MX2019010541A - Compuestos de imidazo-piperidina fusionada como inhibidores de jak. - Google Patents
Compuestos de imidazo-piperidina fusionada como inhibidores de jak.Info
- Publication number
- MX2019010541A MX2019010541A MX2019010541A MX2019010541A MX2019010541A MX 2019010541 A MX2019010541 A MX 2019010541A MX 2019010541 A MX2019010541 A MX 2019010541A MX 2019010541 A MX2019010541 A MX 2019010541A MX 2019010541 A MX2019010541 A MX 2019010541A
- Authority
- MX
- Mexico
- Prior art keywords
- compounds
- jak inhibitors
- piperidine
- fused imidazo
- imidazo
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pulmonology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Peptides Or Proteins (AREA)
Abstract
Los compuestos de fórmula (I): (ver fórmula I) donde las variables se definen en la memoria descriptiva, o una sal farmacéuticamente aceptable del mismo, son útiles como inhibidores de la quinasa JAK. También se proveen composiciones farmacéuticas que comprenden tales compuestos, métodos para usar tales compuestos para tratar procesos y enfermedades respiratorias, e intermediarios útiles para preparar tales compuestos.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201762469073P | 2017-03-09 | 2017-03-09 | |
PCT/US2018/021492 WO2018165395A1 (en) | 2017-03-09 | 2018-03-08 | Fused imidazo-piperidine jak inhibitors |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2019010541A true MX2019010541A (es) | 2019-10-21 |
Family
ID=61683956
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2019010541A MX2019010541A (es) | 2017-03-09 | 2018-03-08 | Compuestos de imidazo-piperidina fusionada como inhibidores de jak. |
MX2019010539A MX2019010539A (es) | 2017-03-09 | 2018-03-08 | Compuestos de imidazo-piperidina fusionada que contienen una amida heterociclica de 4 miembros como inhibidores de jak. |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2019010539A MX2019010539A (es) | 2017-03-09 | 2018-03-08 | Compuestos de imidazo-piperidina fusionada que contienen una amida heterociclica de 4 miembros como inhibidores de jak. |
Country Status (20)
Country | Link |
---|---|
US (10) | US10196393B2 (es) |
EP (2) | EP3592742B1 (es) |
JP (2) | JP7134990B2 (es) |
KR (2) | KR102533646B1 (es) |
CN (2) | CN110461839B (es) |
AR (2) | AR111242A1 (es) |
AU (2) | AU2018231035B2 (es) |
BR (2) | BR112019018649A2 (es) |
CA (1) | CA2997772A1 (es) |
DK (1) | DK3592742T3 (es) |
EA (2) | EA037748B1 (es) |
ES (1) | ES2882186T3 (es) |
IL (2) | IL268689B2 (es) |
MX (2) | MX2019010541A (es) |
PH (2) | PH12019501941A1 (es) |
PT (1) | PT3592742T (es) |
SG (2) | SG11201907544VA (es) |
TW (2) | TWI779016B (es) |
WO (2) | WO2018165395A1 (es) |
ZA (2) | ZA201905585B (es) |
Families Citing this family (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
MX2018005446A (es) | 2015-11-03 | 2018-08-01 | Theravance Biopharma R&D Ip Llc | Compuestos inhibidores de jak quinasa para el tratamiento de enfermedad respiratoria. |
US10556901B2 (en) * | 2015-11-03 | 2020-02-11 | Topivert Pharma Limited | 4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine and 1,4,5,6,7,8-hexahydroimidazo[4,5-d]azepine derivatives as Janus kinase inhibitors |
JP7134990B2 (ja) | 2017-03-09 | 2022-09-12 | セラヴァンス バイオファーマ アール&ディー アイピー, エルエルシー | 縮合イミダゾ-ピペリジンjak阻害剤 |
AR111495A1 (es) | 2017-05-01 | 2019-07-17 | Theravance Biopharma R&D Ip Llc | Compuestos de imidazo-piperidina fusionada como inhibidores de jak |
SG11201909019SA (en) | 2017-05-01 | 2019-10-30 | Theravance Biopharma R&D Ip Llc | Methods of treatment using a jak inhibitor compound |
EP3837253B1 (en) | 2018-09-04 | 2023-06-07 | Theravance Biopharma R&D IP, LLC | Process for preparing jak inhibitors and intermediates thereof |
AR116114A1 (es) * | 2018-09-04 | 2021-03-31 | Theravance Biopharma R&D Ip Llc | Amidas heterocíclicas de entre 5 y 7 miembros como inhibidores de jak |
MX2021002521A (es) * | 2018-09-04 | 2021-04-28 | Theravance Biopharma R&D Ip Llc | Dimetilaminoazetidinaminas como inhibidores de jak. |
CN112955451A (zh) * | 2018-10-29 | 2021-06-11 | 施万生物制药研发Ip有限责任公司 | 作为jak抑制剂的2-氮杂双环已烷化合物 |
AU2020228799A1 (en) | 2019-02-25 | 2021-10-07 | Henan Medinno Pharmaceutical Technology Co., Ltd. | JAK inhibitor compound and use thereof |
CN114007621A (zh) | 2019-03-05 | 2022-02-01 | 因赛特公司 | 用于治疗慢性肺同种异体移植物功能障碍的jak1途径抑制剂 |
CN114901659A (zh) * | 2019-11-26 | 2022-08-12 | 施万生物制药研发Ip有限责任公司 | 作为jak抑制剂的稠合嘧啶吡啶酮化合物 |
JP2023508772A (ja) * | 2019-12-30 | 2023-03-03 | 路良 | Jak阻害剤化合物及びその使用 |
TW202144343A (zh) | 2020-03-02 | 2021-12-01 | 美商施萬生物製藥研發 Ip有限責任公司 | Jak抑制劑化合物之結晶水合物 |
EP3944859A1 (en) * | 2020-07-30 | 2022-02-02 | Assistance Publique Hôpitaux de Paris | Method for treating immune toxicities induced by immune checkpoint inhibitors |
WO2022178215A1 (en) * | 2021-02-19 | 2022-08-25 | Theravance Biopharma R&D Ip, Llc | Amino amide tetrahydro imidazo pyridines as jak inhibitors |
TW202317550A (zh) * | 2021-06-25 | 2023-05-01 | 美商施萬生物製藥研發 Ip有限責任公司 | 作為jak抑制劑之咪唑吲唑化合物 |
Family Cites Families (26)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
TWI262914B (en) | 1999-07-02 | 2006-10-01 | Agouron Pharma | Compounds and pharmaceutical compositions for inhibiting protein kinases |
CA2532800C (en) | 2003-07-23 | 2013-06-18 | Exelixis, Inc. | Anaplastic lymphoma kinase modulators and methods of use |
US20050090529A1 (en) | 2003-07-31 | 2005-04-28 | Pfizer Inc | 3,5 Disubstituted indazole compounds with nitrogen-bearing 5-membered heterocycles, pharmaceutical compositions, and methods for mediating or inhibiting cell proliferation |
US7884109B2 (en) | 2005-04-05 | 2011-02-08 | Wyeth Llc | Purine and imidazopyridine derivatives for immunosuppression |
US8648069B2 (en) | 2007-06-08 | 2014-02-11 | Abbvie Inc. | 5-substituted indazoles as kinase inhibitors |
JP2010111624A (ja) | 2008-11-06 | 2010-05-20 | Shionogi & Co Ltd | Ttk阻害作用を有するインダゾール誘導体 |
CA2756989A1 (en) | 2009-04-03 | 2010-10-07 | Douglas Burdi | Compounds for treating disorders mediated by metabotropic glutamate receptor 5, and methods of use thereof |
JP5822844B2 (ja) | 2009-12-21 | 2015-11-24 | サミュメッド リミテッド ライアビリティ カンパニー | 1H−ピラゾロ[3,4−b]ピリジンおよびその治療的使用 |
EP2338888A1 (en) | 2009-12-24 | 2011-06-29 | Almirall, S.A. | Imidazopyridine derivatives as JAK inhibitors |
US8575336B2 (en) * | 2011-07-27 | 2013-11-05 | Pfizer Limited | Indazoles |
EP2771340B1 (en) | 2011-10-25 | 2016-04-13 | Sanofi | 6-(4-hydroxy-phenyl)-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
PT3077395T (pt) | 2013-12-05 | 2018-01-03 | Pfizer | Pirrolo[2,3-d]pirimidinilo, pirrolo[2,3-b]pirazinilo e pirrolo[2,3-d]piridinilo acrilamidas |
EP3143021B1 (en) | 2014-05-14 | 2019-06-12 | Pfizer Inc | Pyrazolopyridines and pyrazolopyrimidines |
WO2016026078A1 (en) | 2014-08-19 | 2016-02-25 | Changzhou Jiekai Pharmatech Co., Ltd. | Heterocyclic compounds as erk inhibitors |
KR101663277B1 (ko) | 2015-03-30 | 2016-10-06 | 주식회사 녹십자 | TNIK, IKKε 및 TBK1 억제제로서의 피라졸계 유도체 및 이를 포함하는 약학적 조성물 |
MX2018005446A (es) | 2015-11-03 | 2018-08-01 | Theravance Biopharma R&D Ip Llc | Compuestos inhibidores de jak quinasa para el tratamiento de enfermedad respiratoria. |
US10556901B2 (en) * | 2015-11-03 | 2020-02-11 | Topivert Pharma Limited | 4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine and 1,4,5,6,7,8-hexahydroimidazo[4,5-d]azepine derivatives as Janus kinase inhibitors |
EP3712152B1 (en) | 2015-11-03 | 2021-01-13 | Topivert Pharma Limited | 4,5,6,7-tetrahydro-1h-imidazo[4,5-c]pyridine and 1,4,5,6,7,8-hexahydroimidazo[4,5-d]azepine derivatives as janus kinase inhibitors |
JP7134990B2 (ja) | 2017-03-09 | 2022-09-12 | セラヴァンス バイオファーマ アール&ディー アイピー, エルエルシー | 縮合イミダゾ-ピペリジンjak阻害剤 |
AR111495A1 (es) | 2017-05-01 | 2019-07-17 | Theravance Biopharma R&D Ip Llc | Compuestos de imidazo-piperidina fusionada como inhibidores de jak |
SG11201909019SA (en) | 2017-05-01 | 2019-10-30 | Theravance Biopharma R&D Ip Llc | Methods of treatment using a jak inhibitor compound |
SG11201909376TA (en) | 2017-05-01 | 2019-11-28 | Theravance Biopharma R&D Ip Llc | Crystalline forms of a jak inhibitor compound |
KR102032418B1 (ko) | 2017-06-15 | 2019-10-16 | 한국화학연구원 | 접합 피리미딘 유도체, 이의 제조방법 및 이를 유효성분으로 포함하는 브루톤티로신 키나제 활성 관련 질환의 예방 또는 치료용 약학적 조성물 |
AR116114A1 (es) | 2018-09-04 | 2021-03-31 | Theravance Biopharma R&D Ip Llc | Amidas heterocíclicas de entre 5 y 7 miembros como inhibidores de jak |
MX2021002521A (es) | 2018-09-04 | 2021-04-28 | Theravance Biopharma R&D Ip Llc | Dimetilaminoazetidinaminas como inhibidores de jak. |
EP3837253B1 (en) | 2018-09-04 | 2023-06-07 | Theravance Biopharma R&D IP, LLC | Process for preparing jak inhibitors and intermediates thereof |
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2018
- 2018-03-08 JP JP2019548369A patent/JP7134990B2/ja active Active
- 2018-03-08 US US15/915,418 patent/US10196393B2/en active Active
- 2018-03-08 CA CA2997772A patent/CA2997772A1/en active Pending
- 2018-03-08 TW TW107107936A patent/TWI779016B/zh active
- 2018-03-08 CN CN201880017046.0A patent/CN110461839B/zh active Active
- 2018-03-08 AU AU2018231035A patent/AU2018231035B2/en active Active
- 2018-03-08 WO PCT/US2018/021492 patent/WO2018165395A1/en unknown
- 2018-03-08 EP EP18711796.5A patent/EP3592742B1/en active Active
- 2018-03-08 SG SG11201907544VA patent/SG11201907544VA/en unknown
- 2018-03-08 PT PT187117965T patent/PT3592742T/pt unknown
- 2018-03-08 JP JP2019548449A patent/JP6974487B2/ja active Active
- 2018-03-08 AR ARP180100543A patent/AR111242A1/es unknown
- 2018-03-08 EP EP18712398.9A patent/EP3592743A1/en active Pending
- 2018-03-08 MX MX2019010541A patent/MX2019010541A/es unknown
- 2018-03-08 US US15/915,434 patent/US10208040B2/en active Active
- 2018-03-08 WO PCT/US2018/021489 patent/WO2018165392A1/en unknown
- 2018-03-08 BR BR112019018649A patent/BR112019018649A2/pt unknown
- 2018-03-08 ES ES18711796T patent/ES2882186T3/es active Active
- 2018-03-08 AU AU2018231032A patent/AU2018231032B2/en active Active
- 2018-03-08 TW TW107107939A patent/TWI754019B/zh active
- 2018-03-08 DK DK18711796.5T patent/DK3592742T3/da active
- 2018-03-08 SG SG11201907840RA patent/SG11201907840RA/en unknown
- 2018-03-08 KR KR1020197029543A patent/KR102533646B1/ko active IP Right Grant
- 2018-03-08 AR ARP180100542A patent/AR111241A1/es unknown
- 2018-03-08 BR BR112019018648-4A patent/BR112019018648A2/pt unknown
- 2018-03-08 EA EA201992128A patent/EA037748B1/ru unknown
- 2018-03-08 KR KR1020197029560A patent/KR102526764B1/ko active IP Right Grant
- 2018-03-08 CN CN201880016693.XA patent/CN110382498B/zh active Active
- 2018-03-08 EA EA201992126A patent/EA037261B1/ru not_active IP Right Cessation
- 2018-03-08 MX MX2019010539A patent/MX2019010539A/es unknown
- 2018-12-17 US US16/222,647 patent/US10392386B2/en active Active
- 2018-12-19 US US16/225,473 patent/US10519153B2/en active Active
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2019
- 2019-07-15 US US16/511,410 patent/US10550118B2/en active Active
- 2019-08-13 IL IL268689A patent/IL268689B2/en unknown
- 2019-08-13 IL IL268679A patent/IL268679B/en unknown
- 2019-08-22 PH PH12019501941A patent/PH12019501941A1/en unknown
- 2019-08-23 ZA ZA2019/05585A patent/ZA201905585B/en unknown
- 2019-08-26 ZA ZA2019/05618A patent/ZA201905618B/en unknown
- 2019-08-29 PH PH12019501985A patent/PH12019501985A1/en unknown
- 2019-11-11 US US16/679,676 patent/US11254669B2/en active Active
- 2019-12-03 US US16/701,426 patent/US10954237B2/en active Active
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2021
- 2021-02-12 US US17/248,907 patent/US11453668B2/en active Active
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2022
- 2022-01-14 US US17/576,089 patent/US11667637B2/en active Active
- 2022-08-10 US US17/885,475 patent/US11878977B2/en active Active
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