MX2018012619A - Derivados de bisfenol y su uso como moduladores de la actividad del receptor de androgeno. - Google Patents

Derivados de bisfenol y su uso como moduladores de la actividad del receptor de androgeno.

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Publication number
MX2018012619A
MX2018012619A MX2018012619A MX2018012619A MX2018012619A MX 2018012619 A MX2018012619 A MX 2018012619A MX 2018012619 A MX2018012619 A MX 2018012619A MX 2018012619 A MX2018012619 A MX 2018012619A MX 2018012619 A MX2018012619 A MX 2018012619A
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MX
Mexico
Prior art keywords
androgen receptor
receptor activity
activity modulators
bisphenol derivatives
compounds
Prior art date
Application number
MX2018012619A
Other languages
English (en)
Inventor
Dorothy Sadar Marianne
Wang Jun
Andersen Raymond
Adriana Banuelos Carmen
Chi Yang Yu-
Jian Kunzhong
R Mawil Nasrin
Original Assignee
British Columbia Cancer Agency Branch
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by British Columbia Cancer Agency Branch filed Critical British Columbia Cancer Agency Branch
Publication of MX2018012619A publication Critical patent/MX2018012619A/es

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    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
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    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A61K31/222—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin with compounds having aromatic groups, e.g. dipivefrine, ibopamine
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    • C07C233/18—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of an acyclic saturated carbon skeleton
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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
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  • General Health & Medical Sciences (AREA)
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  • General Chemical & Material Sciences (AREA)
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  • Dermatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
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  • Physical Education & Sports Medicine (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Urology & Nephrology (AREA)
  • Emergency Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Se proporcionan los compuestos que tienen una estructura de la Fórmula I: (ver Fórmula) o una sal, tautómero o estereoisómero farmacéuticamente aceptable de estos, donde R1, R2, R3, R11a, R11b, R11c, R11d, y X, son tal como se definen en la. También se proporcionan usos de tales compuestos para modular la actividad del receptor de andrógeno, diagnósticos por imaginología de cáncer y terapéutica, y métodos para el tratamiento de sujetos que lo necesitan, que incluye el cáncer de próstata.
MX2018012619A 2016-04-15 2017-04-18 Derivados de bisfenol y su uso como moduladores de la actividad del receptor de androgeno. MX2018012619A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201662323196P 2016-04-15 2016-04-15
PCT/CA2017/000083 WO2017177307A1 (en) 2016-04-15 2017-04-18 Bisphenol derivatives and their use as androgen receptor activity modulators

Publications (1)

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MX2018012619A true MX2018012619A (es) 2019-06-24

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MX2018012619A MX2018012619A (es) 2016-04-15 2017-04-18 Derivados de bisfenol y su uso como moduladores de la actividad del receptor de androgeno.

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US (3) US20170298033A1 (es)
EP (1) EP3442942B1 (es)
JP (2) JP7142577B2 (es)
KR (1) KR102409651B1 (es)
CN (1) CN109311807B (es)
AU (1) AU2017250025B2 (es)
BR (1) BR112018071183B1 (es)
CA (1) CA3021008A1 (es)
ES (1) ES2969445T3 (es)
IL (1) IL262338B (es)
MX (1) MX2018012619A (es)
NZ (1) NZ748200A (es)
RU (1) RU2767257C2 (es)
WO (1) WO2017177307A1 (es)

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HUE057962T2 (hu) 2015-01-13 2022-06-28 British Columbia Cancer Agency Branch Heterociklusos vegyületek rák képalkotására és kezelésére és eljárás ezek alkalamzására
US10471023B2 (en) 2015-03-12 2019-11-12 British Columbia Cancer Agency Branch Bisphenol ether derivatives and methods for using the same
US20170298033A1 (en) 2016-04-15 2017-10-19 The University Of British Columbia Bisphenol derivatives and their use as androgen receptor activity modulators
WO2018045450A1 (en) * 2016-09-09 2018-03-15 British Columbia Cancer Agency Branch Bisphenol a compounds and methods for treating drug-resistant androgen receptor mediated cancers
US11485713B2 (en) 2018-05-25 2022-11-01 Essa Pharma, Inc. Androgen receptor modulators and methods for their use
PE20211543A1 (es) * 2018-10-18 2021-08-16 Essa Pharma Inc Moduladores del receptor de androgenos y metodos para su uso
CN114502539A (zh) * 2019-03-28 2022-05-13 埃萨制药股份有限公司 包含雄激素受体的抑制剂的药物组合物和组合及其用途
WO2020198712A1 (en) * 2019-03-28 2020-10-01 Essa Pharma, Inc. Pharmaceutical compositions and combinations comprising inhibitors of the androgen receptor and uses thereof
CN118085015A (zh) * 2019-09-06 2024-05-28 江西济民可信集团有限公司 作为蛋白降解剂的并环类化合物及其制备方法和用途
JP2023522040A (ja) 2020-04-17 2023-05-26 エッサ ファーマ，インコーポレイテッド Ｎ末端ドメインアンドロゲン受容体阻害剤の固体形態およびその使用
CN113648418B (zh) * 2021-05-08 2022-08-05 南方医科大学 Apelin-APJ抑制剂在制备治疗血睾屏障损伤药物中的应用
KR20220157089A (ko) * 2021-05-20 2022-11-29 연세대학교 산학협력단 암의 예방, 개선 또는 치료용 조성물
KR20220157096A (ko) * 2021-05-20 2022-11-29 연세대학교 산학협력단 암의 예방, 개선 또는 치료용 조성물
WO2023046283A1 (en) 2021-09-22 2023-03-30 Fundació Institut De Recerca Biomèdica (Irb Barcelona) Compounds and their use in a method for modulating ar (androgen receptor) transcriptional activity

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