MX2017003082A - Composiciones farmaceuticas resistentes al abuso. - Google Patents
Composiciones farmaceuticas resistentes al abuso.Info
- Publication number
- MX2017003082A MX2017003082A MX2017003082A MX2017003082A MX2017003082A MX 2017003082 A MX2017003082 A MX 2017003082A MX 2017003082 A MX2017003082 A MX 2017003082A MX 2017003082 A MX2017003082 A MX 2017003082A MX 2017003082 A MX2017003082 A MX 2017003082A
- Authority
- MX
- Mexico
- Prior art keywords
- population
- beads
- active ingredient
- gelling agent
- abuse
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/485—Morphinan derivatives, e.g. morphine, codeine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1635—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/167—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface
- A61K9/1676—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface having a drug-free core with discrete complete coating layer containing drug
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
- A61K9/5078—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings with drug-free core
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5084—Mixtures of one or more drugs in different galenical forms, at least one of which being granules, microcapsules or (coated) microparticles according to A61K9/16 or A61K9/50, e.g. for obtaining a specific release pattern or for combining different drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Emergency Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Pain & Pain Management (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Inorganic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
Abstract
La presente invención hace referencia a una composición que comprende ingredientes activos farmacéuticos activos susceptibles o con potencial para el abuso. La invención brinda una composición farmacéutica oral que comprende una primera población de microesferas y una segunda población de microesferas. La primera población de microesferas comprende un ingrediente farmacéuticamente activo susceptible o con potencial para el abuso. La segunda población de microesferas comprende un agente gelificador y un recubrimiento que rodea substancialmente el agente gelificador, pero que no contiene ingrediente farmacéuticamente activo. La primera población de microesfreas y la segunda población de microesferas se pueden separar físicamente, pero son visualmente indistinguibles para el ojo desnudo. Tras el ingreso de agua en la segunda población de microesferas, se provoca la expansión del agente gelificador, lo que genera una masa viscosa que inhibe o evita la extracción del ingrediente activo.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US14/484,761 US9132096B1 (en) | 2014-09-12 | 2014-09-12 | Abuse resistant pharmaceutical compositions |
PCT/IB2015/056993 WO2016038584A1 (en) | 2014-09-12 | 2015-09-11 | Abuse resistant pharmaceutical compositions |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2017003082A true MX2017003082A (es) | 2017-07-24 |
Family
ID=54063391
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2017003082A MX2017003082A (es) | 2014-09-12 | 2015-09-11 | Composiciones farmaceuticas resistentes al abuso. |
Country Status (23)
Country | Link |
---|---|
US (6) | US9132096B1 (es) |
EP (1) | EP3191085B1 (es) |
JP (2) | JP6687624B2 (es) |
CN (2) | CN111632041B (es) |
AU (2) | AU2015313785B2 (es) |
CA (1) | CA2870380C (es) |
CR (1) | CR20170142A (es) |
CY (1) | CY1124757T1 (es) |
DK (1) | DK3191085T3 (es) |
ES (1) | ES2877058T3 (es) |
HR (1) | HRP20210973T1 (es) |
HU (1) | HUE054778T2 (es) |
IL (1) | IL251011B (es) |
LT (1) | LT3191085T (es) |
MX (1) | MX2017003082A (es) |
NZ (1) | NZ730882A (es) |
PL (1) | PL3191085T3 (es) |
PT (1) | PT3191085T (es) |
RS (1) | RS62056B1 (es) |
RU (1) | RU2764569C2 (es) |
SG (1) | SG11201701845XA (es) |
SI (1) | SI3191085T1 (es) |
WO (1) | WO2016038584A1 (es) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9132096B1 (en) * | 2014-09-12 | 2015-09-15 | Alkermes Pharma Ireland Limited | Abuse resistant pharmaceutical compositions |
US10335405B1 (en) | 2016-05-04 | 2019-07-02 | Patheon Softgels, Inc. | Non-burst releasing pharmaceutical composition |
WO2019070581A1 (en) * | 2017-10-02 | 2019-04-11 | Purdue Pharma L.P | PHARMACEUTICAL COMPOSITIONS COMPRISING GELIFYING AGENT COMPOSITIONS |
EP3473246A1 (en) | 2017-10-19 | 2019-04-24 | Capsugel Belgium NV | Immediate release abuse deterrent formulations |
US10624856B2 (en) | 2018-01-31 | 2020-04-21 | Dharma Laboratories LLC | Non-extractable oral solid dosage forms |
CN114105875B (zh) * | 2021-12-06 | 2023-11-03 | 四川大学 | 一种吗啡衍生物二氢埃托啡的合成方法 |
Family Cites Families (141)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3980766A (en) | 1973-08-13 | 1976-09-14 | West Laboratories, Inc. | Orally administered drug composition for therapy in the treatment of narcotic drug addiction |
DE2530563C2 (de) | 1975-07-09 | 1986-07-24 | Bayer Ag, 5090 Leverkusen | Analgetische Arzneimittel mit vermindertem Mißbrauchspotential |
US4457933A (en) | 1980-01-24 | 1984-07-03 | Bristol-Myers Company | Prevention of analgesic abuse |
US4684516A (en) | 1983-08-01 | 1987-08-04 | Alra Laboratories, Inc. | Sustained release tablets and method of making same |
IT1188212B (it) | 1985-12-20 | 1988-01-07 | Paolo Colombo | Sistema per il rilascio a velocita' controllata di sostanze attive |
US5236714A (en) | 1988-11-01 | 1993-08-17 | Alza Corporation | Abusable substance dosage form having reduced abuse potential |
IT1237904B (it) | 1989-12-14 | 1993-06-18 | Ubaldo Conte | Compresse a rilascio a velocita' controllata delle sostanze attive |
US5132142A (en) | 1991-03-19 | 1992-07-21 | Glatt Gmbh | Apparatus and method for producing pellets by layering power onto particles |
US5654009A (en) | 1991-03-25 | 1997-08-05 | Fujisawa Pharmaceutical Co., Ltd. | Delayed action preparation |
US5149538A (en) | 1991-06-14 | 1992-09-22 | Warner-Lambert Company | Misuse-resistive transdermal opioid dosage form |
US5478577A (en) | 1993-11-23 | 1995-12-26 | Euroceltique, S.A. | Method of treating pain by administering 24 hour oral opioid formulations exhibiting rapid rate of initial rise of plasma drug level |
US5958459A (en) | 1991-12-24 | 1999-09-28 | Purdue Pharma L.P. | Opioid formulations having extended controlled released |
US5681585A (en) | 1991-12-24 | 1997-10-28 | Euro-Celtique, S.A. | Stabilized controlled release substrate having a coating derived from an aqueous dispersion of hydrophobic polymer |
US5580578A (en) | 1992-01-27 | 1996-12-03 | Euro-Celtique, S.A. | Controlled release formulations coated with aqueous dispersions of acrylic polymers |
IL110014A (en) | 1993-07-01 | 1999-11-30 | Euro Celtique Sa | Solid controlled-release oral dosage forms of opioid analgesics |
GB9401894D0 (en) | 1994-02-01 | 1994-03-30 | Rhone Poulenc Rorer Ltd | New compositions of matter |
US7060293B1 (en) | 1994-05-25 | 2006-06-13 | Purdue Pharma | Powder-layered oral dosage forms |
US6077533A (en) | 1994-05-25 | 2000-06-20 | Purdue Pharma L.P. | Powder-layered oral dosage forms |
US5411745A (en) | 1994-05-25 | 1995-05-02 | Euro-Celtique, S.A. | Powder-layered morphine sulfate formulations |
US6491945B1 (en) | 1994-09-16 | 2002-12-10 | Alza Corporation | Hydrocodone therapy |
US5773031A (en) | 1996-02-27 | 1998-06-30 | L. Perrigo Company | Acetaminophen sustained-release formulation |
EP0914097B1 (en) | 1996-03-12 | 2002-01-16 | Alza Corporation | Composition and dosage form comprising opioid antagonist |
WO1997049384A1 (en) | 1996-06-26 | 1997-12-31 | Board Of Regents, The University Of Texas System | Hot-melt extrudable pharmaceutical formulation |
WO1998006385A1 (de) | 1996-08-15 | 1998-02-19 | Losan Pharma Gmbh | Gut schluckbare orale arzneiform |
GB9619074D0 (en) | 1996-09-12 | 1996-10-23 | Smithkline Beecham Plc | Composition |
DE19651551C2 (de) | 1996-12-11 | 2000-02-03 | Klinge Co Chem Pharm Fab | Opioidantagonisthaltige galenische Formulierung |
JP3677156B2 (ja) * | 1997-09-05 | 2005-07-27 | 武田薬品工業株式会社 | 医薬 |
GB9721746D0 (en) | 1997-10-15 | 1997-12-10 | Panos Therapeutics Limited | Compositions |
US6066339A (en) | 1997-10-17 | 2000-05-23 | Elan Corporation, Plc | Oral morphine multiparticulate formulation |
ES2412409T3 (es) | 1997-12-22 | 2013-07-11 | Euro-Celtique S.A. | Forma farmacéutica para dosificación oral que comprende una combinación de un agonista opiáceo y un antagonista opiáceo |
NZ505192A (en) | 1997-12-22 | 2003-05-30 | Euro Celtique S | A method of preventing abuse of opioid dosage forms , whereby opioid agonist and opioid antagonist are only extractable together |
FR2772615B1 (fr) | 1997-12-23 | 2002-06-14 | Lipha | Comprime multicouche pour la liberation instantanee puis prolongee de substances actives |
US6245357B1 (en) | 1998-03-06 | 2001-06-12 | Alza Corporation | Extended release dosage form |
HU230454B1 (hu) | 1998-11-02 | 2016-07-28 | Alkermes Pharma Ireland Limited | Metilfenidátot tartalmazó módosított felszabadulású sokszemcsés készítmény |
US20060240105A1 (en) | 1998-11-02 | 2006-10-26 | Elan Corporation, Plc | Multiparticulate modified release composition |
CN1407884B (zh) | 1999-10-29 | 2012-06-20 | 欧罗赛铁克股份有限公司 | 控释氢可酮制剂 |
IT1315274B1 (it) | 1999-12-29 | 2003-02-03 | Cip Ninety Two 92 Sa | Composizioni farmaceutiche per la somministrazione localizzata nelcavo orale di farmaci antiinfiammatori non stereoidei utili per la |
KR20020071032A (ko) | 2000-02-08 | 2002-09-11 | 유로-셀티크 소시에떼 아노뉨 | 오피오이드 효능제와 길항제를 함유하는 서방성 조성물 |
FR2811571B1 (fr) | 2000-07-11 | 2002-10-11 | Flamel Tech Sa | Composition pharmaceutique orale, permettant la liberation controlee et l'absorption prolongee d'un principe actif |
MXPA03003895A (es) * | 2000-10-30 | 2003-07-28 | Euro Celtique Sa | Formulaciones de hidrocodona de liberacion controlada. |
AU2002221412B2 (en) | 2000-12-05 | 2006-04-13 | Alexander Macgregor | Hydrostatic delivery system for controlled delivery of agent |
CN101439024A (zh) | 2001-05-11 | 2009-05-27 | 恩德制药公司 | 抗滥用阿片样物质剂型 |
US7125561B2 (en) | 2001-05-22 | 2006-10-24 | Euro-Celtique S.A. | Compartmentalized dosage form |
US20030064122A1 (en) | 2001-05-23 | 2003-04-03 | Endo Pharmaceuticals, Inc. | Abuse resistant pharmaceutical composition containing capsaicin |
US7968119B2 (en) | 2001-06-26 | 2011-06-28 | Farrell John J | Tamper-proof narcotic delivery system |
US7141250B2 (en) | 2001-08-06 | 2006-11-28 | Euro-Celtique S.A. | Pharmaceutical formulation containing bittering agent |
US7332182B2 (en) | 2001-08-06 | 2008-02-19 | Purdue Pharma L.P. | Pharmaceutical formulation containing opioid agonist, opioid antagonist and irritant |
US20030068375A1 (en) | 2001-08-06 | 2003-04-10 | Curtis Wright | Pharmaceutical formulation containing gelling agent |
US7842307B2 (en) | 2001-08-06 | 2010-11-30 | Purdue Pharma L.P. | Pharmaceutical formulation containing opioid agonist, opioid antagonist and gelling agent |
SI1414451T1 (sl) | 2001-08-06 | 2009-10-31 | Euro Celtique Sa | Formulacije opioidnega agonista s sproščanja sposobnim in sekvestriranim antagonistom |
US7144587B2 (en) | 2001-08-06 | 2006-12-05 | Euro-Celtique S.A. | Pharmaceutical formulation containing opioid agonist, opioid antagonist and bittering agent |
WO2003013479A1 (en) * | 2001-08-06 | 2003-02-20 | Euro-Celtique S.A. | Compositions and methods to prevent abuse of opioids |
US7157103B2 (en) | 2001-08-06 | 2007-01-02 | Euro-Celtique S.A. | Pharmaceutical formulation containing irritant |
US8900498B2 (en) | 2001-10-12 | 2014-12-02 | Monosol Rx, Llc | Process for manufacturing a resulting multi-layer pharmaceutical film |
AU2003220551A1 (en) | 2002-03-26 | 2003-10-13 | Euro-Celtique S.A. | Sustained-release gel coated compositions |
US7300670B2 (en) | 2002-04-03 | 2007-11-27 | Unilab Pharmatech, Ltd. | Oral suspension formulation |
US7776314B2 (en) | 2002-06-17 | 2010-08-17 | Grunenthal Gmbh | Abuse-proofed dosage system |
CA2491572C (en) | 2002-07-05 | 2010-03-23 | Collegium Pharmaceutical, Inc. | Abuse-deterrent pharmaceutical compositions of opiods and other drugs |
DE10250084A1 (de) | 2002-10-25 | 2004-05-06 | Grünenthal GmbH | Gegen Missbrauch gesicherte Darreichungsform |
US20040091528A1 (en) | 2002-11-12 | 2004-05-13 | Yamanouchi Pharma Technologies, Inc. | Soluble drug extended release system |
AU2003291828A1 (en) | 2002-11-27 | 2004-06-23 | The University Of Georgia Research Foundation, Inc. | Microspheres and related processes and pharmaceutical compositions |
EP2301526B1 (en) | 2003-03-26 | 2016-03-23 | Egalet Ltd. | Morphine controlled release system |
TWI357815B (en) | 2003-06-27 | 2012-02-11 | Euro Celtique Sa | Multiparticulates |
DE10336400A1 (de) | 2003-08-06 | 2005-03-24 | Grünenthal GmbH | Gegen Missbrauch gesicherte Darreichungsform |
US20090304793A1 (en) | 2003-09-22 | 2009-12-10 | Alpharma, Inc. | Sustained release opioid formulations and methods of use |
PL1663229T3 (pl) * | 2003-09-25 | 2010-09-30 | Euro Celtique Sa | Farmaceutyczne kombinacje hydrokodonu i naltreksonu |
US7201920B2 (en) | 2003-11-26 | 2007-04-10 | Acura Pharmaceuticals, Inc. | Methods and compositions for deterring abuse of opioid containing dosage forms |
AU2005201455A1 (en) | 2004-02-04 | 2005-08-25 | Foamix Ltd. | Cosmetic and pharmaceutical foam with solid matter |
TWI350762B (en) | 2004-02-12 | 2011-10-21 | Euro Celtique Sa | Particulates |
SI1765292T1 (en) | 2004-06-12 | 2018-04-30 | Collegium Pharmaceutical, Inc. | Formulations of medicines to discourage abuse |
DE102004032103A1 (de) | 2004-07-01 | 2006-01-19 | Grünenthal GmbH | Gegen Missbrauch gesicherte, orale Darreichungsform |
DE102004032049A1 (de) | 2004-07-01 | 2006-01-19 | Grünenthal GmbH | Gegen Missbrauch gesicherte, orale Darreichungsform |
US20060051298A1 (en) * | 2004-09-03 | 2006-03-09 | Groenewoud Pieter J | Abuse resistent pharmaceutical dosage and method of making same |
FR2878161B1 (fr) | 2004-11-23 | 2008-10-31 | Flamel Technologies Sa | Forme medicamenteuse orale, solide et concue pour eviter le mesusage |
US20060177380A1 (en) | 2004-11-24 | 2006-08-10 | Acura Pharmaceuticals, Inc. | Methods and compositions for deterring abuse of orally administered pharmaceutical products |
US20060110327A1 (en) | 2004-11-24 | 2006-05-25 | Acura Pharmaceuticals, Inc. | Methods and compositions for deterring abuse of orally administered pharmaceutical products |
US20070231268A1 (en) | 2004-11-24 | 2007-10-04 | Acura Pharmaceuticals, Inc. | Methods and compositions for deterring abuse of orally administered pharmaceutical products |
US20080152595A1 (en) | 2004-11-24 | 2008-06-26 | Acura Pharmaceuticals, Inc. | Methods and compositions for deterring abuse of orally administered pharmaceutical products |
FR2881652B1 (fr) | 2005-02-08 | 2007-05-25 | Flamel Technologies Sa | Forme pharmaceutique orale microparticulaire anti-mesuage |
CA2609953A1 (en) | 2005-05-09 | 2007-04-12 | Foamix Ltd. | Saccharide foamable compositions |
WO2006133733A1 (en) | 2005-06-13 | 2006-12-21 | Flamel Technologies | Oral dosage form comprising an antimisuse system |
WO2007048220A2 (en) | 2005-09-09 | 2007-05-03 | Labopharm Inc. | Trazodone composition for once a day adminisitiation |
PL116330U1 (en) | 2005-10-31 | 2007-04-02 | Alza Corp | Method for the reduction of alcohol provoked rapid increase in the released dose of the orally administered opioide with prolonged liberation |
US8652529B2 (en) | 2005-11-10 | 2014-02-18 | Flamel Technologies | Anti-misuse microparticulate oral pharmaceutical form |
US20070184115A1 (en) * | 2005-12-30 | 2007-08-09 | Biovail Laboratories International S.R.L. | Modified release formulations of tramadol and uses thereof |
US20070264346A1 (en) * | 2006-02-16 | 2007-11-15 | Flamel Technologies | Multimicroparticulate pharmaceutical forms for oral administration |
WO2007096906A2 (en) | 2006-02-27 | 2007-08-30 | Panacea Biotec Ltd. | Novel buccoadhesive compositions and process of preparation thereof |
WO2007106550A2 (en) | 2006-03-15 | 2007-09-20 | Acura Pharmaceuticals, Inc. | Methods and compositions for deterring abuse of orally administered pharmaceutical products |
WO2007107787A2 (en) | 2006-03-20 | 2007-09-27 | Karrar Ahmad Khan | Liquid and solid dosage formulations containing date fruit (phoenix dactylifera) |
EP2007360B1 (en) | 2006-04-03 | 2014-11-26 | Isa Odidi | Controlled release delivery device comprising an organosol coat |
EP2010162A4 (en) | 2006-04-03 | 2013-01-09 | Isa Odidi | COMPOSITION FOR DISPOSING A MEDICINAL PRODUCT |
US9023400B2 (en) | 2006-05-24 | 2015-05-05 | Flamel Technologies | Prolonged-release multimicroparticulate oral pharmaceutical form |
US8679540B2 (en) | 2006-06-09 | 2014-03-25 | Flamel Technologies | Pharmaceutical formulations for the prolonged release of active principle(s), and their applications, especially therapeutic applications |
US20080069891A1 (en) * | 2006-09-15 | 2008-03-20 | Cima Labs, Inc. | Abuse resistant drug formulation |
KR20090024284A (ko) | 2006-06-23 | 2009-03-06 | 엘란 파마 인터내셔널 리미티드 | 나노입자형 나프록센 및 조절 방출형 하이드로코돈을 포함하는 조성물 |
CN101484169A (zh) | 2006-06-23 | 2009-07-15 | 依兰药物国际有限公司 | 包含纳米颗粒美洛昔康和控释氢可酮的组合物 |
CA2655596C (en) | 2006-06-27 | 2011-10-25 | Biovail Laboratories International Srl | Multiparticulate osmotic delivery system |
WO2008021394A2 (en) | 2006-08-15 | 2008-02-21 | Theraquest Biosciences, Llc | Pharmaceutical formulations of cannabinoids and method of use |
WO2008024490A2 (en) | 2006-08-24 | 2008-02-28 | Theraquest Biosciences, Inc. | Oral pharmaceutical formulations of abuse deterrent cannabinoids and method of use |
SA07280459B1 (ar) | 2006-08-25 | 2011-07-20 | بيورديو فارما إل. بي. | أشكال جرعة صيدلانية للتناول عن طريق الفم مقاومة للعبث تشتمل على مسكن شبه أفيوني |
US8445018B2 (en) | 2006-09-15 | 2013-05-21 | Cima Labs Inc. | Abuse resistant drug formulation |
US8187636B2 (en) * | 2006-09-25 | 2012-05-29 | Atlantic Pharmaceuticals, Inc. | Dosage forms for tamper prone therapeutic agents |
CN101646419A (zh) | 2006-11-08 | 2010-02-10 | 诺瓦瓦克斯股份有限公司 | 制备多相药物组合物的固体剂型的方法 |
WO2008122993A1 (en) | 2007-04-09 | 2008-10-16 | Panacea Biotec Limited | Controlled release formulation of coated microparticles |
US8821928B2 (en) | 2007-06-04 | 2014-09-02 | Egalet Ltd. | Controlled release pharmaceutical compositions for prolonged effect |
US20090004281A1 (en) | 2007-06-26 | 2009-01-01 | Biovail Laboratories International S.R.L. | Multiparticulate osmotic delivery system |
US8110226B2 (en) | 2007-07-20 | 2012-02-07 | Mylan Pharmaceuticals Inc. | Drug formulations having inert sealed cores |
BRPI0821732A2 (pt) | 2007-12-17 | 2015-06-16 | Labopharm Inc | Formulações de liberação controlada , forma de dosagem sólida, e, uso da formulação de liberação controlada |
KR101616246B1 (ko) | 2008-01-25 | 2016-05-02 | 그뤼넨탈 게엠베하 | 약제학적 투여형 |
US9226907B2 (en) | 2008-02-01 | 2016-01-05 | Abbvie Inc. | Extended release hydrocodone acetaminophen and related methods and uses thereof |
US20110097395A1 (en) | 2008-03-08 | 2011-04-28 | Najib Babul | Oral Pharmaceutical Compositions of Buprenorphine and Method of Use |
TWI519322B (zh) | 2008-04-15 | 2016-02-01 | 愛戴爾製藥股份有限公司 | 包含弱鹼性藥物及控制釋放劑型之組合物 |
JP5214312B2 (ja) * | 2008-04-16 | 2013-06-19 | ホソカワミクロン株式会社 | 固形製剤およびその製造方法 |
US20110053866A1 (en) | 2008-08-12 | 2011-03-03 | Biovail Laboratories International (Barbados) S.R.L. | Pharmaceutical compositions |
US20120208773A1 (en) | 2008-08-12 | 2012-08-16 | Valeant International (Barbados) Srl | Pharmaceutical compositions with tetrabenazine |
CA2746888C (en) | 2008-12-16 | 2015-05-12 | Labopharm (Barbados) Limited | Misuse preventative, controlled release formulation |
WO2010088911A1 (en) | 2009-02-06 | 2010-08-12 | Egalet A/S | Pharmaceutical compositions resistant to abuse |
DK3045043T3 (da) | 2009-02-26 | 2020-08-03 | Relmada Therapeutics Inc | Orale farmaceutiske sammensætninger af 3-hydroxy-n-methylmorphinan med forlænget frigivelse og fremgangsmåde til anvendelse |
CN106390129A (zh) * | 2009-05-01 | 2017-02-15 | 艾戴尔医药公司 | 含有高剂量和低剂量药物的组合的口腔崩解片组合物 |
EP2477614A2 (en) | 2009-09-17 | 2012-07-25 | Cadila Healthcare Limited | Pharmaceutical compositions for reducing alcohol-induced dose dumping |
WO2011041414A1 (en) | 2009-09-30 | 2011-04-07 | Acura Pharmaceuticals, Inc. | Methods and compositions for deterring abuse |
NZ600640A (en) | 2009-12-17 | 2014-11-28 | Cima Labs Inc | Abuse-resistant formulations |
US20130022646A1 (en) | 2010-02-09 | 2013-01-24 | Rudnic Edward M | Controlled Release Formulations of Opioids |
US20120321674A1 (en) | 2011-02-17 | 2012-12-20 | Michael Vachon | Technology for Preventing Abuse of Solid Dosage Forms |
NZ602075A (en) | 2010-02-24 | 2014-01-31 | Cima Labs Inc | Abuse-resistant formulations |
FR2959130A1 (fr) | 2010-04-21 | 2011-10-28 | Sanofi Aventis | Procede de preparation de compositions pharmaceutiques destinees a l'administration par voie orale comprenant un ou plusieurs principes actifs et les compositions les comprenant. |
FR2960775A1 (fr) | 2010-06-07 | 2011-12-09 | Ethypharm Sa | Microgranules resistants au detournement |
US8861890B2 (en) | 2010-11-24 | 2014-10-14 | Douglas Alan Lefler | System and method for assembling and displaying individual images as a continuous image |
BR112013021026A2 (pt) | 2011-02-17 | 2016-10-11 | Qrxpharma Ltd | tecnologia para prevenção de abuso de formas de dosagem sólidas |
EP2688556B1 (en) | 2011-03-25 | 2015-05-06 | Purdue Pharma L.P. | Controlled release pharmaceutical dosage forms |
EP2726066B1 (en) | 2011-06-28 | 2021-03-31 | Neos Therapeutics, LP | Dosage forms of amphetamine for oral administration |
MX348491B (es) * | 2011-07-29 | 2017-06-15 | Gruenenthal Gmbh | Tableta a prueba de manipulacion que proporciona liberacion inmediata de fármaco. |
US9065156B2 (en) | 2011-08-08 | 2015-06-23 | Wisconsin Alumni Research Foundation | Photovoltaic capacitor for direct solar energy conversion and storage |
US20140294947A1 (en) | 2011-09-16 | 2014-10-02 | Purdue Pharma L.P. | Tamper resistant immediate release formulations |
EP2755640B1 (en) | 2011-09-16 | 2017-07-26 | Purdue Pharma LP | Tamper resistant pharmaceutical formulations |
WO2013084059A1 (en) * | 2011-12-09 | 2013-06-13 | Purdue Pharma L.P. | Pharmaceutical dosage forms comprising poly (epsilon- caprolactone) and polyethylene oxide |
SG11201405011PA (en) | 2012-03-02 | 2014-09-26 | Rhodes Pharmaceuticals Lp | Tamper resistant immediate release formulations |
JP2015521988A (ja) * | 2012-07-06 | 2015-08-03 | イガレット・リミテッド | 制御放出用乱用防止性医薬組成物 |
US10322120B2 (en) | 2012-07-31 | 2019-06-18 | Persion Pharmaceuticals Llc | Treating pain in patients with hepatic impairment |
CA2888278A1 (en) | 2012-10-15 | 2014-04-24 | Isa Odidi | Oral drug delivery formulations |
US9132096B1 (en) * | 2014-09-12 | 2015-09-15 | Alkermes Pharma Ireland Limited | Abuse resistant pharmaceutical compositions |
-
2014
- 2014-09-12 US US14/484,761 patent/US9132096B1/en active Active
- 2014-11-10 CA CA2870380A patent/CA2870380C/en active Active
-
2015
- 2015-09-11 MX MX2017003082A patent/MX2017003082A/es unknown
- 2015-09-11 CN CN202010694395.5A patent/CN111632041B/zh active Active
- 2015-09-11 HU HUE15771283A patent/HUE054778T2/hu unknown
- 2015-09-11 CR CR20170142A patent/CR20170142A/es unknown
- 2015-09-11 PT PT157712837T patent/PT3191085T/pt unknown
- 2015-09-11 SI SI201531624T patent/SI3191085T1/sl unknown
- 2015-09-11 NZ NZ730882A patent/NZ730882A/en unknown
- 2015-09-11 AU AU2015313785A patent/AU2015313785B2/en active Active
- 2015-09-11 US US14/851,056 patent/US9486451B2/en active Active
- 2015-09-11 US US14/851,019 patent/US9452163B2/en active Active
- 2015-09-11 RS RS20210793A patent/RS62056B1/sr unknown
- 2015-09-11 WO PCT/IB2015/056993 patent/WO2016038584A1/en active Application Filing
- 2015-09-11 EP EP15771283.7A patent/EP3191085B1/en active Active
- 2015-09-11 CN CN201580054813.1A patent/CN107106503B/zh active Active
- 2015-09-11 DK DK15771283.7T patent/DK3191085T3/da active
- 2015-09-11 ES ES15771283T patent/ES2877058T3/es active Active
- 2015-09-11 JP JP2017534015A patent/JP6687624B2/ja active Active
- 2015-09-11 LT LTEP15771283.7T patent/LT3191085T/lt unknown
- 2015-09-11 PL PL15771283T patent/PL3191085T3/pl unknown
- 2015-09-11 RU RU2017112301A patent/RU2764569C2/ru active
- 2015-09-11 SG SG11201701845XA patent/SG11201701845XA/en unknown
-
2016
- 2016-06-03 US US15/172,643 patent/US9713611B2/en active Active
-
2017
- 2017-03-08 IL IL251011A patent/IL251011B/en active IP Right Grant
- 2017-06-19 US US15/626,268 patent/US10092559B2/en active Active
-
2018
- 2018-09-07 US US16/124,899 patent/US10960000B2/en active Active
-
2020
- 2020-04-01 JP JP2020065498A patent/JP6929407B2/ja active Active
- 2020-06-10 AU AU2020203841A patent/AU2020203841B2/en active Active
-
2021
- 2021-06-18 HR HRP20210973TT patent/HRP20210973T1/hr unknown
- 2021-06-23 CY CY20211100555T patent/CY1124757T1/el unknown
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
NZ730882A (en) | Abuse resistant pharmaceutical compositions | |
SG11202011886TA (en) | PHARMACEUTICAL COMBINATION, COMPOSITION AND FORMULATION CONTAINING GLUCOKINASE ACTIVATOR AND a-GLUCOSIDASE INHIBITOR, PREPARATION METHODS THEREFOR AND USES THEREOF | |
SG11202104687SA (en) | Ret inhibitors, pharmaceutical compositions and uses thereof | |
EP3705118A4 (en) | COMPOSITION OF AN ORAL SOLID DOSAGE FORM WITH IMPROVED RESOLUTION AND METHOD FOR MANUFACTURING IT | |
PH12017502431A1 (en) | Pharmaceutical formulations comprising tenofovir and emtrictabine | |
WO2011128630A3 (en) | Anti-abuse gelled pharmaceutical compositions | |
MX2018012618A (es) | Composiciones farmaceuticas orales de mesalazina. | |
MX2017016802A (es) | Formulaciones farmaceuticas. | |
SG11202104686QA (en) | Ret inhibitors, pharmaceutical compositions and uses thereof | |
PH12017502376A1 (en) | Oral solid formulation containing irinotecan and method of preparing the same | |
EP3684371A4 (en) | PHARMACEUTICAL FORMULATIONS OF ABIRATERONE CYCLIC OLIGOMERS AND METHOD FOR PREPARATION AND ADMINISTRATION THEREOF | |
IL272284A (en) | History of thiazolopyridines, their preparation and pharmaceutical preparations containing them | |
PH12020550815A1 (en) | Delayed release deferiprone tablets and methods of using the same | |
IL285421A (en) | History of indazolyl-isoxazole, their preparation and pharmaceutical preparations containing them | |
EP3616685A4 (en) | PROCESS FOR DETERMINING THE AUTHENTICITY OF A PHARMACEUTICAL COMPOSITION FOR ORAL ADMINISTRATION, PHARMACEUTICAL COMPOSITION FOR ORAL ADMINISTRATION, AND SYSTEM FOR DETERMINING THE AUTHENTICITY OF A PHARMACEUTICAL COMPOSITION FOR ORAL ADMINISTRATION | |
EP3582759A4 (en) | BIOEQUIVALENT PHARMACEUTICAL COMPOSITION OF PRE-ORDIOXETINE HYDROBROMIDE | |
HUE055193T2 (hu) | Eljárás és kompozíció zselatin-alapú gumicukorkák elõállítására | |
EP3773900A4 (en) | HINOKITIOL ANALOGUES, PROCESSES FOR THE PREPARATION AND PHARMACEUTICAL COMPOSITIONS THEREOF | |
EP3332764A4 (en) | BIOFILM TRAINING PREVENTION AGENT AND COMPOSITION FOR ORAL USE | |
EP3648745A4 (en) | PHARMACEUTICAL COMPOSITION CONSISTING OF A MULTI-UNIT SPHEROIDAL TABLET CONTAINING ESOMEPRAZOLE AND A PHARMACEUTICAL SALT OF THE SAME, AND PROCESS FOR THE PREPARATION OF THE PHARMACEUTICAL COMPOSITION | |
EP3801539A4 (en) | SOLID ORAL PHARMACEUTICAL COMPOSITIONS OF LINAGLIPTIN | |
WO2019151964A3 (en) | Orally disintegrating formulations of saxagliptin | |
PT3326619T (pt) | Composições farmacêuticas orais sólidas compreendendo tenofovir e emtricitabina | |
EP3601392A4 (en) | NON-IONIC SEQUENCED COPOLYMERS AND PHARMACEUTICAL COMPOSITIONS DERIVED THEREOF | |
PH12016502527A1 (en) | Stabilized desmopressin |