MX2021007006A - Anticuerpo anti-calicreina-2 humanizado. - Google Patents

Anticuerpo anti-calicreina-2 humanizado.

Info

Publication number
MX2021007006A
MX2021007006A MX2021007006A MX2021007006A MX2021007006A MX 2021007006 A MX2021007006 A MX 2021007006A MX 2021007006 A MX2021007006 A MX 2021007006A MX 2021007006 A MX2021007006 A MX 2021007006A MX 2021007006 A MX2021007006 A MX 2021007006A
Authority
MX
Mexico
Prior art keywords
seq
chain variable
variable region
antibody
amino acid
Prior art date
Application number
MX2021007006A
Other languages
English (en)
Inventor
Pär Oskar Vilhelmsson Timmermand
Urpo Juhani Lamminmäki
Kjell Sjöström
Sven- Erik STRAND
Amanda Thuy Tran
Original Assignee
Fredax Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB1320408.6A external-priority patent/GB2520353A/en
Priority claimed from GB201401973A external-priority patent/GB201401973D0/en
Application filed by Fredax Ab filed Critical Fredax Ab
Publication of MX2021007006A publication Critical patent/MX2021007006A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3069—Reproductive system, e.g. ovaria, uterus, testes, prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
    • A61K51/1045—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody against animal or human tumor cells or tumor cell determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
    • A61K51/1075—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody the antibody being against an enzyme
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
    • A61K51/1093—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody conjugates with carriers being antibodies
    • A61K51/1096—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody conjugates with carriers being antibodies radioimmunotoxins, i.e. conjugates being structurally as defined in A61K51/1093, and including a radioactive nucleus for use in radiotherapeutic applications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57407—Specifically defined cancers
    • G01N33/57434—Specifically defined cancers of prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Physics & Mathematics (AREA)
  • Epidemiology (AREA)
  • Optics & Photonics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cell Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Food Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • Hospice & Palliative Care (AREA)
  • Pathology (AREA)
  • Biotechnology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pregnancy & Childbirth (AREA)
  • Reproductive Health (AREA)
  • Peptides Or Proteins (AREA)

Abstract

La presente invención proporciona polipéptidos de anticuerpo con especificidad de unión por la calicreína-2 humana (hK2), en donde el polipéptido de anticuerpo comprende (a) una región variable de la cadena pesada que comprende las secuencias de aminoácidos de SEQ ID NO: 1 y SEQ ID NO: 2 y SEQ ID NO: 3 y/o (b) una región variable de cadena ligera que comprende las secuencias de aminoácidos de SEQ ID NO: 4 y SEQ ID NO: 5 y SEQ ID NO: 6, y en donde la región variable de la cadena pesada y la región variable de la cadena ligera comprenden secuencias de aminoácidos marco de uno o más anticuerpos humanos. La descripción proporciona además el uso de dichos polipéptidos de anticuerpo en el diagnóstico y el tratamiento del cáncer de próstata.
MX2021007006A 2013-11-19 2016-05-19 Anticuerpo anti-calicreina-2 humanizado. MX2021007006A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB1320408.6A GB2520353A (en) 2013-11-19 2013-11-19 Antibody polypeptides and uses thereof
GB201401973A GB201401973D0 (en) 2014-02-05 2014-02-05 Antibody polypeptides and uses thereof

Publications (1)

Publication Number Publication Date
MX2021007006A true MX2021007006A (es) 2021-09-08

Family

ID=52114029

Family Applications (2)

Application Number Title Priority Date Filing Date
MX2016006561A MX2016006561A (es) 2013-11-19 2014-11-19 Anticuerpo anti-calicreina-2 humanizado.
MX2021007006A MX2021007006A (es) 2013-11-19 2016-05-19 Anticuerpo anti-calicreina-2 humanizado.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
MX2016006561A MX2016006561A (es) 2013-11-19 2014-11-19 Anticuerpo anti-calicreina-2 humanizado.

Country Status (22)

Country Link
US (3) US10100125B2 (es)
EP (2) EP3071595B1 (es)
JP (3) JP6599859B2 (es)
KR (3) KR102442738B1 (es)
CN (2) CN112898431B (es)
AU (3) AU2014351611B2 (es)
BR (1) BR112016011025B1 (es)
CA (1) CA2930493A1 (es)
CY (1) CY1121900T1 (es)
DK (1) DK3071595T3 (es)
ES (1) ES2728515T3 (es)
HR (1) HRP20191095T1 (es)
HU (1) HUE043875T2 (es)
IL (4) IL297678B2 (es)
LT (1) LT3071595T (es)
MX (2) MX2016006561A (es)
PL (1) PL3071595T3 (es)
PT (1) PT3071595T (es)
RS (1) RS58831B1 (es)
RU (1) RU2687163C1 (es)
SI (1) SI3071595T1 (es)
WO (1) WO2015075445A1 (es)

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HRP20191095T1 (hr) 2019-09-20
JP2016540503A (ja) 2016-12-28
AU2014351611B2 (en) 2020-04-23
IL297678B1 (en) 2024-05-01
IL311788A (en) 2024-05-01
IL297678A (en) 2022-12-01
EP3071595A1 (en) 2016-09-28
US10100125B2 (en) 2018-10-16
CY1121900T1 (el) 2020-10-14
KR20220020406A (ko) 2022-02-18
RU2687163C1 (ru) 2019-05-07
ES2728515T3 (es) 2019-10-25
CN105980404A (zh) 2016-09-28
MX2016006561A (es) 2016-12-12
IL278493A (en) 2022-12-01
AU2023222879A1 (en) 2023-09-14
JP2022062048A (ja) 2022-04-19
IL278493B2 (en) 2023-04-01
AU2014351611A1 (en) 2016-06-30
AU2020207775B2 (en) 2023-06-15
RS58831B1 (sr) 2019-07-31
IL297678B2 (en) 2024-09-01
CN105980404B (zh) 2021-01-12
CA2930493A1 (en) 2015-05-28
LT3071595T (lt) 2019-05-10
EP3553088A1 (en) 2019-10-16
US11230609B2 (en) 2022-01-25
BR112016011025A2 (pt) 2017-12-05
PT3071595T (pt) 2019-06-11
US20160369009A1 (en) 2016-12-22
JP7051777B2 (ja) 2022-04-11
KR102574537B1 (ko) 2023-09-06
IL245617B (en) 2021-02-28
SI3071595T1 (sl) 2019-08-30
KR20230132599A (ko) 2023-09-15
US20190169312A1 (en) 2019-06-06
EP3071595B1 (en) 2019-03-20
DK3071595T3 (da) 2019-07-01
US20220064333A1 (en) 2022-03-03
IL245617A0 (en) 2016-06-30
JP6599859B2 (ja) 2019-10-30
CN112898431B (zh) 2024-05-28
WO2015075445A1 (en) 2015-05-28
KR102442738B1 (ko) 2022-09-15
PL3071595T3 (pl) 2019-09-30
BR112016011025A8 (pt) 2018-01-30
JP2020022470A (ja) 2020-02-13
BR112016011025B1 (pt) 2024-01-23
AU2020207775A1 (en) 2020-08-06
KR20160096621A (ko) 2016-08-16
RU2016124229A (ru) 2017-12-25
CN112898431A (zh) 2021-06-04
HUE043875T2 (hu) 2019-09-30

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