JOP20190103B1 - شدفة Fab جديدة لجسم مضاد ضد MUC1 بشري - Google Patents

شدفة Fab جديدة لجسم مضاد ضد MUC1 بشري

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Publication number
JOP20190103B1
JOP20190103B1 JOP/2019/0103A JOP20190103A JOP20190103B1 JO P20190103 B1 JOP20190103 B1 JO P20190103B1 JO P20190103 A JOP20190103 A JO P20190103A JO P20190103 B1 JOP20190103 B1 JO P20190103B1
Authority
JO
Jordan
Prior art keywords
fab fragment
muc1 antibody
human muc1
antibody fab
novel anti
Prior art date
Application number
JOP/2019/0103A
Other languages
English (en)
Inventor
Morinaka Akifumi
Hirayama Kazunori
Hosogai Naomi
Doihara Hitoshi
Shirai Hiroki
Original Assignee
Astellas Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astellas Pharma Inc filed Critical Astellas Pharma Inc
Publication of JOP20190103A1 publication Critical patent/JOP20190103A1/ar
Application granted granted Critical
Publication of JOP20190103B1 publication Critical patent/JOP20190103B1/ar

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    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
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Abstract

تتمثل المشكلة المراد حلها في تزويد شدفة Fab لجسم مضاد ضد MUC1 بشري حيث يكون من المتوقع أن تكون مفيدةً في تشخيص و/أو معالجة السرطان، بالتحديد، تشخيص و/أو معالجة سرطان الثدي أو سرطان المثانة، وطريقة تشخيص و/أو طريقة معالجة باستخدام مادة اقتران حيث تشتمل على الشدفة Fab. ويتمثل الحل في شدفة Fab لجسم مضاد ضد MUC1 بشري حيث تشتمل على شدفة لسلسلة ثقيلة تشتمل على منطقة متغيرة لسلسلة ثقيلة مكونة من سياق الأحماض الأمينية الممثل بسياق برقم تعريف: 8 أو 10، وسلسلة خفيفة حيث تشتمل على منطقة متغيرة لسلسلة خفيفة مكونة من سياق الأحماض الأمينية الممثل بسياق برقم تعريف: 12، ومادة اقتران تشتمل على الشدفة Fab.
JOP/2019/0103A 2016-11-18 2017-11-17 شدفة Fab جديدة لجسم مضاد ضد MUC1 بشري JOP20190103B1 (ar)

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