MX2020012972A - Combinacion farmaceutica, composicion y preparacion de compuestos que contienen activador de glucocinasa y bloqueador de canales k-atp, metodo de preparacion y uso de los mismos. - Google Patents
Combinacion farmaceutica, composicion y preparacion de compuestos que contienen activador de glucocinasa y bloqueador de canales k-atp, metodo de preparacion y uso de los mismos.Info
- Publication number
- MX2020012972A MX2020012972A MX2020012972A MX2020012972A MX2020012972A MX 2020012972 A MX2020012972 A MX 2020012972A MX 2020012972 A MX2020012972 A MX 2020012972A MX 2020012972 A MX2020012972 A MX 2020012972A MX 2020012972 A MX2020012972 A MX 2020012972A
- Authority
- MX
- Mexico
- Prior art keywords
- pharmaceutical combination
- channel blocker
- composition
- atp channel
- glucokinase activator
- Prior art date
Links
- 238000002360 preparation method Methods 0.000 title abstract 4
- 150000001875 compounds Chemical class 0.000 title abstract 3
- 229940124828 glucokinase activator Drugs 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 abstract 2
- 239000013078 crystal Substances 0.000 abstract 1
- 230000000155 isotopic effect Effects 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
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- A61K31/4155—1,2-Diazoles non condensed and containing further heterocyclic rings
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- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
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Abstract
La presente invención se refiere a una combinación farmacéutica, la combinación farmacéutica comprende un activador de glucocinasa o una sal farmacéuticamente aceptable del mismo, un marcador isotópico del mismo, una forma cristalina del mismo, un hidrato, un solvato, un diastereoisómero o enantiómero y un bloqueador de canal de K-ATP. La presente invención se refiere además a una composición farmacéutica, una preparación de compuesto de dosis fija y un método para preparar la composición farmacéutica y la preparación de compuesto de dosis fija, así como un uso de la misma.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
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CN201810556685 | 2018-05-31 | ||
PCT/CN2019/088862 WO2019228363A1 (zh) | 2018-05-31 | 2019-05-28 | 含有葡萄糖激酶激活剂和k-atp通道阻断剂的药物组合、组合物和复方制剂及其制备方法和用途 |
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MX2020012972A true MX2020012972A (es) | 2021-02-16 |
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MX2020012969A MX2020012969A (es) | 2018-05-31 | 2019-05-28 | Combinacion y composicion farmaceutica y preparacion combinada que contiene activador de glucocinasa y farmaco hipoglucemico biguanida, asi como metodo de preparacion y uso del mismo. |
MX2020012965A MX2020012965A (es) | 2018-05-31 | 2019-05-28 | Combinacion, composicion y preparacion de compuesto farmaceutico que comprende activador de glucocinasa e inhibidor de dpp-iv, metodo de preparacion y uso del mismo. |
MX2020012972A MX2020012972A (es) | 2018-05-31 | 2019-05-28 | Combinacion farmaceutica, composicion y preparacion de compuestos que contienen activador de glucocinasa y bloqueador de canales k-atp, metodo de preparacion y uso de los mismos. |
MX2020012970A MX2020012970A (es) | 2018-05-31 | 2019-05-28 | Combinacion, composicion y formulacion farmaceutica que contiene activador de glucocinasa e inhibidor de alfa-glucosidasa, metodos de preparacion y usos de los mismos. |
MX2020012967A MX2020012967A (es) | 2018-05-31 | 2019-05-28 | Combinacion farmaceutica que contiene activador de glucosacinasa y activador del receptor ppar, composicion, preparacion del compuesto, metodo de preparacion para el mismo y usos del mismo. |
MX2020012966A MX2020012966A (es) | 2018-05-31 | 2019-05-28 | Combinacion, composicion y preparacion de combinacion farmaceutica que comprende activador de glucocinasa e inhibidor de sglt-2, metodos de preparacion y usos de las mismas. |
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Application Number | Title | Priority Date | Filing Date |
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MX2020012969A MX2020012969A (es) | 2018-05-31 | 2019-05-28 | Combinacion y composicion farmaceutica y preparacion combinada que contiene activador de glucocinasa y farmaco hipoglucemico biguanida, asi como metodo de preparacion y uso del mismo. |
MX2020012965A MX2020012965A (es) | 2018-05-31 | 2019-05-28 | Combinacion, composicion y preparacion de compuesto farmaceutico que comprende activador de glucocinasa e inhibidor de dpp-iv, metodo de preparacion y uso del mismo. |
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Application Number | Title | Priority Date | Filing Date |
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MX2020012970A MX2020012970A (es) | 2018-05-31 | 2019-05-28 | Combinacion, composicion y formulacion farmaceutica que contiene activador de glucocinasa e inhibidor de alfa-glucosidasa, metodos de preparacion y usos de los mismos. |
MX2020012967A MX2020012967A (es) | 2018-05-31 | 2019-05-28 | Combinacion farmaceutica que contiene activador de glucosacinasa y activador del receptor ppar, composicion, preparacion del compuesto, metodo de preparacion para el mismo y usos del mismo. |
MX2020012966A MX2020012966A (es) | 2018-05-31 | 2019-05-28 | Combinacion, composicion y preparacion de combinacion farmaceutica que comprende activador de glucocinasa e inhibidor de sglt-2, metodos de preparacion y usos de las mismas. |
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US (8) | US11992477B2 (es) |
EP (6) | EP3804712A4 (es) |
JP (12) | JP2021525741A (es) |
KR (6) | KR102695132B1 (es) |
CN (12) | CN114028574A (es) |
AU (6) | AU2019278017A1 (es) |
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US11872221B2 (en) | 2020-01-31 | 2024-01-16 | Hua Medicine (Shanghai) Ltd. | Treating untreated or treatment-resistant diabetes with glucokinase activator |
AU2020426356A1 (en) * | 2020-01-31 | 2022-08-25 | Hua Medicine (Shanghai) Ltd. | Treating treatment-resistant diabetes with glucokinase activator |
WO2021212360A1 (en) * | 2020-04-22 | 2021-10-28 | Hua Medicine (Shanghai) Ltd. | Treating untreated or treatment-resistant diabetes with glucokinase activator and sodium-glucose cotransporter-2 inhibitor |
US11813274B2 (en) | 2020-04-22 | 2023-11-14 | Hua Medicine (Shanghai) Ltd. | Treating untreated or treatment-resistant diabetes with glucokinase activator and sodium-glucose cotransporter-2 inhibitor |
US11857536B2 (en) | 2020-06-04 | 2024-01-02 | Hua Medicine (Shanghai) Ltd. | Glucokinase activator for treating diabetes with renal impairment |
WO2021243646A1 (en) * | 2020-06-04 | 2021-12-09 | Hua Medicine (Shanghai) Ltd. | Glucokinase activator for treating diabetes with hepatic impairment |
WO2021243645A1 (en) * | 2020-06-04 | 2021-12-09 | Hua Medicine (Shanghai) Ltd. | Glucokinase activator for treating diabetes with renal impairment |
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CN113527265B9 (zh) * | 2021-02-02 | 2022-07-19 | 湖南南新制药股份有限公司 | 一种氘代吡咯烷酮衍生物、药物组合物及其用途 |
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