MX2017005152A - Dosificacion y administracion de anticuerpos anti-cd40 no fucosilados. - Google Patents

Dosificacion y administracion de anticuerpos anti-cd40 no fucosilados.

Info

Publication number
MX2017005152A
MX2017005152A MX2017005152A MX2017005152A MX2017005152A MX 2017005152 A MX2017005152 A MX 2017005152A MX 2017005152 A MX2017005152 A MX 2017005152A MX 2017005152 A MX2017005152 A MX 2017005152A MX 2017005152 A MX2017005152 A MX 2017005152A
Authority
MX
Mexico
Prior art keywords
antibodies
dosage
administration
fucosylated anti
fucosylated
Prior art date
Application number
MX2017005152A
Other languages
English (en)
Inventor
Yang Jing
Gardai Shyra
Leung Law Che-
Peng Stanford
NEFF-LAFORD Haley
Original Assignee
Seattle Genetics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=55858352&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MX2017005152(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Seattle Genetics Inc filed Critical Seattle Genetics Inc
Publication of MX2017005152A publication Critical patent/MX2017005152A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00—Catheters; Hollow probes
    • A61M25/0009—Making of catheters or other medical or surgical tubes
    • A61M25/0012—Making of catheters or other medical or surgical tubes with embedded structures, e.g. coils, braids, meshes, strands or radiopaque coils
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00—Catheters; Hollow probes
    • A61M25/0017—Catheters; Hollow probes specially adapted for long-term hygiene care, e.g. urethral or indwelling catheters to prevent infections
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00—Catheters; Hollow probes
    • A61M25/002—Packages specially adapted therefor ; catheter kit packages
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2878—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A61K2039/507—Comprising a combination of two or more separate antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00—Catheters; Hollow probes
    • A61M25/0067—Catheters; Hollow probes characterised by the distal end, e.g. tips
    • A61M25/0068—Static characteristics of the catheter tip, e.g. shape, atraumatic tip, curved tip or tip structure
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
    • C07K2317/41—Glycosylation, sialylation, or fucosylation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pulmonology (AREA)
  • Anesthesiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Endocrinology (AREA)
  • Urology & Nephrology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Esta invención se refiere a métodos de uso de un anticuerpo anti-CD40 no fucosilado para el tratamiento de cáncer y enfermedades infecciosas crónicas.
MX2017005152A 2014-10-29 2015-10-29 Dosificacion y administracion de anticuerpos anti-cd40 no fucosilados. MX2017005152A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462072031P 2014-10-29 2014-10-29
US201562134955P 2015-03-18 2015-03-18
PCT/US2015/058108 WO2016069919A1 (en) 2014-10-29 2015-10-29 Dosage and administration of non-fucosylated anti-cd40 antibodies

Publications (1)

Publication Number Publication Date
MX2017005152A true MX2017005152A (es) 2017-08-04

Family

ID=55858352

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2017005152A MX2017005152A (es) 2014-10-29 2015-10-29 Dosificacion y administracion de anticuerpos anti-cd40 no fucosilados.

Country Status (22)

Country Link
US (8) US11213584B2 (es)
EP (2) EP3831847A1 (es)
JP (5) JP6691113B2 (es)
KR (1) KR20170072884A (es)
CN (2) CN107073118B (es)
AU (2) AU2015339128C1 (es)
BR (1) BR112017008959A2 (es)
CA (1) CA2963720C (es)
CY (1) CY1124033T1 (es)
DK (1) DK3212230T3 (es)
EA (1) EA036498B1 (es)
ES (1) ES2864756T3 (es)
HK (1) HK1243328A1 (es)
HU (1) HUE054075T2 (es)
IL (2) IL299075A (es)
MX (1) MX2017005152A (es)
PL (1) PL3212230T3 (es)
PT (1) PT3212230T (es)
SG (2) SG11201702598XA (es)
SI (1) SI3212230T1 (es)
WO (1) WO2016069919A1 (es)
ZA (2) ZA201702347B (es)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL3212230T3 (pl) * 2014-10-29 2021-07-26 Seagen Inc. Dawkowanie i podawanie niefukozylowanych przeciwciał anty-CD40
US20210001032A1 (en) * 2015-03-27 2021-01-07 Eliaz Therapeutics, Inc. Galectin-3 plasmapheresis therapy
JP7152309B2 (ja) 2016-02-17 2022-10-12 シージェン インコーポレイテッド 癌及び免疫学的障害を治療するためのｂｃｍａ抗生物質及びその使用
PE20190562A1 (es) 2016-05-27 2019-04-22 Abbvie Biotherapeutics Inc Proteinas de union biespecificas que se unen a una proteina inmunomoduladora y un antigeno tumoral
MX2018014630A (es) 2016-05-27 2019-06-10 Abbvie Biotherapeutics Inc Anticuerpos anti-cd40 y sus usos.
KR102019033B1 (ko) 2016-11-11 2019-09-06 다이노나(주) Cd40에 특이적으로 결합하는 항체 및 그의 용도
MX2020005463A (es) 2017-12-01 2020-09-07 Seattle Genetics Inc Anticuerpos anti grupo de diferenciacion 47 (anti-cd47) y sus usos para tratar cancer.
CA3093820A1 (en) * 2018-03-13 2019-09-19 Hibercell, Inc. Beta glucan and cd40 agonist combination immunotherapy
CA3103629A1 (en) 2018-06-15 2019-12-19 Flagship Pioneering Innovations V, Inc. Increasing immune activity through modulation of postcellular signaling factors
MX2021002002A (es) 2018-08-23 2021-05-31 Seagen Inc Anticuerpos anti inmunorreceptor de celulas t con dominios ig y motivo inhibidor inmunorreceptor basado en tirosina (tigit).
WO2020104690A1 (en) 2018-11-23 2020-05-28 Quine Medical Ab Bi-specific conjugates
FR3089597B1 (fr) 2018-12-06 2020-11-20 Gaztransport Et Technigaz Cuve étanche et thermiquement isolante
SG11202106481SA (en) * 2018-12-19 2021-07-29 Seagen Inc Controlled fucosylation of antibodies
KR20220007849A (ko) * 2019-03-18 2022-01-19 스코어 파마, 인코포레이티드 푸코실화를 억제하기 위한 화합물 및 그의 사용 방법
EP3962493A2 (en) 2019-05-03 2022-03-09 Flagship Pioneering Innovations V, Inc. Methods of modulating immune activity/level of irf or sting or of treating cancer, comprising the administration of a sting modulator and/or purinergic receptor modulator or postcellular signaling factor
JP2022536982A (ja) * 2019-06-21 2022-08-22 ボード オブ リージェンツ，ザ ユニバーシティ オブ テキサス システム 癌およびその他の疾患の処置のためのα３β１インテグリンの標的化
US20220370418A1 (en) 2019-09-09 2022-11-24 Basilea Pharmaceutica International AG Pharmaceutical combinations comprising a furazanobenzimidazoles and a cd40 agonist for use in the treatment of neoplastic diseases
JP2023509359A (ja) 2019-12-17 2023-03-08 フラグシップ パイオニアリング イノベーションズ ブイ，インコーポレーテッド 鉄依存性細胞分解の誘導物質との併用抗癌療法
TW202206100A (zh) 2020-04-27 2022-02-16 美商西健公司 癌症之治療
GB202008003D0 (en) 2020-05-28 2020-07-15 Quine Medical Ab Anti-CD40 antibody
CA3184366A1 (en) 2020-06-29 2022-01-06 Darby Rye Schmidt Viruses engineered to promote thanotransmission and their use in treating cancer
EP4221751A1 (en) 2020-09-30 2023-08-09 Seagen Inc. Uveal melanoma treatment using sea-cd40
KR20230104659A (ko) 2020-11-08 2023-07-10 씨젠 인크. 면역 세포 억제제를 이용한 조합-요법 항체 약물 접합체
JP2024500847A (ja) 2020-12-18 2024-01-10 センチュリー セラピューティクス，インコーポレイテッド 適合可能な受容体特異性を有するキメラ抗原受容体システム
EP4313109A1 (en) 2021-03-31 2024-02-07 Flagship Pioneering Innovations V, Inc. Thanotransmission polypeptides and their use in treating cancer
WO2022251311A1 (en) 2021-05-25 2022-12-01 Seagen Inc. Methods of quantifying anti-cd40 antibodies
AU2022303363A1 (en) 2021-06-29 2024-01-18 Flagship Pioneering Innovations V, Inc. Immune cells engineered to promote thanotransmission and uses thereof
WO2023010080A1 (en) 2021-07-30 2023-02-02 Seagen Inc. Treatment for cancer
WO2024077191A1 (en) 2022-10-05 2024-04-11 Flagship Pioneering Innovations V, Inc. Nucleic acid molecules encoding trif and additionalpolypeptides and their use in treating cancer

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1990005144A1 (en) 1988-11-11 1990-05-17 Medical Research Council Single domain ligands, receptors comprising said ligands, methods for their production, and use of said ligands and receptors
US5874082A (en) 1992-07-09 1999-02-23 Chiron Corporation Humanized anti-CD40 monoclonal antibodies and fragments capable of blocking B cell proliferation
US6051228A (en) 1998-02-19 2000-04-18 Bristol-Myers Squibb Co. Antibodies against human CD40
US6946129B1 (en) 1999-06-08 2005-09-20 Seattle Genetics, Inc. Recombinant anti-CD40 antibody and uses thereof
US6482411B1 (en) 1999-08-27 2002-11-19 Board Of Regents, The University Of Texas System Methods of reducing bone loss with CD40 ligand
DE60035057T2 (de) 1999-10-04 2008-01-31 Novartis Vaccines and Diagnostics, Inc., Emeryville CD40 Antagonist zur Behandlung von Psoriasis
JP2004505927A (ja) 2000-04-19 2004-02-26 タノックス　インコーポレイテッド 乾癬及び他の炎症性皮膚状態の治療用ｃｄ４０アンタゴニスト
US7063845B2 (en) 2000-04-28 2006-06-20 Gemini Science, Inc. Human anti-CD40 antibodies
WO2002028480A2 (en) 2000-10-02 2002-04-11 Chiron Corporation Methods of therapy for b-cell malignancies
EP2009027B1 (en) 2001-04-27 2014-05-21 Kyowa Hakko Kirin Co., Ltd. Anti-CD40 monoclonal antibody
AR039067A1 (es) * 2001-11-09 2005-02-09 Pfizer Prod Inc Anticuerpos para cd40
US20080199471A1 (en) 2002-03-01 2008-08-21 Bernett Matthew J Optimized cd40 antibodies and methods of using the same
US20050136055A1 (en) 2003-12-22 2005-06-23 Pfizer Inc CD40 antibody formulation and methods
ES2354865T3 (es) * 2005-05-26 2011-03-18 Seattle Genetics, Inc. Anticuerpos anti-cd40 humanizados y métodos para utilizarlos.
KR20080079301A (ko) * 2005-12-09 2008-08-29 시애틀 지네틱스, 인크. Ｃｄ４０ 결합제를 이용하는 방법
EP2007423A2 (en) 2006-04-05 2008-12-31 Pfizer Products Incorporated Ctla4 antibody combination therapy
CA2704499C (en) 2007-11-07 2020-03-10 Genentech, Inc. Methods and compositions for assessing responsiveness of b-cell lymphoma to treatment with anti-cd40 antibodies
AU2009206506B2 (en) * 2008-01-23 2013-01-10 Xencor, Inc. Optimized CD40 antibodies and methods of using the same
PL2282773T3 (pl) 2008-05-02 2014-08-29 Seattle Genetics Inc Sposoby i kompozycje do wytwarzania przeciwciał i pochodnych przeciwciał o obniżonej fukozylacji rdzeniowej
US20120258496A1 (en) * 2010-09-27 2012-10-11 Boehringer Ingelheim International Gmbh Production of low fucose antibodies in h4-ii-e rat cells
WO2013043569A1 (en) * 2011-09-20 2013-03-28 Vical Incorporated Synergistic anti-tumor efficacy using alloantigen combination immunotherapy
US9682143B2 (en) * 2012-08-14 2017-06-20 Ibc Pharmaceuticals, Inc. Combination therapy for inducing immune response to disease
PL3212230T3 (pl) * 2014-10-29 2021-07-26 Seagen Inc. Dawkowanie i podawanie niefukozylowanych przeciwciał anty-CD40

Also Published As

Publication number Publication date
EP3212230B1 (en) 2021-01-20
IL251552A0 (en) 2017-05-29
CN107073118B (zh) 2022-03-01
AU2015339128A1 (en) 2017-04-20
JP2020050677A (ja) 2020-04-02
US20170137528A1 (en) 2017-05-18
CA2963720C (en) 2024-05-14
CY1124033T1 (el) 2022-05-27
ES2864756T3 (es) 2021-10-14
US20230201343A1 (en) 2023-06-29
SI3212230T1 (sl) 2021-08-31
JP2020200343A (ja) 2020-12-17
KR20170072884A (ko) 2017-06-27
EA201790932A1 (ru) 2017-08-31
US20220265822A1 (en) 2022-08-25
EP3831847A1 (en) 2021-06-09
HK1243328A1 (zh) 2018-07-13
US20240075134A1 (en) 2024-03-07
EP3212230A1 (en) 2017-09-06
ZA201702347B (en) 2021-07-28
BR112017008959A2 (pt) 2018-01-16
EA036498B1 (ru) 2020-11-17
EP3212230A4 (en) 2018-06-20
JP6833080B2 (ja) 2021-02-24
AU2015339128B2 (en) 2021-01-21
SG10201913099YA (en) 2020-02-27
AU2021202407A1 (en) 2021-05-20
JP6691113B2 (ja) 2020-04-28
HUE054075T2 (hu) 2021-08-30
JP2021088609A (ja) 2021-06-10
WO2016069919A1 (en) 2016-05-06
JP7165166B2 (ja) 2022-11-02
US20220249662A1 (en) 2022-08-11
JP2023126406A (ja) 2023-09-07
IL299075A (en) 2023-02-01
IL251552B1 (en) 2023-01-01
US11213584B2 (en) 2022-01-04
AU2015339128C1 (en) 2021-12-16
CN107073118A (zh) 2017-08-18
US20170333556A1 (en) 2017-11-23
JP2017533909A (ja) 2017-11-16
CN114522228A (zh) 2022-05-24
DK3212230T3 (da) 2021-04-19
US20240075135A1 (en) 2024-03-07
PL3212230T3 (pl) 2021-07-26
PT3212230T (pt) 2021-04-19
US11202827B2 (en) 2021-12-21
US20230201344A1 (en) 2023-06-29
SG11201702598XA (en) 2017-05-30
CA2963720A1 (en) 2016-05-06
IL251552B2 (en) 2023-05-01
ZA202102219B (en) 2022-10-26

Similar Documents

Publication Publication Date Title
MX2017005152A (es) Dosificacion y administracion de anticuerpos anti-cd40 no fucosilados.
IL247936A0 (en) Antibodies against egfr and drug antibody conjugates
HK1219486A1 (zh) 用於治療癌症的涉及抗密蛋白 的抗體的療法
PH12017500002A1 (en) Anti-cdh6 antibody drug conjugates
HK1213925A1 (zh) 用於治療癌症的涉及抗密蛋白 抗體的組合療法
IL268479A (en) Anti-PD-1 antibodies for the treatment of lung cancer
PH12017500406A1 (en) Novel anti-mfi2 antibodies and methods of use
MX2017007595A (es) Inmunoterapia para enfermedad angiogenica.
EP3297684A4 (en) Infusion administration of conjugated monoclonal antibodies
HK1250949A1 (zh) 使用由減毒細菌遞送的回憶抗原治療癌症
MX2017001686A (es) Anticuerpos anti-ceramida.
EP3289084A4 (en) siRNA INHIBITION OF HUMAN ANTIGEN R EXPRESSION FOR TREATMENT OF CANCER
SI2976360T1 (sl) Terapija, ki vključuje protitelesa proti Klavdinu 18.2 za zdravljenje raka
EA202091925A3 (ru) Дозировка и введение нефукозилированных анти-cd40 антител
GB201509827D0 (en) Antibody drug conjugate for treatment of cancer