EP3804714A4 - Pharmaceutical combination and composition, and combination preparation containing glucokinase activator and biguanide hypoglycemic drug as well as preparation method and use thereof - Google Patents

Pharmaceutical combination and composition, and combination preparation containing glucokinase activator and biguanide hypoglycemic drug as well as preparation method and use thereof Download PDF

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Publication number
EP3804714A4
EP3804714A4 EP19810783.1A EP19810783A EP3804714A4 EP 3804714 A4 EP3804714 A4 EP 3804714A4 EP 19810783 A EP19810783 A EP 19810783A EP 3804714 A4 EP3804714 A4 EP 3804714A4
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EP
European Patent Office
Prior art keywords
combination
preparation
composition
well
glucokinase activator
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
EP19810783.1A
Other languages
German (de)
French (fr)
Other versions
EP3804714A1 (en
Inventor
Li Chen
Yongguo Li
Gaosen WANG
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hua Medicine Shanghai Ltd
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Hua Medicine Shanghai Ltd
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Filing date
Publication date
Application filed by Hua Medicine Shanghai Ltd filed Critical Hua Medicine Shanghai Ltd
Publication of EP3804714A1 publication Critical patent/EP3804714A1/en
Publication of EP3804714A4 publication Critical patent/EP3804714A4/en
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/133—Amines having hydroxy groups, e.g. sphingosine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/4155—1,2-Diazoles non condensed and containing further heterocyclic rings
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    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
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    • A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
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EP19810783.1A 2018-05-31 2019-05-28 Pharmaceutical combination and composition, and combination preparation containing glucokinase activator and biguanide hypoglycemic drug as well as preparation method and use thereof Pending EP3804714A4 (en)

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EP19810783.1A Pending EP3804714A4 (en) 2018-05-31 2019-05-28 Pharmaceutical combination and composition, and combination preparation containing glucokinase activator and biguanide hypoglycemic drug as well as preparation method and use thereof
EP19811377.1A Pending EP3804715A4 (en) 2018-05-31 2019-05-28 Pharmaceutical combination, composition and compound preparation comprising glucokinase activator and dpp-iv inhibitor, and preparation method and use thereof
EP19810210.5A Pending EP3804712A4 (en) 2018-05-31 2019-05-28 Pharmaceutical combination containing glucose kinase activator and ppar receptor activator, composition, compound preparation, preparation method for same, and uses thereof
EP19810441.6A Pending EP3804713A4 (en) 2018-05-31 2019-05-28 Pharmaceutical combination, composition and compound preparation containing glucokinase activator and k-atp channel blocker, preparation method therefor and use thereof
EP19812252.5A Pending EP3811939A4 (en) 2018-05-31 2019-05-28 Pharmaceutical combination, composition and formulation containing glucokinase activator and alpha-glucoside inhibitor, preparation methods therefor and uses thereof
EP19811691.5A Pending EP3804716A4 (en) 2018-05-31 2019-05-28 Pharmaceutical combination, composition, and combination preparation comprising glucokinase activator and sglt-2 inhibitor and preparation methods and uses thereof

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EP19810210.5A Pending EP3804712A4 (en) 2018-05-31 2019-05-28 Pharmaceutical combination containing glucose kinase activator and ppar receptor activator, composition, compound preparation, preparation method for same, and uses thereof
EP19810441.6A Pending EP3804713A4 (en) 2018-05-31 2019-05-28 Pharmaceutical combination, composition and compound preparation containing glucokinase activator and k-atp channel blocker, preparation method therefor and use thereof
EP19812252.5A Pending EP3811939A4 (en) 2018-05-31 2019-05-28 Pharmaceutical combination, composition and formulation containing glucokinase activator and alpha-glucoside inhibitor, preparation methods therefor and uses thereof
EP19811691.5A Pending EP3804716A4 (en) 2018-05-31 2019-05-28 Pharmaceutical combination, composition, and combination preparation comprising glucokinase activator and sglt-2 inhibitor and preparation methods and uses thereof

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