SG11202106481SA - Controlled fucosylation of antibodies - Google Patents

Controlled fucosylation of antibodies

Info

Publication number
SG11202106481SA
SG11202106481SA SG11202106481SA SG11202106481SA SG11202106481SA SG 11202106481S A SG11202106481S A SG 11202106481SA SG 11202106481S A SG11202106481S A SG 11202106481SA SG 11202106481S A SG11202106481S A SG 11202106481SA SG 11202106481S A SG11202106481S A SG 11202106481SA
Authority
SG
Singapore
Prior art keywords
antibodies
fucosylation
controlled
controlled fucosylation
Prior art date
Application number
SG11202106481SA
Inventor
Shanta Boddapati
Aaron Chen
Swapnil Bhargava
Original Assignee
Seagen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Seagen Inc filed Critical Seagen Inc
Publication of SG11202106481SA publication Critical patent/SG11202106481SA/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/10Immunoglobulins specific features characterized by their source of isolation or production
    • C07K2317/14Specific host cells or culture conditions, e.g. components, pH or temperature
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/40Immunoglobulins specific features characterized by post-translational modification
    • C07K2317/41Glycosylation, sialylation, or fucosylation

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
SG11202106481SA 2018-12-19 2019-12-18 Controlled fucosylation of antibodies SG11202106481SA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201862781691P 2018-12-19 2018-12-19
PCT/US2019/067222 WO2020132096A1 (en) 2018-12-19 2019-12-18 Controlled fucosylation of antibodies

Publications (1)

Publication Number Publication Date
SG11202106481SA true SG11202106481SA (en) 2021-07-29

Family

ID=71100565

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11202106481SA SG11202106481SA (en) 2018-12-19 2019-12-18 Controlled fucosylation of antibodies

Country Status (11)

Country Link
US (1) US20220081477A1 (en)
EP (1) EP3897664A4 (en)
JP (1) JP2022514299A (en)
KR (1) KR20210104837A (en)
CN (1) CN113438951A (en)
AU (1) AU2019402923A1 (en)
CA (1) CA3123591A1 (en)
IL (1) IL284086A (en)
MX (1) MX2021007327A (en)
SG (1) SG11202106481SA (en)
WO (1) WO2020132096A1 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA3197930A1 (en) * 2020-10-15 2022-04-21 Amgen Inc. Relative unpaired glycans in antibody production methods

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2013201195A1 (en) * 2006-10-24 2013-03-21 Emergent Product Development Seattle, Llc A method for increasing antibody-dependent cytotoxicity with castanospermine
CA2723197C (en) * 2008-05-02 2017-09-19 Seattle Genetics, Inc. Methods and compositions for making antibodies and antibody derivatives with reduced core fucosylation
US20120258496A1 (en) * 2010-09-27 2012-10-11 Boehringer Ingelheim International Gmbh Production of low fucose antibodies in h4-ii-e rat cells
SG10201913099YA (en) * 2014-10-29 2020-02-27 Seattle Genetics Inc Dosage and administration of non-fucosylated anti-cd40 antibodies
KR20180086233A (en) * 2015-12-04 2018-07-30 시애틀 지네틱스, 인크. Cancer treatments using 2-deoxy-2-fluoro-L-fucose in combination with checkpoint inhibitors
MX2018008447A (en) * 2016-01-06 2019-05-30 Oncobiologics Inc Modulation of afucosylated species in a monoclonal antibody composition.
IL260732B1 (en) * 2016-02-17 2024-04-01 Seagen Inc Bcma antibodies and use of same to treat cancer and immunological disorders
EP3257866A1 (en) * 2016-06-17 2017-12-20 Academisch Medisch Centrum Modified anti-tnf antibody and use thereof in the treatment of ibd

Also Published As

Publication number Publication date
IL284086A (en) 2021-08-31
JP2022514299A (en) 2022-02-10
WO2020132096A1 (en) 2020-06-25
EP3897664A1 (en) 2021-10-27
MX2021007327A (en) 2021-09-08
KR20210104837A (en) 2021-08-25
CN113438951A (en) 2021-09-24
US20220081477A1 (en) 2022-03-17
AU2019402923A1 (en) 2021-07-15
CA3123591A1 (en) 2020-06-25
EP3897664A4 (en) 2022-12-07

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