MX2016010266A - Formas solidas cristalinas de n-{4-[(6,7-dimetoxiquinolin-4-il)oxi ]fenil}-n'-(4-fluorofenil)ciclopropan-1,1-dicarboxamida, procesos para elaboracion y metodos de uso. - Google Patents

Formas solidas cristalinas de n-{4-[(6,7-dimetoxiquinolin-4-il)oxi ]fenil}-n'-(4-fluorofenil)ciclopropan-1,1-dicarboxamida, procesos para elaboracion y metodos de uso.

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Publication number
MX2016010266A
MX2016010266A MX2016010266A MX2016010266A MX2016010266A MX 2016010266 A MX2016010266 A MX 2016010266A MX 2016010266 A MX2016010266 A MX 2016010266A MX 2016010266 A MX2016010266 A MX 2016010266A MX 2016010266 A MX2016010266 A MX 2016010266A
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MX
Mexico
Prior art keywords
crystalline solid
solid forms
cancer
dimethoxyquinolin
dicarboxamide
Prior art date
Application number
MX2016010266A
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English (en)
Inventor
T Aftab Dana
Guz Nathan
Lau Stephen
HAMILL Noel
Walker Tracy
Galbraith Jana
Yau Simon
Shah Khalid
Original Assignee
Exelixis Inc
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Filing date
Publication date
Application filed by Exelixis Inc filed Critical Exelixis Inc
Publication of MX2016010266A publication Critical patent/MX2016010266A/es

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/22—Oxygen atoms attached in position 2 or 4
    • C07D215/233—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/22—Oxygen atoms attached in position 2 or 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Quinoline Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Medicinal Preparation (AREA)

Abstract

La presente invención se refiere a nuevas formas sólidas cristalinas del compuesto químico N-{4-[(6,7- dimetoxiquinolin-4-il)oxi]feni1}-N'-(4- fluorofenil)ciclopropan-1, 1-dicarboxamida (Compuesto 1), y solvatos del mismo, que incluye hidratos, que son útiles para el tratamiento de cáncer. También se describen composiciones farmacéuticas que comprenden las formas sólidas cristalinas y procesos para elaborar las formas sólidas cristalinas, así como también métodos para usar las mismas para el tratamiento de cáncer, particularmente cáncer tiroideo, cáncer de próstata, cáncer hepatocelular, cáncer renal, y carcinoma de pulmón de células no pequeñas. Las formas sólidas cristalinas pueden ser usadas para hacer la sal de L-malato de cabozantinib.
MX2016010266A 2014-02-14 2015-02-16 Formas solidas cristalinas de n-{4-[(6,7-dimetoxiquinolin-4-il)oxi ]fenil}-n'-(4-fluorofenil)ciclopropan-1,1-dicarboxamida, procesos para elaboracion y metodos de uso. MX2016010266A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201461939985P 2014-02-14 2014-02-14
PCT/US2015/016052 WO2015123639A1 (en) 2014-02-14 2015-02-16 Crystalline solid forms of n-{4-[(6,7-dimethoxyquinolin-4-yl)oxy]phenyl}-n'-(4-fluorophenyl) cyclopropane-1, 1-dicarboxamide, processes for making, and methods of use

Publications (1)

Publication Number Publication Date
MX2016010266A true MX2016010266A (es) 2017-02-08

Family

ID=52684662

Family Applications (2)

Application Number Title Priority Date Filing Date
MX2021001583A MX2021001583A (es) 2014-02-14 2015-02-16 Formas sólidas cristalinas de n-{4-[(6,7-dimetoxiquinolin-4-il)oxi ] fenil}-n'-(4-fluorofenil)ciclopropan-1,1-dicarboxamida, procesos para elaboración y métodos de uso.
MX2016010266A MX2016010266A (es) 2014-02-14 2015-02-16 Formas solidas cristalinas de n-{4-[(6,7-dimetoxiquinolin-4-il)oxi ]fenil}-n'-(4-fluorofenil)ciclopropan-1,1-dicarboxamida, procesos para elaboracion y metodos de uso.

Family Applications Before (1)

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MX2021001583A MX2021001583A (es) 2014-02-14 2015-02-16 Formas sólidas cristalinas de n-{4-[(6,7-dimetoxiquinolin-4-il)oxi ] fenil}-n'-(4-fluorofenil)ciclopropan-1,1-dicarboxamida, procesos para elaboración y métodos de uso.

Country Status (14)

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US (5) US10501418B2 (es)
EP (2) EP3738952A1 (es)
JP (2) JP6756617B2 (es)
KR (1) KR102354963B1 (es)
CN (1) CN106068255A (es)
AU (3) AU2015218236B2 (es)
BR (1) BR112016018450A2 (es)
CA (2) CA3181899A1 (es)
EA (1) EA032757B1 (es)
IL (1) IL247035B2 (es)
MX (2) MX2021001583A (es)
UA (1) UA123534C2 (es)
WO (1) WO2015123639A1 (es)
ZA (1) ZA201605424B (es)

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MX2021001583A (es) 2023-02-08
WO2015123639A1 (en) 2015-08-20
JP2019163337A (ja) 2019-09-26
US11724986B2 (en) 2023-08-15
JP6756617B2 (ja) 2020-09-16
US10501418B2 (en) 2019-12-10
CA2939546C (en) 2023-01-17
AU2019226302A1 (en) 2019-09-26
US10851061B2 (en) 2020-12-01
US20210206722A1 (en) 2021-07-08
US11760726B2 (en) 2023-09-19
US20200190033A1 (en) 2020-06-18
AU2021204278B2 (en) 2023-10-26
ZA201605424B (en) 2022-12-21
UA123534C2 (uk) 2021-04-21
CN106068255A (zh) 2016-11-02
EP3105204A1 (en) 2016-12-21
EA032757B1 (ru) 2019-07-31
IL247035B (en) 2022-11-01
KR102354963B1 (ko) 2022-01-21
US20210198205A1 (en) 2021-07-01
KR20160121544A (ko) 2016-10-19
IL247035B2 (en) 2023-03-01
AU2015218236A1 (en) 2016-09-15
US20230382867A1 (en) 2023-11-30
AU2015218236B2 (en) 2019-06-13
CA3181899A1 (en) 2015-08-20
IL247035A0 (en) 2016-09-29
NZ723714A (en) 2021-03-26
BR112016018450A2 (pt) 2018-09-18
JP2017505796A (ja) 2017-02-23
US20170044106A1 (en) 2017-02-16
EA201691629A1 (ru) 2016-11-30
AU2019226302B2 (en) 2021-04-01
EP3738952A1 (en) 2020-11-18
AU2021204278A1 (en) 2021-07-22
CA2939546A1 (en) 2015-08-20

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