IL279039A - Pharmaceutical combination, composition and compound preparation comprising glucokinase activator and dpp-iv inhibitor, and preparation method and use thereof - Google Patents

Pharmaceutical combination, composition and compound preparation comprising glucokinase activator and dpp-iv inhibitor, and preparation method and use thereof

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Publication number
IL279039A
IL279039A IL279039A IL27903920A IL279039A IL 279039 A IL279039 A IL 279039A IL 279039 A IL279039 A IL 279039A IL 27903920 A IL27903920 A IL 27903920A IL 279039 A IL279039 A IL 279039A
Authority
IL
Israel
Prior art keywords
preparation
dpp
inhibitor
composition
pharmaceutical combination
Prior art date
Application number
IL279039A
Other languages
Hebrew (he)
Original Assignee
Hua Medicine Shanghai Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Hua Medicine Shanghai Ltd filed Critical Hua Medicine Shanghai Ltd
Publication of IL279039A publication Critical patent/IL279039A/en

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    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4151,2-Diazoles
    • A61K31/41551,2-Diazoles non condensed and containing further heterocyclic rings
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    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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    • A61K31/13Amines
    • A61K31/133Amines having hydroxy groups, e.g. sphingosine
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    • A61K31/155Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
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IL279039A 2018-05-31 2020-11-27 Pharmaceutical combination, composition and compound preparation comprising glucokinase activator and dpp-iv inhibitor, and preparation method and use thereof IL279039A (en)

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Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11872221B2 (en) 2020-01-31 2024-01-16 Hua Medicine (Shanghai) Ltd. Treating untreated or treatment-resistant diabetes with glucokinase activator
AU2020426356A1 (en) * 2020-01-31 2022-08-25 Hua Medicine (Shanghai) Ltd. Treating treatment-resistant diabetes with glucokinase activator
WO2021212360A1 (en) * 2020-04-22 2021-10-28 Hua Medicine (Shanghai) Ltd. Treating untreated or treatment-resistant diabetes with glucokinase activator and sodium-glucose cotransporter-2 inhibitor
US11813274B2 (en) 2020-04-22 2023-11-14 Hua Medicine (Shanghai) Ltd. Treating untreated or treatment-resistant diabetes with glucokinase activator and sodium-glucose cotransporter-2 inhibitor
US11857536B2 (en) 2020-06-04 2024-01-02 Hua Medicine (Shanghai) Ltd. Glucokinase activator for treating diabetes with renal impairment
WO2021243646A1 (en) * 2020-06-04 2021-12-09 Hua Medicine (Shanghai) Ltd. Glucokinase activator for treating diabetes with hepatic impairment
WO2021243645A1 (en) * 2020-06-04 2021-12-09 Hua Medicine (Shanghai) Ltd. Glucokinase activator for treating diabetes with renal impairment
CN111759838B (en) * 2020-07-02 2022-01-25 深圳微芯生物科技股份有限公司 Pharmaceutical composition of pharmaceutically acceptable salt of sitagliptin and application thereof
CN112206216B (en) * 2020-10-15 2023-03-17 江西华士药业有限公司 Preparation method of sustained-release dapagliflozin
CN116234545A (en) * 2020-11-19 2023-06-06 北京睿创康泰医药研究院有限公司 Composition of fixed dose SGLT-2 inhibitor and angiotensin converting enzyme inhibitor and application
CN113527265B9 (en) * 2021-02-02 2022-07-19 湖南南新制药股份有限公司 Deuterated pyrrolidone derivative, pharmaceutical composition and application thereof
CN117500923A (en) 2021-04-07 2024-02-02 巴特尔纪念研究院 Rapid design, construction, testing and learning techniques for identification and use of non-viral vectors
CN113750100B (en) * 2021-08-31 2022-12-30 海南中济医药科技有限公司 Pharmaceutical composition containing polyagliflozin Ai Ting and sitagliptin and preparation method thereof
AR127064A1 (en) 2021-09-15 2023-12-13 Hua Medicine Shanghai Ltd PRODRUGS OF PYRROLIDONE DERIVATIVES AS A GLUCOKINASE ACTIVATOR
WO2024005755A1 (en) * 2022-06-29 2024-01-04 Sanovel Ilac Sanayi Ve Ticaret Anonim Sirketi A tablet comprising empagliflozin

Family Cites Families (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9511220D0 (en) * 1995-06-02 1995-07-26 Glaxo Group Ltd Solid dispersions
US20040081697A1 (en) * 1998-11-12 2004-04-29 Smithkline Beecham P.L.C. Pharmaceutical composition for modified release of an insulin sensitiser and another antidiabetic agent
MXPA06004698A (en) 2003-10-27 2006-07-05 Innodia Inc Methods and composition for use in treating diabetes.
AU2004285354B2 (en) 2003-10-31 2009-09-17 Takeda Pharmaceutical Company Limited Solid preparation comprising an insulin sensitizer, an insulin secretagogue and a polyoxyethylene sorbitan fatty acid ester
EP1734040A4 (en) 2004-03-23 2007-11-28 Banyu Pharma Co Ltd Substituted quinazoline or pyridopyrimidine derivative
BRPI0609464A2 (en) 2005-05-23 2010-04-13 Japan Tobacco Inc pyrazole compound and therapeutic agent for diabetes comprising the same
PE20110235A1 (en) 2006-05-04 2011-04-14 Boehringer Ingelheim Int PHARMACEUTICAL COMBINATIONS INCLUDING LINAGLIPTIN AND METMORPHINE
US7910747B2 (en) 2006-07-06 2011-03-22 Bristol-Myers Squibb Company Phosphonate and phosphinate pyrazolylamide glucokinase activators
US20080107725A1 (en) * 2006-10-13 2008-05-08 Albano Antonio A Pharmaceutical Solid Dosage Forms Comprising Amorphous Compounds Micro-Embedded in Ionic Water-Insoluble Polymers
CA2669043A1 (en) 2006-11-09 2008-05-15 Boehringer Ingelheim International Gmbh Combination therapy with sglt-2 inhibitors and their pharmaceutical compositions
MX2010002772A (en) 2007-09-21 2010-03-31 Array Biopharma Inc Pyridin-2 -yl-amino-i, 2, 4 -thiadiazole derivatives as glucokinase activators for the treatment of diabetes mellitus.
US7741327B2 (en) * 2008-04-16 2010-06-22 Hoffmann-La Roche Inc. Pyrrolidinone glucokinase activators
UY31830A (en) 2008-05-16 2010-01-05 Takeda Pharmaceutical GLUCOQUINASE ACTIVATORS
TWI472525B (en) 2008-12-05 2015-02-11 Otsuka Pharma Co Ltd Quinolone compound and pharmaceutical composition
WO2010092163A2 (en) * 2009-02-13 2010-08-19 Boehringer Ingelheim International Gmbh Antidiabetic medications
CA2754681C (en) * 2009-03-11 2014-01-07 Pfizer Inc. Benzofuranyl derivatives used as glucokinase inhibitors
WO2010107610A1 (en) 2009-03-17 2010-09-23 Merck Sharp & Dohme Corp. Method for treatment of diabetes and related conditions with combination therapy and compositions containing such compounds
EP2435033A1 (en) 2009-05-27 2012-04-04 Bristol-Myers Squibb Company Methods for treating type 2 diabetes in patients resistant to previous treatment with other anti-diabetic drugs employing an sglt2 inhibitor and compositions thereof
RU2564901C2 (en) 2009-11-13 2015-10-10 Бристол-Майерс Сквибб Кампани Compositions of metformin with reduced weight
PL2498759T3 (en) * 2009-11-13 2019-03-29 Astrazeneca Ab Immediate release tablet formulations
US9359313B2 (en) * 2010-05-26 2016-06-07 Vtv Therapeutics Llc Use of metformin in combination with a glucokinase activator and compositions comprising metformin and a glucokinase activator
CN102558167A (en) 2010-12-29 2012-07-11 中国医学科学院药物研究所 Thiazolidine derivant with GK and PPAR double excitation activity
EP2529742B1 (en) 2011-06-03 2013-11-20 ratiopharm GmbH Pharmaceutical composition comprising dapagliflozin and cyclodextrin
KR102371364B1 (en) * 2012-05-17 2022-03-07 브이티브이 테라퓨틱스 엘엘씨 Glucokinase activator compositions for the treatment of diabetes
IN2015DN03869A (en) * 2012-11-13 2015-10-02 Taisho Pharmaceutical Co Ltd
TW201446286A (en) * 2013-01-31 2014-12-16 Gilead Pharmasset Llc Solid dispersion formulation of an antiviral compound
CA2812519A1 (en) 2013-04-05 2014-10-05 Boehringer Ingelheim International Gmbh Pharmaceutical composition, methods for treating and uses thereof
CN104208034B (en) * 2013-12-11 2017-11-07 重庆康刻尔制药有限公司 A kind of Glimepiride medicinal composition tablets, preparation method and applications
CN103655539B (en) 2013-12-13 2019-09-13 重庆医药工业研究院有限责任公司 A kind of oral solid formulation of canagliflozin and preparation method thereof
CN104840960A (en) * 2014-02-14 2015-08-19 广东东阳光药业有限公司 Antidiabetic pharmaceutical composition and preparation method thereof
TW201625605A (en) * 2014-04-04 2016-07-16 賽諾菲公司 Substituted fused heterocycles as GPR119 modulators for the treatment of diabetes, obesity, dyslipidemia and related disorders
WO2015176267A1 (en) 2014-05-22 2015-11-26 Merck Sharp & Dohme Corp. Antidiabetic tricyclic compounds
WO2017083925A1 (en) 2015-11-19 2017-05-26 Garvan Institute Of Medical Research Compounds and methods for treating metabolic disorders
WO2017153939A1 (en) 2016-03-10 2017-09-14 Aurobindo Pharma Limited Pharmaceutical composition comprising canagliflozin, process of preparation and use thereof
CN106474480A (en) 2016-11-15 2017-03-08 深圳奥萨医疗有限公司 Medical composition and its use containing glucokinase activator and B family vitamin
EP3556354A4 (en) * 2016-12-15 2020-07-01 Hua Medicine (Shanghai) Ltd. Oral preparation of glucokinase activator and preparation method therefor

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