UA107459C2 - Карбоксамідні сполуки і їх застосування як інгібіторів кальпаїну - Google Patents

Карбоксамідні сполуки і їх застосування як інгібіторів кальпаїну

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Publication number
UA107459C2
UA107459C2 UAA201114464A UAA201114464A UA107459C2 UA 107459 C2 UA107459 C2 UA 107459C2 UA A201114464 A UAA201114464 A UA A201114464A UA A201114464 A UAA201114464 A UA A201114464A UA 107459 C2 UA107459 C2 UA 107459C2
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UA
Ukraine
Prior art keywords
compounds
carboxamide compounds
meanings mentioned
carboxamide
tautomers
Prior art date
Application number
UAA201114464A
Other languages
English (en)
Russian (ru)
Inventor
Хельмут Мак
Андреас КЛІНГ
Катя ЯНТОС
Ахім Меллер
Вільфрід Хорнбергер
Чарльз В. Хатчінс
Original Assignee
Ебботт Гмбх Унд Ко. Кг
Еббві Інк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=42470549&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=UA107459(C2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Ебботт Гмбх Унд Ко. Кг, Еббві Інк. filed Critical Ебботт Гмбх Унд Ко. Кг
Publication of UA107459C2 publication Critical patent/UA107459C2/uk

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    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
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  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Даний винахід стосується нових карбоксамідних сполук та їх застосування для виробництва лікарського засобу. Карбоксамідні сполуки є інгібіторами кальпаїну (кальційзалежних цистеїнпротеаз). Отже, винахід також стосується застосування таких карбоксамідних сполук для лікування розладу, асоційованого з підвищеною активністю кальпаїну. Карбоксамідні сполуки являють собою сполуки загальної формули (І), де R1, R2, R3a, R3b, R4, Q, Y, А і X мають значення, вказані у формулі винаходу і в описі, їх таутомери й їх фармацевтично прийнятні солі. Зокрема, сполуки мають загальну формулу (Іа) і (Іb), де R1, r, R2b, R3a, R3b, R4, Y і X мають значення, вказані у формулі винаходу, включаючи їх таутомери і їх фармацевтично прийнятні солі. Серед таких сполук переважними є такі сполуки, де Y являє собою фрагмент СН2-СН2, СН2-СН2-СН2, N(Ry#)-CH2, N(Ry#)-CH2-CH2 або СН=СН-СН=, кожний з яких необов'язково містить 1 або 2 атоми Н, які замінені однаковими або різними радикалами Ry, де Ry і Ry# мають значення, вказані у формулі винаходу. EMBED ISISServer , (I) EMBED ISISServer , (Ia) EMBED ISISServer (Ib).
UAA201114464A 2009-05-07 2010-05-06 Карбоксамідні сполуки і їх застосування як інгібіторів кальпаїну UA107459C2 (uk)

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