MX2016013985A - Cepas de vacunas de listeria recombinante y metodos para producir las mismas. - Google Patents
Cepas de vacunas de listeria recombinante y metodos para producir las mismas.Info
- Publication number
- MX2016013985A MX2016013985A MX2016013985A MX2016013985A MX2016013985A MX 2016013985 A MX2016013985 A MX 2016013985A MX 2016013985 A MX2016013985 A MX 2016013985A MX 2016013985 A MX2016013985 A MX 2016013985A MX 2016013985 A MX2016013985 A MX 2016013985A
- Authority
- MX
- Mexico
- Prior art keywords
- recombinant
- recombinant listeria
- producing
- methods
- same
- Prior art date
Links
- 241000186781 Listeria Species 0.000 title abstract 4
- 229960005486 vaccine Drugs 0.000 title 1
- 206010028980 Neoplasm Diseases 0.000 abstract 2
- 108700026244 Open Reading Frames Proteins 0.000 abstract 2
- 239000000427 antigen Substances 0.000 abstract 1
- 102000036639 antigens Human genes 0.000 abstract 1
- 108091007433 antigens Proteins 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 239000012634 fragment Substances 0.000 abstract 1
- 230000028993 immune response Effects 0.000 abstract 1
- 230000001939 inductive effect Effects 0.000 abstract 1
- 210000004898 n-terminal fragment Anatomy 0.000 abstract 1
- 229920001184 polypeptide Polymers 0.000 abstract 1
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0011—Cancer antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/36—Adaptation or attenuation of cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/52—Bacterial cells; Fungal cells; Protozoal cells
- A61K2039/522—Bacterial cells; Fungal cells; Protozoal cells avirulent or attenuated
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/52—Bacterial cells; Fungal cells; Protozoal cells
- A61K2039/523—Bacterial cells; Fungal cells; Protozoal cells expressing foreign proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
- A61K2039/572—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2 cytotoxic response
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/58—Medicinal preparations containing antigens or antibodies raising an immune response against a target which is not the antigen used for immunisation
- A61K2039/585—Medicinal preparations containing antigens or antibodies raising an immune response against a target which is not the antigen used for immunisation wherein the target is cancer
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/55—Fusion polypeptide containing a fusion with a toxin, e.g. diphteria toxin
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/20011—Papillomaviridae
- C12N2710/20034—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/20011—Papillomaviridae
- C12N2710/20051—Methods of production or purification of viral material
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Microbiology (AREA)
- Immunology (AREA)
- Biochemistry (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Virology (AREA)
- Biotechnology (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Biomedical Technology (AREA)
- General Engineering & Computer Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Oncology (AREA)
- Cell Biology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201461983732P | 2014-04-24 | 2014-04-24 | |
| PCT/US2015/025690 WO2015164121A1 (en) | 2014-04-24 | 2015-04-14 | Recombinant listeria vaccine strains and methods of producing the same |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2016013985A true MX2016013985A (es) | 2017-01-11 |
Family
ID=54333010
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2016013985A MX2016013985A (es) | 2014-04-24 | 2015-04-14 | Cepas de vacunas de listeria recombinante y metodos para producir las mismas. |
Country Status (15)
| Country | Link |
|---|---|
| US (2) | US10258679B2 (enExample) |
| EP (1) | EP3134510B1 (enExample) |
| JP (3) | JP7009061B2 (enExample) |
| KR (2) | KR102491332B1 (enExample) |
| CN (1) | CN106459887A (enExample) |
| AU (1) | AU2015250111A1 (enExample) |
| BR (1) | BR112016024352A2 (enExample) |
| CA (1) | CA2946716A1 (enExample) |
| IL (1) | IL248483A0 (enExample) |
| MA (1) | MA39849A (enExample) |
| MX (1) | MX2016013985A (enExample) |
| RU (1) | RU2016145464A (enExample) |
| SG (2) | SG11201608820WA (enExample) |
| TW (2) | TWI692525B (enExample) |
| WO (1) | WO2015164121A1 (enExample) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9012141B2 (en) | 2000-03-27 | 2015-04-21 | Advaxis, Inc. | Compositions and methods comprising KLK3 of FOLH1 antigen |
| WO2012125551A1 (en) | 2011-03-11 | 2012-09-20 | Advaxis | Listeria-based adjuvants |
| EP2825195A4 (en) | 2012-03-12 | 2015-10-07 | Advaxis Inc | INHIBITION OF SUPPRESSOR CELL FUNCTION AFTER TREATMENT WITH A LISTERIAL VACCINE |
| MX2016010791A (es) | 2014-02-18 | 2017-04-27 | Advaxis Inc | Inmunoterapia con multiples objetivos dirigida por biomarcadores. |
| MA39849A (fr) | 2014-04-24 | 2017-03-01 | Advaxis Inc | Souches de listeria utilisées comme vaccin recombinant et procédé de production |
| US20160228530A1 (en) * | 2014-10-14 | 2016-08-11 | The Trustees Of The University Of Pennsylvania | Combination therapy for use in cancer therapy |
| MA41644A (fr) | 2015-03-03 | 2018-01-09 | Advaxis Inc | Compositions à base de listeria comprenant un système d'expression de minigènes codant pour des peptides, et leurs procédés d'utilisation |
| CN108601731A (zh) | 2015-12-16 | 2018-09-28 | 磨石肿瘤生物技术公司 | 新抗原的鉴别、制造及使用 |
| MX2019005685A (es) | 2016-11-30 | 2019-09-04 | Advaxis Inc | Composiciones inmunogenicas contra mutaciones de cancer recurrentes y metodos de uso de las mismas. |
| CN106978381A (zh) * | 2017-03-23 | 2017-07-25 | 上海理工大学 | prfA基因缺失单核细胞增生李斯特氏菌及制备方法 |
| KR102748132B1 (ko) | 2017-09-19 | 2025-01-02 | 어드박시스, 인크. | 박테리아 또는 리스테리아 균주의 동결건조를 위한 조성물 및 방법 |
| EP4576103A3 (en) | 2017-10-10 | 2025-08-27 | Gritstone bio, Inc. | Neoantigen identification using hotspots |
| CA3080835A1 (en) | 2017-10-31 | 2019-05-09 | Pantarhei Bioscience B.V. | Immunotherapeutic methods for treating and/or preventing lung cancer |
| EP3714275A4 (en) | 2017-11-22 | 2021-10-27 | Gritstone bio, Inc. | REDUCTION OF JUNCTION EPITOPIC PRESENTATION FOR NEOANTIGENS |
| KR20200130399A (ko) * | 2018-03-09 | 2020-11-18 | 어드박시스, 인크. | 리스테리아 균주의 약독화 및 감염성을 평가하기 위한 조성물 및 방법 |
| CN110408634B (zh) | 2018-04-27 | 2021-08-03 | 苏州若泰医药科技有限公司 | 一种非整合李斯特菌疫苗及抗肿瘤免疫应答方法 |
| US10973908B1 (en) | 2020-05-14 | 2021-04-13 | David Gordon Bermudes | Expression of SARS-CoV-2 spike protein receptor binding domain in attenuated salmonella as a vaccine |
| WO2021259963A1 (en) | 2020-06-23 | 2021-12-30 | Pandora Endocrine Innovation B.V. | Immunization against wnt4 for treatment and prophylaxis of breast cancer |
| US20250026818A1 (en) | 2021-10-19 | 2025-01-23 | Sciencemed Spóka z ograniczon odpowiedzialnoci | Male contraception |
| CN116218754B (zh) * | 2023-04-10 | 2025-06-03 | 四川大学 | 一种提高绵羊李斯特菌膜囊泡产量的方法及应用 |
| CN119060155B (zh) * | 2024-11-07 | 2025-03-07 | 山东大学 | 一种蛋白在调节肠道稳态及抵抗致病菌感染中的应用 |
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| US5830702A (en) | 1990-10-31 | 1998-11-03 | The Trustees Of The University Of Pennsylvania | Live, recombinant listeria monocytogenes and production of cytotoxic T-cell response |
| US8791237B2 (en) | 1994-11-08 | 2014-07-29 | The Trustees Of The University Of Pennsylvania | Compositions and methods for treatment of non-hodgkins lymphoma |
| US6051237A (en) | 1994-11-08 | 2000-04-18 | The Trustees Of The University Of Pennsylvania | Specific immunotherapy of cancer using a live recombinant bacterial vaccine vector |
| US8114414B2 (en) | 1994-11-08 | 2012-02-14 | The Trustees Of The University Of Pennsylvania | Compositions and methods for treatment of cervical cancer |
| US20070264279A1 (en) * | 1994-11-08 | 2007-11-15 | Claudia Gravekamp | Compositions and methods comprising a MAGE-b antigen |
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| US7662396B2 (en) | 2001-03-26 | 2010-02-16 | The Trustees Of The University Of Pennsylvania | Compositions and methods for enhancing the immunogenicity of antigens |
| US8956621B2 (en) | 1994-11-08 | 2015-02-17 | The Trustees Of The University Of Pennsylvania | Compositions and methods for treatment of cervical dysplasia |
| US6099848A (en) | 1997-11-18 | 2000-08-08 | The Trustees Of The University Of Pennsylvania | Immunogenic compositions comprising DAL/DAT double-mutant, auxotrophic, attenuated strains of Listeria and their methods of use |
| US9012141B2 (en) | 2000-03-27 | 2015-04-21 | Advaxis, Inc. | Compositions and methods comprising KLK3 of FOLH1 antigen |
| JP2004500405A (ja) | 2000-03-29 | 2004-01-08 | ザ トラスティーズ オブ ザ ユニバーシティー オブ ペンシルヴァニア | 抗原の免疫原性を増強するための組成物および方法 |
| US6855320B2 (en) | 2000-03-29 | 2005-02-15 | The Trustees Of The University Of Pennsylvania | Fusion of non-hemolytic, truncated form of listeriolysin O to antigens to enhance immunogenicity |
| US8771702B2 (en) | 2001-03-26 | 2014-07-08 | The Trustees Of The University Of Pennsylvania | Non-hemolytic LLO fusion proteins and methods of utilizing same |
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| JP2005527240A (ja) | 2002-05-29 | 2005-09-15 | ザ・レジェンツ・オブ・ザ・ユニバーシティ・オブ・カリフォルニア | 弱毒リステリア種とこれを使用する方法 |
| CA2512812A1 (en) | 2003-01-09 | 2004-07-29 | The Trustees Of The University Of Pennsylvania | Compositions, methods and kits for enhancing the immunogenicity of a bacterial vaccine vector |
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| ES2684749T3 (es) | 2004-08-13 | 2018-10-04 | The Trustees Of The University Of Pennsylvania | Métodos para construir vacunas sin resistencia a antibióticos |
| US7858097B2 (en) * | 2004-08-13 | 2010-12-28 | The Trustees Of The University Of Pennsylvania | Antibiotic resistance free Listeria strains and methods for constructing and using same |
| AU2005295158A1 (en) * | 2004-10-18 | 2006-04-27 | Medimmune, Llc | High cell density process for growth of Listeria |
| US7935804B2 (en) | 2006-03-01 | 2011-05-03 | Aduro Biotech | Engineered Listeria and methods of use thereof |
| US8268326B2 (en) | 2006-08-15 | 2012-09-18 | The Trustees Of The University Of Pennsylvania | Compositions comprising HMW-MAA and fragments thereof, and methods of use thereof |
| PT2977456T (pt) | 2006-08-15 | 2018-02-05 | Univ Pennsylvania | Composições compreendendo hmw-maa e seus fragmentos para tratamento do cancro |
| WO2008130551A2 (en) | 2007-04-16 | 2008-10-30 | The Trustees Of The University Of Pennsylvania | Antibiotic resistance free listeria strains and methods for constructing and using same |
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| US10016617B2 (en) | 2009-11-11 | 2018-07-10 | The Trustees Of The University Of Pennsylvania | Combination immuno therapy and radiotherapy for the treatment of Her-2-positive cancers |
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| US20110223187A1 (en) | 2010-02-15 | 2011-09-15 | Vafa Shahabi | Live listeria-based vaccines for central nervous system therapy |
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| WO2012138377A2 (en) | 2010-10-01 | 2012-10-11 | Trustees Of The University Of Pennsylvania | The use of listeria vaccine vectors to reverse vaccine unresponsiveness in parasitically infected individuals |
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| WO2012125551A1 (en) * | 2011-03-11 | 2012-09-20 | Advaxis | Listeria-based adjuvants |
| EP2825195A4 (en) | 2012-03-12 | 2015-10-07 | Advaxis Inc | INHIBITION OF SUPPRESSOR CELL FUNCTION AFTER TREATMENT WITH A LISTERIAL VACCINE |
| MX2016010791A (es) | 2014-02-18 | 2017-04-27 | Advaxis Inc | Inmunoterapia con multiples objetivos dirigida por biomarcadores. |
| CN106661538A (zh) | 2014-02-25 | 2017-05-10 | 阿德瓦希斯公司 | 用于治疗her2/neu过表达肿瘤的组合物和方法 |
| MA39717A (fr) | 2014-03-05 | 2017-01-11 | Advaxis Inc | Procédés et compositions pour accroître le rapport des lymphocytes t effecteurs aux lymphocytes t régulateurs |
| MA39849A (fr) | 2014-04-24 | 2017-03-01 | Advaxis Inc | Souches de listeria utilisées comme vaccin recombinant et procédé de production |
| SG11201609135VA (en) | 2014-05-02 | 2016-11-29 | Univ Pennsylvania | Combination immuno therapy and radiotherapy for the treatment of her-2-positive cancers |
| SG11201700092XA (en) | 2014-07-18 | 2017-02-27 | Advaxis Inc | Recombinant listeria strain expressing heterologous antigen fusion proteins and methods of use thereof |
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| MX2017000857A (es) | 2014-07-18 | 2017-10-11 | Advaxis Inc | Combinación de un antagonista de la proteina de muerte programada (pd-1) y una vacuna basada en listeria para tratar el cáncer de próstata. |
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| US20160228530A1 (en) | 2014-10-14 | 2016-08-11 | The Trustees Of The University Of Pennsylvania | Combination therapy for use in cancer therapy |
| MA41217A (fr) | 2014-12-19 | 2017-10-24 | Advaxis Inc | Polythérapies ayant des souches de listeria recombinées |
| WO2016126878A2 (en) | 2015-02-03 | 2016-08-11 | The Trustees Of The University Of Pennsylvania | Listeria-based immunomodulation |
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| WO2018129306A1 (en) | 2017-01-05 | 2018-07-12 | Advaxis, Inc. | Recombinant listeria vaccine strains and methods of using the same in cancer immunotherapy |
-
2015
- 2015-04-14 MA MA039849A patent/MA39849A/fr unknown
- 2015-04-14 RU RU2016145464A patent/RU2016145464A/ru not_active Application Discontinuation
- 2015-04-14 EP EP15782800.5A patent/EP3134510B1/en active Active
- 2015-04-14 BR BR112016024352-8A patent/BR112016024352A2/pt not_active Application Discontinuation
- 2015-04-14 SG SG11201608820WA patent/SG11201608820WA/en unknown
- 2015-04-14 JP JP2016564032A patent/JP7009061B2/ja not_active Expired - Fee Related
- 2015-04-14 AU AU2015250111A patent/AU2015250111A1/en not_active Abandoned
- 2015-04-14 SG SG10202011841WA patent/SG10202011841WA/en unknown
- 2015-04-14 KR KR1020227003655A patent/KR102491332B1/ko active Active
- 2015-04-14 CN CN201580021074.6A patent/CN106459887A/zh active Pending
- 2015-04-14 WO PCT/US2015/025690 patent/WO2015164121A1/en not_active Ceased
- 2015-04-14 CA CA2946716A patent/CA2946716A1/en not_active Abandoned
- 2015-04-14 US US15/306,289 patent/US10258679B2/en active Active
- 2015-04-14 KR KR1020167029990A patent/KR102359691B1/ko not_active Expired - Fee Related
- 2015-04-14 MX MX2016013985A patent/MX2016013985A/es unknown
- 2015-04-21 TW TW104112751A patent/TWI692525B/zh not_active IP Right Cessation
- 2015-04-21 TW TW109111533A patent/TWI722858B/zh not_active IP Right Cessation
-
2016
- 2016-10-25 IL IL248483A patent/IL248483A0/en unknown
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2019
- 2019-02-14 US US16/276,520 patent/US20190240303A1/en not_active Abandoned
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2020
- 2020-03-18 JP JP2020047632A patent/JP2020099352A/ja not_active Withdrawn
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2022
- 2022-05-30 JP JP2022087587A patent/JP7300041B2/ja active Active
Also Published As
| Publication number | Publication date |
|---|---|
| SG10202011841WA (en) | 2021-01-28 |
| TW202041671A (zh) | 2020-11-16 |
| JP7009061B2 (ja) | 2022-01-25 |
| WO2015164121A1 (en) | 2015-10-29 |
| JP7300041B2 (ja) | 2023-06-28 |
| IL248483A0 (en) | 2016-12-29 |
| KR20160145627A (ko) | 2016-12-20 |
| TWI692525B (zh) | 2020-05-01 |
| JP2022105768A (ja) | 2022-07-14 |
| RU2016145464A (ru) | 2018-05-24 |
| BR112016024352A2 (pt) | 2018-01-23 |
| JP2020099352A (ja) | 2020-07-02 |
| CN106459887A (zh) | 2017-02-22 |
| EP3134510B1 (en) | 2023-11-01 |
| US20190240303A1 (en) | 2019-08-08 |
| JP2017513502A (ja) | 2017-06-01 |
| EP3134510A1 (en) | 2017-03-01 |
| US10258679B2 (en) | 2019-04-16 |
| KR20220021021A (ko) | 2022-02-21 |
| MA39849A (fr) | 2017-03-01 |
| KR102491332B1 (ko) | 2023-01-27 |
| US20170042996A1 (en) | 2017-02-16 |
| EP3134510A4 (en) | 2018-04-25 |
| TW201546276A (zh) | 2015-12-16 |
| AU2015250111A1 (en) | 2016-12-08 |
| KR102359691B1 (ko) | 2022-02-10 |
| CA2946716A1 (en) | 2015-10-29 |
| TWI722858B (zh) | 2021-03-21 |
| SG11201608820WA (en) | 2016-11-29 |
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