JP5886326B2 - 三環式キナーゼ阻害薬 - Google Patents

三環式キナーゼ阻害薬 Download PDF

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Publication number
JP5886326B2
JP5886326B2 JP2013556755A JP2013556755A JP5886326B2 JP 5886326 B2 JP5886326 B2 JP 5886326B2 JP 2013556755 A JP2013556755 A JP 2013556755A JP 2013556755 A JP2013556755 A JP 2013556755A JP 5886326 B2 JP5886326 B2 JP 5886326B2
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JP
Japan
Prior art keywords
pyrimido
amino
imidazo
pyrimidin
phenyl
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JP2013556755A
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English (en)
Japanese (ja)
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JP2014506929A5 (https=
JP2014506929A (ja
Inventor
トン，ユンソン
ペニング，トーマス・デイー
フロールジヤンシツク，アラン
ミヤシロ，ジユリー
ウツズ，キース・ダブリユ
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AbbVie Inc
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AbbVie Inc
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
JP2013556755A 2011-02-28 2012-02-27 三環式キナーゼ阻害薬 Expired - Fee Related JP5886326B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161447405P 2011-02-28 2011-02-28
US61/447,405 2011-02-28
PCT/US2012/026685 WO2012161812A1 (en) 2011-02-28 2012-02-27 Tricyclic inhibitors of kinases

Publications (3)

Publication Number Publication Date
JP2014506929A JP2014506929A (ja) 2014-03-20
JP2014506929A5 JP2014506929A5 (https=) 2015-04-16
JP5886326B2 true JP5886326B2 (ja) 2016-03-16

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ID=46000328

Family Applications (1)

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JP2013556755A Expired - Fee Related JP5886326B2 (ja) 2011-02-28 2012-02-27 三環式キナーゼ阻害薬

Country Status (11)

Country Link
US (1) US8710065B2 (https=)
EP (1) EP2681221B1 (https=)
JP (1) JP5886326B2 (https=)
CN (1) CN103703005A (https=)
AR (1) AR085502A1 (https=)
CA (1) CA2827648A1 (https=)
ES (1) ES2587514T3 (https=)
MX (1) MX340402B (https=)
TW (1) TWI532742B (https=)
UY (1) UY33925A (https=)
WO (1) WO2012161812A1 (https=)

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US10851105B2 (en) 2014-10-22 2020-12-01 Incyte Corporation Bicyclic heterocycles as FGFR4 inhibitors
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CR20200590A (es) 2018-05-04 2021-04-26 Incyte Corp Formas sólidas de un inhibidor de fgfr y procesos para prepararlas
CN108727249A (zh) * 2018-07-07 2018-11-02 台州学院 3-二氟甲基哌啶盐酸盐及其衍生物的合成方法
AU2019348120A1 (en) * 2018-09-27 2021-05-06 Betta Pharmaceuticals Co., Ltd FGFR4 inhibitor and use thereof
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JP7481336B2 (ja) 2018-10-26 2024-05-10 ウーシー・バイオシティ・バイオファーマシューティクス・カンパニー・リミテッド Ｗｅｅ１阻害剤としてのピリミドピラゾロン類誘導体及びその使用
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WO2020180959A1 (en) 2019-03-05 2020-09-10 Incyte Corporation Pyrazolyl pyrimidinylamine compounds as cdk2 inhibitors
WO2020185532A1 (en) 2019-03-08 2020-09-17 Incyte Corporation Methods of treating cancer with an fgfr inhibitor
WO2020205560A1 (en) 2019-03-29 2020-10-08 Incyte Corporation Sulfonylamide compounds as cdk2 inhibitors
CN113784968B (zh) 2019-04-30 2024-03-15 无锡智康弘义生物科技有限公司 Wee1抑制剂化合物的晶型及其应用
WO2020223558A1 (en) * 2019-05-01 2020-11-05 Incyte Corporation Tricyclic amine compounds as cdk2 inhibitors
US11440914B2 (en) 2019-05-01 2022-09-13 Incyte Corporation Tricyclic amine compounds as CDK2 inhibitors
WO2021007269A1 (en) 2019-07-09 2021-01-14 Incyte Corporation Bicyclic heterocycles as fgfr inhibitors
TW202115024A (zh) 2019-08-14 2021-04-16 美商英塞特公司 作為cdk2 抑制劑之咪唑基嘧啶基胺化合物
CN112442049A (zh) * 2019-09-03 2021-03-05 微境生物医药科技(上海)有限公司 作为Wee1抑制剂的嘧啶衍生物
WO2021067374A1 (en) 2019-10-01 2021-04-08 Incyte Corporation Bicyclic heterocycles as fgfr inhibitors
AU2020364007A1 (en) 2019-10-11 2022-04-28 Incyte Corporation Bicyclic amines as CDK2 inhibitors
TWI891666B (zh) 2019-10-14 2025-08-01 美商英塞特公司 作為ｆｇｆｒ抑制劑之雙環雜環
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US20240010655A1 (en) * 2019-10-16 2024-01-11 Impact Therapeutics (Shanghai), Inc Dihydroimidazo pyrimido pyrimidinone compound
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US11976073B2 (en) 2021-12-10 2024-05-07 Incyte Corporation Bicyclic amines as CDK2 inhibitors
CN116836184B (zh) * 2022-03-25 2025-07-25 药雅科技(上海)有限公司 Wee1激酶抑制剂的制备及其应用
WO2024199388A1 (zh) * 2023-03-29 2024-10-03 微境生物医药科技(上海)有限公司 作为myt1抑制剂的化合物
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Also Published As

Publication number Publication date
ES2587514T3 (es) 2016-10-25
US20120220572A1 (en) 2012-08-30
MX340402B (es) 2016-07-07
US8710065B2 (en) 2014-04-29
TWI532742B (zh) 2016-05-11
UY33925A (es) 2012-09-28
CA2827648A1 (en) 2012-11-29
MX2013009873A (es) 2014-03-12
TW201247675A (en) 2012-12-01
JP2014506929A (ja) 2014-03-20
CN103703005A (zh) 2014-04-02
EP2681221A1 (en) 2014-01-08
AR085502A1 (es) 2013-10-09
EP2681221B1 (en) 2016-05-18
WO2012161812A1 (en) 2012-11-29

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