IN2012DN00456A - - Google Patents

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Publication number
IN2012DN00456A
IN2012DN00456A IN456DEN2012A IN2012DN00456A IN 2012DN00456 A IN2012DN00456 A IN 2012DN00456A IN 456DEN2012 A IN456DEN2012 A IN 456DEN2012A IN 2012DN00456 A IN2012DN00456 A IN 2012DN00456A
Authority
IN
India
Prior art keywords
therapeutic
research
rapid
systems
animal protein
Prior art date
Application number
Inventor
L Ton Jennifer
A Patel Hemant
C Bates Ronald
M Ahmad Wajdie
Original Assignee
Allergan Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=42537891&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=IN2012DN00456(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Allergan Inc filed Critical Allergan Inc
Publication of IN2012DN00456A publication Critical patent/IN2012DN00456A/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/52—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from bacteria or Archaea
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/33—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Clostridium (G)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/36—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving ionic interaction, e.g. ion-exchange, ion-pair, ion-suppression or ion-exclusion
    • B01D15/361—Ion-exchange
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/36—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving ionic interaction, e.g. ion-exchange, ion-pair, ion-suppression or ion-exclusion
    • B01D15/361—Ion-exchange
    • B01D15/362—Cation-exchange
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/36—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving ionic interaction, e.g. ion-exchange, ion-pair, ion-suppression or ion-exclusion
    • B01D15/361—Ion-exchange
    • B01D15/363—Anion-exchange
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/18—Ion-exchange chromatography
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/145—Clostridium
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/24—Metalloendopeptidases (3.4.24)
    • C12Y304/24069—Bontoxilysin (3.4.24.69), i.e. botulinum neurotoxin
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Analytical Chemistry (AREA)
  • Biotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biomedical Technology (AREA)
  • Virology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Immunology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

Rapid, animal protein free, chromatographic processes and systems for obtaining high potency, high yield botulinum neurotoxin for research, therapeutic and cosmetic use.
IN456DEN2012 2009-07-13 2010-07-12 IN2012DN00456A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US12/502,181 US8129139B2 (en) 2009-07-13 2009-07-13 Process for obtaining botulinum neurotoxin
PCT/US2010/041745 WO2011008713A1 (en) 2009-07-13 2010-07-12 Process and system for obtaining botulinum neurotoxin

Publications (1)

Publication Number Publication Date
IN2012DN00456A true IN2012DN00456A (en) 2015-05-15

Family

ID=42537891

Family Applications (1)

Application Number Title Priority Date Filing Date
IN456DEN2012 IN2012DN00456A (en) 2009-07-13 2010-07-12

Country Status (18)

Country Link
US (19) US8129139B2 (en)
EP (5) EP4141024A1 (en)
JP (6) JP5887268B2 (en)
KR (5) KR20180122039A (en)
CN (2) CN106117325B (en)
BR (1) BR112012000784A2 (en)
CA (1) CA2767760C (en)
CY (2) CY1119519T1 (en)
DK (2) DK2454275T3 (en)
ES (2) ES2770031T3 (en)
HU (2) HUE047362T2 (en)
IN (1) IN2012DN00456A (en)
MX (4) MX375629B (en)
PL (2) PL2454275T3 (en)
PT (2) PT3252070T (en)
RU (1) RU2561459C2 (en)
SI (2) SI2454275T1 (en)
WO (1) WO2011008713A1 (en)

Families Citing this family (43)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8632785B2 (en) * 2000-02-08 2014-01-21 Allergan, Inc. Clostridial toxin pharmaceutical composition containing a gelatin fragment
BRPI0508374A (en) 2005-03-03 2007-07-31 Allergan Inc means for clostridial bacteria and process for obtaining a clostridial toxin
US8168206B1 (en) 2005-10-06 2012-05-01 Allergan, Inc. Animal protein-free pharmaceutical compositions
US8129139B2 (en) 2009-07-13 2012-03-06 Allergan, Inc. Process for obtaining botulinum neurotoxin
LT2490986T (en) 2009-10-21 2018-11-26 Revance Therapeutics, Inc. Methods and systems for purifying non-complexed botulinum neurotoxin
KR20110046178A (en) * 2009-10-28 2011-05-04 엘지전자 주식회사 Mobile terminal
KR101134146B1 (en) 2010-05-31 2012-04-19 메덱스젠 주식회사 A method of isolating a non-diffusible and local-paralyzing botulinum toxin subfraction from conventional toxin preparations for clinical use
US9605887B2 (en) 2011-07-29 2017-03-28 Hdt Expeditionary Systems, Inc. Transportable packaged ice supply system for high temperature environments
GB201113544D0 (en) * 2011-08-05 2011-09-21 Fujifilm Diosynth Biotechnologies Uk Ltd Purification process
WO2014197837A1 (en) * 2013-06-06 2014-12-11 University Of Florida Research Foundation, Inc. Materials and methods for producing a biological toxin
KR102272580B1 (en) 2013-07-30 2021-07-05 메르츠 파마 게엠베하 운트 코. 카가아 Process for preparing a highly pure neurotoxic component of a botulinum toxin and uses thereof
KR101339349B1 (en) 2013-08-02 2013-12-09 주식회사 대웅 Methods for preparing botulinum toxin
US20160287693A1 (en) * 2013-11-15 2016-10-06 Novartis Ag Removal of residual cell culture impurities
US9480731B2 (en) * 2013-12-12 2016-11-01 Medy-Tox, Inc. Long lasting effect of new botulinum toxin formulations
GB201407525D0 (en) * 2014-04-29 2014-06-11 Syntaxin Ltd Manufacture of recombinant clostridium botulinum neurotoxins
KR101729251B1 (en) * 2015-04-28 2017-04-21 주식회사 대웅 Medium Composition for Preparing Botulinum Toxin
GB201517450D0 (en) * 2015-10-02 2015-11-18 Ipsen Biopharm Ltd Method
KR101775682B1 (en) * 2015-11-30 2017-09-06 주식회사 대웅 Methods for Preparing Botulinum Toxin
WO2017161345A1 (en) 2016-03-18 2017-09-21 Biomadison, Inc. Improved cell based assay
AU2017326253B2 (en) 2016-09-13 2021-10-21 Allergan, Inc. Stabilized non-protein clostridial toxin compositions
KR102463881B1 (en) * 2016-10-04 2022-11-07 (주)메디톡스 Method for isolating botulinum toxin from a solution containing botulinum toxin
RU2766147C2 (en) * 2017-03-22 2022-02-08 Бонти, Инк. Use of botulinum neurotoxins in treatment
US20210108187A1 (en) * 2017-04-28 2021-04-15 Bonti, Inc. Botulinum neurotoxins production methods
US20210145955A1 (en) * 2017-06-26 2021-05-20 Bonti, Inc. Clostridial neurotoxin formulations and use
KR102140531B1 (en) * 2018-08-07 2020-08-04 (주)휴온스 The processing method of Gly-Tβ4
CN113056478A (en) 2018-12-21 2021-06-29 一般财团法人阪大微生物病研究会 Method for producing botulinum toxin
KR102209159B1 (en) 2019-03-29 2021-01-29 (주)제테마 A Method for Producing a Toxin
KR102197224B1 (en) 2019-03-29 2020-12-31 (주)제테마 A Composition for Culturing Bacteria
KR102516203B1 (en) * 2019-04-15 2023-03-30 (주)제테마 Method for preparing Botulinum Toxin
KR102485146B1 (en) * 2019-04-15 2023-01-06 (주)제테마 Method for preparing Botulinum Toxin
US10851363B1 (en) * 2019-05-22 2020-12-01 Boke Zhang Multilayer nano-cell containing biomolecules
KR102287437B1 (en) * 2019-08-14 2021-08-09 주식회사 프로톡스 Method for preparing botulinum toxin
TW202136286A (en) * 2019-12-20 2021-10-01 瑞士商葛德瑪控股公司 Method of purifying botulinum toxin
TWI854077B (en) * 2019-12-20 2024-09-01 瑞士商葛德瑪控股公司 Method of producing botulinum toxin
CN114958887B (en) * 2021-02-26 2024-10-25 重庆誉颜制药有限公司 Preparation method of modified toxin polypeptide
KR102724651B1 (en) * 2021-07-08 2024-11-01 주식회사 파마리서치바이오 A method for purifying clostridium botulinum neurotoxin with reduced non-toxic proteins
KR102427362B1 (en) * 2021-11-11 2022-08-01 (주)이니바이오 Drying system for Botulinum toxin formulation
KR102850152B1 (en) * 2022-07-27 2025-08-25 (주)이니바이오 Drying apparatus under reduced pressure and drying method therefor
US20250295741A1 (en) 2022-11-07 2025-09-25 Allergan, Inc. Prevention of post-operative atrial fibrillation with a botulinum toxin
CH720447A2 (en) 2023-01-20 2024-07-31 Abbvie Inc COMPOSITIONS OF CLOSTRIDIUM BOTULINUM NEUROTOXIN SEROTYPE A
CH720444A2 (en) 2023-01-20 2024-07-31 Abbvie Inc CLOSTRIDIUM BOTULINUM SEROTYPE A NEUROTOXIN (BONT/A) SEQUENCE VARIANTS
WO2025111258A1 (en) * 2023-11-20 2025-05-30 Abbvie Inc. Clostridium botulinum neurotoxin serotype a compositions and improved filtration processes
DE102025101336A1 (en) * 2024-01-19 2025-07-24 Abbvie Inc. COMPOSITIONS OF CLOSTRIDIUM BOTULINUM NEUROTOXIN SEROTYPE A AND IMPROVED DRYING PROCESSES

Family Cites Families (62)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4401683A (en) * 1981-07-06 1983-08-30 Fmc Corporation Carbohydrate food products resistant to Clostridium botulinum and the formation of enterotoxin
AU4646393A (en) 1992-06-23 1994-01-24 Interactive Biologics Associates Pharmaceutical composition containing botulinum b complex
TW257792B (en) * 1992-10-01 1995-09-21 Lilly Co Eli
ES2148116T1 (en) 1992-10-13 2000-10-16 Univ Duke METHODS OF DETECTING ALZHEIMER'S DISEASE.
US5314822A (en) 1992-10-15 1994-05-24 Merck & Co., Inc. Method of clonal growth of Streptococcus pneumoniae
GB9411138D0 (en) 1994-06-03 1994-07-27 Microbiological Res Authority Toxin assay
US5962637A (en) 1994-06-03 1999-10-05 Microbiological Research Authority Toxin assay
WO1996005222A1 (en) 1994-08-08 1996-02-22 Wisconsin Alumni Research Foundation Purification and pharmaceutical compositions containing type g botulinum neurotoxin
US5756468A (en) 1994-10-13 1998-05-26 Wisconsin Alumni Research Foundation Pharmaceutical compositions of botulinum toxin or botulinum neurotoxin and methods of preparation
US5512547A (en) 1994-10-13 1996-04-30 Wisconsin Alumni Research Foundation Pharmaceutical composition of botulinum neurotoxin and method of preparation
ES2198484T3 (en) 1995-06-06 2004-02-01 L. Bruce Pearce COMPOSITIONS AND IMPROVED PROCEDURES FOR CHEMICALDERVATION USING NEUROTOXINS.
US6444209B1 (en) 1996-10-28 2002-09-03 Wisconsin Alumni Research Foundation Hybrid botulinal neurotoxins
EP2199382A3 (en) 1997-05-28 2010-09-22 Novartis Vaccines and Diagnostics S.r.l. Culture medium with yeast or soy bean extract as aminoacid source and no protein complexes of animal origin
JP4055248B2 (en) 1998-05-25 2008-03-05 味の素株式会社 Purified human activin and method for producing the same
GB9902000D0 (en) 1999-01-30 1999-03-17 Delta Biotechnology Ltd Process
DE19925739A1 (en) 1999-06-07 2000-12-21 Biotecon Ges Fuer Biotechnologische Entwicklung & Consulting Mbh Therapeutic with a botulinum neurotoxin
US6558926B1 (en) 1999-07-16 2003-05-06 Massachusetts Institute Of Technology Method for production of tetanus toxin using media substantially free of animal products
WO2001036655A2 (en) 1999-11-12 2001-05-25 Eli Lilly And Company Method for optimization of a medium for glycopeptide fermentation
WO2001036635A2 (en) 1999-11-15 2001-05-25 Curagen Corporation Neurite outgrowth-promoting factor homologue and nucleic acids encoding same
DE10004024A1 (en) 2000-01-31 2001-08-02 Guenther Bebenroth Circuit arrangement for operating light-emitting diodes
PT1253932E (en) 2000-02-08 2005-07-29 Allergan Inc PHARMACEUTICAL COMPOUNDS OF BOTULINIC TOXIN
US8632785B2 (en) 2000-02-08 2014-01-21 Allergan, Inc. Clostridial toxin pharmaceutical composition containing a gelatin fragment
US20030118598A1 (en) * 2000-02-08 2003-06-26 Allergan, Inc. Clostridial toxin pharmaceutical compositions
US20060269575A1 (en) * 2000-02-08 2006-11-30 Allergan, Inc. Botulinum toxin pharmaceutical compositions formulated with recombinant albumin
US6811067B2 (en) 2000-02-10 2004-11-02 Magna International Inc. Vehicle tailgate with storage capacity
JP2003009897A (en) * 2001-07-03 2003-01-14 Keiji Oguma Method for separating and purifying botulinus toxin
JP2005508892A (en) * 2001-08-14 2005-04-07 スタテンズ セーラム インスティテュート Purification method for large-scale production of Gc-globulin, substances obtained thereby and their pharmaceutical use
US7208285B2 (en) 2001-08-28 2007-04-24 Allergan, Inc. Fret protease assays for botulinum serotype A/E toxins
US8022172B2 (en) 2001-08-28 2011-09-20 Allergan, Inc. Luminescence resonance energy transfer (LRET) assays for clostridial toxin activity
US7332567B2 (en) 2001-08-28 2008-02-19 Allergan, Inc. Fret protease assays for clostridial toxins
KR20030060150A (en) 2002-01-07 2003-07-16 (주)메디톡스 Method for purifying clostridium botulinum a type toxin
RU2230325C2 (en) * 2002-08-15 2004-06-10 Научно-исследовательский институт микробиологии Министерства обороны Российской Федерации Method for preparing purified preparation of botulinic toxin type a
US7183066B2 (en) 2002-09-27 2007-02-27 Allergan, Inc. Cell-based fluorescence resonance energy transfer (FRET) assays for clostridial toxins
US20040235139A1 (en) * 2002-12-23 2004-11-25 Demain Arnold L. Clostridium difficile culture and toxin production methods
CA2472611C (en) * 2003-07-02 2009-09-15 Filtertek Inc. Multiple retainer bridge
US7452697B2 (en) * 2003-09-25 2008-11-18 Allergan, Inc. Chromatographic method and system for purifying a botulinum toxin
US7160699B2 (en) 2003-09-25 2007-01-09 Allergan, Inc. Media for clostridium bacterium and processes for obtaining a clostridial toxin
US7148041B2 (en) * 2003-09-25 2006-12-12 Allergan, Inc. Animal product free media and processes for obtaining a botulinum toxin
US20070264373A1 (en) 2004-01-26 2007-11-15 Ian Carroll Toxin Induced Sympathectomy
US7598027B2 (en) 2004-02-24 2009-10-06 Allergan, Inc. Botulinum toxin screening assays
CN102139099A (en) 2004-07-26 2011-08-03 莫茨药物股份两合公司 Therapeutic composition with a botulinum neurotoxin
US20060069562A1 (en) 2004-09-10 2006-03-30 Adams Marilyn J Word categories
US7399607B2 (en) 2004-09-22 2008-07-15 Allergan, Inc. Fluorescence polarization assays for determining clostridial toxin activity
WO2006042149A2 (en) 2004-10-06 2006-04-20 Allergan, Inc. Determining and reducing immunoresistance to botulinum toxin therapy using botulinum toxin a peptides
US20070277577A1 (en) * 2004-10-29 2007-12-06 Allen Clyde G Sheet metal brake and hinge mechanism therefor
CN101098883B (en) * 2004-12-23 2013-01-23 诺和诺德医疗保健公司 Reduction of the content of protein contaminants in compositions comprising a vitamin k-dependent protein of interest
BRPI0508374A (en) 2005-03-03 2007-07-31 Allergan Inc means for clostridial bacteria and process for obtaining a clostridial toxin
EP1869459B1 (en) 2005-04-05 2010-06-09 Allergan, Inc. Lipophilic dye-based fret assays for clostridial toxin activity
US8323666B2 (en) 2005-08-01 2012-12-04 Allergan, Inc. Botulinum toxin compositions
US7744904B1 (en) 2005-09-26 2010-06-29 B.B. Scientific L.L.C. Stabilization of Clostridium botulinum neurotoxin complex
AU2006315117A1 (en) 2005-11-17 2007-05-24 Revance Therapeutics, Inc. Compositions and methods of topical application and transdermal delivery of botulinum toxins with reduced non-toxin proteins
LT3031825T (en) 2008-03-14 2020-02-10 Allergan, Inc. METHODS OF IMMUNITY TESTING FOR BOTULIN TOXIN SEROTYPE A ACTIVITY
KR20090120222A (en) 2008-05-19 2009-11-24 (주)메디톡스 Method for producing Clostridium botulinum toxin using a plant-derived component-containing medium and a flexible closed container
JP5826635B2 (en) 2009-03-13 2015-12-02 アラーガン、インコーポレイテッドＡｌｌｅｒｇａｎ，Ｉｎｃｏｒｐｏｒａｔｅｄ Immune system-regulated endopeptidase activity assay
US8129139B2 (en) 2009-07-13 2012-03-06 Allergan, Inc. Process for obtaining botulinum neurotoxin
LT2490986T (en) 2009-10-21 2018-11-26 Revance Therapeutics, Inc. Methods and systems for purifying non-complexed botulinum neurotoxin
NL2010545C2 (en) 2013-03-28 2014-09-30 Ihc Holland Ie Bv Skidding system for an offshore installation or vessel.
KR101339349B1 (en) 2013-08-02 2013-12-09 주식회사 대웅 Methods for preparing botulinum toxin
US9889608B2 (en) 2014-11-10 2018-02-13 International Business Machines Corporation Matching the scale of independent objects or intelligently scaling objects when 3D printing
KR101723167B1 (en) 2015-04-28 2017-04-05 주식회사 대웅 Medium Composition for Preparing Botulinum Toxin
KR101775682B1 (en) 2015-11-30 2017-09-06 주식회사 대웅 Methods for Preparing Botulinum Toxin
KR102463881B1 (en) 2016-10-04 2022-11-07 (주)메디톡스 Method for isolating botulinum toxin from a solution containing botulinum toxin

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