PT3543337T - Novo fragmento fab do anticorpo muc1 anti-humano - Google Patents

Novo fragmento fab do anticorpo muc1 anti-humano

Info

Publication number
PT3543337T
PT3543337T PT178706727T PT17870672T PT3543337T PT 3543337 T PT3543337 T PT 3543337T PT 178706727 T PT178706727 T PT 178706727T PT 17870672 T PT17870672 T PT 17870672T PT 3543337 T PT3543337 T PT 3543337T
Authority
PT
Portugal
Prior art keywords
fab fragment
novel anti
antibody fab
muc1 antibody
human muc1
Prior art date
Application number
PT178706727T
Other languages
English (en)
Original Assignee
Astellas Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astellas Pharma Inc filed Critical Astellas Pharma Inc
Publication of PT3543337T publication Critical patent/PT3543337T/pt

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    • A61K39/39533Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
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    • G01N2333/4725Mucins, e.g. human intestinal mucin

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PT178706727T 2016-11-18 2017-11-17 Novo fragmento fab do anticorpo muc1 anti-humano PT3543337T (pt)

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Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MA46851A (fr) 2016-11-18 2019-09-25 Astellas Pharma Inc NOUVEAU FRAGMENT Fab D'ANTICORPS ANTI-MUC1 HUMAIN
TWI795415B (zh) 2017-07-07 2023-03-11 日商安斯泰來製藥股份有限公司 新穎的抗人類CEACAM5抗體Fab片段
EP3795590A4 (en) * 2018-05-17 2022-05-04 Astellas Pharma Inc. COMPLEX HAVING ANTI-HUMAN MUC1 ANTIBODY FAB FRAGMENT, PEPTIDE LINKER AND/OR LIGAND
SG11202103670XA (en) * 2018-10-10 2021-05-28 Astellas Pharma Inc Pharmaceutical composition containing tagged site-antihuman antibody fab fragment complex
EP3909606A4 (en) * 2019-01-07 2023-01-18 Astellas Pharma Inc. COMPLEX WITH LIGAND AND CEACAM5 ANTIBODY FAB FRAGMENT
US20240285810A1 (en) * 2019-06-28 2024-08-29 University Of Cincinnati Development of a novel pet probe for targeted bacterial imaging
KR20220092432A (ko) 2020-12-24 2022-07-01 주식회사 엘지화학 뮤신 1에 특이적인 폴리펩티드 및 이의 이용
WO2023240135A2 (en) 2022-06-07 2023-12-14 Actinium Pharmaceuticals, Inc. Bifunctional chelators and conjugates

Family Cites Families (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL162181A (en) 1988-12-28 2006-04-10 Pdl Biopharma Inc A method of producing humanized immunoglubulin, and polynucleotides encoding the same
AU4314900A (en) 1999-04-28 2000-11-17 Yamanouchi Pharmaceutical Co., Ltd. Parenteral medicinal composition containing humanized monoclonal antibody fragment and method for stabilizing the same
WO2001075110A2 (en) * 2000-03-30 2001-10-11 Dyax Corp. Mucin-1 specific binding members and methods of use thereof
DE10303664A1 (de) 2003-01-23 2004-08-12 Nemod Immuntherapie Ag Erkennungsmoleküle zur Behandlung und Detektion von Tumoren
WO2005086875A2 (en) 2004-03-11 2005-09-22 City Of Hope A humanized anti-cea t84.66 antibody and uses thereof
US20100111856A1 (en) 2004-09-23 2010-05-06 Herman Gill Zirconium-radiolabeled, cysteine engineered antibody conjugates
BRPI0614100A2 (pt) 2005-08-03 2011-03-09 Immunogen Inc formulações de imunoconjugado lìquidas
EA015860B1 (ru) 2005-10-13 2011-12-30 Хьюман Дженом Сайенсиз, Инк. Способы лечения аутоиммунных заболеваний при использовании антагониста нейтрокина-альфа
EP2083868A2 (en) 2006-10-04 2009-08-05 Københavns Universitet Generation of a cancer-specific immune response toward muc1 and cancer specific muc1 antibodies
CN102264765B (zh) * 2008-10-28 2016-01-20 盐野义制药株式会社 抗muc1抗体
EP2196476A1 (en) 2008-12-10 2010-06-16 Novartis Ag Antibody formulation
WO2011005322A2 (en) 2009-07-08 2011-01-13 Lantheus Medical Imaging, Inc. N-alkoxyamide conjugates as imaging agents
EP2281844A1 (en) 2009-07-31 2011-02-09 Glycotope GmbH MUC 1 antibodies
EP2478110B1 (en) 2009-09-16 2016-01-06 Immunomedics, Inc. Class i anti-cea antibodies and uses thereof
KR101809761B1 (ko) * 2009-09-24 2017-12-15 가부시키가이샤 진 테크노 사이언스 세포 외 기질 단백질의 아미노산 서열 rgd에 특이적인 인간화된 항체 및 그의 용도
EP2347769A1 (en) * 2010-01-20 2011-07-27 Glycotope GmbH Cancer stem cell markers and uses thereof
JP5916017B2 (ja) 2010-04-28 2016-05-11 塩野義製薬株式会社 新規なmuc1抗体
CN101928347B (zh) 2010-05-05 2013-03-27 上海海抗中医药科技发展有限公司 抗癌胚抗原抗体及其应用
EP3797847A1 (en) 2010-07-30 2021-03-31 Medlmmune, LLC Purified active polypeptides or immunoconjugates
LT2681244T (lt) 2011-03-02 2018-02-12 Roche Glycart Ag Cea antikūnai
WO2013081091A1 (ja) 2011-12-01 2013-06-06 国立大学法人 千葉大学 非特異的腎集積が低減された放射性標識ポリペプチド作製用薬剤
RU2493165C1 (ru) * 2012-02-28 2013-09-20 Общество с ограниченной ответственностью "Технофарма" Наноантитело, специфически связывающее белок muc1, способ детекции белка muc1 с помощью наноантител
DK3199552T3 (da) 2012-11-20 2020-03-30 Sanofi Sa Anti-ceacam5-antistoffer og anvendelser heraf
ES2673583T3 (es) 2013-02-28 2018-06-22 National Cancer Center Anticuerpo contra fibrina insoluble
US9216859B2 (en) 2013-05-03 2015-12-22 Habasit Ag Rod retention system and method
KR102553717B1 (ko) 2013-08-26 2023-07-11 바이오엔테크 리서치 앤드 디벨롭먼트 인코포레이티드 시알릴-루이스 a에 대한 사람 항체 코드화 핵산
TWI541022B (zh) 2013-12-18 2016-07-11 應克隆公司 針對纖維母細胞生長因子受體-3(fgfr3)之化合物及治療方法
CN106132434A (zh) 2014-04-07 2016-11-16 西雅图基因公司 抗‑cd19抗体和抗体‑药物偶联物的稳定制剂
KR102262720B1 (ko) 2014-04-28 2021-06-08 이카가쿠 소우야쿠 가부시키가이샤 항muc1 항체 또는 그의 항원 결합성 단편 및 그 용도
TWI705827B (zh) 2014-11-07 2020-10-01 瑞士商諾華公司 治療眼部疾病之方法
AU2016219350A1 (en) * 2015-02-10 2017-08-24 Minerva Biotechnologies Corporation Humanized anti-MUC1* antibodies
EP3424940A4 (en) 2016-03-01 2019-10-30 National University Corporation Chiba University RADIOMARCED MEDICINE
MA46851A (fr) 2016-11-18 2019-09-25 Astellas Pharma Inc NOUVEAU FRAGMENT Fab D'ANTICORPS ANTI-MUC1 HUMAIN
US10758632B2 (en) 2017-02-06 2020-09-01 City Of Hope NIR-conjugated tumor-specific antibodies and uses thereof
TWI795415B (zh) 2017-07-07 2023-03-11 日商安斯泰來製藥股份有限公司 新穎的抗人類CEACAM5抗體Fab片段
WO2019065774A1 (ja) 2017-09-26 2019-04-04 国立大学法人 千葉大学 放射性薬剤
EP3795590A4 (en) 2018-05-17 2022-05-04 Astellas Pharma Inc. COMPLEX HAVING ANTI-HUMAN MUC1 ANTIBODY FAB FRAGMENT, PEPTIDE LINKER AND/OR LIGAND
SG11202103670XA (en) 2018-10-10 2021-05-28 Astellas Pharma Inc Pharmaceutical composition containing tagged site-antihuman antibody fab fragment complex
EP3909606A4 (en) 2019-01-07 2023-01-18 Astellas Pharma Inc. COMPLEX WITH LIGAND AND CEACAM5 ANTIBODY FAB FRAGMENT

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