MX2019012505A - Formas solidas cristalinas de sales de ciclopropano-1,1-dicarboxam ida de n-{4-[(6,7-dimetoxiquinolin-4-il)oxi]fenil}-n'-(4-fluorofen il), procesos para realizarlas y metodos de uso. - Google Patents

Formas solidas cristalinas de sales de ciclopropano-1,1-dicarboxam ida de n-{4-[(6,7-dimetoxiquinolin-4-il)oxi]fenil}-n'-(4-fluorofen il), procesos para realizarlas y metodos de uso.

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Publication number
MX2019012505A
MX2019012505A MX2019012505A MX2019012505A MX2019012505A MX 2019012505 A MX2019012505 A MX 2019012505A MX 2019012505 A MX2019012505 A MX 2019012505A MX 2019012505 A MX2019012505 A MX 2019012505A MX 2019012505 A MX2019012505 A MX 2019012505A
Authority
MX
Mexico
Prior art keywords
crystalline solid
solid forms
dimethoxyquinolin
cyclopropane
oxy
Prior art date
Application number
MX2019012505A
Other languages
English (en)
Inventor
M Blazey Charles
Shah Khalid
Original Assignee
Exelixis Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=62683441&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MX2019012505(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Exelixis Inc filed Critical Exelixis Inc
Publication of MX2019012505A publication Critical patent/MX2019012505A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/22—Oxygen atoms attached in position 2 or 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Quinoline Compounds (AREA)

Abstract

La invención se relaciona con formas sólidas cristalinas nuevas de sales del compuesto químico ciclopropano-1,1-dicarboxamida de N-{4-[(6,7-dimetoxiquinolin-4-il)oxi] fenil}-N'-(4-fluorofenilo) y solvatos de este, que incluyen hidratos, que son útiles para el tratamiento del cáncer. También se describen composiciones farmacéuticas que comprenden las formas sólidas cristalinas y procesos para realizar las formas sólidas cristalinas, así como también métodos para usarlos para el tratamiento del cáncer, particularmente carcinoma de células renales (RCC) y cáncer medular de tiroides (MTC).
MX2019012505A 2017-05-26 2018-05-26 Formas solidas cristalinas de sales de ciclopropano-1,1-dicarboxam ida de n-{4-[(6,7-dimetoxiquinolin-4-il)oxi]fenil}-n'-(4-fluorofen il), procesos para realizarlas y metodos de uso. MX2019012505A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201762511714P 2017-05-26 2017-05-26
PCT/US2018/034784 WO2018218233A1 (en) 2017-05-26 2018-05-26 Crystalline solid forms of salts of n-{4-[(6,7-dimethoxyquinolin-4-yl) oxy]phenyl}-n'-(4-fluorphenyl) cyclopropane-1,1-dicarboxamide, processes for making, and methods of use

Publications (1)

Publication Number Publication Date
MX2019012505A true MX2019012505A (es) 2019-12-19

Family

ID=62683441

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2019012505A MX2019012505A (es) 2017-05-26 2018-05-26 Formas solidas cristalinas de sales de ciclopropano-1,1-dicarboxam ida de n-{4-[(6,7-dimetoxiquinolin-4-il)oxi]fenil}-n'-(4-fluorofen il), procesos para realizarlas y metodos de uso.

Country Status (20)

Country Link
US (3) US11279675B2 (es)
EP (1) EP3630726B1 (es)
JP (3) JP7166292B2 (es)
KR (1) KR102611445B1 (es)
CN (1) CN110621662B (es)
AU (1) AU2018272088C1 (es)
CA (1) CA3060370A1 (es)
DK (1) DK3630726T3 (es)
EA (1) EA039654B1 (es)
ES (1) ES2909390T3 (es)
HU (1) HUE058196T2 (es)
IL (1) IL270780A (es)
MA (1) MA48776A (es)
MX (1) MX2019012505A (es)
PL (1) PL3630726T3 (es)
PT (1) PT3630726T (es)
SG (1) SG11201909161PA (es)
UA (1) UA127760C2 (es)
WO (1) WO2018218233A1 (es)
ZA (1) ZA201906127B (es)

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CN110621662B (zh) 2017-05-26 2023-06-23 埃克塞里艾克西斯公司 一种盐的结晶性固体形式、制备工艺和使用方法
KR20200115582A (ko) 2018-01-26 2020-10-07 엑셀리시스, 인코포레이티드 키나제-의존성 장애의 치료용 화합물
MX2021014773A (es) * 2019-06-03 2022-01-18 Exelixis Inc Formas de sales cristalinas de un inhibidor de cinasas.
WO2023165948A1 (en) 2022-03-01 2023-09-07 Synthon B.V. Cabozantinib salt with l-(+)-tartaric acid and solid forms thereof
US11814356B1 (en) 2023-03-29 2023-11-14 Apotex Inc. Salt of cabozantinib

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US8877776B2 (en) 2009-01-16 2014-11-04 Exelixis, Inc. (L)-malate salt of N-(4-{[6,7-bis(methyloxy) quinolin-4-yl]oxy}phenyl)-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide
UA108618C2 (uk) 2009-08-07 2015-05-25 Застосування c-met-модуляторів в комбінації з темозоломідом та/або променевою терапією для лікування раку
US20120070368A1 (en) 2010-04-16 2012-03-22 Exelixis, Inc. Methods of Using C-Met Modulators
US9724342B2 (en) 2010-07-16 2017-08-08 Exelixis, Inc. C-met modulator pharmaceutical compositions
CN103391773A (zh) 2010-09-27 2013-11-13 埃克塞里艾克西斯公司 用于治疗去势抵抗性前列腺癌和成骨性骨转移的met和vegf的双重抑制剂
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KR20230158644A (ko) 2011-02-10 2023-11-20 엑셀리시스, 인코포레이티드 퀴놀린 화합물들의 제조 방법들 및 상기 화합물들을 함유하는 약학 조성물들
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BR112014006702A2 (pt) 2011-09-22 2017-06-13 Exelixis Inc método para tratar osteoporose
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CN110621662B (zh) 2017-05-26 2023-06-23 埃克塞里艾克西斯公司 一种盐的结晶性固体形式、制备工艺和使用方法

Also Published As

Publication number Publication date
PL3630726T3 (pl) 2022-05-09
JP2020521732A (ja) 2020-07-27
DK3630726T3 (da) 2022-03-07
AU2018272088A8 (en) 2019-10-24
MA48776A (fr) 2020-04-08
IL270780A (en) 2020-01-30
US20220162166A1 (en) 2022-05-26
EA039654B1 (ru) 2022-02-22
ES2909390T3 (es) 2022-05-06
JP7437460B2 (ja) 2024-02-22
CN110621662B (zh) 2023-06-23
EP3630726B1 (en) 2021-12-22
AU2018272088C1 (en) 2022-09-22
PT3630726T (pt) 2022-03-02
EP3630726A1 (en) 2020-04-08
KR102611445B1 (ko) 2023-12-06
SG11201909161PA (en) 2019-10-30
EA201992803A1 (ru) 2020-04-16
JP2024036690A (ja) 2024-03-15
US20240010621A1 (en) 2024-01-11
CN110621662A (zh) 2019-12-27
AU2018272088B2 (en) 2022-06-16
WO2018218233A1 (en) 2018-11-29
KR20200010205A (ko) 2020-01-30
JP7166292B2 (ja) 2022-11-07
US20210261509A1 (en) 2021-08-26
AU2018272088A1 (en) 2019-10-17
CA3060370A1 (en) 2018-11-29
UA127760C2 (uk) 2023-12-27
JP2022145852A (ja) 2022-10-04
HUE058196T2 (hu) 2022-07-28
US11731941B2 (en) 2023-08-22
US11279675B2 (en) 2022-03-22
ZA201906127B (en) 2022-11-30

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