MX342782B - Anticuerpos de peptido beta amiloide anti-n3pglu y usos de los mismos. - Google Patents
Anticuerpos de peptido beta amiloide anti-n3pglu y usos de los mismos.Info
- Publication number
- MX342782B MX342782B MX2013001716A MX2013001716A MX342782B MX 342782 B MX342782 B MX 342782B MX 2013001716 A MX2013001716 A MX 2013001716A MX 2013001716 A MX2013001716 A MX 2013001716A MX 342782 B MX342782 B MX 342782B
- Authority
- MX
- Mexico
- Prior art keywords
- amyloid beta
- beta peptide
- peptide antibodies
- n3pglu
- n3pglu amyloid
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/567—Framework region [FR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/28—Neurological disorders
- G01N2800/2814—Dementia; Cognitive disorders
- G01N2800/2821—Alzheimer
Abstract
La presente invención se refiere a un anticuerpos Aß anti-N3pGlu o su fragmento de unión a antígeno del mismo diseñado por ingeniería, que comprende una región variable de cadena ligera (LCVR) y una región variable de cadena pesada (HCVR), caracterizado porque tal LCVR comprende los polipépitdos LCDR1, LCDR2, y LCDR3, y la HCVR comprende los polipéptidos LCDR1, LCDR2, y LCDR3, los cuales se seleccionan a partir de a) SEQ ID NO: 3, SEQ ID NO: 4 LDCR3 es SEQ ID NO: 5, HCDR1 es SEQ ID NO: 6, HCDR2 es SEQ ID NO: 8, y HCDR3 SEQ ID NO: 9 b) LCDR1 es SEQ ID NO: 3, LCDR2 SEQ ID NO: 4 LCDR3 es SEQ IDNO:5 HCDR1 SEQ ID NO: 7 HCDR2 es SEQ ID NO: 8 y HCDR3 es SEQ ID NO:10 c) LCDR1 es SEQ ID NO:3, LCDR2 es SEQ ID NO:4 LCDR3 SEQ ID NO: 5 HCDR1 SEQ ID NO: 40 HCDR2 SEQ ID NO:8, y HCDR3 SEQ ID NO: 41 d) LDR1 SEQ ID NO:3 LCDR2 SEQ ID NO: 35, LCDR3 SEQ ID NO:5, HCDR1 SEQ ID NO: 7, HCDR2 SEQ ID NO: 8 y HCDR3 SEQ ID NO:10, y e) LCDR1 SEQ ID NO: 45 LCDR2 SEQ ID NO: 4, LCDR3 es SEQ ID NO:5, HCDR1 SEQ ID NO:40, HCDR2 SEQ ID NO: 8 y HCDR3 SEQ ID NO: 46.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US37302610P | 2010-08-12 | 2010-08-12 | |
| PCT/US2011/046994 WO2012021469A1 (en) | 2010-08-12 | 2011-08-09 | ANTI-N3pGlu AMYLOID BETA PEPTIDE ANTIBODIES AND USES THEREOF |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MX2013001716A MX2013001716A (es) | 2013-10-28 |
| MX342782B true MX342782B (es) | 2016-10-12 |
Family
ID=44543826
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2013001716A MX342782B (es) | 2010-08-12 | 2011-08-09 | Anticuerpos de peptido beta amiloide anti-n3pglu y usos de los mismos. |
| MX2016005533A MX355268B (es) | 2010-08-12 | 2013-02-12 | Anticuerpos de peptido beta amiloide anti-n3pglu y usos de los mismos. |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2016005533A MX355268B (es) | 2010-08-12 | 2013-02-12 | Anticuerpos de peptido beta amiloide anti-n3pglu y usos de los mismos. |
Country Status (38)
| Country | Link |
|---|---|
| US (2) | US8679498B2 (es) |
| EP (3) | EP2603523B1 (es) |
| JP (2) | JP5980207B2 (es) |
| KR (1) | KR101498833B1 (es) |
| CN (2) | CN103068848B (es) |
| AU (1) | AU2011289629B2 (es) |
| BR (1) | BR112013004056B8 (es) |
| CA (1) | CA2805114C (es) |
| CL (1) | CL2013000390A1 (es) |
| CO (1) | CO6670526A2 (es) |
| CR (1) | CR20130016A (es) |
| CY (2) | CY1120144T1 (es) |
| DK (3) | DK3042917T3 (es) |
| DO (1) | DOP2013000029A (es) |
| EA (1) | EA023021B1 (es) |
| EC (1) | ECSP13012436A (es) |
| ES (3) | ES2664128T3 (es) |
| GT (1) | GT201300036A (es) |
| HK (1) | HK1180703A1 (es) |
| HR (3) | HRP20160151T1 (es) |
| HU (2) | HUE037524T2 (es) |
| IL (2) | IL224030B (es) |
| LT (2) | LT3042917T (es) |
| MA (1) | MA34461B1 (es) |
| ME (3) | ME03661B (es) |
| MX (2) | MX342782B (es) |
| MY (2) | MY181969A (es) |
| NO (1) | NO3042917T3 (es) |
| NZ (2) | NZ626665A (es) |
| PE (1) | PE20130817A1 (es) |
| PL (3) | PL3339323T3 (es) |
| PT (2) | PT3339323T (es) |
| RS (3) | RS57026B1 (es) |
| SG (2) | SG187586A1 (es) |
| SI (3) | SI3339323T1 (es) |
| UA (1) | UA107600C2 (es) |
| WO (1) | WO2012021469A1 (es) |
| ZA (1) | ZA201300437B (es) |
Families Citing this family (44)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL199534A (en) | 2007-01-05 | 2013-01-31 | Univ Zuerich | An isolated human antibody capable of detecting a neoepitope in a disease-related protein, a polynucleotide encoding an antibody, a vector containing the polynucleotide, a host cell containing the polynucleotide or vector, a preparation containing the antibody and related methods and uses. |
| PL3339323T3 (pl) * | 2010-08-12 | 2020-05-18 | Eli Lilly And Company | Przeciwciała przeciwko peptydowi N3pGlu amyloidu beta i ich zastosowania |
| US9499610B2 (en) | 2011-04-08 | 2016-11-22 | H. Lundbeck A/S | Antibodies specific to pyroglutamated Aβ |
| EP3102611A4 (en) * | 2014-02-03 | 2017-08-23 | Cangene Corporation | Humanized beta-amyloid binding molecules and uses thereof |
| WO2015175769A1 (en) | 2014-05-15 | 2015-11-19 | Biogen Ma Inc. | Methods for the detection of amyloid beta oligomers in biological samples |
| AU2015287227B2 (en) | 2014-07-10 | 2021-02-18 | Universitat Zurich | Immune-stimulating monoclonal antibodies against human interleukin-2 |
| TWI599358B (zh) * | 2014-09-16 | 2017-09-21 | 美國禮來大藥廠 | 組合療法 |
| MA41115A (fr) | 2014-12-02 | 2017-10-10 | Biogen Int Neuroscience Gmbh | Procédé de traitement de la maladie d'alzheimer |
| US20170363645A1 (en) | 2014-12-19 | 2017-12-21 | Probiodrug Ag | Novel Method for the Detection of pGlu-Abeta Peptides |
| JO3627B1 (ar) | 2015-04-30 | 2020-08-27 | H Lundbeck As | إيميدازو بيرازينونات على هيئة مثبطات pde1 |
| CN106699888B (zh) * | 2015-07-28 | 2020-11-06 | 上海昀怡健康科技发展有限公司 | 一种pd-1抗体及其制备方法和应用 |
| MD3353212T2 (ro) * | 2015-09-23 | 2022-03-31 | Regeneron Pharma | Anticorpi bispecifici anti-CD3 optimizați și utilizările acestora |
| CN108473569B (zh) | 2016-01-11 | 2022-11-22 | 苏黎世大学 | 针对人白介素-2的免疫刺激性人源化单克隆抗体及其融合蛋白 |
| JOP20170004B1 (ar) | 2016-01-15 | 2022-09-15 | Lilly Co Eli | الأجسام المضادة لببتيد بيتا النشوي مضاد N3pGlu واستخداماته |
| TW201740944A (zh) * | 2016-03-15 | 2017-12-01 | 美國禮來大藥廠 | 組合療法 |
| TW201740954A (zh) * | 2016-03-16 | 2017-12-01 | 美國禮來大藥廠 | 組合療法 |
| TWI735600B (zh) * | 2016-07-01 | 2021-08-11 | 美商美國禮來大藥廠 | 抗－N3pGlu類澱粉β肽抗體及其用途 |
| US10034861B2 (en) | 2016-07-04 | 2018-07-31 | H. Lundbeck A/S | 1H-pyrazolo[4,3-b]pyridines as PDE1 inhibitors |
| EP3496750A2 (en) * | 2016-08-09 | 2019-06-19 | Eli Lilly and Company | Combination therapy |
| EP3500296A1 (en) * | 2016-08-18 | 2019-06-26 | Eli Lilly and Company | Combination therapy of bace-1 inhibitor and anti-n3pglu abeta antibody |
| AR110470A1 (es) * | 2016-10-21 | 2019-04-03 | Lilly Co Eli | Terapia de combinación para tratar la enfermedad de alzheimer |
| WO2018078038A1 (en) | 2016-10-28 | 2018-05-03 | H. Lundbeck A/S | Combination treatments comprising imidazopyrazinones for the treatment of psychiatric and/or cognitive disorders |
| EP3532053A1 (en) | 2016-10-28 | 2019-09-04 | H. Lundbeck A/S | Combination treatments comprising administration of imidazopyrazinones |
| TW201827467A (zh) * | 2016-11-03 | 2018-08-01 | 比利時商健生藥品公司 | 焦穀胺酸類澱粉蛋白－β之抗體及其用途 |
| JOP20190247A1 (ar) * | 2017-04-20 | 2019-10-20 | Lilly Co Eli | أجسام بيتا ببتيد النشوانية المضادة لـ N3pGlu واستخداماتها |
| EA202090555A1 (ru) | 2017-08-22 | 2020-06-08 | Байоджен Ма Инк. | Фармацевтические композиции, содержащие антитела к бета-амилоиду |
| HUE057202T2 (hu) | 2017-12-14 | 2022-04-28 | H Lundbeck As | Kombinációs kezelések 1H-pirazolo[4,3-b]piridinek alkalmazásával |
| AR113926A1 (es) | 2017-12-14 | 2020-07-01 | H Lundbeck As | Derivados de 1h-pirazolo[4,3-b]piridinas |
| US11535611B2 (en) | 2017-12-20 | 2022-12-27 | H. Lundbeck A/S | Pyrazolo[3,4-B]pyridines and imidazo[1,5-B]pyridazines as PDE1 inhibitors |
| CR20210492A (es) | 2019-03-26 | 2021-11-19 | Janssen Pharmaceutica Nv | ANTICUERPOS CONTRA AMILOIDES-ß CON PIROGLUTAMATO Y USOS DE ESTOS |
| MX2022004311A (es) | 2019-10-15 | 2022-05-10 | Lilly Co Eli | Estirpes celulares de mamiferos con deficiencia de lipasa/esterasa modificadas geneticamente de manera recombinante. |
| WO2021257808A2 (en) * | 2020-06-17 | 2021-12-23 | Proviva Therapeutics (Hong Kong) Limited | Antibodies to fibroblast activation protein and b7h3 |
| JP2023535024A (ja) | 2020-07-23 | 2023-08-15 | オター プロシーナ リミテッド | 抗ａベータ抗体 |
| PE20231507A1 (es) * | 2020-10-02 | 2023-09-26 | Lilly Co Eli | Metodos para reducir el contenido de proteinas de la celula huesped en procesos de purificacion de anticuerpos y composiciones de anticuerpos que tienen un contenido reducido de proteinas de la celula huesped |
| TW202243690A (zh) | 2021-01-11 | 2022-11-16 | 美商美國禮來大藥廠 | 抗N3pGlu類澱粉β抗體及其用途 |
| TW202300518A (zh) | 2021-03-12 | 2023-01-01 | 美商美國禮來大藥廠 | 抗N3pGlu類澱粉β抗體及其用途 |
| TW202300517A (zh) | 2021-03-12 | 2023-01-01 | 美商美國禮來大藥廠 | 抗類澱粉β抗體及其用途 |
| WO2023070064A1 (en) | 2021-10-22 | 2023-04-27 | Eli Lilly And Company | O-glcnacase (oga) inhibitor combination therapy |
| WO2023076971A1 (en) | 2021-10-29 | 2023-05-04 | Eli Lilly Company | Compounds and methods targeting interleukin-34 |
| JP2023067832A (ja) | 2021-10-29 | 2023-05-16 | イーライ リリー アンド カンパニー | インターロイキン－３４を標的とする化合物及び方法 |
| TW202334210A (zh) | 2021-10-29 | 2023-09-01 | 美商美國禮來大藥廠 | 靶向介白素-34之化合物及方法 |
| WO2023076970A1 (en) | 2021-10-29 | 2023-05-04 | Eli Lilly And Company | Compounds and methods targeting interleukin-34 |
| WO2023150483A1 (en) | 2022-02-03 | 2023-08-10 | Eli Lilly And Company | Regional tau imaging for diagnosing and treating alzheimer's disease |
| WO2024020470A1 (en) | 2022-07-21 | 2024-01-25 | Eli Lilly And Company | PHARMACEUTICAL SOLUTIONS OF ANTI-N3pGlu Aβ ANTIBODIES AND USES THEREOF |
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|---|---|---|---|---|
| GB8308235D0 (en) | 1983-03-25 | 1983-05-05 | Celltech Ltd | Polypeptides |
| US5225539A (en) | 1986-03-27 | 1993-07-06 | Medical Research Council | Recombinant altered antibodies and methods of making altered antibodies |
| US5530101A (en) | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
| US7122374B1 (en) * | 2002-04-09 | 2006-10-17 | Takaomi Saido | Amyloid beta-protein 3(pE)-42 antibodies and uses thereof |
| AU2003250102B2 (en) | 2002-07-24 | 2009-09-17 | Innogenetics N.V. | Fragments of beta-amyloid as targets for vaccination against alzheimer disease |
| WO2005018424A2 (en) * | 2003-08-18 | 2005-03-03 | Research Foundation For Mental Hygiene, Inc. | Antibodies specific for fibrillar amyloid and a procedure to detect fibrillar amyloid deposits |
| CA2538220A1 (en) | 2003-09-09 | 2005-03-24 | Takeda Pharmaceutical Company Limited | Use of antibody |
| PL1720909T3 (pl) * | 2004-02-23 | 2012-04-30 | Lilly Co Eli | Przeciwciało anty-abeta |
| MX2007000998A (es) * | 2004-07-30 | 2007-07-11 | Rinat Neuroscience Corp | Anticuerpos dirigidos peptido beta-amiloide y procedimientos que usan los mismos. |
| AR062065A1 (es) | 2006-07-14 | 2008-10-15 | Ac Immune Sa | Anticuerpo humanizado |
| BRPI0810118A8 (pt) * | 2007-04-18 | 2015-09-29 | Janssen Alzheimer Immunotherap | Método para tratar doença, método para efetuar profilaxia contra caa, uso de um agente, método para reduzir amilóide vascular em um paciente, e, kit para tratamento |
| MX2010013647A (es) | 2008-06-12 | 2011-04-05 | Affiris Ag | Compuestos para tratar sintomas asociados con la enfermedad de parkinson. |
| EP2321348A2 (en) | 2008-07-09 | 2011-05-18 | University of Zürich | Method of promoting neurogenesis |
| WO2010009987A2 (en) * | 2008-07-21 | 2010-01-28 | Probiodrug Ag | Diagnostic antibody assay |
| US8795664B2 (en) | 2010-06-04 | 2014-08-05 | Georg-August-Universität Göttingen Stiftung Öffentlichen Rechts, Universitätsmedizin | Monoclonal antibodies targeting amyloid beta oligomers |
| PL3339323T3 (pl) * | 2010-08-12 | 2020-05-18 | Eli Lilly And Company | Przeciwciała przeciwko peptydowi N3pGlu amyloidu beta i ich zastosowania |
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2011
- 2011-08-09 PL PL18150424T patent/PL3339323T3/pl unknown
- 2011-08-09 SI SI201131817T patent/SI3339323T1/sl unknown
- 2011-08-09 LT LTEP15196358.4T patent/LT3042917T/lt unknown
- 2011-08-09 EP EP11745672.3A patent/EP2603523B1/en active Active
- 2011-08-09 BR BR112013004056A patent/BR112013004056B8/pt active IP Right Grant
- 2011-08-09 DK DK15196358.4T patent/DK3042917T3/en active
- 2011-08-09 EP EP18150424.2A patent/EP3339323B1/en active Active
- 2011-08-09 EA EA201270813A patent/EA023021B1/ru not_active IP Right Cessation
- 2011-08-09 US US13/810,895 patent/US8679498B2/en active Active
- 2011-08-09 HU HUE15196358A patent/HUE037524T2/hu unknown
- 2011-08-09 CN CN201180039876.1A patent/CN103068848B/zh active Active
- 2011-08-09 PE PE2013000253A patent/PE20130817A1/es active IP Right Grant
- 2011-08-09 KR KR1020137003412A patent/KR101498833B1/ko active IP Right Grant
- 2011-08-09 SG SG2013005210A patent/SG187586A1/en unknown
- 2011-08-09 DK DK11745672.3T patent/DK2603523T3/en active
- 2011-08-09 CN CN201510613319.6A patent/CN105111308B/zh active Active
- 2011-08-09 SG SG10201509330XA patent/SG10201509330XA/en unknown
- 2011-08-09 HU HUE11745672A patent/HUE028678T2/en unknown
- 2011-08-09 LT LTEP18150424.2T patent/LT3339323T/lt unknown
- 2011-08-09 RS RS20180323A patent/RS57026B1/sr unknown
- 2011-08-09 AU AU2011289629A patent/AU2011289629B2/en active Active
- 2011-08-09 PT PT181504242T patent/PT3339323T/pt unknown
- 2011-08-09 ES ES15196358.4T patent/ES2664128T3/es active Active
- 2011-08-09 EP EP15196358.4A patent/EP3042917B1/en active Active
- 2011-08-09 MX MX2013001716A patent/MX342782B/es active IP Right Grant
- 2011-08-09 ME MEP-2019-356A patent/ME03661B/me unknown
- 2011-08-09 RS RS20160129A patent/RS54685B1/en unknown
- 2011-08-09 WO PCT/US2011/046994 patent/WO2012021469A1/en active Application Filing
- 2011-08-09 SI SI201131449T patent/SI3042917T1/en unknown
- 2011-08-09 PL PL11745672T patent/PL2603523T3/pl unknown
- 2011-08-09 ME MEP-2018-79A patent/ME03032B/me unknown
- 2011-08-09 MY MYPI2016001651A patent/MY181969A/en unknown
- 2011-08-09 DK DK18150424.2T patent/DK3339323T3/da active
- 2011-08-09 CA CA2805114A patent/CA2805114C/en active Active
- 2011-08-09 SI SI201130740T patent/SI2603523T1/sl unknown
- 2011-08-09 ME MEP-2016-28A patent/ME02352B/me unknown
- 2011-08-09 RS RS20191581A patent/RS59652B1/sr unknown
- 2011-08-09 JP JP2013524156A patent/JP5980207B2/ja active Active
- 2011-08-09 NO NO15196358A patent/NO3042917T3/no unknown
- 2011-08-09 PT PT151963584T patent/PT3042917T/pt unknown
- 2011-08-09 NZ NZ626665A patent/NZ626665A/en unknown
- 2011-08-09 PL PL15196358T patent/PL3042917T3/pl unknown
- 2011-08-09 ES ES11745672.3T patent/ES2564252T3/es active Active
- 2011-08-09 MA MA35653A patent/MA34461B1/fr unknown
- 2011-08-09 ES ES18150424T patent/ES2764728T3/es active Active
- 2011-08-09 MY MYPI2013700226A patent/MY163521A/en unknown
- 2011-08-09 NZ NZ606095A patent/NZ606095A/en unknown
- 2011-09-08 UA UAA201301508A patent/UA107600C2/ru unknown
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2012
- 2012-12-31 IL IL224030A patent/IL224030B/en unknown
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2013
- 2013-01-16 CR CR20130016A patent/CR20130016A/es unknown
- 2013-01-16 ZA ZA2013/00437A patent/ZA201300437B/en unknown
- 2013-02-05 DO DO2013000029A patent/DOP2013000029A/es unknown
- 2013-02-08 EC ECSP13012436 patent/ECSP13012436A/es unknown
- 2013-02-08 GT GT201300036A patent/GT201300036A/es unknown
- 2013-02-08 CL CL2013000390A patent/CL2013000390A1/es unknown
- 2013-02-12 CO CO13028596A patent/CO6670526A2/es unknown
- 2013-02-12 MX MX2016005533A patent/MX355268B/es unknown
- 2013-07-11 HK HK13108135.4A patent/HK1180703A1/zh unknown
- 2013-09-27 US US14/039,113 patent/US8961972B2/en active Active
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2016
- 2016-02-10 HR HRP20160151TT patent/HRP20160151T1/hr unknown
- 2016-04-22 JP JP2016086317A patent/JP6395755B2/ja active Active
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2018
- 2018-04-18 HR HRP20180616TT patent/HRP20180616T1/hr unknown
- 2018-04-20 CY CY20181100420T patent/CY1120144T1/el unknown
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2019
- 2019-12-12 HR HRP20192233TT patent/HRP20192233T1/hr unknown
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2020
- 2020-01-07 CY CY20201100005T patent/CY1122458T1/el unknown
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2021
- 2021-07-29 IL IL285226A patent/IL285226B2/en unknown
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