MX2020009725A - Metodo para tratar canceres de mama positivos a receptor de androgeno (ar) con modulador de receptor de androgeno selectivo (sarms). - Google Patents

Metodo para tratar canceres de mama positivos a receptor de androgeno (ar) con modulador de receptor de androgeno selectivo (sarms).

Info

Publication number
MX2020009725A
MX2020009725A MX2020009725A MX2020009725A MX2020009725A MX 2020009725 A MX2020009725 A MX 2020009725A MX 2020009725 A MX2020009725 A MX 2020009725A MX 2020009725 A MX2020009725 A MX 2020009725A MX 2020009725 A MX2020009725 A MX 2020009725A
Authority
MX
Mexico
Prior art keywords
breast cancer
treating
subject
subject suffering
positive
Prior art date
Application number
MX2020009725A
Other languages
English (en)
Inventor
Mitchell S Steiner
Ramesh Narayanan
Sunjoo Ahn
James T Dalton
Original Assignee
Gtx Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gtx Inc filed Critical Gtx Inc
Publication of MX2020009725A publication Critical patent/MX2020009725A/es

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/02—Carbamic acids; Salts of carbamic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/325—Carbamic acids; Thiocarbamic acids; Anhydrides or salts thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/14—Drugs for genital or sexual disorders; Contraceptives for lactation disorders, e.g. galactorrhoea
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Rheumatology (AREA)
  • Oncology (AREA)
  • Pregnancy & Childbirth (AREA)
  • Gynecology & Obstetrics (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Electrotherapy Devices (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Esta invención se refiere al tratamiento del cáncer de mama positivo a receptor de andrógeno en un sujeto, por ejemplo, una mujer. Por consiguiente, esta invención proporciona métodos para: a) tratar a un sujeto que padece cáncer de mama; b) tratar a un sujeto que padece cáncer de mama metastásico; c) tratar a un sujeto que padece cáncer de mama refractario; d) tratar a un sujeto que padece cáncer de mama positivo a AR; e) tratar a un sujeto que padece cáncer de mama refractario positivo a AR; f) tratar a un sujeto que padece cáncer de mama metastásico positivo para AR; g) tratar a un sujeto que padece cáncer de mama positivo a AR y positivo a ER; h) tratar a un sujeto que padece cáncer de mama triple negativo; i) tratar a un sujeto que padece cáncer de mama avanzado; j) tratar a un sujeto que padece cáncer de mama que ha fallado a tratamientos con SERM (tamoxifeno, toremifeno), un inhibidor de aromatasa, trastuzumab (Herceptin, ado-trastuzumab emtansina), pertuzumab (Perjeta), lapatinib, exemestano (Aromasin), bevacizumab (Avastin) y/o fulvestrant; k) tratar, prevenir, suprimir o inhibir metástasis en un sujeto que padece cáncer de mama; l) prolongar la supervivencia de un sujeto con cáncer de mama; y/o m) prolongar la supervivencia libre de progresión de un sujeto con cáncer de mama; que comprende administrar al sujeto una cantidad terapéuticamente efectiva de un compuesto modulador de receptor de andrógeno selectivo (SARM), que comprende administrar al sujeto una cantidad terapéuticamente efectiva de un compuesto SARM de esta invención.
MX2020009725A 2012-07-13 2015-01-13 Metodo para tratar canceres de mama positivos a receptor de androgeno (ar) con modulador de receptor de androgeno selectivo (sarms). MX2020009725A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261671366P 2012-07-13 2012-07-13
US201261726274P 2012-11-14 2012-11-14

Publications (1)

Publication Number Publication Date
MX2020009725A true MX2020009725A (es) 2020-10-08

Family

ID=49914508

Family Applications (2)

Application Number Title Priority Date Filing Date
MX2015000572A MX2015000572A (es) 2012-07-13 2013-03-07 Metodo para tratar canceres de mama positivos a receptor de androgeno (ar) con modulador de receptor de androgeno selectivo (sarms).
MX2020009725A MX2020009725A (es) 2012-07-13 2015-01-13 Metodo para tratar canceres de mama positivos a receptor de androgeno (ar) con modulador de receptor de androgeno selectivo (sarms).

Family Applications Before (1)

Application Number Title Priority Date Filing Date
MX2015000572A MX2015000572A (es) 2012-07-13 2013-03-07 Metodo para tratar canceres de mama positivos a receptor de androgeno (ar) con modulador de receptor de androgeno selectivo (sarms).

Country Status (20)

Country Link
US (1) US9604916B2 (es)
EP (2) EP3733170A1 (es)
JP (3) JP6226978B2 (es)
KR (2) KR102122941B1 (es)
CN (3) CN108143728A (es)
AU (3) AU2013203600C1 (es)
CA (1) CA2879049C (es)
CY (1) CY1123542T1 (es)
DK (1) DK2872482T3 (es)
ES (1) ES2818915T3 (es)
HR (1) HRP20201463T1 (es)
HU (1) HUE052574T2 (es)
IL (1) IL236681B (es)
IN (1) IN2015DN01046A (es)
LT (1) LT2872482T (es)
MX (2) MX2015000572A (es)
PL (1) PL2872482T3 (es)
PT (1) PT2872482T (es)
RU (2) RU2717835C2 (es)
WO (1) WO2014011220A2 (es)

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