MX2016010950A - Proteinas de fusion de inhibidor de tripsina urinaria (uti). - Google Patents

Proteinas de fusion de inhibidor de tripsina urinaria (uti).

Info

Publication number
MX2016010950A
MX2016010950A MX2016010950A MX2016010950A MX2016010950A MX 2016010950 A MX2016010950 A MX 2016010950A MX 2016010950 A MX2016010950 A MX 2016010950A MX 2016010950 A MX2016010950 A MX 2016010950A MX 2016010950 A MX2016010950 A MX 2016010950A
Authority
MX
Mexico
Prior art keywords
fusion proteins
tripsine
uti
urinary
inhibitor fusion
Prior art date
Application number
MX2016010950A
Other languages
English (en)
Spanish (es)
Inventor
Schmidt Mathias
Chamberlain Aaron
Liu Qiang
Original Assignee
Takeda Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Gmbh filed Critical Takeda Gmbh
Publication of MX2016010950A publication Critical patent/MX2016010950A/es

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81Protease inhibitors
    • C07K14/8107Endopeptidase (E.C. 3.4.21-99) inhibitors
    • C07K14/811Serine protease (E.C. 3.4.21) inhibitors
    • C07K14/8114Kunitz type inhibitors
    • C07K14/8117Bovine/basic pancreatic trypsin inhibitor (BPTI, aprotinin)
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81Protease inhibitors
    • C07K14/8107Endopeptidase (E.C. 3.4.21-99) inhibitors
    • C07K14/811Serine protease (E.C. 3.4.21) inhibitors
    • C07K14/8114Kunitz type inhibitors
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/55Protease inhibitors
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/06Antiasthmatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/12Drugs for disorders of the urinary system of the kidneys
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/02Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/06Immunosuppressants, e.g. drugs for graft rejection
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/08Plasma substitutes; Perfusion solutions; Dialytics or haemodialytics; Drugs for electrolytic or acid-base disorders, e.g. hypovolemic shock
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • C07K2319/30Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • C07K2319/50Fusion polypeptide containing protease site
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • C07K2319/90Fusion polypeptide containing a motif for post-translational modification
    • C07K2319/91Fusion polypeptide containing a motif for post-translational modification containing a motif for glycosylation
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02ATECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Pulmonology (AREA)
  • Urology & Nephrology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Epidemiology (AREA)
  • Cardiology (AREA)
  • Virology (AREA)
  • Diabetes (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Vascular Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Dermatology (AREA)
  • Pain & Pain Management (AREA)
  • Transplantation (AREA)
  • Peptides Or Proteins (AREA)
MX2016010950A 2014-02-24 2015-02-23 Proteinas de fusion de inhibidor de tripsina urinaria (uti). MX2016010950A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201461943617P 2014-02-24 2014-02-24
PCT/US2015/017152 WO2015127391A1 (en) 2014-02-24 2015-02-23 Uti fusion proteins

Publications (1)

Publication Number Publication Date
MX2016010950A true MX2016010950A (es) 2017-04-25

Family

ID=52629709

Family Applications (4)

Application Number Title Priority Date Filing Date
MX2016010950A MX2016010950A (es) 2014-02-24 2015-02-23 Proteinas de fusion de inhibidor de tripsina urinaria (uti).
MX2020000537A MX384070B (es) 2014-02-24 2015-02-23 Proteínas de fusión de inhibidor de tripsina urinaria (uti).
MX2024000004A MX2024000004A (es) 2014-02-24 2016-08-23 Proteinas de fusion de inhibidor de tripsina urinaria (uti).
MX2019013124A MX2019013124A (es) 2014-02-24 2016-08-23 Proteinas de fusion de inhibidor de tripsina urinaria (uti).

Family Applications After (3)

Application Number Title Priority Date Filing Date
MX2020000537A MX384070B (es) 2014-02-24 2015-02-23 Proteínas de fusión de inhibidor de tripsina urinaria (uti).
MX2024000004A MX2024000004A (es) 2014-02-24 2016-08-23 Proteinas de fusion de inhibidor de tripsina urinaria (uti).
MX2019013124A MX2019013124A (es) 2014-02-24 2016-08-23 Proteinas de fusion de inhibidor de tripsina urinaria (uti).

Country Status (38)

Country Link
US (4) US9856310B2 (enExample)
EP (2) EP3443978A1 (enExample)
JP (4) JP6574431B2 (enExample)
KR (3) KR102461210B1 (enExample)
CN (2) CN106232135B (enExample)
AR (1) AR101597A1 (enExample)
AU (4) AU2015218704B2 (enExample)
BR (1) BR112016019390B1 (enExample)
CA (2) CA2939639C (enExample)
CL (1) CL2016002136A1 (enExample)
CR (1) CR20160444A (enExample)
CY (1) CY1120997T1 (enExample)
DK (1) DK3110434T3 (enExample)
DO (1) DOP2016000202A (enExample)
EA (2) EA202091567A1 (enExample)
EC (1) ECSP16076535A (enExample)
ES (1) ES2700149T3 (enExample)
GE (2) GEAP201814277A (enExample)
HR (1) HRP20182029T1 (enExample)
IL (1) IL247321B (enExample)
JO (1) JO3729B1 (enExample)
LT (1) LT3110434T (enExample)
MA (1) MA39347B2 (enExample)
MX (4) MX2016010950A (enExample)
MY (1) MY178774A (enExample)
NZ (3) NZ724196A (enExample)
PE (1) PE20170257A1 (enExample)
PH (1) PH12016501629B1 (enExample)
PL (1) PL3110434T3 (enExample)
PT (1) PT3110434T (enExample)
RS (1) RS58285B1 (enExample)
SG (2) SG11201606691QA (enExample)
SI (1) SI3110434T1 (enExample)
SM (1) SMT201800674T1 (enExample)
TW (1) TWI694084B (enExample)
UA (1) UA118866C2 (enExample)
WO (1) WO2015127391A1 (enExample)
ZA (1) ZA201606327B (enExample)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MA39347B2 (fr) * 2014-02-24 2020-05-29 Takeda Pharmaceuticals Co Protéines de fusion d'uti
KR20250030036A (ko) * 2017-06-07 2025-03-05 스파크 테라퓨틱스, 인코포레이티드 개선된 세포 트랜스펙션 및/또는 rAAV 벡터 생산을 위한 증진제
WO2020106881A1 (en) * 2018-11-20 2020-05-28 Diamedica Inc. Modified ulinastatin polypeptides
JP2021050161A (ja) 2019-09-25 2021-04-01 武田薬品工業株式会社 複素環化合物及びその用途
JP2021080177A (ja) 2019-11-14 2021-05-27 武田薬品工業株式会社 複素環化合物及びその用途
BR112022017718A2 (pt) * 2020-03-05 2022-11-16 Diamedica Usa Inc Polipeptídeos de ulinastatina
JP2024505073A (ja) * 2021-01-29 2024-02-02 ダイアメディカ ユーエスエー インコーポレイテッド 疾患を処置するためのウリナスタチンポリペプチド
CN116903721A (zh) * 2023-06-16 2023-10-20 成都佩德生物医药有限公司 多肽pdbpe-001、其药物组合物和用途

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5663143A (en) * 1988-09-02 1997-09-02 Dyax Corp. Engineered human-derived kunitz domains that inhibit human neutrophil elastase
ES2066033T3 (es) 1989-05-13 1995-03-01 Bayer Ag Inhibidores de las proteinasas, procedimiento para su preparacion y composiciones farmaceuticas que los contienen.
CA2055425A1 (en) 1990-11-13 1992-05-14 Hideaki Morishita Polypeptide, dna fragment encoding the same and process for producing the same, and enzyme inhibition process, drug composition and methods of treating using the same
JP2769083B2 (ja) 1993-02-22 1998-06-25 日清食品株式会社 エラスターゼ阻害活性を有する新規ペプチドおよびその製造方法
WO1997033996A2 (en) 1996-03-11 1997-09-18 Bayer Corporation Human bikunin
DE19725014A1 (de) 1997-06-13 1998-12-17 Bayer Ag Aprotininvarianten mit verbesserten Eigenschaften und Bikunine von Aprotininvarianten
SI1730191T1 (sl) * 2004-03-30 2011-11-30 Glaxo Group Ltd Imunoglobulin-vezavni hOSM
CA2578613A1 (en) 2004-08-11 2007-01-25 Trubion Pharmaceuticals, Inc. Binding domain fusion proteins
WO2006129849A1 (ja) * 2005-06-03 2006-12-07 Mochida Pharmaceutical Co., Ltd. 抗cd14抗体融合蛋白質
US8828703B2 (en) 2005-12-29 2014-09-09 Dyax Corp. Protease inhibition
WO2010035012A1 (en) * 2008-09-26 2010-04-01 Ucb Pharma S.A. Biological products
CN102580085B (zh) * 2008-10-13 2013-09-18 成都康弘生物科技有限公司 Vegf受体融合蛋白在制备治疗脓毒症药物中的应用
CN101721699B (zh) * 2008-10-13 2012-11-07 成都康弘生物科技有限公司 Vegf受体融合蛋白在制备治疗伴随vegf升高的炎症反应的药物中的应用
US20120052069A1 (en) * 2009-05-05 2012-03-01 Amgen Inc Fgf21 mutants and uses thereof
PL3053932T3 (pl) * 2010-02-19 2021-03-08 Xencor, Inc. Nowe immunoadhezyny CTLA4-IG
PH12013502441B1 (en) * 2011-04-29 2019-02-08 Univ Washington Therapeutic nuclease compositions and methods
US8619331B2 (en) 2011-07-19 2013-12-31 Xerox Corporation Simulated paper texture using clear toner and glossmark on texture-less stock
JP6138815B2 (ja) * 2011-12-01 2017-05-31 エーピー バイオサイエンシーズ, インコーポレイテッド 補体経路およびvegf経路に対するタンパク質インヒビターおよびそれらの使用方法
WO2013162050A1 (ja) * 2012-04-23 2013-10-31 株式会社Nrlファーマ ラクトフェリン融合タンパク質及びその製造方法
JP2013253079A (ja) * 2012-05-14 2013-12-19 Xuhua (Shanghai) Biological Research & Development Center Co Ltd 生物学的に活性なヒト尿中トリプシンインヒビターのFc融合タンパク質並びにその調製および使用
CN103044554B (zh) 2012-05-14 2014-08-27 旭华(上海)生物研发中心有限公司 重组二聚化人尿胰蛋白酶抑制剂、其制备方法及其应用
MA39347B2 (fr) * 2014-02-24 2020-05-29 Takeda Pharmaceuticals Co Protéines de fusion d'uti

Also Published As

Publication number Publication date
JP2017512058A (ja) 2017-05-18
MA39347A1 (fr) 2018-06-29
TWI694084B (zh) 2020-05-21
US9856310B2 (en) 2018-01-02
SG11201606691QA (en) 2016-09-29
CN110092837B (zh) 2024-01-02
GEP20196970B (en) 2019-04-25
EP3443978A1 (en) 2019-02-20
US20220127334A1 (en) 2022-04-28
US20160362475A1 (en) 2016-12-15
TW201630931A (zh) 2016-09-01
UA118866C2 (uk) 2019-03-25
CR20160444A (es) 2017-04-21
US20180072795A1 (en) 2018-03-15
AU2023200875A1 (en) 2023-04-27
EA202091567A1 (ru) 2021-07-30
GEAP201814277A (en) 2018-12-25
PH12016501629A1 (en) 2017-02-06
NZ724196A (en) 2022-01-28
RS58285B1 (sr) 2019-03-29
CN106232135A (zh) 2016-12-14
NZ760008A (en) 2023-03-31
CA2939639A1 (en) 2015-08-27
KR20240155987A (ko) 2024-10-29
IL247321B (en) 2020-06-30
KR20220151005A (ko) 2022-11-11
PH12016501629B1 (en) 2023-10-20
AR101597A1 (es) 2016-12-28
DK3110434T3 (en) 2019-01-14
BR112016019390B1 (pt) 2023-11-14
US10351618B2 (en) 2019-07-16
WO2015127391A1 (en) 2015-08-27
CN106232135B (zh) 2019-12-10
MY178774A (en) 2020-10-20
MX2019013124A (es) 2020-08-31
KR20160141718A (ko) 2016-12-09
CL2016002136A1 (es) 2017-08-11
JP2022002513A (ja) 2022-01-11
NZ760789A (en) 2023-03-31
JP2023123763A (ja) 2023-09-05
SMT201800674T1 (it) 2019-01-11
BR112016019390A2 (pt) 2017-10-24
AU2021225156A1 (en) 2021-09-30
JO3729B1 (ar) 2021-01-31
IL247321A0 (en) 2016-09-29
AU2019204448B2 (en) 2021-06-10
DOP2016000202A (es) 2016-12-15
LT3110434T (lt) 2018-12-27
AU2015218704B2 (en) 2019-05-02
JP2019187427A (ja) 2019-10-31
SI3110434T1 (sl) 2019-02-28
MX384070B (es) 2025-03-14
CN110092837A (zh) 2019-08-06
JP6574431B2 (ja) 2019-09-11
MX2024000004A (es) 2024-02-20
US20200040062A1 (en) 2020-02-06
EP3110434B1 (en) 2018-09-19
PE20170257A1 (es) 2017-03-30
JP6938565B2 (ja) 2021-09-22
EA201691702A1 (ru) 2017-01-30
CA3178241A1 (en) 2015-08-27
SG10201708400QA (en) 2017-11-29
EP3110434A1 (en) 2017-01-04
KR102722304B1 (ko) 2024-10-28
ECSP16076535A (es) 2017-08-31
KR102461210B1 (ko) 2022-10-31
MA39347B2 (fr) 2020-05-29
AU2021225156B2 (en) 2022-11-24
ZA201606327B (en) 2019-01-30
PT3110434T (pt) 2018-12-19
AU2015218704A1 (en) 2016-09-22
PL3110434T3 (pl) 2019-01-31
AU2019204448A1 (en) 2019-07-11
EA037256B1 (ru) 2021-02-26
CY1120997T1 (el) 2019-12-11
CA2939639C (en) 2023-01-24
ES2700149T3 (es) 2019-02-14
HRP20182029T1 (hr) 2019-02-08

Similar Documents

Publication Publication Date Title
CY1125029T1 (el) Τροποποιημενοι νουκλεοζιτες, νουκλεοτιδια, και νουκλεϊκα οξεα και χρησεις αυτων
CY1124215T1 (el) Μκ2 αναστολεις και χρησεις αυτων
IL264142A (en) Multispecific antibodies against cd40 and cd137
BR112019012343A2 (pt) anticorpos il-11ra
EA201791029A1 (ru) Антитела против интерлейкина-33 и их применение
EA201890493A1 (ru) РЕПРЕССОРЫ Htt И ИХ ПРИМЕНЕНИЕ
DK4023755T5 (da) Kunstige nukleinsyremolekyler til forbedret proteinudtrykkelse
IL252755A0 (en) Methods and compositions for targeted genetic modification through single-step multiple targeting
DK3325669T3 (da) Sammensætninger og fremgangsmåder til RNA-analyse
AR101845A1 (es) Anticuerpos anti-her2 e inmunoconjugados
DK3292137T3 (da) Proteiner specifikke for cd137
CR20160444A (es) Proteínas de fusión uti
DK3186233T3 (da) Prober til billeddannelse af huntingtin-protein
DK3115457T3 (da) Fremgangsmåde til modificering af genomsekvens til specifikt at konvertere nukleinsyrebaser af målrettet dna-sekvens og molekylært kompleks til anvendelse i samme
EA201790505A1 (ru) Соединение, нацеленое на ил-23а и фно-альфа, и его применение
MX375524B (es) Anticuerpos anti-axl.
MX389703B (es) Anticuerpos anti-c1s humanizados y metodos para usarlos.
JOP20210010A1 (ar) بروتينات مخصصة ل baff و b7rp1 وإستخداماتها
DK3186241T3 (da) Prober til billeddannelse af huntington-protein
MX377774B (es) Formulaciones de proteinas.
DK3197277T3 (da) Prober til billeddannelse af huntingtin-protein
BR112018009097A8 (pt) spodoptera frugiperda resistente a vip3a
DK3663407T3 (da) Fremgangsmåde til nukleinsyresekvensering
UY36277A (es) Proteínas de fusión uti
KR101940900B9 (ko) 표적 핵산 분자를 생성하는 방법 및 조성물

Legal Events

Date Code Title Description
FG Grant or registration