MX338808B - Metodo para producir acido 2-bromo-4,5-dialcoxibenzoico. - Google Patents

Metodo para producir acido 2-bromo-4,5-dialcoxibenzoico.

Info

Publication number
MX338808B
MX338808B MX2013006405A MX2013006405A MX338808B MX 338808 B MX338808 B MX 338808B MX 2013006405 A MX2013006405 A MX 2013006405A MX 2013006405 A MX2013006405 A MX 2013006405A MX 338808 B MX338808 B MX 338808B
Authority
MX
Mexico
Prior art keywords
benzoic acid
producing
bromo
dialkoxy
dialkoxy benzoic
Prior art date
Application number
MX2013006405A
Other languages
English (en)
Other versions
MX2013006405A (es
Inventor
Ryu Nakao
Original Assignee
Zeria Pharm Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zeria Pharm Co Ltd filed Critical Zeria Pharm Co Ltd
Publication of MX2013006405A publication Critical patent/MX2013006405A/es
Publication of MX338808B publication Critical patent/MX338808B/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/347—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups
    • C07C51/363—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups by introduction of halogen; by substitution of halogen atoms by other halogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B61/00—Other general methods
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/347—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups
    • C07C51/367—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups by introduction of functional groups containing oxygen only in singly bound form
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C65/00—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C65/21—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing ether groups, groups, groups, or groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

Se proporciona un método para producir de manera efectiva un ácido 4,5-dialcoxi-2-hidroxibenzoico a partir de una materia prima económica; un método para producir un ácido 2-bromo-4,5-dialcoxibenzoico representado por la siguiente fórmula (2): (en donde cada uno de R1 y R2 representa un grupo alquilo inferior), el método incluye hacer que un ácido 3,4-dialcoxibenzoico representado por la siguiente fórmula (1): (en donde R1 y R2 tienen los mismos significados que se definieron antes) reaccione con bromo en ácido clorhídrico concentrado (Ver Formulas).
MX2013006405A 2010-12-07 2011-12-06 Metodo para producir acido 2-bromo-4,5-dialcoxibenzoico. MX338808B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2010272668 2010-12-07
PCT/JP2011/078169 WO2012077673A1 (ja) 2010-12-07 2011-12-06 ２－ブロモ－４，５－ジアルコキシ安息香酸の製造法

Publications (2)

Publication Number Publication Date
MX2013006405A MX2013006405A (es) 2013-08-26
MX338808B true MX338808B (es) 2016-04-29

Family

ID=46207161

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2013006405A MX338808B (es) 2010-12-07 2011-12-06 Metodo para producir acido 2-bromo-4,5-dialcoxibenzoico.

Country Status (15)

Country Link
US (1) US9096511B2 (es)
EP (1) EP2650277B1 (es)
JP (1) JP5853957B2 (es)
KR (1) KR101906617B1 (es)
CN (1) CN103237781B (es)
AU (1) AU2011339438B2 (es)
BR (1) BR112013013256B1 (es)
CA (1) CA2819119C (es)
ES (1) ES2679280T3 (es)
MX (1) MX338808B (es)
RU (1) RU2576520C2 (es)
SG (1) SG190721A1 (es)
TW (1) TWI498318B (es)
WO (1) WO2012077673A1 (es)
ZA (1) ZA201303500B (es)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104447612A (zh) * 2013-09-16 2015-03-25 天津市汉康医药生物技术有限公司 阿考替胺水合物晶型及其制备方法和用途
EP3049148B1 (en) 2013-09-27 2020-05-20 The Regents Of The University Of California Engaging the cervical spinal cord circuitry to re-enable volitional control of hand function in tetraplegic subjects
CN103508893A (zh) * 2013-10-09 2014-01-15 江苏弘和药物研发有限公司 一种2-羟基-4,5-二甲氧基苯甲酸苯酯的合成方法
CN103896873B (zh) * 2013-10-23 2015-11-25 山东诚创医药技术开发有限公司 一种盐酸阿考替胺的精制方法
CN104672163A (zh) * 2013-12-03 2015-06-03 山东富创医药科技有限公司 一种盐酸阿考替胺的制备方法
CN104045606B (zh) * 2014-07-11 2015-09-30 杭州新博思生物医药有限公司 一锅法制备阿考替胺盐酸盐的方法
CN105439977A (zh) * 2014-09-26 2016-03-30 广州朗圣药业有限公司 一种阿考替胺及其盐酸盐的制备方法
US10364206B2 (en) 2015-04-13 2019-07-30 Sumitomo Seika Chemicals Co., Ltd. Method for producing 2-halogenated benzoic acids
CN105924406B (zh) * 2016-05-04 2018-04-10 河北国龙制药有限公司 一种盐酸阿考替胺三水合物的制备方法
CN106316979B (zh) * 2016-08-22 2018-11-27 山东罗欣药业集团股份有限公司 一种盐酸阿考替胺的制备方法
DE20168827T1 (de) 2017-06-30 2021-01-21 Gtx Medical B.V. System zur neuromodulierung
WO2019110400A1 (en) 2017-12-05 2019-06-13 Ecole Polytechnique Federale De Lausanne (Epfl) A system for planning and/or providing neuromodulation
EP3653256B1 (en) 2018-11-13 2022-03-30 ONWARD Medical N.V. Control system for movement reconstruction and/or restoration for a patient
EP3695878B1 (en) 2019-02-12 2023-04-19 ONWARD Medical N.V. A system for neuromodulation
DE19211698T1 (de) 2019-11-27 2021-09-02 Onward Medical B.V. Neuromodulation system
CN111440128A (zh) * 2020-05-27 2020-07-24 廊坊市泽康医药科技有限公司 一种盐酸阿考替胺杂质的制备方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SU76781A1 (ru) * 1948-11-05 1948-11-30 Н.М. Косникова Способ получени альфа-бромпиридина
DE4423356A1 (de) 1994-07-04 1996-01-11 Bayer Ag Verbessertes Verfahren zur Herstellung von 3,5-Dihydroxy-4-brombenzoesäure
JP2003252826A (ja) 2002-02-26 2003-09-10 Mitsui Chemicals Inc アルコキシ安息香酸類の製造方法
KR101273795B1 (ko) 2004-08-23 2013-06-11 제리아 신야쿠 고교 가부시키 가이샤 아미노티아졸 유도체의 제조법 및 제조 중간체
US8586761B2 (en) 2004-08-23 2013-11-19 Zeria Pharmaceutical Co., Ltd. Method for producing aminothiazole derivative and production intermediate
US20090099175A1 (en) 2006-03-01 2009-04-16 Arrington Mark P Phosphodiesterase 10 inhibitors
US7335791B1 (en) 2006-11-28 2008-02-26 E.I. Du Pont De Nemours And Company Process for the synthesis of hydroxy aromatic acids

Also Published As

Publication number Publication date
RU2013130734A (ru) 2015-01-20
AU2011339438B2 (en) 2016-05-26
CN103237781B (zh) 2016-01-20
JPWO2012077673A1 (ja) 2014-05-19
CA2819119C (en) 2018-02-13
KR101906617B1 (ko) 2018-10-10
TW201229024A (en) 2012-07-16
RU2576520C2 (ru) 2016-03-10
JP5853957B2 (ja) 2016-02-09
BR112013013256B1 (pt) 2020-10-27
SG190721A1 (en) 2013-07-31
AU2011339438A1 (en) 2013-06-27
EP2650277A1 (en) 2013-10-16
ZA201303500B (en) 2014-07-30
US9096511B2 (en) 2015-08-04
MX2013006405A (es) 2013-08-26
ES2679280T3 (es) 2018-08-23
EP2650277B1 (en) 2018-07-11
EP2650277A4 (en) 2015-01-21
BR112013013256A2 (pt) 2016-09-13
CN103237781A (zh) 2013-08-07
KR20130140006A (ko) 2013-12-23
CA2819119A1 (en) 2012-06-14
TWI498318B (zh) 2015-09-01
WO2012077673A1 (ja) 2012-06-14
US20130253222A1 (en) 2013-09-26

Similar Documents

Publication Publication Date Title
MX338808B (es) Metodo para producir acido 2-bromo-4,5-dialcoxibenzoico.
BR112014006237A2 (pt) método para produzir para-xileno, uso do para-xileno, método para produzir ácido tereftálico, método para produzir um composto
BRPI0919826A2 (pt) Micro-organismo para a producao de acido succinico.
ES2485825T3 (es) Intermedio de rosuvastatina cálcica y método de preparación del mismo
MX356674B (es) Proceso novedoso para preparar sílices.
FR2959737B1 (fr) Procede de production d'alkylbenzenes ramifies utilisant une source de carbone renouvelable.
BR112012011961A2 (pt) processo para produzir cloretos de ácido 5-flúor-1-alquil-3-fluoralquil-1h-pirazol-4-carboxílico
NZ601805A (en) Method for preparing tetrazole methanesulfonic acid salts, and novel compound used in same
PL2771475T3 (pl) Proces konwersji lignocelulozy w kwas organiczny z recyklingiem rozpuszczonych soli
UA106619C2 (uk) Спосіб отримання похідних 1-(2-галогенбіфеніл-4-іл)-циклопропанкарбонової кислоти
UA111868C2 (uk) Спосіб одержання естерів (5-фтор-2-метил-3-хінолін-2-ілметиліндол-1-іл)-оцтової кислоти
JP2009221198A5 (es)
UY33339A (es) Proceso para la preparación de amidas de ácido pirazol carboxílico
IN2015DN02668A (es)
MX2012001722A (es) Nuevo procedimiento de sintesis de la ivabradina y de sus sales de adicion a un acido farmaceuticamente aceptable.
NZ598278A (en) Process for preparing biphenyl imidazole compounds
WO2015022702A3 (en) Process for preparation of 4,5-dimethoxybenzene derivatives and use in the synthesis of ivabradine and salts thereof
JO3189B1 (ar) طريقة جديدة لتخليق (e2) -3- (3, 4- داي ميثوكسي فينيل)بروب-2 - يننيتريل واستخدامها لتخليق ايفابرادين والاملاح المضافة منها مع حمض مقبول صيدلانيا
IN2015DN02241A (es)
UA111329C2 (uk) Спосіб синтезу івабрадину і його адитивних солей з фармацевтично прийнятною кислотою
MX2014007421A (es) Proceso para la manufactura de ariloxiacetamidas.
HK1212321A1 (en) Crystalline phase of (3s.3s) 4,4-disulfanediylbis(3-aminobutane 1 - sulfonic acid) with l-lysine (3s3s)-44-(3--1-) l-
MX355337B (es) Compuesto novedoso de ester de acido acetico o una sal del mismo.
MX349425B (es) Nuevo procedimiento de sintesis del 3-(2-bromo-4,5-dimetoxifenil) propanonitrilo, y aplicacion a la sintesis de la ivabradina y de sus sales de adicion a un acido farmaceuticamente aceptable.
MX2013011705A (es) Nuevo procedimiento de sintesis del 3-(2-bromo-4,5-dimetoxifenil)p ropanonitrilo, y aplicacion a la sintesis de la ivabradina y de sus sales de adicion a un acido farmaceuticamente aceptable.

Legal Events

Date Code Title Description
FG Grant or registration