MX340402B - Inhibidores triciclicos de cinasas. - Google Patents
Inhibidores triciclicos de cinasas.Info
- Publication number
- MX340402B MX340402B MX2013009873A MX2013009873A MX340402B MX 340402 B MX340402 B MX 340402B MX 2013009873 A MX2013009873 A MX 2013009873A MX 2013009873 A MX2013009873 A MX 2013009873A MX 340402 B MX340402 B MX 340402B
- Authority
- MX
- Mexico
- Prior art keywords
- kinases
- tricyclic inhibitors
- compounds
- relates
- present
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
- C07D487/14—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161447405P | 2011-02-28 | 2011-02-28 | |
| PCT/US2012/026685 WO2012161812A1 (en) | 2011-02-28 | 2012-02-27 | Tricyclic inhibitors of kinases |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MX2013009873A MX2013009873A (es) | 2014-03-12 |
| MX340402B true MX340402B (es) | 2016-07-07 |
Family
ID=46000328
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2013009873A MX340402B (es) | 2011-02-28 | 2012-02-27 | Inhibidores triciclicos de cinasas. |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US8710065B2 (https=) |
| EP (1) | EP2681221B1 (https=) |
| JP (1) | JP5886326B2 (https=) |
| CN (1) | CN103703005A (https=) |
| AR (1) | AR085502A1 (https=) |
| CA (1) | CA2827648A1 (https=) |
| ES (1) | ES2587514T3 (https=) |
| MX (1) | MX340402B (https=) |
| TW (1) | TWI532742B (https=) |
| UY (1) | UY33925A (https=) |
| WO (1) | WO2012161812A1 (https=) |
Families Citing this family (61)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8754114B2 (en) | 2010-12-22 | 2014-06-17 | Incyte Corporation | Substituted imidazopyridazines and benzimidazoles as inhibitors of FGFR3 |
| ES2704744T3 (es) | 2012-06-13 | 2019-03-19 | Incyte Holdings Corp | Compuestos tricíclicos sustituidos como inhibidores de FGFR |
| US9388185B2 (en) | 2012-08-10 | 2016-07-12 | Incyte Holdings Corporation | Substituted pyrrolo[2,3-b]pyrazines as FGFR inhibitors |
| US9266892B2 (en) | 2012-12-19 | 2016-02-23 | Incyte Holdings Corporation | Fused pyrazoles as FGFR inhibitors |
| EA035095B1 (ru) | 2013-04-19 | 2020-04-27 | Инсайт Холдингс Корпорейшн | Бициклические гетероциклы в качестве ингибиторов fgfr |
| WO2015029447A1 (ja) * | 2013-08-30 | 2015-03-05 | 興和株式会社 | 光学活性カルビノール化合物の製造方法 |
| GB201322602D0 (en) * | 2013-12-19 | 2014-02-05 | Almac Discovery Ltd | Pharmaceutical compounds |
| US10300055B2 (en) | 2014-04-10 | 2019-05-28 | Dalhousie University | Treatment of parkinson's disease through ARFGAP1 inhibition |
| WO2016033105A1 (en) * | 2014-08-29 | 2016-03-03 | The Board Of Regents Of The University Of Texas System | Novel capsazepine analogs for the treatment of cancer and other proliferative diseases |
| US10851105B2 (en) | 2014-10-22 | 2020-12-01 | Incyte Corporation | Bicyclic heterocycles as FGFR4 inhibitors |
| MA41551A (fr) | 2015-02-20 | 2017-12-26 | Incyte Corp | Hétérocycles bicycliques utilisés en tant qu'inhibiteurs de fgfr4 |
| MX373169B (es) | 2015-02-20 | 2020-04-24 | Incyte Holdings Corp | Heterociclos bicíclicos como inhibidores de receptores del factor de crecimiento fibroblástico (fgfr). |
| WO2016134294A1 (en) | 2015-02-20 | 2016-08-25 | Incyte Corporation | Bicyclic heterocycles as fgfr4 inhibitors |
| US10703759B2 (en) | 2016-11-16 | 2020-07-07 | Impact Therapeutics, Inc | 8,9-dihydroimidazo[1,2-a]pyrimido[5,4-e]pyrimidin-5(6H)-ones |
| WO2018133829A1 (zh) * | 2017-01-23 | 2018-07-26 | 南京明德新药研发股份有限公司 | 作为Wee1抑制剂的1,2-二氢-3H-吡唑[3,4-d]嘧啶-3-酮衍生物 |
| US20200108074A1 (en) | 2017-03-31 | 2020-04-09 | Seattle Genetics, Inc. | Combinations of chk1- and wee1- inhibitors |
| AR111960A1 (es) | 2017-05-26 | 2019-09-04 | Incyte Corp | Formas cristalinas de un inhibidor de fgfr y procesos para su preparación |
| US11345710B2 (en) | 2017-07-10 | 2022-05-31 | Impact Therapeutics (Shanghai), Inc | Imidazo[1,2-b]pyrimido[4,5-d]pyridazin-5(6H)-ones and the use thereof |
| CA3071795A1 (en) | 2017-08-04 | 2019-02-07 | Bayer Aktiengesellschaft | 6-phenyl-4,5-dihydropyridazin-3(2h)-one derivatives as pde3a and pde3b inhibitors for treating cancer |
| JOP20200024A1 (ar) | 2017-08-04 | 2020-02-02 | Bayer Ag | مركبات ثنائي هيدروكساديازينون |
| CN107821390A (zh) * | 2017-10-13 | 2018-03-23 | 南京扬子鸿利源化学品有限责任公司 | 一种甲基磺草酮油悬浮剂及其制备方法 |
| DK3712150T3 (da) | 2017-11-01 | 2024-07-29 | Wuxi Biocity Biopharmaceutics Co Ltd | Makrocyklisk forbindelse, der tjener som wee1-hæmmer, og anvendelser deraf |
| MA52493A (fr) | 2018-05-04 | 2021-03-10 | Incyte Corp | Sels d'un inhibiteur de fgfr |
| CR20200590A (es) | 2018-05-04 | 2021-04-26 | Incyte Corp | Formas sólidas de un inhibidor de fgfr y procesos para prepararlas |
| CN108727249A (zh) * | 2018-07-07 | 2018-11-02 | 台州学院 | 3-二氟甲基哌啶盐酸盐及其衍生物的合成方法 |
| AU2019348120A1 (en) * | 2018-09-27 | 2021-05-06 | Betta Pharmaceuticals Co., Ltd | FGFR4 inhibitor and use thereof |
| US11066404B2 (en) | 2018-10-11 | 2021-07-20 | Incyte Corporation | Dihydropyrido[2,3-d]pyrimidinone compounds as CDK2 inhibitors |
| JP7481336B2 (ja) | 2018-10-26 | 2024-05-10 | ウーシー・バイオシティ・バイオファーマシューティクス・カンパニー・リミテッド | Ｗｅｅ１阻害剤としてのピリミドピラゾロン類誘導体及びその使用 |
| WO2020157194A1 (en) | 2019-02-01 | 2020-08-06 | Bayer Aktiengesellschaft | 1,2,4-triazin-3(2h)-one compounds for the treatment of hyperproliferative diseases |
| WO2020168197A1 (en) | 2019-02-15 | 2020-08-20 | Incyte Corporation | Pyrrolo[2,3-d]pyrimidinone compounds as cdk2 inhibitors |
| WO2020180959A1 (en) | 2019-03-05 | 2020-09-10 | Incyte Corporation | Pyrazolyl pyrimidinylamine compounds as cdk2 inhibitors |
| WO2020185532A1 (en) | 2019-03-08 | 2020-09-17 | Incyte Corporation | Methods of treating cancer with an fgfr inhibitor |
| WO2020205560A1 (en) | 2019-03-29 | 2020-10-08 | Incyte Corporation | Sulfonylamide compounds as cdk2 inhibitors |
| CN113784968B (zh) | 2019-04-30 | 2024-03-15 | 无锡智康弘义生物科技有限公司 | Wee1抑制剂化合物的晶型及其应用 |
| WO2020223558A1 (en) * | 2019-05-01 | 2020-11-05 | Incyte Corporation | Tricyclic amine compounds as cdk2 inhibitors |
| US11440914B2 (en) | 2019-05-01 | 2022-09-13 | Incyte Corporation | Tricyclic amine compounds as CDK2 inhibitors |
| WO2021007269A1 (en) | 2019-07-09 | 2021-01-14 | Incyte Corporation | Bicyclic heterocycles as fgfr inhibitors |
| TW202115024A (zh) | 2019-08-14 | 2021-04-16 | 美商英塞特公司 | 作為cdk2 抑制劑之咪唑基嘧啶基胺化合物 |
| CN112442049A (zh) * | 2019-09-03 | 2021-03-05 | 微境生物医药科技(上海)有限公司 | 作为Wee1抑制剂的嘧啶衍生物 |
| WO2021067374A1 (en) | 2019-10-01 | 2021-04-08 | Incyte Corporation | Bicyclic heterocycles as fgfr inhibitors |
| AU2020364007A1 (en) | 2019-10-11 | 2022-04-28 | Incyte Corporation | Bicyclic amines as CDK2 inhibitors |
| TWI891666B (zh) | 2019-10-14 | 2025-08-01 | 美商英塞特公司 | 作為ｆｇｆｒ抑制劑之雙環雜環 |
| WO2021076728A1 (en) | 2019-10-16 | 2021-04-22 | Incyte Corporation | Bicyclic heterocycles as fgfr inhibitors |
| US20240010655A1 (en) * | 2019-10-16 | 2024-01-11 | Impact Therapeutics (Shanghai), Inc | Dihydroimidazo pyrimido pyrimidinone compound |
| EP4069696A1 (en) | 2019-12-04 | 2022-10-12 | Incyte Corporation | Tricyclic heterocycles as fgfr inhibitors |
| BR112022010664A2 (pt) | 2019-12-04 | 2022-08-16 | Incyte Corp | Derivados de um inibidor de fgfr |
| WO2021146424A1 (en) | 2020-01-15 | 2021-07-22 | Incyte Corporation | Bicyclic heterocycles as fgfr inhibitors |
| US12522607B2 (en) | 2020-06-17 | 2026-01-13 | Wigen Biomedicine Technology (shanghai) Co., Ltd. | Substituted pyrazolo[3,4-d]pyrimidines as wee-1 inhibitors |
| US12551584B1 (en) | 2020-12-07 | 2026-02-17 | Actinium Pharmaceuticals, Inc. | Lewis Y radioimmunotherapy for the treatment of cancer |
| US20240182447A1 (en) * | 2021-02-19 | 2024-06-06 | Wigen Biomedicine Technology (shanghai) Co., Ltd. | Fused ring compound as wee-1 inhibitor |
| TW202304459A (zh) | 2021-04-12 | 2023-02-01 | 美商英塞特公司 | 包含ｆｇｆｒ抑制劑及ｎｅｃｔｉｎ－４靶向劑之組合療法 |
| AU2022265032A1 (en) * | 2021-04-30 | 2023-11-16 | Wigen Biomedicine Technology (shanghai) Co., Ltd. | Fused ring compound as wee-1 inhibitor, and preparation method therefor and use thereof |
| WO2022261159A1 (en) | 2021-06-09 | 2022-12-15 | Incyte Corporation | Tricyclic heterocycles as fgfr inhibitors |
| EP4352059A1 (en) | 2021-06-09 | 2024-04-17 | Incyte Corporation | Tricyclic heterocycles as fgfr inhibitors |
| US11981671B2 (en) | 2021-06-21 | 2024-05-14 | Incyte Corporation | Bicyclic pyrazolyl amines as CDK2 inhibitors |
| JP2024543405A (ja) * | 2021-11-09 | 2024-11-21 | ハンジョウ グルバイオ ファーマシューティカル カンパニー リミテッド | Ｗｅｅ１プロテインキナーゼ分解剤及びその使用 |
| US11976073B2 (en) | 2021-12-10 | 2024-05-07 | Incyte Corporation | Bicyclic amines as CDK2 inhibitors |
| CN116836184B (zh) * | 2022-03-25 | 2025-07-25 | 药雅科技(上海)有限公司 | Wee1激酶抑制剂的制备及其应用 |
| WO2024199388A1 (zh) * | 2023-03-29 | 2024-10-03 | 微境生物医药科技(上海)有限公司 | 作为myt1抑制剂的化合物 |
| CN119039287A (zh) * | 2023-05-29 | 2024-11-29 | 中国药科大学 | 一类四氢吡啶并嘧啶酮衍生物及其制备方法与应用 |
| WO2025188106A1 (ko) * | 2024-03-08 | 2025-09-12 | 보로노이 주식회사 | 헤테로아릴 유도체 화합물 및 이의 용도 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE482205T1 (de) | 2003-07-25 | 2010-10-15 | Novartis Ag | P-38-kinasehemmer |
| US20050070554A1 (en) * | 2003-08-27 | 2005-03-31 | Amgen Inc. | Substituted heterocyclic compounds and methods of use |
| US20050250836A1 (en) * | 2004-05-03 | 2005-11-10 | Pfizer Inc | Inhibitors of checkpoint kinases (Wee1 and Chk1) |
| AR058277A1 (es) | 2005-12-09 | 2008-01-30 | Solvay Pharm Gmbh | N- sulfamoil - piperidin - amidas, composiciones farmaceuticas que las comprenden y procedimiento para su preparacion |
| CA2671980C (en) * | 2006-12-13 | 2015-05-05 | Aska Pharmaceutical Co., Ltd. | Quinoxaline derivatives |
| EP2213673B1 (en) * | 2007-10-23 | 2013-06-05 | Msd K.K. | Pyridone-substituted-dihydropyrazolopyrimidinone derivative |
| ES2430053T3 (es) | 2008-06-12 | 2013-11-18 | Merck Sharp & Dohme Corp. | Procedimiento para producir derivados de bicicloanilina |
| EP2376493B1 (en) * | 2008-12-12 | 2016-10-05 | Msd K.K. | Dihydropyrimidopyrimidine derivative |
-
2012
- 2012-02-24 TW TW101106325A patent/TWI532742B/zh not_active IP Right Cessation
- 2012-02-27 MX MX2013009873A patent/MX340402B/es active IP Right Grant
- 2012-02-27 WO PCT/US2012/026685 patent/WO2012161812A1/en not_active Ceased
- 2012-02-27 CN CN201280018862.6A patent/CN103703005A/zh active Pending
- 2012-02-27 CA CA2827648A patent/CA2827648A1/en not_active Abandoned
- 2012-02-27 EP EP12716781.5A patent/EP2681221B1/en not_active Not-in-force
- 2012-02-27 UY UY0001033925A patent/UY33925A/es not_active Application Discontinuation
- 2012-02-27 JP JP2013556755A patent/JP5886326B2/ja not_active Expired - Fee Related
- 2012-02-27 ES ES12716781.5T patent/ES2587514T3/es active Active
- 2012-02-28 US US13/406,937 patent/US8710065B2/en active Active
- 2012-02-28 AR ARP120100641A patent/AR085502A1/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ES2587514T3 (es) | 2016-10-25 |
| US20120220572A1 (en) | 2012-08-30 |
| US8710065B2 (en) | 2014-04-29 |
| TWI532742B (zh) | 2016-05-11 |
| UY33925A (es) | 2012-09-28 |
| CA2827648A1 (en) | 2012-11-29 |
| MX2013009873A (es) | 2014-03-12 |
| TW201247675A (en) | 2012-12-01 |
| JP2014506929A (ja) | 2014-03-20 |
| CN103703005A (zh) | 2014-04-02 |
| EP2681221A1 (en) | 2014-01-08 |
| AR085502A1 (es) | 2013-10-09 |
| EP2681221B1 (en) | 2016-05-18 |
| WO2012161812A1 (en) | 2012-11-29 |
| JP5886326B2 (ja) | 2016-03-16 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant or registration |