MX2019008701A - Terapia de combinacion que involucra compuestos macrociclicos de diarilo. - Google Patents
Terapia de combinacion que involucra compuestos macrociclicos de diarilo.Info
- Publication number
- MX2019008701A MX2019008701A MX2019008701A MX2019008701A MX2019008701A MX 2019008701 A MX2019008701 A MX 2019008701A MX 2019008701 A MX2019008701 A MX 2019008701A MX 2019008701 A MX2019008701 A MX 2019008701A MX 2019008701 A MX2019008701 A MX 2019008701A
- Authority
- MX
- Mexico
- Prior art keywords
- combination therapy
- macrocyclic compounds
- therapy involving
- diaryl
- diaryl macrocyclic
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4995—Pyrazines or piperazines forming part of bridged ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D498/18—Bridged systems
Abstract
La presente invención se refiere a métodos y composiciones para el tratamiento de cáncer con un macrociclo de diarilo en combinación con al menos otro terapéuticos contra el cáncer, tal como un inhibidor de EGFR.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201762450455P | 2017-01-25 | 2017-01-25 | |
US201862619165P | 2018-01-19 | 2018-01-19 | |
PCT/US2018/015150 WO2018140554A1 (en) | 2017-01-25 | 2018-01-25 | Combination therapy involving diaryl macrocyclic compounds |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2019008701A true MX2019008701A (es) | 2019-09-13 |
Family
ID=62979021
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2019008701A MX2019008701A (es) | 2017-01-25 | 2018-01-25 | Terapia de combinacion que involucra compuestos macrociclicos de diarilo. |
Country Status (13)
Country | Link |
---|---|
US (1) | US11291667B2 (es) |
EP (1) | EP3573991A4 (es) |
JP (1) | JP7193475B2 (es) |
KR (1) | KR102618773B1 (es) |
CN (1) | CN110291092A (es) |
AU (1) | AU2018212647B2 (es) |
BR (1) | BR112019015115A2 (es) |
CA (1) | CA3049548A1 (es) |
IL (1) | IL267992B2 (es) |
MX (1) | MX2019008701A (es) |
SG (1) | SG11201906386XA (es) |
TW (1) | TWI808958B (es) |
WO (1) | WO2018140554A1 (es) |
Families Citing this family (15)
Publication number | Priority date | Publication date | Assignee | Title |
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EA031863B1 (ru) | 2014-01-24 | 2019-03-29 | ТиПи ТЕРАПЬЮТИКС, ИНК. | Диарильные макроциклы в качестве модуляторов протеинкиназ |
US10316044B2 (en) | 2015-07-02 | 2019-06-11 | Tp Therapeutics, Inc. | Chiral diaryl macrocycles as modulators of protein kinases |
EP3325488B1 (en) | 2015-07-21 | 2020-06-24 | Turning Point Therapeutics, Inc. | Chiral diaryl macrocycle and use thereof in the treatment of cancer |
TW201815799A (zh) | 2016-07-28 | 2018-05-01 | 美商Tp生物醫藥公司 | 巨環激酶抑制劑 |
TWI808958B (zh) | 2017-01-25 | 2023-07-21 | 美商特普醫葯公司 | 涉及二芳基巨環化合物之組合療法 |
BR112020001695A2 (pt) | 2017-07-28 | 2020-07-21 | Turning Point Therapeutics, Inc. | compostos macrocíclicos e usos dos mesmos |
RS63787B1 (sr) | 2017-12-19 | 2022-12-30 | Turning Point Therapeutics Inc | Makrociklična jedinjenja za lečenje bolesti |
CA3117200A1 (en) | 2018-10-22 | 2020-04-30 | Esker Therapeutics, Inc. | Tyk2 inhibitors and uses thereof |
CN111171049B (zh) * | 2018-11-09 | 2021-06-04 | 山东轩竹医药科技有限公司 | 酪氨酸激酶抑制剂及其用途 |
KR20220133866A (ko) | 2019-11-27 | 2022-10-05 | 터닝 포인트 테라퓨틱스, 인크. | 디아릴 매크로시클릭 화합물을 수반하는 병용 요법 |
WO2021108672A1 (en) * | 2019-11-27 | 2021-06-03 | Turning Point Therapeutics, Inc. | Combination therapy involving diaryl macrocyclic compounds |
CN113121568A (zh) * | 2019-12-31 | 2021-07-16 | 成都倍特药业股份有限公司 | 一种大环结构化合物的盐及其制备方法 |
CN113754682B (zh) * | 2020-06-04 | 2023-01-06 | 赛诺哈勃药业(成都)有限公司 | 具有大环结构的化合物及其用途 |
CN114057771B (zh) * | 2020-12-03 | 2023-10-03 | 北京鞍石生物科技有限责任公司 | 大环化合物及其制备方法和应用 |
WO2023129667A1 (en) | 2021-12-30 | 2023-07-06 | Biomea Fusion, Inc. | Pyrazine compounds as inhibitors of flt3 |
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GB9800569D0 (en) | 1998-01-12 | 1998-03-11 | Glaxo Group Ltd | Heterocyclic compounds |
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JP2004526676A (ja) | 2000-12-08 | 2004-09-02 | オーソ−マクニール・フアーマシユーチカル・インコーポレーテツド | キナーゼ阻害剤として有用な大員複素環式化合物 |
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EP3325488B1 (en) * | 2015-07-21 | 2020-06-24 | Turning Point Therapeutics, Inc. | Chiral diaryl macrocycle and use thereof in the treatment of cancer |
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TW201815799A (zh) | 2016-07-28 | 2018-05-01 | 美商Tp生物醫藥公司 | 巨環激酶抑制劑 |
TWI808958B (zh) | 2017-01-25 | 2023-07-21 | 美商特普醫葯公司 | 涉及二芳基巨環化合物之組合療法 |
BR112020001695A2 (pt) | 2017-07-28 | 2020-07-21 | Turning Point Therapeutics, Inc. | compostos macrocíclicos e usos dos mesmos |
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-
2018
- 2018-01-24 TW TW107102558A patent/TWI808958B/zh active
- 2018-01-25 WO PCT/US2018/015150 patent/WO2018140554A1/en unknown
- 2018-01-25 SG SG11201906386XA patent/SG11201906386XA/en unknown
- 2018-01-25 AU AU2018212647A patent/AU2018212647B2/en active Active
- 2018-01-25 KR KR1020197021227A patent/KR102618773B1/ko active IP Right Grant
- 2018-01-25 US US16/480,557 patent/US11291667B2/en active Active
- 2018-01-25 MX MX2019008701A patent/MX2019008701A/es unknown
- 2018-01-25 EP EP18745012.7A patent/EP3573991A4/en active Pending
- 2018-01-25 BR BR112019015115-0A patent/BR112019015115A2/pt active Search and Examination
- 2018-01-25 CA CA3049548A patent/CA3049548A1/en active Pending
- 2018-01-25 CN CN201880008596.6A patent/CN110291092A/zh active Pending
- 2018-01-25 JP JP2019560071A patent/JP7193475B2/ja active Active
-
2019
- 2019-07-11 IL IL267992A patent/IL267992B2/en unknown
Also Published As
Publication number | Publication date |
---|---|
JP2020514409A (ja) | 2020-05-21 |
TW201831188A (zh) | 2018-09-01 |
KR20190111939A (ko) | 2019-10-02 |
WO2018140554A1 (en) | 2018-08-02 |
IL267992A (en) | 2019-09-26 |
EP3573991A1 (en) | 2019-12-04 |
TWI808958B (zh) | 2023-07-21 |
IL267992B2 (en) | 2023-02-01 |
AU2018212647B2 (en) | 2022-02-03 |
RU2019126642A3 (es) | 2021-03-31 |
JP7193475B2 (ja) | 2022-12-20 |
IL267992B (en) | 2022-10-01 |
CN110291092A (zh) | 2019-09-27 |
US11291667B2 (en) | 2022-04-05 |
EP3573991A4 (en) | 2021-01-20 |
US20190381048A1 (en) | 2019-12-19 |
AU2018212647A1 (en) | 2019-07-11 |
SG11201906386XA (en) | 2019-08-27 |
KR102618773B1 (ko) | 2023-12-27 |
CA3049548A1 (en) | 2018-08-02 |
RU2019126642A (ru) | 2021-02-26 |
BR112019015115A2 (pt) | 2020-03-10 |
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