WO2019235856A1 - Anticorps se liant à tie2 et son utilisation - Google Patents

Anticorps se liant à tie2 et son utilisation Download PDF

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Publication number
WO2019235856A1
WO2019235856A1 PCT/KR2019/006820 KR2019006820W WO2019235856A1 WO 2019235856 A1 WO2019235856 A1 WO 2019235856A1 KR 2019006820 W KR2019006820 W KR 2019006820W WO 2019235856 A1 WO2019235856 A1 WO 2019235856A1
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WIPO (PCT)
Prior art keywords
cancer
seq
amino acid
antibody
variable region
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PCT/KR2019/006820
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English (en)
Korean (ko)
Inventor
고규영
배점일
김재령
Original Assignee
기초과학연구원
한국과학기술원
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Application filed by 기초과학연구원, 한국과학기술원 filed Critical 기초과학연구원
Priority to CN201980038199.8A priority Critical patent/CN112399975B/zh
Priority to EP19814472.7A priority patent/EP3805265A4/fr
Priority to AU2019283520A priority patent/AU2019283520A1/en
Priority to JP2020567832A priority patent/JP7390317B2/ja
Priority to CA3101506A priority patent/CA3101506A1/fr
Priority claimed from KR1020190066622A external-priority patent/KR20190139148A/ko
Publication of WO2019235856A1 publication Critical patent/WO2019235856A1/fr
Priority to US17/111,413 priority patent/US20210179719A1/en
Priority to JP2023150164A priority patent/JP2023175830A/ja

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Immunology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Peptides Or Proteins (AREA)

Abstract

La présente invention concerne un anticorps dirigé contre le Tie-2 ou un fragment de liaison à l'antigène de celui-ci, un acide nucléique codant pour celui-ci, un vecteur comprenant ledit acide nucléique, une cellule transformée avec ledit vecteur, un procédé de production dudit anticorps ou du fragment de liaison à l'antigène de celui-ci, et une composition pour la prévention ou le traitement de maladies angiogéniques, comprenant ledit anticorps ou son fragment de liaison à l'antigène.
PCT/KR2019/006820 2018-06-07 2019-06-05 Anticorps se liant à tie2 et son utilisation WO2019235856A1 (fr)

Priority Applications (7)

Application Number Priority Date Filing Date Title
CN201980038199.8A CN112399975B (zh) 2018-06-07 2019-06-05 与Tie2结合的抗体及其用途
EP19814472.7A EP3805265A4 (fr) 2018-06-07 2019-06-05 Anticorps se liant à tie2 et son utilisation
AU2019283520A AU2019283520A1 (en) 2018-06-07 2019-06-05 Antibody binding to Tie2 and use thereof
JP2020567832A JP7390317B2 (ja) 2018-06-07 2019-06-05 抗Tie2抗体およびその使用
CA3101506A CA3101506A1 (fr) 2018-06-07 2019-06-05 Anticorps se liant a tie2 et son utilisation
US17/111,413 US20210179719A1 (en) 2018-06-07 2020-12-03 Antibody Binding To Tie2 And Use Thereof
JP2023150164A JP2023175830A (ja) 2018-06-07 2023-09-15 抗Tie2抗体およびその使用

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201862682042P 2018-06-07 2018-06-07
US62/682,042 2018-06-07
KR10-2019-0066622 2019-06-05
KR1020190066622A KR20190139148A (ko) 2018-06-07 2019-06-05 Tie2에 결합하는 항체 및 이의 용도

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US17/111,413 Continuation US20210179719A1 (en) 2018-06-07 2020-12-03 Antibody Binding To Tie2 And Use Thereof

Publications (1)

Publication Number Publication Date
WO2019235856A1 true WO2019235856A1 (fr) 2019-12-12

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Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/KR2019/006820 WO2019235856A1 (fr) 2018-06-07 2019-06-05 Anticorps se liant à tie2 et son utilisation

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WO (1) WO2019235856A1 (fr)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2021194913A1 (fr) * 2020-03-24 2021-09-30 Genentech, Inc. Agents de liaison à tie2 et leurs procédés d'utilisation
CN113993897A (zh) * 2019-08-14 2022-01-28 药物抗体公司 抗tie2抗体及其用途

Citations (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6365154B1 (en) 1998-09-28 2002-04-02 Smithkline Beecham Corporation Tie2 agonist antibodies
US7658924B2 (en) 2001-10-11 2010-02-09 Amgen Inc. Angiopoietin-2 specific binding agents
JP2011102273A (ja) 2009-11-11 2011-05-26 Shiseido Co Ltd Tie2活性化剤、血管の成熟化、正常化又は安定化剤、リンパ管安定化剤並びにしわ防止・改善剤及びむくみ改善・予防剤
KR20140054303A (ko) * 2011-08-19 2014-05-08 리제너론 파아마슈티컬스, 인크. 항-Tie2 항체 및 이의 용도
US8987420B2 (en) 2009-07-29 2015-03-24 Regeneron Pharmaceuticals, Inc. High affinity human antibodies to human angiopoietin-2
KR20150032075A (ko) * 2013-09-17 2015-03-25 삼성전자주식회사 Tie2와 결합을 유도하는 항 Ang2 항체를 포함하는 항암제
JP2015168656A (ja) 2014-03-07 2015-09-28 丸善製薬株式会社 Tie2活性化剤、血管新生抑制剤、血管の成熟化剤、血管の正常化剤、及び血管の安定化剤、並びに医薬品組成物
KR20170029508A (ko) * 2014-07-15 2017-03-15 아스텔라스세이야쿠 가부시키가이샤 신규 항인간 Tie2 항체
US20170174789A1 (en) 2011-08-19 2017-06-22 Regeneron Pharmaceuticals, Inc. Anti-TIE2 Antibodies and Uses Thereof
JP2018043949A (ja) 2016-09-15 2018-03-22 サンスター株式会社 Tie2活性用組成物

Patent Citations (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6365154B1 (en) 1998-09-28 2002-04-02 Smithkline Beecham Corporation Tie2 agonist antibodies
US7658924B2 (en) 2001-10-11 2010-02-09 Amgen Inc. Angiopoietin-2 specific binding agents
US8987420B2 (en) 2009-07-29 2015-03-24 Regeneron Pharmaceuticals, Inc. High affinity human antibodies to human angiopoietin-2
JP2011102273A (ja) 2009-11-11 2011-05-26 Shiseido Co Ltd Tie2活性化剤、血管の成熟化、正常化又は安定化剤、リンパ管安定化剤並びにしわ防止・改善剤及びむくみ改善・予防剤
KR20140054303A (ko) * 2011-08-19 2014-05-08 리제너론 파아마슈티컬스, 인크. 항-Tie2 항체 및 이의 용도
US20170174789A1 (en) 2011-08-19 2017-06-22 Regeneron Pharmaceuticals, Inc. Anti-TIE2 Antibodies and Uses Thereof
KR20150032075A (ko) * 2013-09-17 2015-03-25 삼성전자주식회사 Tie2와 결합을 유도하는 항 Ang2 항체를 포함하는 항암제
JP2015168656A (ja) 2014-03-07 2015-09-28 丸善製薬株式会社 Tie2活性化剤、血管新生抑制剤、血管の成熟化剤、血管の正常化剤、及び血管の安定化剤、並びに医薬品組成物
KR20170029508A (ko) * 2014-07-15 2017-03-15 아스텔라스세이야쿠 가부시키가이샤 신규 항인간 Tie2 항체
JP2018043949A (ja) 2016-09-15 2018-03-22 サンスター株式会社 Tie2活性用組成物

Non-Patent Citations (14)

* Cited by examiner, † Cited by third party
Title
CHO ET AL., PNAS, 2004
DATABASE GenBank 20 March 2018 (2018-03-20), "angiopoietin-1 receptor isoform X3 [Pan troglodytes", Database accession no. XP_016816188 .1 *
DAVID S ET AL., AM J PHYSIOL LUNG CELL MOL PHYSIOL, 2011
FRYE M, J EXP. MED, 2015
GOEL S, J NATL CANCER INST, 2013
HAN ET AL., SCIENCE, 2016
HAYASHI M, NATURE COMMUNICATION, 2013
HOUDE DENGEN JR, METHODS MOL. BIOL., vol. 988, 2013, pages 269 - 89
HOUDE ET AL., J. PHARM. SCI., vol. 100, no. 6, 2011, pages 2071
MARTH C ET AL., EUR. J. CANCER, 2017
MELLBERG S ET AL., FASEB J, 2009
MOORE, J. O. ET AL.: "Dimerization of Tie2 mediated by its membrane-proximal FNIII domains", PNAS, vol. 114, no. 17, 25 April 2017 (2017-04-25), pages 4382 - 4387, XP055661385 *
SAHARINEN P ET AL., NATURE REVIEW DRUG DISCOVERY, 2017
ZHANG ET AL., JBC, vol. 277, 2002, pages 45276 - 45284

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113993897A (zh) * 2019-08-14 2022-01-28 药物抗体公司 抗tie2抗体及其用途
WO2021194913A1 (fr) * 2020-03-24 2021-09-30 Genentech, Inc. Agents de liaison à tie2 et leurs procédés d'utilisation

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