EA201492282A1 - Антагонистические антигенсвязывающие белки к двум рецепторам и их применение - Google Patents

Антагонистические антигенсвязывающие белки к двум рецепторам и их применение

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Publication number
EA201492282A1
EA201492282A1 EA201492282A EA201492282A EA201492282A1 EA 201492282 A1 EA201492282 A1 EA 201492282A1 EA 201492282 A EA201492282 A EA 201492282A EA 201492282 A EA201492282 A EA 201492282A EA 201492282 A1 EA201492282 A1 EA 201492282A1
Authority
EA
Eurasian Patent Office
Prior art keywords
receptors
binding proteins
antagonistic
antibodies
antigens
Prior art date
Application number
EA201492282A
Other languages
English (en)
Inventor
Хуйцюань Хань
Сяолань Чжоу
Цин Чэнь
Мэй-Мэй Цзай
Original Assignee
Амген Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Амген Инк. filed Critical Амген Инк.
Publication of EA201492282A1 publication Critical patent/EA201492282A1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/42—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • C07K16/468—Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/75—Agonist effect on antigen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Abstract

Изобретение относится к антагонистическим антигенсвязывающим белкам к двум рецепторам, например антителам, и способам с использованием антител к двум рецепторам для лечения патологических заболеваний. Антитела к двум рецепторам могут включать антитела к рецепторам ActRII и могут быть использованы для лечения патологического состояния. Патологические состояния могут включать атрофию мышц или какие-либо заболевания, которые требуют стимуляции роста мышц.
EA201492282A 2012-06-11 2013-06-11 Антагонистические антигенсвязывающие белки к двум рецепторам и их применение EA201492282A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261658237P 2012-06-11 2012-06-11
PCT/US2013/045245 WO2013188448A2 (en) 2012-06-11 2013-06-11 Dual receptor antagonistic antigen-binding proteins and uses thereof

Publications (1)

Publication Number Publication Date
EA201492282A1 true EA201492282A1 (ru) 2015-07-30

Family

ID=49758865

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201492282A EA201492282A1 (ru) 2012-06-11 2013-06-11 Антагонистические антигенсвязывающие белки к двум рецепторам и их применение

Country Status (21)

Country Link
US (4) US9453080B2 (ru)
EP (3) EP2859114B1 (ru)
JP (1) JP2015525230A (ru)
KR (1) KR20150030706A (ru)
CN (1) CN104540961A (ru)
AU (1) AU2013274347B2 (ru)
BR (1) BR112014031028A2 (ru)
CA (1) CA2877669A1 (ru)
CL (1) CL2014003372A1 (ru)
CO (1) CO7240399A2 (ru)
EA (1) EA201492282A1 (ru)
HK (1) HK1208499A1 (ru)
IL (1) IL236133A0 (ru)
MA (1) MA37761A1 (ru)
MX (1) MX2014015195A (ru)
NZ (1) NZ703724A (ru)
PE (1) PE20150642A1 (ru)
PH (1) PH12014502754A1 (ru)
SG (2) SG11201408228QA (ru)
TN (2) TN2015000448A1 (ru)
WO (1) WO2013188448A2 (ru)

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KR20200109330A (ko) 2018-01-12 2020-09-22 케로스 테라퓨틱스, 인크. 액티빈 수용체 유형 iib 변이체 및 그의 사용 방법
JP2022534966A (ja) * 2019-05-30 2022-08-04 アクセレロン ファーマ インコーポレーテッド Ａｃｔｒｉｉ結合性タンパク質及びその使用
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Also Published As

Publication number Publication date
BR112014031028A2 (pt) 2017-08-15
EP3498857A1 (en) 2019-06-19
EP2859114A2 (en) 2015-04-15
TN2015000448A1 (en) 2017-04-06
CA2877669A1 (en) 2013-12-19
NZ703724A (en) 2017-06-30
PH12014502754A1 (en) 2015-03-02
US20170107288A1 (en) 2017-04-20
JP2015525230A (ja) 2015-09-03
EP2859114A4 (en) 2016-08-03
AU2013274347A1 (en) 2015-02-05
KR20150030706A (ko) 2015-03-20
CL2014003372A1 (es) 2015-04-10
EP3540070A1 (en) 2019-09-18
MX2014015195A (es) 2015-02-17
CO7240399A2 (es) 2015-04-17
AU2013274347B2 (en) 2018-03-08
CN104540961A (zh) 2015-04-22
IL236133A0 (en) 2015-01-29
US10266598B2 (en) 2019-04-23
WO2013188448A8 (en) 2014-05-08
SG10201610356YA (en) 2017-01-27
MA37761A1 (fr) 2017-09-29
HK1208499A1 (en) 2016-03-04
US20210340262A1 (en) 2021-11-04
US20150152194A1 (en) 2015-06-04
US10981999B2 (en) 2021-04-20
WO2013188448A2 (en) 2013-12-19
SG11201408228QA (en) 2015-01-29
EP2859114B1 (en) 2019-05-15
US9453080B2 (en) 2016-09-27
PE20150642A1 (es) 2015-05-26
TN2014000513A1 (en) 2016-03-30
WO2013188448A3 (en) 2014-04-10
US20190256605A1 (en) 2019-08-22

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