MA40182A - NOUVEL ANTICORPS ANTI-Tie2 HUMAIN - Google Patents
NOUVEL ANTICORPS ANTI-Tie2 HUMAINInfo
- Publication number
- MA40182A MA40182A MA040182A MA40182A MA40182A MA 40182 A MA40182 A MA 40182A MA 040182 A MA040182 A MA 040182A MA 40182 A MA40182 A MA 40182A MA 40182 A MA40182 A MA 40182A
- Authority
- MA
- Morocco
- Prior art keywords
- chain variable
- variable regions
- human tie2
- amino acid
- heavy chain
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/10—Antioedematous agents; Diuretics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2896—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/35—Valency
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/51—Complete heavy chain or Fd fragment, i.e. VH + CH1
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/515—Complete light chain, i.e. VL + CL
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/567—Framework region [FR]
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/64—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising a combination of variable region and constant region components
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/75—Agonist effect on antigen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2510/00—Genetically modified cells
- C12N2510/02—Cells for production
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Microbiology (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Endocrinology (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Heart & Thoracic Surgery (AREA)
- Diabetes (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Ophthalmology & Optometry (AREA)
- Cell Biology (AREA)
Abstract
L'invention concerne un anticorps anti-tie2 humain qui prévient ou traite l'œdème maculaire diabétique, la rétinopathie diabétique ou l'ischémie critique de membre inférieur en se liant au tie2 humain et en activant le tie2 humain. Les auteurs de la présente invention ont étudié les anticorps anti-tie2 humain et ont fourni un anticorps anti-tie2 humain comprenant quatre régions variables de chaîne lourde et quatre régions variables de chaîne légère. Les régions variables de chaîne lourde comprennent une séquence d'acides aminés provenant de l'acide aminé n°1 à 122 de la seq id no:2, et les régions variables de chaîne légère comprennent une séquence d'acides aminés provenant de l'acide aminé n°1 à 113 de seq id no:4. L'une des régions variables de chaîne lourde et l'une des régions variables de chaîne légère constituent un site de liaison à l'antigène, et l'anticorps comprend quatre sites de liaison à l'antigène.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2014145135 | 2014-07-15 |
Publications (1)
Publication Number | Publication Date |
---|---|
MA40182A true MA40182A (fr) | 2017-05-24 |
Family
ID=55078504
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MA040182A MA40182A (fr) | 2014-07-15 | 2015-07-14 | NOUVEL ANTICORPS ANTI-Tie2 HUMAIN |
Country Status (18)
Country | Link |
---|---|
US (2) | US9683051B2 (fr) |
EP (1) | EP3170841A4 (fr) |
JP (2) | JP6699551B2 (fr) |
KR (1) | KR102455680B1 (fr) |
CN (1) | CN106687478B (fr) |
AR (1) | AR101202A1 (fr) |
AU (1) | AU2015290673B2 (fr) |
BR (1) | BR112017000689A2 (fr) |
CA (1) | CA2954754C (fr) |
IL (1) | IL249964B (fr) |
MA (1) | MA40182A (fr) |
MX (1) | MX2017000615A (fr) |
MY (1) | MY185811A (fr) |
PH (1) | PH12017500094A1 (fr) |
RU (1) | RU2702553C2 (fr) |
SG (1) | SG11201700271RA (fr) |
TW (1) | TWI685502B (fr) |
WO (1) | WO2016010014A1 (fr) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2018226750A1 (fr) * | 2017-06-06 | 2018-12-13 | Relinia, Inc. | Protéines de fusion agonistes du récepteur 2 du tnf monocaténaire |
AU2019232523A1 (en) * | 2018-03-05 | 2020-09-03 | Etablissement Francais Du Sang | Recombinant single chain immunoglobulins |
WO2019235856A1 (fr) * | 2018-06-07 | 2019-12-12 | 기초과학연구원 | Anticorps se liant à tie2 et son utilisation |
CA3113059A1 (fr) | 2018-09-21 | 2020-03-26 | The University Of North Carolina At Chapel Hill | Agents de liaison synthetiques permettant de limiter la permeation a travers le mucus |
US20220213201A1 (en) * | 2019-08-14 | 2022-07-07 | Pharmabcine Inc. | Anti-tie2 antibody and use thereof |
KR20220131894A (ko) * | 2019-11-21 | 2022-09-29 | 유니티 바이오테크놀로지, 인크. | Tie-2에 지향성인 항체 및 사용 방법 |
CN115867649A (zh) * | 2020-03-24 | 2023-03-28 | 基因泰克公司 | Tie2结合剂及其使用方法 |
KR20220059924A (ko) * | 2020-11-03 | 2022-05-10 | 한국생명공학연구원 | 신규 항-Tie2 항체 또는 이의 항원 결합 단편, 및 이의 용도 |
EP4335871A1 (fr) * | 2021-05-06 | 2024-03-13 | Institute for Basic Science | Anticorps agonistes de tie2 et leurs utilisations |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5879672A (en) * | 1994-10-07 | 1999-03-09 | Regeneron Pharmaceuticals, Inc. | Tie-2 ligand 1 |
AUPM379494A0 (en) | 1994-02-10 | 1994-03-03 | Ludwig Institute For Cancer Research | Immunointeractive molecules - ii |
US6376653B1 (en) * | 1998-09-28 | 2002-04-23 | Smithkline Beecham Plc | Tie2 antagonist antibodies |
US6365154B1 (en) * | 1998-09-28 | 2002-04-02 | Smithkline Beecham Corporation | Tie2 agonist antibodies |
PL357939A1 (en) * | 2000-04-11 | 2004-08-09 | Genentech, Inc. | Multivalent antibodies and uses therefor |
US7485297B2 (en) | 2003-08-12 | 2009-02-03 | Dyax Corp. | Method of inhibition of vascular development using an antibody |
US8298532B2 (en) * | 2004-01-16 | 2012-10-30 | Regeneron Pharmaceuticals, Inc. | Fusion polypeptides capable of activating receptors |
US9758594B2 (en) * | 2008-04-25 | 2017-09-12 | Kyowa Hakko Kirin Co., Ltd. | Stable multivalent antibody |
CA2818215C (fr) * | 2010-10-07 | 2015-07-21 | Aerpio Therapeutics Inc. | Compositions et methodes de traitement d'un oedeme oculaire, de neovascularisation et de maladies associees |
CN103874709B (zh) | 2011-08-19 | 2016-12-21 | 瑞泽恩制药公司 | 抗tie2抗体及其用途 |
CA2876099A1 (fr) * | 2012-08-02 | 2014-02-06 | F. Hoffmann-La Roche Ag | Procede de production de molecules monomeres et multimeres et leurs utilisations |
-
2015
- 2015-07-14 JP JP2016534433A patent/JP6699551B2/ja active Active
- 2015-07-14 AR ARP150102238A patent/AR101202A1/es unknown
- 2015-07-14 RU RU2017104642A patent/RU2702553C2/ru active
- 2015-07-14 SG SG11201700271RA patent/SG11201700271RA/en unknown
- 2015-07-14 CA CA2954754A patent/CA2954754C/fr active Active
- 2015-07-14 MX MX2017000615A patent/MX2017000615A/es unknown
- 2015-07-14 TW TW104122782A patent/TWI685502B/zh active
- 2015-07-14 CN CN201580038358.6A patent/CN106687478B/zh active Active
- 2015-07-14 EP EP15822476.6A patent/EP3170841A4/fr active Pending
- 2015-07-14 AU AU2015290673A patent/AU2015290673B2/en active Active
- 2015-07-14 MY MYPI2017700117A patent/MY185811A/en unknown
- 2015-07-14 WO PCT/JP2015/070089 patent/WO2016010014A1/fr active Application Filing
- 2015-07-14 BR BR112017000689-8A patent/BR112017000689A2/pt active Search and Examination
- 2015-07-14 KR KR1020177001003A patent/KR102455680B1/ko active IP Right Grant
- 2015-07-14 MA MA040182A patent/MA40182A/fr unknown
-
2016
- 2016-04-21 US US15/134,803 patent/US9683051B2/en active Active
-
2017
- 2017-01-08 IL IL249964A patent/IL249964B/en active IP Right Grant
- 2017-01-13 PH PH12017500094A patent/PH12017500094A1/en unknown
- 2017-05-03 US US15/585,374 patent/US9902782B2/en active Active
-
2020
- 2020-02-28 JP JP2020032764A patent/JP6860103B2/ja active Active
Also Published As
Publication number | Publication date |
---|---|
IL249964A0 (en) | 2017-03-30 |
BR112017000689A2 (pt) | 2018-01-23 |
TW201617366A (zh) | 2016-05-16 |
RU2017104642A (ru) | 2018-08-15 |
AR101202A1 (es) | 2016-11-30 |
US9683051B2 (en) | 2017-06-20 |
WO2016010014A1 (fr) | 2016-01-21 |
CN106687478B (zh) | 2020-08-28 |
CN106687478A (zh) | 2017-05-17 |
CA2954754C (fr) | 2023-01-17 |
JP6699551B2 (ja) | 2020-05-27 |
RU2017104642A3 (fr) | 2019-03-07 |
JP2020103302A (ja) | 2020-07-09 |
AU2015290673A1 (en) | 2017-02-02 |
TWI685502B (zh) | 2020-02-21 |
MX2017000615A (es) | 2017-05-01 |
KR102455680B1 (ko) | 2022-10-17 |
US20160222130A1 (en) | 2016-08-04 |
CA2954754A1 (fr) | 2016-01-21 |
RU2702553C2 (ru) | 2019-10-08 |
AU2015290673B2 (en) | 2020-10-29 |
US20170253669A1 (en) | 2017-09-07 |
JP6860103B2 (ja) | 2021-04-14 |
US9902782B2 (en) | 2018-02-27 |
IL249964B (en) | 2020-11-30 |
EP3170841A4 (fr) | 2018-01-10 |
EP3170841A1 (fr) | 2017-05-24 |
KR20170029508A (ko) | 2017-03-15 |
PH12017500094A1 (en) | 2017-05-22 |
JPWO2016010014A1 (ja) | 2017-04-27 |
SG11201700271RA (en) | 2017-04-27 |
MY185811A (en) | 2021-06-10 |
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