MX341176B - Compuestos de carboxamida y su uso como inhibidores de calpaina. - Google Patents

Compuestos de carboxamida y su uso como inhibidores de calpaina.

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Publication number
MX341176B
MX341176B MX2013007461A MX2013007461A MX341176B MX 341176 B MX341176 B MX 341176B MX 2013007461 A MX2013007461 A MX 2013007461A MX 2013007461 A MX2013007461 A MX 2013007461A MX 341176 B MX341176 B MX 341176B
Authority
MX
Mexico
Prior art keywords
compounds
carboxamide compounds
meanings mentioned
carboxamide
tautomers
Prior art date
Application number
MX2013007461A
Other languages
English (en)
Inventor
Hornberger Wilfried
W Hutchins Charles
Kling Andreas
Moeller Achim
Mack Helmut
Jantos Katja
Original Assignee
Abbott Gmbh & Co Kg
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=42470549&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MX341176(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Abbott Gmbh & Co Kg filed Critical Abbott Gmbh & Co Kg
Publication of MX341176B publication Critical patent/MX341176B/es

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    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/24—Oxygen or sulfur atoms
    • C07D207/26—2-Pyrrolidones
    • C07D207/273—2-Pyrrolidones with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to other ring carbon atoms
    • C07D207/277—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
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    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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Abstract

La presente invención se refiere a compuestos de carboxamida novedosos y su uso para la fabricación de un medicamento. Los compuestos de carboxamida son inhibidores de calpaína (cisteína proteasas dependientes de calcio). Por lo tanto, la invención también se refiere al uso de dichos compuestos de carboxamida para tratar un trastorno asociado con una alta actividad de calpaína. Los compuestos de carboxamida son compuestos de la fórmula general I, donde R1, R2, R3a, R3b, R4, Q, Y, A y X tienen los significados que se mencionan en las reivindicaciones y la descripción, los tautómeros de los mismos y las sales de los mismos apropiados para uso farmacéutico. En particular, los compuestos tienen la fórmula general la e Ib, donde R1, r, R2b, R3a, R3b, R4, Y y X tienen los significados que se mencionan en las reivindicaciones, incluyendo a los tautómeros de los mismos y a las sales farmacéuticamente apropiadas de los mismos. De dichos compuestos, se prefieren aquellos donde Y es una unidad CH2-CH2, CH2-CH2-CH2, N(RY#)-CH2, N(RY#)-CH2-CH2 o CH=CH-CH, en cada uno de los cuales opcionalmente se han reemplazado 1 ó 2 átomos de H por radicales RY idénticos o diferentes, donde RY# y RY# tienen los significados que se mencionan en las reivindicaciones.
MX2013007461A 2009-05-07 2010-05-06 Compuestos de carboxamida y su uso como inhibidores de calpaina. MX341176B (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US17613809P 2009-05-07 2009-05-07
US28975309P 2009-12-23 2009-12-23
PCT/EP2010/056166 WO2010128102A1 (en) 2009-05-07 2010-05-06 Carboxamide compounds and their use as calpain inhibitors

Publications (1)

Publication Number Publication Date
MX341176B true MX341176B (es) 2016-08-10

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AU2010244443B2 (en) 2014-07-31
PE20120901A1 (es) 2012-08-30
AU2010244443A1 (en) 2011-11-17
UY32615A (es) 2010-12-31
BRPI1014184A8 (pt) 2017-11-07
BRPI1014184A2 (pt) 2017-05-16
CO6470862A2 (es) 2012-06-29
SG2014014740A (en) 2014-07-30
ECSP11011503A (es) 2012-01-31
CA2760464A1 (en) 2010-11-11
EP2427429A1 (en) 2012-03-14
IL215835A (en) 2015-11-30
RU2011149635A (ru) 2013-06-20
US20110086879A1 (en) 2011-04-14
US8236798B2 (en) 2012-08-07
PH12013502359A1 (en) 2014-11-10
KR20140014388A (ko) 2014-02-06
WO2010128102A1 (en) 2010-11-11
ES2625437T3 (es) 2017-07-19
US20130150367A1 (en) 2013-06-13
DOP2011000338A (es) 2012-01-31
TW201041876A (en) 2010-12-01
MX2011011764A (es) 2012-02-28
SG175320A1 (en) 2011-11-28
CR20110630A (es) 2012-04-12
AR076755A1 (es) 2011-07-06
NZ596000A (en) 2013-10-25
JP5709846B2 (ja) 2015-04-30
PH12013502359B1 (en) 2014-11-10
US20150099786A1 (en) 2015-04-09
UA107459C2 (uk) 2015-01-12
EP2427429B1 (en) 2017-02-15
CN102482212A (zh) 2012-05-30
DOP2012000210A (es) 2012-09-30
US9018206B2 (en) 2015-04-28
JP2012526082A (ja) 2012-10-25
IL215835A0 (en) 2012-01-31
CN102482212B (zh) 2015-08-26
US20100286146A1 (en) 2010-11-11
TWI457334B (zh) 2014-10-21
US8283363B2 (en) 2012-10-09
CL2011002766A1 (es) 2012-05-25
RU2540856C2 (ru) 2015-02-10
US9527811B2 (en) 2016-12-27

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