UA115527C2 - Застосування n-(4-{[6,7-бic(мeтилoкcи)xiнoлiн-4-iл]oкcи}фeнiл)-n'-(4-фтopфeнiл)циклoпpoпaн-1,1-дикapбoкcaмiду для лікування нирково-клітинної карциноми (варіанти) - Google Patents
Застосування n-(4-{[6,7-бic(мeтилoкcи)xiнoлiн-4-iл]oкcи}фeнiл)-n'-(4-фтopфeнiл)циклoпpoпaн-1,1-дикapбoкcaмiду для лікування нирково-клітинної карциноми (варіанти)Info
- Publication number
- UA115527C2 UA115527C2 UAA201313886A UAA201313886A UA115527C2 UA 115527 C2 UA115527 C2 UA 115527C2 UA A201313886 A UAA201313886 A UA A201313886A UA A201313886 A UAA201313886 A UA A201313886A UA 115527 C2 UA115527 C2 UA 115527C2
- Authority
- UA
- Ukraine
- Prior art keywords
- cancer
- bone
- pain
- treating
- directed
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/20—Oxygen atoms
- C07D215/22—Oxygen atoms attached in position 2 or 4
- C07D215/233—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 4
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/536—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines ortho- or peri-condensed with carbocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
Abstract
Винахід стосується застосування N-(4-{[6,7-бic(мeтилoкcи)xiнoлiн-4-iл]oкcи}фeнiл)-N'-(4-фтopфeнiл)циклoпpoпaн-1,1-дикapбoкcaмiду або його малатної солі один раз на день у вигляді таблетки, що містить 60, 40 або 20 мг N-(4-{[6,7-бic(мeтилoкcи)xiнoлiн-4-iл]oкcи}фeнiл)-N'-(4-фтopфeнiл)циклoпpoпaн-1,1-дикapбoкcaмiду, для лікування метастазів в кістці у пацієнта з нирково-клітинною карциномою; застосування N-(4-{[6,7-бic(мeтилoкcи)xiнoлiн-4-iл]oкcи}фeнiл)-N'-(4-фтopфeнiл)циклoпpoпaн-1,1-дикapбoкcaмiду або його малатної солі для зменшення або стабілізації метастатичних уражень кістки, пов’язаних з нирково-клітинною карциномою; застосування N-(4-{[6,7-бic(мeтилoкcи)xiнoлiн-4-iл]oкcи}фeнiл)-N'-(4-фтopфeнiл)циклoпpoпaн-1,1-дикapбoкcaмiду або його малатної солі для ослаблення болю в кістці через метастатичні ураження кістки, пов’язані з нирково-клітинною карциномою; застосування N-(4-{[6,7-бic(мeтилoкcи)xiнoлiн-4-iл]oкcи}фeнiл)-N'-(4-фтopфeнiл)циклoпpoпaн-1,1-дикapбoкcaмiду або його малатної солі для збільшення загальної виживаності у пацієнтів з нирково-клітинною карциномою, яка метастазувала в кістку.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201161481682P | 2011-05-02 | 2011-05-02 | |
US201161557366P | 2011-11-08 | 2011-11-08 | |
PCT/US2012/036191 WO2012151326A1 (en) | 2011-05-02 | 2012-05-02 | Method of treating cancer and bone cancer pain |
Publications (1)
Publication Number | Publication Date |
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UA115527C2 true UA115527C2 (uk) | 2017-11-27 |
Family
ID=46062768
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
UAA201313886A UA115527C2 (uk) | 2011-05-02 | 2012-05-02 | Застосування n-(4-{[6,7-бic(мeтилoкcи)xiнoлiн-4-iл]oкcи}фeнiл)-n'-(4-фтopфeнiл)циклoпpoпaн-1,1-дикapбoкcaмiду для лікування нирково-клітинної карциноми (варіанти) |
Country Status (16)
Country | Link |
---|---|
US (3) | US20140179736A1 (uk) |
EP (1) | EP2704717A1 (uk) |
JP (4) | JP2014513129A (uk) |
KR (1) | KR20140025496A (uk) |
CN (1) | CN103717221A (uk) |
AR (1) | AR086242A1 (uk) |
AU (2) | AU2012250759B2 (uk) |
BR (1) | BR212013028314U2 (uk) |
CA (1) | CA2834778C (uk) |
EA (1) | EA029506B1 (uk) |
GE (1) | GEP201706678B (uk) |
IL (1) | IL229094A0 (uk) |
MX (1) | MX2013012695A (uk) |
TW (2) | TW201806598A (uk) |
UA (1) | UA115527C2 (uk) |
WO (1) | WO2012151326A1 (uk) |
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SG10201609324UA (en) | 2010-07-16 | 2017-01-27 | Exelixis Inc | C-met modulator pharmaceutical compositions |
EA027476B1 (ru) | 2010-09-27 | 2017-07-31 | Экселиксис, Инк. | Применение n-(4-{[6,7-бис-(метилокси)хинолин-4-ил]окси}фенил)-n'-(4-фторфенил)циклопропан-1,1-дикарбоксамида для лечения кастрационно-резистентного рака простаты и остеобластических метастазов в кости |
ES2905571T3 (es) | 2011-02-10 | 2022-04-11 | Exelixis Inc | Procedimientos para la preparación de compuestos de quinolina y composiciones farmacéuticas que contienen dichos compuestos |
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EA029506B1 (ru) | 2011-05-02 | 2018-04-30 | Экселиксис, Инк. | Способ лечения рака и раковой боли в костях |
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EP2768796B1 (en) | 2011-10-20 | 2019-11-20 | Exelixis, Inc. | Process for preparing quinoline derivatives |
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2012
- 2012-05-02 EA EA201391604A patent/EA029506B1/ru not_active IP Right Cessation
- 2012-05-02 AU AU2012250759A patent/AU2012250759B2/en active Active
- 2012-05-02 KR KR1020137031635A patent/KR20140025496A/ko not_active Application Discontinuation
- 2012-05-02 AR ARP120101544A patent/AR086242A1/es unknown
- 2012-05-02 EP EP12720754.6A patent/EP2704717A1/en not_active Withdrawn
- 2012-05-02 UA UAA201313886A patent/UA115527C2/uk unknown
- 2012-05-02 JP JP2014509417A patent/JP2014513129A/ja active Pending
- 2012-05-02 TW TW106118300A patent/TW201806598A/zh unknown
- 2012-05-02 TW TW101115623A patent/TWI610918B/zh active
- 2012-05-02 CN CN201280026424.4A patent/CN103717221A/zh active Pending
- 2012-05-02 MX MX2013012695A patent/MX2013012695A/es unknown
- 2012-05-02 US US14/115,236 patent/US20140179736A1/en not_active Abandoned
- 2012-05-02 CA CA2834778A patent/CA2834778C/en active Active
- 2012-05-02 GE GEAP201213300A patent/GEP201706678B/en unknown
- 2012-05-02 WO PCT/US2012/036191 patent/WO2012151326A1/en active Application Filing
- 2012-05-02 BR BR212013028314U patent/BR212013028314U2/pt active IP Right Grant
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2013
- 2013-10-27 IL IL229094A patent/IL229094A0/en unknown
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2016
- 2016-08-16 JP JP2016159543A patent/JP6884528B2/ja active Active
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2017
- 2017-09-13 AU AU2017228578A patent/AU2017228578A1/en not_active Abandoned
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2018
- 2018-12-26 JP JP2018243772A patent/JP2019077692A/ja not_active Withdrawn
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2020
- 2020-02-11 US US16/787,212 patent/US11504363B2/en active Active
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2021
- 2021-02-04 JP JP2021016486A patent/JP2021088569A/ja active Pending
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2022
- 2022-10-13 US US17/965,529 patent/US20230149384A1/en active Pending
Also Published As
Publication number | Publication date |
---|---|
US20200255382A1 (en) | 2020-08-13 |
AU2012250759A1 (en) | 2013-11-28 |
NZ716805A (en) | 2017-11-24 |
WO2012151326A1 (en) | 2012-11-08 |
TW201806598A (zh) | 2018-03-01 |
JP2021088569A (ja) | 2021-06-10 |
AR086242A1 (es) | 2013-11-27 |
TWI610918B (zh) | 2018-01-11 |
JP2014513129A (ja) | 2014-05-29 |
EP2704717A1 (en) | 2014-03-12 |
EA201391604A1 (ru) | 2014-03-31 |
JP6884528B2 (ja) | 2021-06-09 |
GEP201706678B (en) | 2017-06-12 |
CA2834778A1 (en) | 2012-11-08 |
CN103717221A (zh) | 2014-04-09 |
US20230149384A1 (en) | 2023-05-18 |
KR20140025496A (ko) | 2014-03-04 |
JP2017105751A (ja) | 2017-06-15 |
AU2012250759B2 (en) | 2017-06-15 |
TW201249800A (en) | 2012-12-16 |
US20140179736A1 (en) | 2014-06-26 |
BR212013028314U2 (pt) | 2015-11-03 |
AU2017228578A1 (en) | 2017-10-05 |
NZ617508A (en) | 2016-04-29 |
JP2019077692A (ja) | 2019-05-23 |
EA029506B1 (ru) | 2018-04-30 |
CA2834778C (en) | 2019-08-13 |
MX2013012695A (es) | 2014-03-27 |
IL229094A0 (en) | 2013-12-31 |
US11504363B2 (en) | 2022-11-22 |
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