MX2018003284A - Compuestos antifungicos y procesos para hacerlos. - Google Patents
Compuestos antifungicos y procesos para hacerlos.Info
- Publication number
- MX2018003284A MX2018003284A MX2018003284A MX2018003284A MX2018003284A MX 2018003284 A MX2018003284 A MX 2018003284A MX 2018003284 A MX2018003284 A MX 2018003284A MX 2018003284 A MX2018003284 A MX 2018003284A MX 2018003284 A MX2018003284 A MX 2018003284A
- Authority
- MX
- Mexico
- Prior art keywords
- mixtures
- processes
- making
- compound
- antifungal compounds
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 4
- 150000001875 compounds Chemical class 0.000 title abstract 3
- 229940121375 antifungal agent Drugs 0.000 title abstract 2
- 230000000843 anti-fungal effect Effects 0.000 title 1
- 239000000203 mixture Substances 0.000 abstract 4
- 229940125898 compound 5 Drugs 0.000 abstract 2
- SZUVGFMDDVSKSI-WIFOCOSTSA-N (1s,2s,3s,5r)-1-(carboxymethyl)-3,5-bis[(4-phenoxyphenyl)methyl-propylcarbamoyl]cyclopentane-1,2-dicarboxylic acid Chemical compound O=C([C@@H]1[C@@H]([C@](CC(O)=O)([C@H](C(=O)N(CCC)CC=2C=CC(OC=3C=CC=CC=3)=CC=2)C1)C(O)=O)C(O)=O)N(CCC)CC(C=C1)=CC=C1OC1=CC=CC=C1 SZUVGFMDDVSKSI-WIFOCOSTSA-N 0.000 abstract 1
- 239000003429 antifungal agent Substances 0.000 abstract 1
- 229940126543 compound 14 Drugs 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/713—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with four or more nitrogen atoms as the only ring hetero atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J31/00—Catalysts comprising hydrides, coordination complexes or organic compounds
- B01J31/02—Catalysts comprising hydrides, coordination complexes or organic compounds containing organic compounds or metal hydrides
- B01J31/0234—Nitrogen-, phosphorus-, arsenic- or antimony-containing compounds
- B01J31/0235—Nitrogen containing compounds
- B01J31/0244—Nitrogen containing compounds with nitrogen contained as ring member in aromatic compounds or moieties, e.g. pyridine
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B53/00—Asymmetric syntheses
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B57/00—Separation of optically-active compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B63/00—Purification; Separation; Stabilisation; Use of additives
- C07B63/02—Purification; Separation; Stabilisation; Use of additives by treatment giving rise to a chemical modification
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C303/00—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides
- C07C303/42—Separation; Purification; Stabilisation; Use of additives
- C07C303/44—Separation; Purification
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
- C07C309/01—Sulfonic acids
- C07C309/28—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C309/29—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton of non-condensed six-membered aromatic rings
- C07C309/30—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton of non-condensed six-membered aromatic rings of six-membered aromatic rings substituted by alkyl groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/28—Radicals substituted by singly-bound oxygen or sulphur atoms
- C07D213/30—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
- C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2231/00—Catalytic reactions performed with catalysts classified in B01J31/00
- B01J2231/30—Addition reactions at carbon centres, i.e. to either C-C or C-X multiple bonds
- B01J2231/34—Other additions, e.g. Monsanto-type carbonylations, addition to 1,2-C=X or 1,2-C-X triplebonds, additions to 1,4-C=C-C=X or 1,4-C=-C-X triple bonds with X, e.g. O, S, NH/N
- B01J2231/341—1,2-additions, e.g. aldol or Knoevenagel condensations
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Materials Engineering (AREA)
- Agronomy & Crop Science (AREA)
- Environmental Sciences (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Dentistry (AREA)
- Plant Pathology (AREA)
- Pest Control & Pesticides (AREA)
- Neurology (AREA)
- Cardiology (AREA)
- Urology & Nephrology (AREA)
- Pain & Pain Management (AREA)
- Biomedical Technology (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Ophthalmology & Optometry (AREA)
- Rheumatology (AREA)
- Heart & Thoracic Surgery (AREA)
- Neurosurgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562220384P | 2015-09-18 | 2015-09-18 | |
| US201662275504P | 2016-01-06 | 2016-01-06 | |
| PCT/US2016/052300 WO2017049196A1 (en) | 2015-09-18 | 2016-09-16 | Antifungal compounds and processes for making |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2018003284A true MX2018003284A (es) | 2018-08-23 |
Family
ID=58289604
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2018003284A MX2018003284A (es) | 2015-09-18 | 2016-09-16 | Compuestos antifungicos y procesos para hacerlos. |
| MX2018003357A MX391538B (es) | 2015-09-18 | 2016-09-16 | Proceso de compuesto antifungico. |
| MX2018003280A MX391539B (es) | 2015-09-18 | 2016-09-16 | Proceso de compuesto antifungico. |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2018003357A MX391538B (es) | 2015-09-18 | 2016-09-16 | Proceso de compuesto antifungico. |
| MX2018003280A MX391539B (es) | 2015-09-18 | 2016-09-16 | Proceso de compuesto antifungico. |
Country Status (17)
| Country | Link |
|---|---|
| US (4) | US10513505B2 (enExample) |
| EP (3) | EP3349587B1 (enExample) |
| JP (4) | JP6887993B2 (enExample) |
| KR (3) | KR20180053393A (enExample) |
| CN (3) | CN108289457B (enExample) |
| AU (3) | AU2016324148B2 (enExample) |
| BR (2) | BR112018005194B1 (enExample) |
| CA (3) | CA2998808A1 (enExample) |
| EA (3) | EA037521B1 (enExample) |
| ES (2) | ES2821021T3 (enExample) |
| HK (3) | HK1263287A1 (enExample) |
| HU (1) | HUE053638T2 (enExample) |
| MX (3) | MX2018003284A (enExample) |
| PL (1) | PL3349586T3 (enExample) |
| TW (3) | TWI766842B (enExample) |
| WO (3) | WO2017049080A1 (enExample) |
| ZA (1) | ZA201801404B (enExample) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10017494B2 (en) | 2014-03-19 | 2018-07-10 | Mycovia Pharmaceuticals, Inc. | Antifungal compound process |
| ES2815373T3 (es) | 2014-03-19 | 2021-03-29 | Mycovia Pharmaceuticals Inc | Procedimiento de compuesto antifúngico |
| CA2942932A1 (en) | 2014-03-19 | 2015-09-24 | Viamet Pharmaceuticals, Inc. | Antifungal compound process |
| ES2800905T3 (es) | 2014-03-19 | 2021-01-05 | Mycovia Pharmaceuticals Inc | Procedimiento para compuesto antifúngico |
| EP3119755B1 (en) | 2014-03-19 | 2019-03-06 | Viamet Pharmaceuticals (NC), Inc. | Antifungal compound process |
| MX2016012060A (es) | 2014-03-19 | 2017-01-19 | Viamet Pharmaceuticals Inc | 2-(2,4-difluorofenil)-1,1-difluoro-1-(5-sustituido-piridin-2-il)- 3-(1h-tetrazol-1-il)propan-2-oles y procesos para su preparacion. |
| US10399943B2 (en) | 2014-03-19 | 2019-09-03 | Mycovia Pharmaceuticals, Inc. | Antifungal compound process |
| US10196375B2 (en) | 2014-03-19 | 2019-02-05 | Mycovia Pharmaceuticals, Inc. | Antifungal compound process |
| CN106103424A (zh) | 2014-03-19 | 2016-11-09 | 维亚梅特制药公司 | 2‑(2,4‑二氟苯基)‑1,1‑二氟‑1‑(5‑经取代的吡啶‑2‑基)‑3‑(1h‑四唑‑1‑基)丙烷‑2‑醇和其制备方法 |
| EA037521B1 (ru) | 2015-09-18 | 2021-04-07 | ВиПиЭс-3, ИНК. | Противогрибковые соединения и способы их получения |
| CN109666019B (zh) * | 2017-10-14 | 2021-04-06 | 朱允涛 | 一种氘代的氮唑醇类化合物及其制备方法和用途 |
| EP3710432A1 (en) | 2017-11-13 | 2020-09-23 | Bayer Aktiengesellschaft | Tetrazolylpropyl derivatives and their use as fungicides |
| WO2021188404A1 (en) * | 2020-03-19 | 2021-09-23 | Assia Chemical Industries Ltd | Solid state forms of oteseconazole and process for preparation thereof |
| CA3226998A1 (en) * | 2021-07-22 | 2023-01-26 | Mycovia Pharmaceuticals, Inc. | Compositions comprising oteseconazole |
| CN114573503B (zh) * | 2022-03-28 | 2024-04-09 | 浙江天宇药业股份有限公司 | 一种制备奥特康唑中间体的方法 |
| CN114573557B (zh) * | 2022-03-28 | 2024-03-08 | 浙江天宇药业股份有限公司 | 一种奥特康唑的制备方法 |
| CN116621816B (zh) * | 2022-09-23 | 2025-07-04 | 北京莱瑞森医药科技有限公司 | 一种伏立康唑对映异构对b的拆分方法 |
| CN119855811A (zh) * | 2022-09-30 | 2025-04-18 | 上海济煜医药科技有限公司 | 双环类化合物的无定形、结晶固体及其制备方法 |
| CN119798219B (zh) * | 2025-01-13 | 2025-07-18 | 长治医学院 | 一种奥特康唑的制备方法 |
Family Cites Families (57)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2854015B2 (de) | 1978-12-14 | 1980-10-09 | Dynamit Nobel Ag, 5210 Troisdorf | Verfahren zur Herstellung von !H-TetrazoI-1-essigsauren und bestimmter Ester derselben |
| CS228931B2 (cs) | 1981-06-06 | 1984-05-14 | Pfizer | Způsob výroby 2-(2,4-difluorfenyl)-l,3-bis(lH-l,2,4-triazol-l-yl)propan- -2-oiu |
| EP0069442B1 (en) | 1981-06-06 | 1985-02-20 | Pfizer Limited | Antifungal agents, processes for their preparation, and pharmaceutical compositions containing them |
| GB8304282D0 (en) | 1983-02-16 | 1983-03-23 | Pfizer Ltd | Antifungal agents |
| US5087240A (en) | 1983-08-18 | 1992-02-11 | Drug Delivery Systems Inc. | Transdermal drug patch with conductive fibers |
| US4921475A (en) | 1983-08-18 | 1990-05-01 | Drug Delivery Systems Inc. | Transdermal drug patch with microtubes |
| US5163899A (en) | 1987-03-20 | 1992-11-17 | Drug Delivery Systems Inc. | Transdermal drug delivery system |
| US5312325A (en) | 1987-05-28 | 1994-05-17 | Drug Delivery Systems Inc | Pulsating transdermal drug delivery system |
| GB8804164D0 (en) | 1988-02-23 | 1988-03-23 | Tucker J M | Bandage for administering physiologically active compound |
| US5008110A (en) | 1988-11-10 | 1991-04-16 | The Procter & Gamble Company | Storage-stable transdermal patch |
| US5088977A (en) | 1988-12-21 | 1992-02-18 | Drug Delivery Systems Inc. | Electrical transdermal drug applicator with counteractor and method of drug delivery |
| PT96059B (pt) | 1989-12-04 | 1998-07-31 | Searle & Co | Sistema de camada unica para a administracao de um medicamento por via transdermica |
| US5352456A (en) | 1991-10-10 | 1994-10-04 | Cygnus Therapeutic Systems | Device for administering drug transdermally which provides an initial pulse of drug |
| CA2123809A1 (en) | 1991-12-18 | 1993-06-24 | Debra L. Wilfong | Multilayered barrier structures |
| EP0553769B1 (de) | 1992-01-29 | 1996-01-03 | FRANZ VÖLKL GmbH & CO. SKI UND TENNIS SPORTARTIKELFABRIK KG | Ballspielschläger, insbesondere Tennisschläger |
| JP2000344744A (ja) | 1999-06-04 | 2000-12-12 | Ss Pharmaceut Co Ltd | アセトフェノン誘導体およびその製法 |
| KR20040050906A (ko) * | 2001-10-08 | 2004-06-17 | 코닌클리케 필립스 일렉트로닉스 엔.브이. | 모션 추정을 위한 장치 및 방법 |
| JP2004359646A (ja) | 2003-06-09 | 2004-12-24 | Ss Pharmaceut Co Ltd | 抗真菌活性を有する新規アゾール誘導体 |
| US7241800B2 (en) * | 2004-03-17 | 2007-07-10 | Mai De Ltd. | Anhydrous amorphous form of fluvastatin sodium |
| US8198448B2 (en) | 2006-07-14 | 2012-06-12 | Amgen Inc. | Fused heterocyclic derivatives and methods of use |
| KR100889937B1 (ko) | 2007-08-06 | 2009-03-20 | 한미약품 주식회사 | 보리코나졸의 제조방법 |
| UA108596C2 (xx) * | 2007-11-09 | 2015-05-25 | Інгібітори пептиддеформілази | |
| KR101109215B1 (ko) | 2009-06-17 | 2012-01-30 | 보령제약 주식회사 | 보리코나졸의 신규 중간체 및 이를 이용한 보리코나졸의 제조방법 |
| US20120088664A1 (en) | 2009-06-18 | 2012-04-12 | Basf Se | Antifungal 1,2,4-triazolyl derivatives having a 5-sulfur subtituent |
| CA2837400C (en) | 2010-04-24 | 2017-12-12 | Viamet Pharmaceuticals, Inc. | 5-(optionally substituted phenyl) pyridin-2-yl compounds as metalloenzyme inhibitors |
| EP2721023B1 (en) | 2011-06-19 | 2018-08-08 | Viamet Pharmaceuticals (NC), Inc. | Metalloenzyme inhibitor compounds |
| CN103764646A (zh) | 2011-06-19 | 2014-04-30 | 威尔金制药有限公司 | 金属酶抑制剂化合物 |
| EA025266B1 (ru) | 2011-06-23 | 2016-12-30 | Ваймет Фармасьютикалс, Инк. | Соединения, ингибирующие металлоферменты |
| TW201329025A (zh) | 2011-11-01 | 2013-07-16 | Astex Therapeutics Ltd | 醫藥化合物 |
| AU2012352555B2 (en) * | 2011-12-11 | 2017-08-03 | Nqp 1598, Ltd. | Metalloenzyme inhibitor compounds |
| MX2014008729A (es) | 2012-01-20 | 2015-02-04 | Viamet Pharmaceuticals Inc | Compuestos inhibidores de metaloenzima. |
| US10221160B2 (en) | 2012-01-20 | 2019-03-05 | Mycovia Pharmaceuticals, Inc. | Metalloenzyme inhibitor compounds |
| TWI662964B (zh) | 2012-06-04 | 2019-06-21 | 美商製藥有限責任公司 | 布魯頓氏酪胺酸激酶抑制劑之結晶形式 |
| KR20140012226A (ko) * | 2012-07-18 | 2014-02-03 | 엘지전자 주식회사 | 태양전지 모듈 |
| EP2894981B1 (en) | 2012-09-12 | 2019-12-04 | Dow AgroSciences LLC | Metalloenzyme inhibitor compounds |
| AU2014209107B2 (en) | 2013-01-28 | 2018-04-12 | Viamet Pharmaceuticals (NC), Inc. | Metalloenzyme inhibitor compounds |
| WO2014165861A1 (en) | 2013-04-05 | 2014-10-09 | The Regents Of The University Of California | Metal-catalyzed coupling of aryl and vinyl halides with alpha, alpha-difluorocarbonyl compounds |
| CA2913914C (en) | 2013-05-28 | 2018-03-20 | Viamet Pharmaceuticals, Inc. | Fungicidal compositions |
| EA201690007A1 (ru) | 2013-06-12 | 2016-04-29 | Ваймет Фармасьютикалс, Инк. | Соединения, ингибирующие металлоферменты |
| CN106103424A (zh) | 2014-03-19 | 2016-11-09 | 维亚梅特制药公司 | 2‑(2,4‑二氟苯基)‑1,1‑二氟‑1‑(5‑经取代的吡啶‑2‑基)‑3‑(1h‑四唑‑1‑基)丙烷‑2‑醇和其制备方法 |
| US10017494B2 (en) | 2014-03-19 | 2018-07-10 | Mycovia Pharmaceuticals, Inc. | Antifungal compound process |
| US10196375B2 (en) | 2014-03-19 | 2019-02-05 | Mycovia Pharmaceuticals, Inc. | Antifungal compound process |
| ES2815373T3 (es) * | 2014-03-19 | 2021-03-29 | Mycovia Pharmaceuticals Inc | Procedimiento de compuesto antifúngico |
| US10399943B2 (en) | 2014-03-19 | 2019-09-03 | Mycovia Pharmaceuticals, Inc. | Antifungal compound process |
| US9802914B2 (en) | 2014-03-19 | 2017-10-31 | Viamet Pharmaceuticals, Inc. | Antifungal compound process |
| CA2942932A1 (en) * | 2014-03-19 | 2015-09-24 | Viamet Pharmaceuticals, Inc. | Antifungal compound process |
| EP3119755B1 (en) | 2014-03-19 | 2019-03-06 | Viamet Pharmaceuticals (NC), Inc. | Antifungal compound process |
| MX2016012060A (es) | 2014-03-19 | 2017-01-19 | Viamet Pharmaceuticals Inc | 2-(2,4-difluorofenil)-1,1-difluoro-1-(5-sustituido-piridin-2-il)- 3-(1h-tetrazol-1-il)propan-2-oles y procesos para su preparacion. |
| ES2800905T3 (es) | 2014-03-19 | 2021-01-05 | Mycovia Pharmaceuticals Inc | Procedimiento para compuesto antifúngico |
| CN107428724B (zh) | 2015-03-19 | 2021-07-02 | 迈科维亚医药公司 | 抗真菌化合物及制备方法 |
| UA120784C2 (uk) | 2015-05-18 | 2020-02-10 | Ваймет Фармасьютікалс (Нк), Інк. | Протигрибкові сполуки |
| EA037521B1 (ru) | 2015-09-18 | 2021-04-07 | ВиПиЭс-3, ИНК. | Противогрибковые соединения и способы их получения |
| CN108473443A (zh) | 2015-11-17 | 2018-08-31 | 美国陶氏益农公司 | 4-((6-(2-(2,4-二氟苯基)-1,1-二氟-2-羟基-3-(1h-1,2,4-三唑-1-基)丙基)吡啶-3-基)氧基)苄腈以及制备方法 |
| US20180354928A1 (en) | 2015-11-17 | 2018-12-13 | Dow Agrosciences Llc | 4-((6-(2-(2,4-difluorophenyl)-1,1-difluoro-2-hydroxy-3-(1h-1,2,4-triazol-1-yl)propyl)pyridin-3-yl)oxy)benzonitrile and processes of preparation |
| KR20180100114A (ko) | 2015-11-17 | 2018-09-07 | 다우 아그로사이언시즈 엘엘씨 | 4-((6-(2-(2,4-디플루오로페닐)-1,1-디플루오로-2-히드록시-3-(1h-1,2,4-트리아졸-1-일)프로필)피리딘-3-일)옥시)벤조니트릴 및 제조방법 |
| CN108882709A (zh) | 2015-11-17 | 2018-11-23 | 美国陶氏益农公司 | 4-((6-(2-(2,4-二氟苯基)-1,1-二氟-2-氧代乙基)吡啶-3-基)氧基)苄腈以及制备方法 |
| EA038421B1 (ru) | 2015-12-30 | 2021-08-26 | ВиПиЭс-3, ИНК. | Соединения, ингибирующие металлоферменты |
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