MX341935B - Metodo para producir piripiropeno. - Google Patents

Metodo para producir piripiropeno.

Info

Publication number
MX341935B
MX341935B MX2012008637A MX2012008637A MX341935B MX 341935 B MX341935 B MX 341935B MX 2012008637 A MX2012008637 A MX 2012008637A MX 2012008637 A MX2012008637 A MX 2012008637A MX 341935 B MX341935 B MX 341935B
Authority
MX
Mexico
Prior art keywords
pyripyropene
manufacturing
biosynthesis
microorganism
culturing
Prior art date
Application number
MX2012008637A
Other languages
English (en)
Other versions
MX2012008637A (es
Inventor
Yamamoto Kentaro
Oyama Kazuhiko
Goto Kimihiko
Tsuchida Mariko
Mitomi Masaaki
Anzai Hiroyuki
Original Assignee
Meiji Seika Pharma Co Ltd *
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Meiji Seika Pharma Co Ltd * filed Critical Meiji Seika Pharma Co Ltd *
Publication of MX2012008637A publication Critical patent/MX2012008637A/es
Publication of MX341935B publication Critical patent/MX341935B/es

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
    • C12P17/181—Heterocyclic compounds containing oxygen atoms as the only ring heteroatoms in the condensed system, e.g. Salinomycin, Septamycin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0071—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1025—Acyltransferases (2.3)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1025—Acyltransferases (2.3)
    • C12N9/1029—Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/88—Lyases (4.)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/93—Ligases (6)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
    • C12P17/182—Heterocyclic compounds containing nitrogen atoms as the only ring heteroatoms in the condensed system
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y114/00—Oxidoreductases acting on paired donors, with incorporation or reduction of molecular oxygen (1.14)
    • C12Y114/13—Oxidoreductases acting on paired donors, with incorporation or reduction of molecular oxygen (1.14) with NADH or NADPH as one donor, and incorporation of one atom of oxygen (1.14.13)
    • C12Y114/13008—Flavin-containing monooxygenase (1.14.13.8), i.e. dimethylaniline-monooxygenase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y114/00—Oxidoreductases acting on paired donors, with incorporation or reduction of molecular oxygen (1.14)
    • C12Y114/14—Oxidoreductases acting on paired donors, with incorporation or reduction of molecular oxygen (1.14) with reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen (1.14.14)
    • C12Y114/14001—Unspecific monooxygenase (1.14.14.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y203/00—Acyltransferases (2.3)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y203/00—Acyltransferases (2.3)
    • C12Y203/01—Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y205/00—Transferases transferring alkyl or aryl groups, other than methyl groups (2.5)
    • C12Y205/01—Transferases transferring alkyl or aryl groups, other than methyl groups (2.5) transferring alkyl or aryl groups, other than methyl groups (2.5.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y406/00—Phosphorus-oxygen lyases (4.6)
    • C12Y406/01—Phosphorus-oxygen lyases (4.6.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y602/00—Ligases forming carbon-sulfur bonds (6.2)
    • C12Y602/01—Acid-Thiol Ligases (6.2.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/645—Fungi ; Processes using fungi
    • C12R2001/66—Aspergillus
    • C12R2001/69—Aspergillus oryzae

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

La presente invención se refiere a un método para fabricar un piripiropeno cultivando un microorganismo, creado mediante la introducción de un polinucleótido especifico, o un vector recombinante que comprende el mismo, junto con un compuesto intermediario necesario para la biosíntesis del piripiropeno A.
MX2012008637A 2010-01-26 2011-01-19 Metodo para producir piripiropeno. MX341935B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2010014727 2010-01-26
PCT/JP2011/050851 WO2011093185A1 (ja) 2010-01-26 2011-01-19 ピリピロペンの製造法

Publications (2)

Publication Number Publication Date
MX2012008637A MX2012008637A (es) 2012-09-07
MX341935B true MX341935B (es) 2016-09-08

Family

ID=44319175

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2012008637A MX341935B (es) 2010-01-26 2011-01-19 Metodo para producir piripiropeno.

Country Status (17)

Country Link
US (1) US9169504B2 (es)
EP (1) EP2530164B1 (es)
JP (1) JP5898960B2 (es)
KR (1) KR101840483B1 (es)
CN (3) CN104531726B (es)
AU (1) AU2011210967B2 (es)
BR (2) BR122021004512B8 (es)
CA (1) CA2788058C (es)
DK (1) DK2530164T3 (es)
ES (1) ES2645980T3 (es)
IL (1) IL221128A (es)
MX (1) MX341935B (es)
NZ (1) NZ601950A (es)
PL (1) PL2530164T3 (es)
RU (1) RU2587632C2 (es)
TW (1) TWI633190B (es)
WO (1) WO2011093185A1 (es)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013073689A1 (ja) * 2011-11-17 2013-05-23 Ｍｅｉｊｉ Ｓｅｉｋａファルマ株式会社 ピリピロペン生合成遺伝子発現植物体
BR112015016463B1 (pt) * 2013-01-16 2021-08-10 Basf Se Método para produzir uma formulação emulsionável
EP2978852B1 (en) 2013-03-28 2018-10-17 Basf Se Production of pyripyropenes from dry biomass
KR102844881B1 (ko) * 2018-06-12 2025-08-12 한국생명공학연구원 고수율의 페닐피로펜 에이 또는 피리피로펜 에이의 제조방법
CN108658949B (zh) * 2018-06-29 2021-05-25 云南大学 一种用作抗肿瘤药物的化合物及其生产方法
WO2020018888A1 (en) 2018-07-20 2020-01-23 The Board Of Regents Of The University Of Oklahoma Antimicrobial peptides and methods of use
US11254619B2 (en) * 2019-04-12 2022-02-22 Jeffrey Hanson Robbins Dry composition including effervescent agents, biostimulant, and plant nutrient
CN114350524B (zh) * 2022-01-07 2024-04-23 暨南大学附属第一医院（广州华侨医院） Mycoleptodiscin型吲哚倍半萜化合物、其生物合成方法及其用途
CN116904328B (zh) * 2023-07-13 2024-08-02 山东大学 一种高表达啶南平a的工程菌及发酵培养基
CN117281804A (zh) * 2023-11-14 2023-12-26 北京大学 烟酸及其新衍生物在制备预防或治疗肝癌药物中的新用途
CN119265049B (zh) * 2024-12-04 2025-04-01 鲁东大学 一株产啶南平a的菌株及应用

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JP2993767B2 (ja) 1991-06-06 1999-12-27 社団法人北里研究所 Ｆｏ−１２８９ａ物質およびその製造法
JP3233476B2 (ja) * 1992-10-22 2001-11-26 社団法人北里研究所 Ｆｏ−１２８９物質およびその製造法
KR0125129B1 (ko) 1993-10-08 1997-11-28 김은영 신규 아실-코에이 : 콜레스테롤 아실전이효소(acat) 활성 저해물질 및 이의 제조 방법
JPH08239385A (ja) 1995-03-03 1996-09-17 Kitasato Inst:The Ｆｏ−１２８９物質およびその製造法
JP3725198B2 (ja) 1995-03-27 2005-12-07 社団法人北里研究所 ピリピロペン誘導体
JPH08269063A (ja) 1995-03-28 1996-10-15 Kitasato Inst:The ピリピロペン誘導体
JPH08269062A (ja) 1995-03-30 1996-10-15 Kitasato Inst:The ピリピロペン誘導体
JPH08269066A (ja) 1995-04-03 1996-10-15 Kitasato Inst:The ピリピロペン誘導体
JPH08269064A (ja) 1995-04-03 1996-10-15 Kitasato Inst:The ピリピロペン誘導体
JPH08269065A (ja) 1995-04-03 1996-10-15 Kitasato Inst:The ピリピロペン誘導体
JP3688337B2 (ja) 1995-04-18 2005-08-24 社団法人北里研究所 ピリピロペン誘導体
GB2304718B (en) 1995-09-05 2000-01-19 Degussa The production of tryptophan by the bacterium escherichia coli
CN1156180A (zh) * 1995-09-05 1997-08-06 底古萨股份公司 用大肠杆菌生产色氨酸
KR100522446B1 (ko) 2003-01-07 2005-10-18 한국생명공학연구원 아실 코에이:콜레스테롤 아실 트란스퍼라제의 저해활성을갖는 화합물 또는 그 염을 유효성분으로 하는 살충제
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TWI388282B (zh) 2005-06-01 2013-03-11 Meiji Seika Pharma Co Ltd 害蟲控制劑
ES2379928T3 (es) 2006-11-30 2012-05-07 Meiji Seika Kaisha Ltd. Agente de control de plagas
NZ583710A (en) 2007-08-13 2012-03-30 Meiji Seika Pharma Co Ltd Method for producing pyripyropene derivative and production intermediate thereof
WO2009133098A2 (en) * 2008-04-29 2009-11-05 Dsm Ip Assets B.V. β-LACTAM PRODUCING STRAINS
PL2319923T3 (pl) * 2008-07-24 2014-05-30 Meiji Seika Pharma Co Ltd Geny biosyntezy pirypiropenu A
ES2655615T3 (es) * 2010-01-26 2018-02-20 Meiji Seika Pharma Co., Ltd. Estructura de ácido nucleico que contiene un grupo de genes de biosintesis de piripiropeno y un gen marcador

Also Published As

Publication number Publication date
JP5898960B2 (ja) 2016-04-06
US20130023017A1 (en) 2013-01-24
TW201139680A (en) 2011-11-16
EP2530164B1 (en) 2017-08-09
PL2530164T3 (pl) 2018-01-31
BR112012019456B8 (pt) 2022-08-02
CA2788058A1 (en) 2011-08-04
CN104017839A (zh) 2014-09-03
CN104531726B (zh) 2017-10-10
BR112012019456B1 (pt) 2021-06-22
US9169504B2 (en) 2015-10-27
CN104531726A (zh) 2015-04-22
CN102762737A (zh) 2012-10-31
CN104017839B (zh) 2017-01-18
NZ601950A (en) 2015-02-27
RU2012136449A (ru) 2014-03-10
AU2011210967A2 (en) 2013-01-10
RU2587632C2 (ru) 2016-06-20
AU2011210967B2 (en) 2016-06-23
MX2012008637A (es) 2012-09-07
TWI633190B (zh) 2018-08-21
KR20120120287A (ko) 2012-11-01
EP2530164A1 (en) 2012-12-05
BR112012019456A2 (pt) 2015-10-06
WO2011093185A1 (ja) 2011-08-04
BR122021004512B8 (pt) 2022-12-13
IL221128A0 (en) 2012-09-24
JPWO2011093185A1 (ja) 2013-06-06
DK2530164T3 (en) 2017-10-16
BR122021004512B1 (pt) 2021-08-17
ES2645980T3 (es) 2017-12-11
CA2788058C (en) 2018-04-17
KR101840483B1 (ko) 2018-05-04
IL221128A (en) 2017-06-29
AU2011210967A1 (en) 2012-09-06
CN102762737B (zh) 2016-05-04
EP2530164A4 (en) 2013-12-25

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