MX2018003036A - Metodo para producir celulas progenitoras renales. - Google Patents

Metodo para producir celulas progenitoras renales.

Info

Publication number
MX2018003036A
MX2018003036A MX2018003036A MX2018003036A MX2018003036A MX 2018003036 A MX2018003036 A MX 2018003036A MX 2018003036 A MX2018003036 A MX 2018003036A MX 2018003036 A MX2018003036 A MX 2018003036A MX 2018003036 A MX2018003036 A MX 2018003036A
Authority
MX
Mexico
Prior art keywords
kidney progenitor
progenitor cells
cells
pluripotent stem
stem cells
Prior art date
Application number
MX2018003036A
Other languages
English (en)
Inventor
Osafune Kenji
Yamagishi Yukiko
kawamoto Tatsuya
Original Assignee
Astellas Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astellas Pharma Inc filed Critical Astellas Pharma Inc
Publication of MX2018003036A publication Critical patent/MX2018003036A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0684—Cells of the urinary tract or kidneys
    • C12N5/0687—Renal stem cells; Renal progenitors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6872—Intracellular protein regulatory factors and their receptors, e.g. including ion channels
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0684—Cells of the urinary tract or kidneys
    • C12N5/0686—Kidney cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/22—Urine; Urinary tract, e.g. kidney or bladder; Intraglomerular mesangial cells; Renal mesenchymal cells; Adrenal gland
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/10—Cells modified by introduction of foreign genetic material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/02—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
    • C12Q1/04—Determining presence or kind of microorganism; Use of selective media for testing antibiotics or bacteriocides; Compositions containing a chemical indicator therefor
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56966—Animal cells
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N61/00—Biocides, pest repellants or attractants, or plant growth regulators containing substances of unknown or undetermined composition, e.g. substances characterised only by the mode of action
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
    • C12N2506/02—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from embryonic cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
    • C12N2506/45—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from artificially induced pluripotent stem cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2513/00—3D culture
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/70596—Molecules with a "CD"-designation not provided for elsewhere in G01N2333/705
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Urology & Nephrology (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Cell Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Virology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Food Science & Technology (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Developmental Biology & Embryology (AREA)
  • Biophysics (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Toxicology (AREA)
  • Plant Pathology (AREA)
  • Agronomy & Crop Science (AREA)
  • Pest Control & Pesticides (AREA)

Abstract

La presente invención aborda el problema de proporcionar un método para obtener y producir células progenitoras renales que tengan un alto grado de pureza, a partir de una población de células obtenida al inducir la diferenciación de células madre pluripotenciales en células progenitoras renales, mediante la identificación de un antígeno marcador de superficie celular específico de células progenitoras renales. La presente invención también se refiere a un método para producir células progenitoras renales obtenidas al inducir la diferenciación de células madre pluripotenciales, en donde el método incluye: (i) un paso de cultivar células madre pluripotenciales bajo condiciones que induzcan su diferenciación en células progenitoras renales; y (ii) un paso de seleccionar una población de células a partir de las células obtenidas en el paso del inciso (i) mediante el uso de por lo menos un marcador de superficie celular que se selecciona del grupo que consiste de CD9(-), CD55(-), CD106(+), CD140a(+), CD140b(+), CD165(+), CD271(+) y CD326(-).
MX2018003036A 2015-09-11 2016-09-09 Metodo para producir celulas progenitoras renales. MX2018003036A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2015179104 2015-09-11
PCT/JP2016/077353 WO2017043666A1 (ja) 2015-09-11 2016-09-09 腎前駆細胞を製造する方法

Publications (1)

Publication Number Publication Date
MX2018003036A true MX2018003036A (es) 2018-05-02

Family

ID=58240847

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2018003036A MX2018003036A (es) 2015-09-11 2016-09-09 Metodo para producir celulas progenitoras renales.

Country Status (14)

Country Link
US (2) US10731133B2 (es)
EP (1) EP3348632B1 (es)
JP (1) JP6830893B2 (es)
KR (1) KR20180042391A (es)
CN (1) CN108138136B (es)
AU (1) AU2016321015B2 (es)
CA (1) CA2998096C (es)
ES (1) ES2897974T3 (es)
IL (1) IL257974B (es)
MX (1) MX2018003036A (es)
RU (1) RU2730861C2 (es)
SG (1) SG11201801970XA (es)
TW (1) TWI746459B (es)
WO (1) WO2017043666A1 (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11674158B2 (en) 2016-07-15 2023-06-13 Salk Institute For Biological Studies Methods and compositions for genome editing in non-dividing cells
CA3064830A1 (en) * 2017-05-25 2018-11-29 Kyoto University Method for inducing differentiation of intermediate mesodermal cell to renal progenitor cell, and method for inducing differentiation of pluripotent stem cell to renal progenitor cell
WO2020022261A1 (ja) 2018-07-23 2020-01-30 国立大学法人京都大学 新規腎前駆細胞マーカーおよびそれを利用した腎前駆細胞の濃縮方法
CN110684855B (zh) * 2019-10-21 2021-08-03 华中农业大学 一种米尔伊丽莎白菌的实时荧光定量rt-pcr检测方法
CN116802276A (zh) 2021-01-08 2023-09-22 国立大学法人京都大学 用于扩增培养肾元祖细胞的培养基、扩增培养肾元祖细胞的方法以及肾脏类器官的制造方法
CN113201560B (zh) * 2021-05-06 2023-05-30 北京起源爱心生物科技有限公司 一种修复型多能肾前体干细胞库的建立方法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5843780A (en) 1995-01-20 1998-12-01 Wisconsin Alumni Research Foundation Primate embryonic stem cells
BRPI0305769A8 (pt) * 2002-08-08 2017-09-12 Baylor College Medicine Isolamento e identificação de células t
AU2006325975B2 (en) 2005-12-13 2011-12-08 Kyoto University Nuclear reprogramming factor
EP2340303B1 (en) * 2008-10-24 2016-10-12 Childrens Hospital Los Angeles Amniotic fluid cells and uses thereof
US8828722B2 (en) * 2009-02-26 2014-09-09 Tel Hashomer Medical Research Infrastructure And Services Ltd. Isolated populations of renal stem cells and methods of isolating and using same
JP5896360B2 (ja) 2010-07-21 2016-04-13 国立大学法人京都大学 ヒト多能性幹細胞から中間中胚葉細胞への分化誘導方法
AU2012279995C1 (en) 2011-07-06 2019-10-24 Cell Therapy Limited Progenitor cells of mesodermal lineage
BR112015030918A2 (pt) 2013-06-11 2017-12-05 Astellas Pharma Inc método para produção de células progenitoras renais, e fármacos contendo células progenitoras renais
MX2015017330A (es) * 2013-07-29 2016-04-06 Hoffmann La Roche Metodo para la diferenciacion de celulas madre pluripotenciales en precursores renales multi-competentes.
ITFI20130303A1 (it) * 2013-12-24 2015-06-25 Azienda Ospedaliero Universitaria M Eyer Metodica per l¿isolamento, purificazione ed amplificazione di progenitori renali cd133+cd24+ dalle urine di pazienti affetti da malattie renali.

Also Published As

Publication number Publication date
CA2998096C (en) 2024-01-30
JP6830893B2 (ja) 2021-02-17
EP3348632A1 (en) 2018-07-18
SG11201801970XA (en) 2018-04-27
AU2016321015B2 (en) 2021-09-30
US20180273905A1 (en) 2018-09-27
EP3348632A4 (en) 2019-05-01
CN108138136B (zh) 2022-02-11
TWI746459B (zh) 2021-11-21
US11746332B2 (en) 2023-09-05
RU2018112687A (ru) 2019-10-11
WO2017043666A1 (ja) 2017-03-16
JPWO2017043666A1 (ja) 2018-06-28
CN108138136A (zh) 2018-06-08
KR20180042391A (ko) 2018-04-25
CA2998096A1 (en) 2017-03-16
ES2897974T3 (es) 2022-03-03
AU2016321015A1 (en) 2018-04-05
IL257974A (en) 2018-05-31
RU2730861C2 (ru) 2020-08-26
RU2018112687A3 (es) 2019-10-11
US20200407692A1 (en) 2020-12-31
US10731133B2 (en) 2020-08-04
TW201723173A (zh) 2017-07-01
IL257974B (en) 2022-07-01
EP3348632B1 (en) 2021-11-03

Similar Documents

Publication Publication Date Title
MX2018003036A (es) Metodo para producir celulas progenitoras renales.
IL285543A (en) Natural killer cells modified for immunotherapy
PH12019501227A1 (en) Synthetic immune receptors and methods of use thereof
TR201900776T4 (tr) Memeli hücre kültürlerinin hasadına ilişkin yöntem.
SG10201900323SA (en) Method for inducing t cells for cell-based immunotherapy from pluripotent stem cells
EP3491134A4 (en) PLURIPOTENT HUMAN INDUCED STEM CELLS FOR HIGH-PERFORMANCE GENETIC ENGINEERING
MX2017006127A (es) Metodos y composiciones para produccion de proteina de clara de huevo.
TW201612312A (en) Meristematic plant cells and method of isolating them
CL2017003287A1 (es) Sistema para la preparación automática del explante y método de uso.
EP4219744A3 (en) Methods of preparing nucleic acids for sequencing
EP3633029A4 (en) PROCESS FOR CULTURING NATURAL KILLER CELLS USING A TRANSFORMED T LYMPHOCYTE
MX2021000459A (es) Metodo para producir celulas t gamma y delta.
MX2017008817A (es) Composiciones y metodos para la glicosilacion de proteinas.
ES2721309T3 (es) Composición para preparar tagatosa y método para preparar tagatosa a partir de fructosa
BR112016020517A2 (pt) método de produção de lipídeo através da utilização de ss-cetoacil-acp sintase
WO2018161049A8 (en) Compositions and methods for inducing hiv-1 antibodies
WO2017048809A8 (en) Nk cells exhibiting an adaptive phenotype and methods for preparing and for using
WO2017152146A3 (en) Compositions and methods for inducing hiv-1 antibodies
MX2017000014A (es) Metodo para producir acido graso de cadena media con el uso de beta-cetoacil-proteina portadora de acilo (acp) sintasa.
AU2015279552A8 (en) Neural cells expressing adenovirus E4ORF1, and methods of making and using the same
ZA202000574B (en) Mesenchymal stem cells as vaccine adjuvants and methods for using the same
MX2021012984A (es) Anticuerpos y metodos para el tratamiento de la infeccion por influenza a.
EP3395939A4 (en) TANK OF CULTURAL SORTING, CULTURE AND GROWTH; AND METHOD OF CELL SORTING, CULTURE AND GROWTH
IL277467A (en) A method for producing natural killer cells
ZA202003831B (en) Modified norovirus vp1 proteins and vlps comprising modified norovirus vp1 proteins