MX340718B - Proceso y sistema para obtener neurotoxina botulinica. - Google Patents
Proceso y sistema para obtener neurotoxina botulinica.Info
- Publication number
- MX340718B MX340718B MX2014008854A MX2014008854A MX340718B MX 340718 B MX340718 B MX 340718B MX 2014008854 A MX2014008854 A MX 2014008854A MX 2014008854 A MX2014008854 A MX 2014008854A MX 340718 B MX340718 B MX 340718B
- Authority
- MX
- Mexico
- Prior art keywords
- botulinum neurotoxin
- obtaining
- obtaining botulinum
- therapeutic
- research
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/52—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from bacteria or Archaea
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
- B01D15/08—Selective adsorption, e.g. chromatography
- B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
- B01D15/36—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving ionic interaction
- B01D15/361—Ion-exchange
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
- B01D15/08—Selective adsorption, e.g. chromatography
- B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
- B01D15/36—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving ionic interaction
- B01D15/361—Ion-exchange
- B01D15/362—Cation-exchange
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
- B01D15/08—Selective adsorption, e.g. chromatography
- B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
- B01D15/36—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving ionic interaction
- B01D15/361—Ion-exchange
- B01D15/363—Anion-exchange
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/16—Extraction; Separation; Purification by chromatography
- C07K1/18—Ion-exchange chromatography
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/33—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Clostridium (G)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/20—Bacteria; Culture media therefor
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
- C12R2001/00—Microorganisms ; Processes using microorganisms
- C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
- C12R2001/145—Clostridium
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/24—Metalloendopeptidases (3.4.24)
- C12Y304/24069—Bontoxilysin (3.4.24.69), i.e. botulinum neurotoxin
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Analytical Chemistry (AREA)
- Biotechnology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biophysics (AREA)
- Microbiology (AREA)
- General Engineering & Computer Science (AREA)
- Gastroenterology & Hepatology (AREA)
- Biomedical Technology (AREA)
- Virology (AREA)
- Tropical Medicine & Parasitology (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Immunology (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
La presente invención se refiere a un sistema cromatográfico sustancialmente libre de producto animal (APF) para obtener una neurotoxina botulínica biológicamente activa, caracterizada porque comprende: un primer aparato para cultivar la bacteria Clostridium botulinum, el primer aparato es capaz de contener un medio de cultivo sustancialmente APF; un segundo aparato para fermentar bacteria Clostridium botulinum, la cual ha sido cultivada en el primer aparato, el segundo aparato es capaz de contener un medio de fermentación sustancialmente APF; un tercer aparato para recolectar el medio de fermentación; un cuarto aparato para concentrar el medio de fermentación cosechado y diluir el medio de fermentación filtrado; un quinto aparato para llevar a cabo una primera purificación de la neurotoxina botulínica del medio cosechado en donde el quinto aparato comprende un medio de cromatografía de intercambio aniónico, por lo que se obtiene una primera neurotoxina botulínica purificada; y un sexto aparato para llevar a cabo una segundo purificación dela primera neurotoxina botulínica purificada en donde el sexto aparato comprende un medio de cromatografía de intercambio catiónico por lo que se obtiene una segunda neurotoxina botulínica purificada, en donde la neurotoxina boltulínica obtenida tiene una potencia de por lo menos aproximadamente 2.0 veces 107 unidades/mg de la neurotoxina botulínica, la neurotoxina botulínica obtenida comprende 1 ng o menos de 1 ng de ácido nucleico residual por cada mg de neurotoxina botulínica obtenida y el proceso se lleva a cabo en una semana o menos.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US12/502,181 US8129139B2 (en) | 2009-07-13 | 2009-07-13 | Process for obtaining botulinum neurotoxin |
PCT/US2010/041745 WO2011008713A1 (en) | 2009-07-13 | 2010-07-12 | Process and system for obtaining botulinum neurotoxin |
Publications (1)
Publication Number | Publication Date |
---|---|
MX340718B true MX340718B (es) | 2016-07-22 |
Family
ID=42537891
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2014008854A MX340718B (es) | 2009-07-13 | 2010-07-12 | Proceso y sistema para obtener neurotoxina botulinica. |
MX2012000615A MX2012000615A (es) | 2009-07-13 | 2010-07-12 | Proceso y sistema para obtener neurotoxina botulinica. |
MX2020009978A MX2020009978A (es) | 2009-07-13 | 2012-01-12 | Proceso y sistema para obtener neurotoxina botulinica. |
Family Applications After (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2012000615A MX2012000615A (es) | 2009-07-13 | 2010-07-12 | Proceso y sistema para obtener neurotoxina botulinica. |
MX2020009978A MX2020009978A (es) | 2009-07-13 | 2012-01-12 | Proceso y sistema para obtener neurotoxina botulinica. |
Country Status (19)
Country | Link |
---|---|
US (19) | US8129139B2 (es) |
EP (5) | EP3252070B1 (es) |
JP (5) | JP5887268B2 (es) |
KR (5) | KR101916139B1 (es) |
CN (2) | CN102482332B (es) |
BR (1) | BR112012000784A2 (es) |
CA (1) | CA2767760C (es) |
CY (2) | CY1119519T1 (es) |
DK (2) | DK2454275T3 (es) |
ES (2) | ES2643554T3 (es) |
HK (1) | HK1247629A1 (es) |
HU (2) | HUE047362T2 (es) |
IN (1) | IN2012DN00456A (es) |
MX (3) | MX340718B (es) |
PL (2) | PL3252070T3 (es) |
PT (2) | PT3252070T (es) |
RU (1) | RU2561459C2 (es) |
SI (2) | SI3252070T1 (es) |
WO (1) | WO2011008713A1 (es) |
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US8168206B1 (en) | 2005-10-06 | 2012-05-01 | Allergan, Inc. | Animal protein-free pharmaceutical compositions |
US8129139B2 (en) * | 2009-07-13 | 2012-03-06 | Allergan, Inc. | Process for obtaining botulinum neurotoxin |
CA2773396C (en) | 2009-10-21 | 2020-12-15 | Revance Therapeutics, Inc. | Methods and systems for purifying non-complexed botulinum neurotoxin |
KR20110046178A (ko) * | 2009-10-28 | 2011-05-04 | 엘지전자 주식회사 | 이동 단말기 |
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KR20190126894A (ko) * | 2017-03-22 | 2019-11-12 | 본티, 인크. | 치료법에서 사용하기 위한 보툴리눔 신경독소 |
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