evitar la formación de c5b.

Info

Publication number
MX342385B
MX342385B MX2015001193A MX2015001193A MX342385B MX 342385 B MX342385 B MX 342385B MX 2015001193 A MX2015001193 A MX 2015001193A MX 2015001193 A MX2015001193 A MX 2015001193A MX 342385 B MX342385 B MX 342385B
Authority
MX
Mexico
Prior art keywords
inhibitors
formation
preventing
complement pathway
pathway inhibitors
Prior art date
Application number
MX2015001193A
Other languages
English (en)
Inventor
Michael S C Fung
Cecily Sun
Meisheng Lu
William Sun
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=23214536&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MX342385(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Genentech Inc filed Critical Genentech Inc
Publication of MX342385B publication Critical patent/MX342385B/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6863—Cytokines, i.e. immune system proteins modifying a biological response such as cell growth proliferation or differentiation, e.g. TNF, CNF, GM-CSF, lymphotoxin, MIF or their receptors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/569—Single domain, e.g. dAb, sdAb, VHH, VNAR or nanobody®
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance

Abstract

La presente invención se refiere a un ácido nucléico aislado que encoda un anticuerpo o un fragmento de unión a antígeno del mismo, en donde el anticuerpo o el fragmento de unión a antígeno del mismo, se une a C5 humano y C5a, y en donde el anticuerpo es una forma quimérica, desinmunizada o humanizada del anticuerpo monoclonal 137-26 producido a partir del hibridoma depositado en la ATCC y designado Pta-3650.
MX2015001193A 2001-08-17 2002-08-17 Inhibidores de la ruta del complemento que se unen a c5 y c5a sin evitar la formación de c5b. MX342385B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US31313701P 2001-08-17 2001-08-17
PCT/US2002/026074 WO2003015819A1 (en) 2001-08-17 2002-08-17 Complement pathway inhibitors binding to c5 and c5a without preventing formation of c5b

Publications (1)

Publication Number Publication Date
MX342385B true MX342385B (es) 2016-09-27

Family

ID=23214536

Family Applications (2)

Application Number Title Priority Date Filing Date
MX2015001193A MX342385B (es) 2001-08-17 2002-08-17 Inhibidores de la ruta del complemento que se unen a c5 y c5a sin evitar la formación de c5b.
MXPA04001301A MXPA04001301A (es) 2001-08-17 2002-08-17 Inhibidores de la ruta del complemento que se unen a c5 y c5a son evitar la formacion de c5b.

Family Applications After (1)

Application Number Title Priority Date Filing Date
MXPA04001301A MXPA04001301A (es) 2001-08-17 2002-08-17 Inhibidores de la ruta del complemento que se unen a c5 y c5a son evitar la formacion de c5b.

Country Status (14)

Country Link
US (6) US7432356B2 (es)
EP (1) EP1425042B2 (es)
JP (2) JP4958387B2 (es)
CN (2) CN100391537C (es)
AT (1) ATE360441T1 (es)
AU (1) AU2002331601B2 (es)
BR (1) BRPI0211953B8 (es)
CA (1) CA2457461C (es)
DE (1) DE60219801T3 (es)
ES (1) ES2283594T5 (es)
HK (1) HK1071304A1 (es)
MX (2) MX342385B (es)
PT (1) PT1425042E (es)
WO (1) WO2003015819A1 (es)

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MXPA04001301A (es) 2004-07-08
BRPI0211953B8 (pt) 2021-05-25
US20150086572A1 (en) 2015-03-26
US8907072B2 (en) 2014-12-09
AU2002331601B2 (en) 2006-04-13
CA2457461C (en) 2013-12-24
US20130230522A1 (en) 2013-09-05
US8206716B2 (en) 2012-06-26
US7432356B2 (en) 2008-10-07
PT1425042E (pt) 2007-07-11
CN101387646B (zh) 2016-08-10
EP1425042A4 (en) 2004-09-29
BRPI0211953B1 (pt) 2019-05-28
ES2283594T5 (es) 2016-03-15
ATE360441T1 (de) 2007-05-15
EP1425042B1 (en) 2007-04-25
DE60219801T2 (de) 2008-01-17
ES2283594T3 (es) 2007-11-01
CA2457461A1 (en) 2003-02-27
US20160200805A1 (en) 2016-07-14
JP2005508889A (ja) 2005-04-07
JP4958387B2 (ja) 2012-06-20
CN1553813A (zh) 2004-12-08
US20080118508A1 (en) 2008-05-22
BR0211953A (pt) 2005-02-01
JP5752374B2 (ja) 2015-07-22
US20120301483A1 (en) 2012-11-29
CN100391537C (zh) 2008-06-04
WO2003015819A1 (en) 2003-02-27
DE60219801D1 (de) 2007-06-06
DE60219801T3 (de) 2016-06-16
US20030129187A1 (en) 2003-07-10
EP1425042A1 (en) 2004-06-09
JP2011051987A (ja) 2011-03-17
CN101387646A (zh) 2009-03-18
EP1425042B2 (en) 2016-02-10
US8372404B2 (en) 2013-02-12
HK1071304A1 (en) 2005-07-15

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