MX2022006759A - Composiciones de proteina anti-vegf y metodos para producir la misma. - Google Patents
Composiciones de proteina anti-vegf y metodos para producir la misma.Info
- Publication number
- MX2022006759A MX2022006759A MX2022006759A MX2022006759A MX2022006759A MX 2022006759 A MX2022006759 A MX 2022006759A MX 2022006759 A MX2022006759 A MX 2022006759A MX 2022006759 A MX2022006759 A MX 2022006759A MX 2022006759 A MX2022006759 A MX 2022006759A
- Authority
- MX
- Mexico
- Prior art keywords
- producing
- methods
- same
- protein compositions
- vegf protein
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title abstract 3
- 102000004169 proteins and genes Human genes 0.000 title abstract 2
- 108090000623 proteins and genes Proteins 0.000 title abstract 2
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/71—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
- A61K38/179—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
- A61K38/1858—Platelet-derived growth factor [PDGF]
- A61K38/1866—Vascular endothelial growth factor [VEGF]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
- C07K1/113—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/16—Extraction; Separation; Purification by chromatography
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/16—Extraction; Separation; Purification by chromatography
- C07K1/18—Ion-exchange chromatography
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/16—Extraction; Separation; Purification by chromatography
- C07K1/22—Affinity chromatography or related techniques based upon selective absorption processes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/36—Extraction; Separation; Purification by a combination of two or more processes of different types
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/283—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against Fc-receptors, e.g. CD16, CD32, CD64
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/66—General methods for inserting a gene into a vector to form a recombinant vector using cleavage and ligation; Use of non-functional linkers or adaptors, e.g. linkers containing the sequence for a restriction endonuclease
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/0018—Culture media for cell or tissue culture
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/0018—Culture media for cell or tissue culture
- C12N5/0031—Serum-free culture media
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/06—Preparation of peptides or proteins produced by the hydrolysis of a peptide bond, e.g. hydrolysate products
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/21—Serine endopeptidases (3.4.21)
- C12Y304/21004—Trypsin (3.4.21.4)
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/80—Fraction collectors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/622—Single chain antibody (scFv)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/33—Fusion polypeptide fusions for targeting to specific cell types, e.g. tissue specific targeting, targeting of a bacterial subspecies
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2529/00—Culture process characterised by the use of electromagnetic stimulation
- C12N2529/10—Stimulation by light
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2800/00—Nucleic acids vectors
- C12N2800/10—Plasmid DNA
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N2030/022—Column chromatography characterised by the kind of separation mechanism
- G01N2030/027—Liquid chromatography
Abstract
La presente invención se refiere a composiciones que comprenden proteínas anti-VEGF y métodos para producir tales composiciones.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201962944635P | 2019-12-06 | 2019-12-06 | |
US202063065012P | 2020-08-13 | 2020-08-13 | |
PCT/US2020/046846 WO2021112928A1 (en) | 2019-12-06 | 2020-08-18 | Anti-vegf protein compositions and methods for producing the same |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2022006759A true MX2022006759A (es) | 2023-01-30 |
Family
ID=76210828
Family Applications (9)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2022006788A MX2022006788A (es) | 2019-12-06 | 2020-08-18 | Composiciones de proteina anti-vegf y metodos para producir la misma. |
MX2022006759A MX2022006759A (es) | 2019-12-06 | 2020-08-18 | Composiciones de proteina anti-vegf y metodos para producir la misma. |
MX2022006758A MX2022006758A (es) | 2019-12-06 | 2020-08-18 | Composiciones de proteina anti-vegf y metodos para producir la misma. |
MX2021014862A MX2021014862A (es) | 2019-12-06 | 2020-08-18 | Composiciones de proteina anti-vegf y metodos para producir la misma. |
MX2022006760A MX2022006760A (es) | 2019-12-06 | 2020-08-18 | Composiciones de proteina anti-vegf y metodos para producir la misma. |
MX2021014863A MX2021014863A (es) | 2019-12-06 | 2020-08-18 | Composiciones de proteina anti-vegf y metodos para producir la misma. |
MX2022012042A MX2022012042A (es) | 2019-12-06 | 2021-12-02 | Composiciones de proteina anti-vegf y metodos para producir la misma. |
MX2023005421A MX2023005421A (es) | 2019-12-06 | 2021-12-02 | Composiciones de proteina anti-vegf y metodos para producir la misma. |
MX2022011973A MX2022011973A (es) | 2019-12-06 | 2021-12-02 | Composiciones de proteina anti-vegf y metodos para producir la misma. |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2022006788A MX2022006788A (es) | 2019-12-06 | 2020-08-18 | Composiciones de proteina anti-vegf y metodos para producir la misma. |
Family Applications After (7)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2022006758A MX2022006758A (es) | 2019-12-06 | 2020-08-18 | Composiciones de proteina anti-vegf y metodos para producir la misma. |
MX2021014862A MX2021014862A (es) | 2019-12-06 | 2020-08-18 | Composiciones de proteina anti-vegf y metodos para producir la misma. |
MX2022006760A MX2022006760A (es) | 2019-12-06 | 2020-08-18 | Composiciones de proteina anti-vegf y metodos para producir la misma. |
MX2021014863A MX2021014863A (es) | 2019-12-06 | 2020-08-18 | Composiciones de proteina anti-vegf y metodos para producir la misma. |
MX2022012042A MX2022012042A (es) | 2019-12-06 | 2021-12-02 | Composiciones de proteina anti-vegf y metodos para producir la misma. |
MX2023005421A MX2023005421A (es) | 2019-12-06 | 2021-12-02 | Composiciones de proteina anti-vegf y metodos para producir la misma. |
MX2022011973A MX2022011973A (es) | 2019-12-06 | 2021-12-02 | Composiciones de proteina anti-vegf y metodos para producir la misma. |
Country Status (18)
Country | Link |
---|---|
US (31) | US11104715B2 (es) |
EP (6) | EP3906302A1 (es) |
JP (11) | JP2022552052A (es) |
KR (12) | KR20230051296A (es) |
CN (6) | CN114423783A (es) |
AU (12) | AU2020398830C1 (es) |
BR (6) | BR112021025158A2 (es) |
CA (4) | CA3172625A1 (es) |
CO (6) | CO2021018181A2 (es) |
IL (16) | IL296512B2 (es) |
MX (9) | MX2022006788A (es) |
MY (12) | MY190625A (es) |
NZ (6) | NZ781143A (es) |
PE (6) | PE20221791A1 (es) |
SG (6) | SG11202110958QA (es) |
TW (6) | TW202128743A (es) |
WO (7) | WO2021112927A1 (es) |
ZA (3) | ZA202107644B (es) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NZ781143A (en) | 2019-12-06 | 2023-05-26 | Regeneron Pharma | Anti-vegf protein compositions and methods for producing the same |
WO2022234412A1 (en) | 2021-05-03 | 2022-11-10 | Lupin Limited | A process for purification of fc-fusion proteins |
TW202326138A (zh) * | 2021-09-08 | 2023-07-01 | 美商再生元醫藥公司 | 用於定量抗體及其他含Fc蛋白之高通量及基於質譜之方法 |
WO2023137143A1 (en) * | 2022-01-14 | 2023-07-20 | Shattuck Labs, Inc. | Methods of contaminant removal from protein isolates |
WO2023230486A2 (en) * | 2022-05-23 | 2023-11-30 | Inhalon Biopharma, Inc. | Compositions and methods for inhalable therapeutics |
Family Cites Families (131)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US1522343A (en) | 1923-05-02 | 1925-01-06 | Thom Clarence | Magnetic separator |
US4534972A (en) | 1983-03-29 | 1985-08-13 | Miles Laboratories, Inc. | Protein compositions substantially free from infectious agents |
DE3871206D1 (de) | 1987-03-24 | 1992-06-25 | Grace W R & Co | Basisnaehrmedium fuer eine zellkultur. |
US5122469A (en) | 1990-10-03 | 1992-06-16 | Genentech, Inc. | Method for culturing Chinese hamster ovary cells to improve production of recombinant proteins |
GB9022545D0 (en) | 1990-10-17 | 1990-11-28 | Wellcome Found | Culture medium |
US20030108545A1 (en) * | 1994-02-10 | 2003-06-12 | Patricia Rockwell | Combination methods of inhibiting tumor growth with a vascular endothelial growth factor receptor antagonist |
WO1996006641A1 (en) * | 1994-08-29 | 1996-03-07 | Prizm Pharmaceuticals, Inc. | Conjugates of vascular endothelial growth factor with targeted agents |
US5705364A (en) | 1995-06-06 | 1998-01-06 | Genentech, Inc. | Mammalian cell culture process |
US5721121A (en) | 1995-06-06 | 1998-02-24 | Genentech, Inc. | Mammalian cell culture process for producing a tumor necrosis factor receptor immunoglobulin chimeric protein |
US6100071A (en) | 1996-05-07 | 2000-08-08 | Genentech, Inc. | Receptors as novel inhibitors of vascular endothelial growth factor activity and processes for their production |
EP1482031B1 (en) | 1996-08-30 | 2015-10-28 | Life Technologies Corporation | Serum-free mammalian cell culture medium, and uses thereof |
US5804420A (en) | 1997-04-18 | 1998-09-08 | Bayer Corporation | Preparation of recombinant Factor VIII in a protein free medium |
US6475725B1 (en) | 1997-06-20 | 2002-11-05 | Baxter Aktiengesellschaft | Recombinant cell clones having increased stability and methods of making and using the same |
SE519827C2 (sv) | 1998-03-30 | 2003-04-15 | Viranative Ab | Näringsmedium innehållande metionin samt användning av detta |
US7396664B2 (en) | 1999-06-08 | 2008-07-08 | Regeneron Pharmaceuticals, Inc. | VEGF-binding fusion proteins and nucleic acids encoding the same |
US7303746B2 (en) | 1999-06-08 | 2007-12-04 | Regeneron Pharmaceuticals, Inc. | Methods of treating eye disorders with modified chimeric polypeptides |
US6833349B2 (en) | 1999-06-08 | 2004-12-21 | Regeneron Pharmaceuticals, Inc. | Methods of treating inflammatory skin diseases |
RS50073B (sr) * | 1999-06-08 | 2009-01-22 | Regeneron Pharmaceuticals I.N.C., | Modifikovani himerni polipeptidi sa poboljšanim farmakokinetičkim osobinama |
US7070959B1 (en) | 1999-06-08 | 2006-07-04 | Regeneron Pharmaceuticals, Inc. | Modified chimeric polypeptides with improved pharmacokinetic properties |
US7306799B2 (en) | 1999-06-08 | 2007-12-11 | Regeneron Pharmaceuticals, Inc. | Use of VEGF inhibitors for treatment of eye disorders |
US7087411B2 (en) | 1999-06-08 | 2006-08-08 | Regeneron Pharmaceuticals, Inc. | Fusion protein capable of binding VEGF |
AU2669501A (en) * | 1999-11-30 | 2001-06-12 | Smithkline Beecham Plc | New use |
PT1248802E (pt) | 2000-05-26 | 2004-11-30 | Bristol Myers Squibb Co | Moleculas mutantes de ctla4 soluveis e as suas utilizacoes |
EP1360314B1 (en) | 2001-02-15 | 2009-01-14 | Centocor, Inc. | Chemically defined medium for cultured mammalian cells |
CA2443493A1 (en) | 2001-04-13 | 2002-10-24 | Wyeth | Surface proteins of streptococcus pyogenes |
AU2002316230A1 (en) | 2001-06-13 | 2002-12-23 | Genentech, Inc. | Methods of culturing animal cells and polypeptide production in animal cells |
GB0130228D0 (en) | 2001-12-18 | 2002-02-06 | Hansa Medica Ab | Protein |
US8777906B1 (en) | 2002-01-24 | 2014-07-15 | Robin Scott Gray | Syringe with inspection window |
WO2004058944A2 (en) | 2002-12-23 | 2004-07-15 | Bristol-Myers Squibb Company | Product quality enhancement in mammalian cell culture processes for protein production |
US7399612B2 (en) | 2003-06-30 | 2008-07-15 | Regeneron Pharmaceuticals, Inc. | VEGF-binding fusion proteins and nucleic acids encoding the same |
CN100537751C (zh) | 2004-05-12 | 2009-09-09 | 华东理工大学 | 一种适合中国仓鼠卵巢细胞培养的无血清培养基 |
US7335491B2 (en) | 2004-08-27 | 2008-02-26 | Wyeth Research Ireland Limited | Production of anti-abeta |
US20060094104A1 (en) | 2004-10-29 | 2006-05-04 | Leopold Grillberger | Animal protein-free media for cultivation of cells |
EP1812557A4 (en) * | 2004-10-29 | 2009-11-04 | Centocor Ortho Biotech Inc | COMPOSITIONS OF CHEMICALLY DEFINED MEDIA |
US7303748B2 (en) | 2005-02-02 | 2007-12-04 | Regeneron Pharmaceuticals, Inc. | Method of treating eye injury with local administration of a VEGF inhibitor |
WO2006104852A2 (en) | 2005-03-25 | 2006-10-05 | Regeneron Pharmaceuticals, Inc. | Vegf antagonist formulations |
GB0511769D0 (en) * | 2005-06-09 | 2005-07-20 | Hansa Medical Ab | Treatment |
WO2006131347A2 (en) * | 2005-06-09 | 2006-12-14 | Hansa Medical Ab | Use of the ides proteinase (from s. pyogenes) for treating autoimmune diseases and graft rejection |
CN1778903A (zh) | 2005-09-29 | 2006-05-31 | 华东理工大学 | 一种动物细胞高密度连续灌注培养方法 |
DK2522717T3 (da) | 2006-01-04 | 2014-04-22 | Baxter Int | Oligopeptid-frie cellekulturmedier |
CN100502945C (zh) | 2006-03-31 | 2009-06-24 | 成都康弘生物科技有限公司 | Vegf受体融合蛋白在治疗眼睛疾病中的应用 |
MX2008016124A (es) | 2006-06-16 | 2009-01-20 | Regeneron Pharma | Formulaciones antagonistas de vegf adecuadas para la administracion intravitreal. |
CN104878064A (zh) | 2006-07-13 | 2015-09-02 | 惠氏公司 | 糖蛋白的产生 |
US20100267932A1 (en) * | 2006-08-28 | 2010-10-21 | Alex Eon-Duval | Process for the purification of fc-fusion proteins |
EP3539981A1 (en) | 2006-09-10 | 2019-09-18 | Glycotope GmbH | Use of human cells of myeloid leukaemia origin for expression of antibodies |
US10259860B2 (en) * | 2007-02-27 | 2019-04-16 | Aprogen Inc. | Fusion proteins binding to VEGF and angiopoietin |
CA2682738A1 (en) | 2007-04-16 | 2008-10-23 | Momenta Pharmaceuticals, Inc. | Defined glycoprotein products and related methods |
WO2008154014A2 (en) | 2007-06-11 | 2008-12-18 | Amgen Inc. | A method for culturing mammalian cells to improve recombinant protein production |
CA2697091A1 (en) | 2007-08-31 | 2009-03-05 | F. Hoffmann-La Roche Ag | Glycosylation profile analysis |
CN101903401B (zh) * | 2007-12-21 | 2013-06-05 | 罗切格利卡特公司 | 抗体的稳定性试验 |
US8877841B2 (en) | 2008-07-31 | 2014-11-04 | Kyoto University | Molding material containing unsaturated polyester resin and microfibrillated plant fiber |
US20110229933A1 (en) | 2008-09-26 | 2011-09-22 | SAchering Corporaton | High titer antibody production |
CA2761817A1 (en) | 2009-05-26 | 2010-12-02 | Momenta Pharmaceuticals, Inc. | Production of glycoproteins |
MY164121A (en) | 2009-06-26 | 2017-11-30 | Regeneron Pharma | Readily isolated bispecific antibodies with native immunoglobulin format |
ES2583258T3 (es) | 2009-07-31 | 2016-09-20 | Baxalta GmbH | Medio de cultivo celular para expresión de proteína ADAMTS |
MX341136B (es) * | 2009-10-20 | 2016-08-09 | Abbvie Inc | Aislamiento y purificacion de los anticuerpos anti-il-13 al usar la cromatografia de afinidad con proteina a. |
EP2325296A1 (en) | 2009-11-20 | 2011-05-25 | LEK Pharmaceuticals d.d. | Production of glycoproteins with low N-glycolylneuraminic acid (Neu5Gc) content |
US20130045492A1 (en) | 2010-02-08 | 2013-02-21 | Regeneron Pharmaceuticals, Inc. | Methods For Making Fully Human Bispecific Antibodies Using A Common Light Chain |
KR20190049934A (ko) | 2011-01-13 | 2019-05-09 | 리제너론 파아마슈티컬스, 인크. | 혈관신생 눈 장애를 치료하기 위한 vegf 길항제의 용도 |
CN102653729B (zh) | 2011-03-04 | 2014-07-16 | 上海赛金生物医药有限公司 | 一种用于中国仓鼠卵巢细胞的培养基 |
EP2697361A1 (en) | 2011-04-11 | 2014-02-19 | Cellcura Asa | Protein-free culture media products for manufacturing viral-based vaccines |
CN104024423B (zh) | 2011-04-29 | 2017-03-15 | 拜康研究有限公司 | 用于降低抗体异质性的方法和产生其抗体的方法 |
CN105189735B (zh) | 2011-04-29 | 2019-04-12 | 拜康研究有限公司 | 在培养期间减少乳酸累积的方法和生产多肽的方法 |
US20120301429A1 (en) | 2011-05-27 | 2012-11-29 | Hartman Taymar E | Dac hyp compositions and methods |
WO2013028330A2 (en) | 2011-08-19 | 2013-02-28 | Emd Millipore Corporation | Methods of reducing level of one of more impurities in a sample during protein purification |
WO2013054250A1 (en) * | 2011-10-10 | 2013-04-18 | Dr Reddy's Laboratories Limited | Purification method |
MX352823B (es) * | 2011-10-28 | 2017-12-04 | Integritybio Inc | Formulaciones de proteinas que contienen aminoacidos. |
US20130281355A1 (en) * | 2012-04-24 | 2013-10-24 | Genentech, Inc. | Cell culture compositions and methods for polypeptide production |
CN102757496B (zh) * | 2012-06-07 | 2014-06-18 | 山东泉港药业有限公司 | 一种抗vegf抗体片段的纯化制备方法 |
AU2012101677B4 (en) * | 2012-07-03 | 2012-12-20 | Novartis Ag | Device |
EP2875131B1 (en) * | 2012-07-18 | 2018-03-14 | Siemens Healthcare Diagnostics Inc. | A method of normalizing biological samples |
AR091967A1 (es) * | 2012-08-02 | 2015-03-11 | Sanofi Sa | Articulo de fabricacion que comprende aflibercept o 2iv-aflibercept |
WO2014035475A1 (en) | 2012-09-02 | 2014-03-06 | Abbvie Inc. | Methods to control protein heterogeneity |
JOP20200236A1 (ar) | 2012-09-21 | 2017-06-16 | Regeneron Pharma | الأجسام المضادة لمضاد cd3 وجزيئات ربط الأنتيجين ثنائية التحديد التي تربط cd3 وcd20 واستخداماتها |
EP2722673B1 (en) * | 2012-10-17 | 2017-07-12 | Hexal AG | Improved method of mapping glycans of glycoproteins |
CN103146648A (zh) | 2013-03-14 | 2013-06-12 | 北京京蒙高科干细胞技术有限公司 | 一种无动物源的淋巴细胞无血清培养基 |
US9217168B2 (en) | 2013-03-14 | 2015-12-22 | Momenta Pharmaceuticals, Inc. | Methods of cell culture |
US8956830B2 (en) | 2013-03-14 | 2015-02-17 | Momenta Pharmaceuticals, Inc. | Methods of cell culture |
US20140271622A1 (en) | 2013-03-14 | 2014-09-18 | Momenta Pharmaceuticals, Inc. | Methods of cell culture |
EP4039281A1 (en) * | 2013-03-15 | 2022-08-10 | Biomolecular Holdings LLC | Hybrid immunoglobulin containing non-peptidyl linkage |
AR095196A1 (es) | 2013-03-15 | 2015-09-30 | Regeneron Pharma | Medio de cultivo celular libre de suero |
BR112015021993A8 (pt) | 2013-03-15 | 2019-12-03 | Genentech Inc | polipeptídeo, métodos para sua produção, métodos para cultivo de uma célula, composição farmacêutica, kit, e meio de cultura celular |
CN103773732B (zh) | 2013-06-08 | 2016-05-11 | 李锋 | 一种化学成分确定的培养基、其应用及大规模培养哺乳动物细胞的生产工艺 |
US10154971B2 (en) | 2013-06-17 | 2018-12-18 | Adamas Pharma, Llc | Methods of administering amantadine |
US9085618B2 (en) | 2013-10-18 | 2015-07-21 | Abbvie, Inc. | Low acidic species compositions and methods for producing and using the same |
WO2015058369A1 (en) | 2013-10-23 | 2015-04-30 | Sanofi (China) Investment Co., Ltd. | Use of aflibercept and docetaxel for the treatment of nasopharyngeal carcinoma |
KR102567586B1 (ko) | 2014-02-04 | 2023-08-16 | 바이오젠 엠에이 인코포레이티드 | 번역 후 변형을 강화시키기 위한 통류 방식 양이온 교환 크로마토그래피의 용도 |
CN104073464A (zh) | 2014-07-08 | 2014-10-01 | 西藏天虹科技股份有限责任公司 | 一种cho细胞无血清培养基及其制备方法 |
AR101262A1 (es) | 2014-07-26 | 2016-12-07 | Regeneron Pharma | Plataforma de purificación para anticuerpos biespecíficos |
GB201502306D0 (en) | 2015-02-12 | 2015-04-01 | Hansa Medical Ab | Protein |
GB201502305D0 (en) * | 2015-02-12 | 2015-04-01 | Hansa Medical Ab | Protein |
AU2016228806B2 (en) * | 2015-03-12 | 2020-10-22 | Medimmune, Llc | Method of purifying albumin-fusion proteins |
KR101867134B1 (ko) * | 2015-03-23 | 2018-06-12 | 한양대학교 산학협력단 | 포유류 세포를 이용하여 목적 물질을 고효율로 생산하기 위한 세포 배양 배지, 이를 이용한 세포 배양 방법 및 목적 물질의 생산 방법 |
US11505784B2 (en) | 2015-04-01 | 2022-11-22 | Boehringer Ingelheim International Gmbh | Cell culture medium |
CN105002242A (zh) | 2015-07-23 | 2015-10-28 | 苏州康聚生物科技有限公司 | 用于cho细胞中高效表达重组人促甲状腺激素的无血清培养基及其应用 |
TW202330904A (zh) * | 2015-08-04 | 2023-08-01 | 美商再生元醫藥公司 | 補充牛磺酸之細胞培養基及用法 |
EP3334842B1 (en) | 2015-08-12 | 2022-03-02 | Novartis AG | Methods of treating ophthalmic disorders |
WO2017069158A1 (ja) * | 2015-10-22 | 2017-04-27 | プロテノバ株式会社 | イムノグロブリン結合ポリペプチド |
KR102354198B1 (ko) * | 2015-11-18 | 2022-01-20 | 에스아이오2 메디컬 프로덕츠, 인크. | Vegf-길항제의 액체 제제를 포함하는 사전-충전된 제약 패키지 |
US20180326126A1 (en) | 2015-11-18 | 2018-11-15 | Formycon Ag | Pre-filled plastic syringe containing a vegf antagonist |
CN105368808B (zh) * | 2015-11-30 | 2019-04-30 | 苏州康聚生物科技有限公司 | 一种IdeS蛋白酶、其制备方法及应用 |
AU2016378573A1 (en) | 2015-12-22 | 2018-07-19 | Regeneron Pharmaceuticals, Inc. | Bispecific anti-CD20/anti-CD3 antibodies to treat acute lymphoblastic leukemia |
MA44146B1 (fr) | 2015-12-22 | 2023-10-31 | Regeneron Pharma | Combinaison d'anticorps anti-pd-1 et d'anticorps bispécifiques anti-cd20/anti-cd3 pour traiter le cancer |
EP3196646B1 (en) * | 2016-01-19 | 2019-12-18 | Hexal AG | Methods of mapping protein variants |
JP6953433B2 (ja) | 2016-01-26 | 2021-10-27 | フォーマイコン アーゲーFormycon Ag | Vegfアンタゴニストを含む液体医薬組成物および同医薬組成物を含有する充填済みシリンジ |
EP3436473A4 (en) * | 2016-03-29 | 2019-10-23 | Navya Biologicals Pvt. Ltd. | PROCESS FOR PURIFYING FC FUSION PROTEINS |
KR101685532B1 (ko) * | 2016-04-26 | 2016-12-13 | 한국프라임제약주식회사 | 혈관내피성장인자 수용체 융합단백질 |
CN106279412A (zh) * | 2016-09-12 | 2017-01-04 | 广东东阳光药业有限公司 | 一种抗vegf类单克隆抗体的纯化方法 |
WO2018058001A1 (en) | 2016-09-23 | 2018-03-29 | Regeneron Pharmaceuticals, Inc. | Anti-steap2 antibodies, antibody-drug conjugates, and bispecific antigen-binding molecules that bind steap2 and cd3, and uses thereof |
CN110214026B (zh) | 2016-09-23 | 2023-12-05 | 瑞泽恩制药公司 | 双特异性抗muc16-cd3抗体和抗muc16药物结合物 |
TWI782930B (zh) | 2016-11-16 | 2022-11-11 | 美商再生元醫藥公司 | 抗met抗體,結合met之雙特異性抗原結合分子及其使用方法 |
WO2018094316A1 (en) | 2016-11-21 | 2018-05-24 | Just Biotherapeutics, Inc. | Aflibercept formulations and uses thereof |
AU2017380842A1 (en) | 2016-12-23 | 2019-07-11 | Serum Institute Of India Private Limited | Improved methods for enhancing antibody productivity in mammalian cell culture and minimizing aggregation during downstream, formulation processes and stable antibody formulations obtained thereof |
US11266745B2 (en) | 2017-02-08 | 2022-03-08 | Imaginab, Inc. | Extension sequences for diabodies |
WO2018170488A1 (en) * | 2017-03-17 | 2018-09-20 | Gilead Sciences, Inc. | Method of purifying an antibody |
KR101861163B1 (ko) | 2017-04-26 | 2018-05-25 | 삼천당제약주식회사 | 안과용 약학 조성물 |
US20210228738A1 (en) * | 2017-07-17 | 2021-07-29 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Compositions and methods for increasing or enhancing transduction of gene therapy vectors and for removing or reducing immunoglobulins |
CA3067735A1 (en) * | 2017-08-17 | 2019-02-21 | Just Biotherapeutics, Inc. | Method of purifying glycosylated protein from host cell galectins and other contaminants |
JP2021500071A (ja) * | 2017-10-18 | 2021-01-07 | リジェネックスバイオ インコーポレイテッド | ヒト翻訳後修飾vegf−trapによる眼疾患および転移性大腸がんの処置 |
JP7183268B2 (ja) * | 2017-11-20 | 2022-12-05 | ジャスト-エヴォテック バイオロジックス、インコーポレイテッド | 等張化剤としてリジン塩を含有するアフリベルセプト製剤及びその使用 |
CN109929038B (zh) * | 2017-12-15 | 2020-10-09 | 山东博安生物技术有限公司 | Vegf捕获剂融合蛋白的纯化方法 |
CN109929027B (zh) * | 2017-12-15 | 2020-10-09 | 山东博安生物技术有限公司 | 采用线性洗脱步骤的重组融合蛋白纯化方法 |
US11426446B2 (en) | 2018-03-08 | 2022-08-30 | Coherus Biosciences, Inc. | Stable aqueous formulations of aflibercept |
EP3761953A1 (en) * | 2018-03-08 | 2021-01-13 | Coherus Biosciences, Inc. | Stable aqueous formulations of aflibercept |
EP3765856B1 (en) * | 2018-03-13 | 2023-09-27 | Amgen Inc. | Methods for the preparation of trypsin-resistant polypeptides for mass spectrometric analysis |
AU2019265005A1 (en) | 2018-05-10 | 2020-12-17 | Regeneron Pharmaceuticals, Inc. | High concentration vegf receptor fusion protein containing formulations |
WO2020102740A2 (en) * | 2018-11-16 | 2020-05-22 | Spark Therapeutics, Inc. | Compositions and methods for increasing or enhancing transduction of gene therapy vectors and for removing or reducing immunoglobulins |
MX2021008983A (es) | 2019-01-30 | 2021-09-08 | Amgen Inc | Atributos de aflibercept y metodos de caracterizacion y modificacion de los mismos. |
US20220204920A1 (en) | 2019-05-16 | 2022-06-30 | Formycon Ag | Method for reducing methionine oxidation in recombinant proteins |
KR102286892B1 (ko) * | 2019-07-08 | 2021-08-06 | 삼천당제약주식회사 | 안과용 단백질 제제의 정제방법 |
NZ781143A (en) * | 2019-12-06 | 2023-05-26 | Regeneron Pharma | Anti-vegf protein compositions and methods for producing the same |
-
2020
- 2020-08-18 NZ NZ781143A patent/NZ781143A/en unknown
- 2020-08-18 KR KR1020237010909A patent/KR20230051296A/ko active Search and Examination
- 2020-08-18 MX MX2022006788A patent/MX2022006788A/es unknown
- 2020-08-18 JP JP2022506130A patent/JP2022552052A/ja active Pending
- 2020-08-18 NZ NZ781145A patent/NZ781145A/en unknown
- 2020-08-18 IL IL296512A patent/IL296512B2/en unknown
- 2020-08-18 KR KR1020227002038A patent/KR102619866B1/ko active IP Right Grant
- 2020-08-18 IL IL301888A patent/IL301888A/en unknown
- 2020-08-18 KR KR1020227002043A patent/KR20220038349A/ko not_active IP Right Cessation
- 2020-08-18 IL IL288367A patent/IL288367B2/en unknown
- 2020-08-18 KR KR1020237010912A patent/KR20230051297A/ko active Application Filing
- 2020-08-18 MX MX2022006759A patent/MX2022006759A/es unknown
- 2020-08-18 BR BR112021025158A patent/BR112021025158A2/pt not_active Application Discontinuation
- 2020-08-18 KR KR1020227002042A patent/KR20220035393A/ko active Application Filing
- 2020-08-18 TW TW109128139A patent/TW202128743A/zh unknown
- 2020-08-18 MY MYPI2021006201A patent/MY190625A/en unknown
- 2020-08-18 EP EP20765397.3A patent/EP3906302A1/en active Pending
- 2020-08-18 CA CA3172625A patent/CA3172625A1/en active Pending
- 2020-08-18 IL IL288351A patent/IL288351B1/en unknown
- 2020-08-18 IL IL302921A patent/IL302921A/en unknown
- 2020-08-18 MX MX2022006758A patent/MX2022006758A/es unknown
- 2020-08-18 BR BR112022001016A patent/BR112022001016A2/pt unknown
- 2020-08-18 AU AU2020398830A patent/AU2020398830C1/en active Active
- 2020-08-18 PE PE2022001026A patent/PE20221791A1/es unknown
- 2020-08-18 CN CN202080055314.5A patent/CN114423783A/zh active Pending
- 2020-08-18 CN CN202080058870.8A patent/CN114401994A/zh active Pending
- 2020-08-18 CA CA3172631A patent/CA3172631C/en active Active
- 2020-08-18 US US16/996,030 patent/US11104715B2/en active Active
- 2020-08-18 IL IL288355A patent/IL288355B2/en unknown
- 2020-08-18 KR KR1020237044969A patent/KR20240007293A/ko active Application Filing
- 2020-08-18 CN CN202080055633.6A patent/CN114206925A/zh active Pending
- 2020-08-18 IL IL309560A patent/IL309560A/en unknown
- 2020-08-18 TW TW109128140A patent/TW202128744A/zh unknown
- 2020-08-18 KR KR1020227002040A patent/KR20220038062A/ko not_active IP Right Cessation
- 2020-08-18 WO PCT/US2020/046842 patent/WO2021112927A1/en active Application Filing
- 2020-08-18 US US16/996,293 patent/US11186625B2/en active Active
- 2020-08-18 SG SG11202110958QA patent/SG11202110958QA/en unknown
- 2020-08-18 IL IL309491A patent/IL309491A/en unknown
- 2020-08-18 PE PE2022001024A patent/PE20221261A1/es unknown
- 2020-08-18 EP EP20765402.1A patent/EP3906303A1/en active Pending
- 2020-08-18 JP JP2022506125A patent/JP2022548197A/ja active Pending
- 2020-08-18 NZ NZ781142A patent/NZ781142A/en unknown
- 2020-08-18 PE PE2022001020A patent/PE20221770A1/es unknown
- 2020-08-18 KR KR1020237044978A patent/KR20240005222A/ko active Application Filing
- 2020-08-18 IL IL296893A patent/IL296893B1/en unknown
- 2020-08-18 CN CN202080055377.0A patent/CN114206914A/zh active Pending
- 2020-08-18 TW TW109128145A patent/TW202128745A/zh unknown
- 2020-08-18 WO PCT/US2020/046823 patent/WO2021112924A1/en active Application Filing
- 2020-08-18 SG SG11202110953UA patent/SG11202110953UA/en unknown
- 2020-08-18 JP JP2022506072A patent/JP2022547651A/ja active Pending
- 2020-08-18 AU AU2020397803A patent/AU2020397803C1/en active Active
- 2020-08-18 AU AU2020398125A patent/AU2020398125C1/en active Active
- 2020-08-18 AU AU2020398547A patent/AU2020398547C1/en active Active
- 2020-08-18 NZ NZ781136A patent/NZ781136A/en unknown
- 2020-08-18 US US16/996,127 patent/US11180540B2/en active Active
- 2020-08-18 IL IL296863A patent/IL296863B2/en unknown
- 2020-08-18 MY MYPI2021006235A patent/MY190627A/en unknown
- 2020-08-18 MX MX2021014862A patent/MX2021014862A/es unknown
- 2020-08-18 SG SG11202110964QA patent/SG11202110964QA/en unknown
- 2020-08-18 CA CA3159586A patent/CA3159586A1/en active Pending
- 2020-08-18 JP JP2022506131A patent/JP2022548818A/ja active Pending
- 2020-08-18 IL IL288357A patent/IL288357B2/en unknown
- 2020-08-18 PE PE2022001025A patent/PE20221790A1/es unknown
- 2020-08-18 US US16/996,007 patent/US11053280B2/en active Active
- 2020-08-18 KR KR1020227002041A patent/KR102519236B1/ko active IP Right Grant
- 2020-08-18 US US16/996,042 patent/US11098112B2/en active Active
- 2020-08-18 CN CN202080055352.0A patent/CN114206907A/zh active Pending
- 2020-08-18 TW TW109128143A patent/TW202122417A/zh unknown
- 2020-08-18 PE PE2022001023A patent/PE20221789A1/es unknown
- 2020-08-18 BR BR112021025769A patent/BR112021025769A2/pt active Search and Examination
- 2020-08-18 NZ NZ781137A patent/NZ781137A/en unknown
- 2020-08-18 IL IL288352A patent/IL288352B2/en unknown
- 2020-08-18 BR BR112021025438A patent/BR112021025438A2/pt unknown
- 2020-08-18 KR KR1020237036668A patent/KR20230152810A/ko active Application Filing
- 2020-08-18 PE PE2022001022A patent/PE20221788A1/es unknown
- 2020-08-18 MX MX2022006760A patent/MX2022006760A/es unknown
- 2020-08-18 IL IL296864A patent/IL296864B2/en unknown
- 2020-08-18 JP JP2022506067A patent/JP2022550930A/ja active Pending
- 2020-08-18 MY MYPI2022002100A patent/MY193355A/en unknown
- 2020-08-18 AU AU2020396490A patent/AU2020396490C1/en active Active
- 2020-08-18 BR BR112021025432A patent/BR112021025432A2/pt unknown
- 2020-08-18 WO PCT/US2020/046831 patent/WO2021112925A1/en active Application Filing
- 2020-08-18 EP EP20765400.5A patent/EP3906250A1/en active Pending
- 2020-08-18 SG SG11202110955VA patent/SG11202110955VA/en unknown
- 2020-08-18 EP EP20775971.3A patent/EP3931204A1/en active Pending
- 2020-08-18 TW TW109128142A patent/TW202134256A/zh unknown
- 2020-08-18 MY MYPI2021006223A patent/MY190623A/en unknown
- 2020-08-18 SG SG11202110972UA patent/SG11202110972UA/en unknown
- 2020-08-18 KR KR1020237044758A patent/KR20240005206A/ko active Application Filing
- 2020-08-18 TW TW109128144A patent/TW202128991A/zh unknown
- 2020-08-18 CN CN202080055393.XA patent/CN114206924A/zh active Pending
- 2020-08-18 AU AU2020397865A patent/AU2020397865C1/en active Active
- 2020-08-18 MY MYPI2022002191A patent/MY193349A/en unknown
- 2020-08-18 EP EP20765403.9A patent/EP3931303A1/en active Pending
- 2020-08-18 WO PCT/US2020/046834 patent/WO2021112926A1/en active Application Filing
- 2020-08-18 EP EP20764873.4A patent/EP3906249A1/en active Pending
- 2020-08-18 WO PCT/US2020/046862 patent/WO2021112929A1/en active Application Filing
- 2020-08-18 MY MYPI2021006189A patent/MY190624A/en unknown
- 2020-08-18 MY MYPI2021006216A patent/MY190626A/en unknown
- 2020-08-18 IL IL288360A patent/IL288360B2/en unknown
- 2020-08-18 WO PCT/US2020/046809 patent/WO2021112923A1/en active Application Filing
- 2020-08-18 CA CA3129193A patent/CA3129193C/en active Active
- 2020-08-18 NZ NZ781138A patent/NZ781138A/en unknown
- 2020-08-18 MY MYPI2022002103A patent/MY193354A/en unknown
- 2020-08-18 MX MX2021014863A patent/MX2021014863A/es unknown
- 2020-08-18 MY MYPI2022002109A patent/MY193350A/en unknown
- 2020-08-18 KR KR1020227002039A patent/KR102519234B1/ko active IP Right Grant
- 2020-08-18 BR BR112021025359A patent/BR112021025359A2/pt unknown
- 2020-08-18 SG SG11202110968VA patent/SG11202110968VA/en unknown
- 2020-08-18 MY MYPI2021006226A patent/MY190686A/en unknown
- 2020-08-18 US US16/996,103 patent/US11098311B2/en active Active
- 2020-08-18 WO PCT/US2020/046846 patent/WO2021112928A1/en active Application Filing
- 2020-08-18 JP JP2022506127A patent/JP2022547652A/ja active Pending
- 2020-08-18 MY MYPI2022002113A patent/MY193353A/en unknown
- 2020-08-18 IL IL302538A patent/IL302538A/en unknown
- 2020-08-18 MY MYPI2022002104A patent/MY193351A/en unknown
-
2021
- 2021-03-18 US US17/205,745 patent/US11174283B2/en active Active
- 2021-03-24 US US17/211,333 patent/US11286290B2/en active Active
- 2021-07-16 US US17/378,362 patent/US11440950B2/en active Active
- 2021-07-22 US US17/383,322 patent/US11535663B2/en active Active
- 2021-08-26 US US17/458,519 patent/US20220098280A1/en active Pending
- 2021-08-30 US US17/460,578 patent/US11306135B2/en active Active
- 2021-09-29 US US17/489,495 patent/US11299532B2/en active Active
- 2021-10-01 US US17/492,440 patent/US11407813B2/en active Active
- 2021-10-11 ZA ZA2021/07644A patent/ZA202107644B/en unknown
- 2021-10-11 ZA ZA2021/07646A patent/ZA202107646B/en unknown
- 2021-10-11 ZA ZA2021/07647A patent/ZA202107647B/en unknown
- 2021-10-13 US US17/500,735 patent/US11459373B2/en active Active
- 2021-12-02 MX MX2022012042A patent/MX2022012042A/es unknown
- 2021-12-02 MX MX2023005421A patent/MX2023005421A/es unknown
- 2021-12-02 MX MX2022011973A patent/MX2022011973A/es unknown
- 2021-12-21 US US17/557,904 patent/US11472861B2/en active Active
- 2021-12-30 CO CONC2021/0018181A patent/CO2021018181A2/es unknown
- 2021-12-30 CO CONC2021/0018234A patent/CO2021018234A2/es unknown
- 2021-12-30 CO CONC2021/0018192A patent/CO2021018192A2/es unknown
- 2021-12-30 CO CONC2021/0018214A patent/CO2021018214A2/es unknown
- 2021-12-30 CO CONC2021/0018203A patent/CO2021018203A2/es unknown
-
2022
- 2022-01-13 US US17/575,425 patent/US11485770B2/en active Active
- 2022-01-13 US US17/575,585 patent/US11649273B2/en active Active
- 2022-01-25 CO CONC2022/0000660A patent/CO2022000660A2/es unknown
- 2022-02-08 US US17/667,298 patent/US11505593B2/en active Active
- 2022-02-08 US US17/667,330 patent/US11459374B2/en active Active
- 2022-04-01 US US17/711,723 patent/US11505594B2/en active Active
- 2022-06-15 US US17/841,349 patent/US11548932B2/en active Active
- 2022-06-16 US US17/842,286 patent/US11542317B1/en active Active
- 2022-07-06 US US17/858,724 patent/US11753459B2/en active Active
- 2022-07-06 US US17/858,629 patent/US20230041349A1/en active Pending
- 2022-11-25 US US17/994,223 patent/US11732025B2/en active Active
-
2023
- 2023-03-01 US US18/116,166 patent/US20230235019A1/en active Pending
- 2023-03-07 US US18/118,558 patent/US20230272044A1/en active Pending
- 2023-03-14 AU AU2023201588A patent/AU2023201588A1/en active Pending
- 2023-03-14 AU AU2023201590A patent/AU2023201590A1/en active Pending
- 2023-03-14 AU AU2023201585A patent/AU2023201585A1/en active Pending
- 2023-03-14 AU AU2023201586A patent/AU2023201586A1/en active Pending
- 2023-03-14 AU AU2023201589A patent/AU2023201589A1/en active Pending
- 2023-03-21 AU AU2023201748A patent/AU2023201748A1/en active Pending
- 2023-06-23 US US18/213,779 patent/US11958894B2/en active Active
- 2023-06-23 US US18/340,707 patent/US20240067701A1/en active Pending
- 2023-06-26 US US18/214,282 patent/US20230357357A1/en active Pending
- 2023-07-11 IL IL304390A patent/IL304390A/en unknown
- 2023-09-08 JP JP2023145749A patent/JP2023171771A/ja active Pending
- 2023-09-22 JP JP2023156642A patent/JP2023179531A/ja active Pending
- 2023-10-12 JP JP2023176837A patent/JP2024009950A/ja active Pending
- 2023-10-12 JP JP2023176817A patent/JP2024009949A/ja active Pending
- 2023-11-20 JP JP2023196342A patent/JP2024026116A/ja active Pending
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
PH12019500540A1 (en) | Anti-pd-1 antibodies and their uses | |
MX2023005421A (es) | Composiciones de proteina anti-vegf y metodos para producir la misma. | |
MX2017006127A (es) | Metodos y composiciones para produccion de proteina de clara de huevo. | |
SG10201914126RA (en) | Anti-ox40 antibodies and their uses | |
PH12018502456A1 (en) | Anti-cd04 antibodies and their uses | |
WO2018132821A3 (en) | Elastomeric proteins |