JP2017512058A - Uti融合タンパク質 - Google Patents
Uti融合タンパク質 Download PDFInfo
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- JP2017512058A JP2017512058A JP2016553562A JP2016553562A JP2017512058A JP 2017512058 A JP2017512058 A JP 2017512058A JP 2016553562 A JP2016553562 A JP 2016553562A JP 2016553562 A JP2016553562 A JP 2016553562A JP 2017512058 A JP2017512058 A JP 2017512058A
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/81—Protease inhibitors
- C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
- C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
- C07K14/8114—Kunitz type inhibitors
- C07K14/8117—Bovine/basic pancreatic trypsin inhibitor (BPTI, aprotinin)
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/81—Protease inhibitors
- C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
- C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
- C07K14/8114—Kunitz type inhibitors
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/55—Protease inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
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- A—HUMAN NECESSITIES
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-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/50—Fusion polypeptide containing protease site
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/90—Fusion polypeptide containing a motif for post-translational modification
- C07K2319/91—Fusion polypeptide containing a motif for post-translational modification containing a motif for glycosylation
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Abstract
Description
本明細書及び特許請求の範囲で用いられる用語は、特に記載がない限り下記に示されるように定義される。
本発明の化合物、即ち、融合タンパク質は、標準的な合成方法、組み換えDNA技術、又はペプチド及び融合タンパク質を調製するその他の方法により調製してもよい。代表的な方法において、hUTIドメインは、UTIドメイン及びFcドメイン及び任意のリンカードメインをエンコードするDNA構築物の発現によりFcドメインに共有結合的に連結させる。
一実施形態では、、本発明は、UTI関連病態の診断方法及び治療方法を提供する。本明細書で用いられる用語「条件」、「障害」及び「疾患」は、任意の不健康な状態又は異常な状態に関連する。用語「UTI関連病態」は、UTIが治療上の利益をもたらす病態、障害、及び疾患を含む。用語「UTI関連病態」は、免疫調節効果又は炎症効果により特徴付けられる病態を含む。特に、用語UTI関連病態は、膵炎(急性膵炎及び慢性膵炎を含む)、全身性炎症反応症候群、急性循環障害(例えば、ショックによって引き起こされるもの)、播種性血管内凝固、及び多臓器不全症候群を含む。また、用語UTI関連病態は、高リスク外科患者における使用を含む。また、用語UTI関連病態は、肺、肝臓、心臓、又は腎臓の感染を含む。また、用語UTI関連病態は、重度の敗血症を含む。また、用語UTI関連病態は、SARSウイルスにより引き起こされる急性肺損傷(ALI)又は急性呼吸窮迫症候群(ARDS)を含む。
AVLPQEEEGSGGGQLVTEVTKKEDSCQLGYSAGPCMGMTSRYFYNGTSMACETFQYGGCMGNGNNFVTEKECLQTCRTVAACNLPIVRGPCRAFIQLWAFDAVKGKCVLFPYGGCQGNGNKFYSEKECREYCGVPGDGDEELLGSGGGGDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPG
GCTGTGCTGCCTCAGGAAGAGGAAGGCTCTGGCGGAGGCCAGCTCGTGACCGAAGTGACCAAGAAAGAGGACTCCTGCCAGCTGGGCTACTCTGCCGGCCCTTGTATGGGCATGACCTCCCGGTACTTCTACAACGGCACCTCCATGGCCTGCGAGACATTCCAGTACGGCGGCTGCATGGGCAACGGCAACAACTTTGTGACAGAGAAAGAGTGCCTGCAGACCTGCAGAACCGTGGCCGCCTGTAACCTGCCTATCGTGCGGGGACCCTGTCGGGCCTTTATCCAGCTGTGGGCCTTCGACGCCGTGAAGGGCAAATGCGTGCTGTTCCCCTATGGCGGCTGCCAGGGAAATGGAAACAAGTTCTACTCCGAGAAAGAATGCCGCGAGTACTGTGGCGTGCCAGGCGACGGGGATGAGGAACTGCTGGGATCAGGCGGCGGAGGCGACAAGACCCATACCTGTCCACCTTGCCCTGCCCCCGAGCTGCTGGGAGGACCTTCTGTGTTCCTGTTCCCCCCAAAGCCCAAGGACACCCTGATGATCTCCCGGACCCCTGAAGTGACCTGCGTGGTGGTGGATGTGTCCCACGAGGATCCCGAAGTGAAGTTCAATTGGTACGTGGACGGCGTGGAAGTGCACAACGCCAAGACCAAGCCCAGAGAGGAACAGTACAACTCCACCTACCGGGTGGTGTCCGTGCTGACCGTGCTGCACCAGGATTGGCTGAACGGCAAAGAGTACAAGTGCAAGGTGTCCAACAAGGCCCTGCCTGCCCCCATCGAAAAGACCATCTCCAAGGCCAAGGGCCAGCCCCGGGAACCCCAGGTGTACACACTGCCCCCTAGCCGGGAAGAGATGACAAAGAACCAGGTGTCCCTGACCTGTCTCGTGAAGGGATTCTACCCCTCCGATATCGCCGTGGAATGGGAGTCCAACGGCCAGCCTGAGAACAACTACAAGACCACCCCCCCTGTGCTGGACTCCGACGGCTCATTCTTCCTGTACTCCAAGCTGACAGTGGACAAGTCCCGGTGGCAGCAGGGCAACGTGTTCTCCTGCTCCGTGATGCACGAGGCCCTGCACAACCACTACACCCAGAAGTCCCTGTCCCTGAGCCCCGGC
avlpqeeegsgggqlvtevtkkedscqlgysagpcmgmtsryfyngtsmacetfqyggcmgngnnfvtekeclqtcrtvaacnlpivrgpcrafiqlwafdavkgkcvlfpyggcqgngnkfysekecreycgvpgdgdeellrepkssdkthtcppcpapellggssvflfppkpkdtlmisrtpevtcvvvdvshedpevkfnwyvdgvevhnaktkpreeqynstyrvvsvltvlhqdwlngkeykckvsnkalpasiektiskakgqprepqvytlppsreemtknqvsltclvkgfypsdiavewesngqpennykttppvldsdgsfflyskltvdksrwqqgnvfscsvmhealhnhytqkslslspg
gctgtgctgcctcaggaagaggaaggctctggcggaggccagctcgtgaccgaagtgaccaagaaagaggactcctgccagctgggctactctgccggcccttgtatgggcatgacctcccggtacttctacaacggcacctccatggcctgcgagacattccagtacggcggctgcatgggcaacggcaacaactttgtgacagagaaagagtgcctgcagacctgcagaaccgtggccgcctgtaacctgcctatcgtgcggggaccctgtcgggcctttatccagctgtgggccttcgacgccgtgaagggcaaatgcgtgctgttcccctatggcggctgccagggaaatggaaacaagttctactccgagaaagaatgccgcgagtactgtggcgtgccaggcgacggggatgaggaactgctgcgggagcccaaatcttccgacaagacccatacctgtccaccttgccctgcccccgagctgctgggaggatcctctgtgttcctgttccccccaaagcccaaggacaccctgatgatctcccggacccctgaagtgacctgcgtggtggtggatgtgtcccacgaggatcccgaagtgaagttcaattggtacgtggacggcgtggaagtgcacaacgccaagaccaagcccagagaggaacagtacaactccacctaccgggtggtgtccgtgctgaccgtgctgcaccaggattggctgaacggcaaagagtacaagtgcaaggtgtccaacaaggccctgcctgcctccatcgaaaagaccatctccaaggccaagggccagccccgggaaccccaggtgtacacactgccccctagccgggaagagatgacaaagaaccaggtgtccctgacctgtctcgtgaagggattctacccctccgatatcgccgtggaatgggagtccaacggccagcctgagaacaactacaagaccaccccccctgtgctggactccgacggctcattcttcctgtactccaagctgacagtggacaagtcccggtggcagcagggcaacgtgttctcctgctccgtgatgcacgaggccctgcacaaccactacacccagaagtccctgtccctgagccccggc
avlpqeeegsgggqlvtevtkkedscqlgysagpcmgmtsryfyngtsmacetfqyggcmgngnnfvtekeclqtcrtvaacnlpivrgpcrafiqlwafdavkgkcvlfpyggcqgngnkfysekecreycgvpgdgdeellrkscvecppcpappvagpsvflfppkpkdtlmisrtpevtcvvvdvshedpevqfnwyvdgmevhnaktkpreeqfnstfrvvsvltvvhqdwlngkeykckvsnkglpapiektisktkgqprepqvytlppsreemtknqvsltclvkgfypsdiavewesngqpennykttppmldsdgsfflyskltvdksrwqqgnvfscsvmhealhnhytqkslslspgk
gctgtgctgcctcaggaagaggaaggctctggcggaggccagctcgtgaccgaagtgaccaagaaagaggactcctgccagctgggctactctgccggcccttgtatgggcatgacctcccggtacttctacaacggcacctccatggcctgcgagacattccagtacggcggctgcatgggcaacggcaacaactttgtgacagagaaagagtgcctgcagacctgcagaaccgtggccgcctgtaacctgcctatcgtgcggggaccctgtcgggcctttatccagctgtgggccttcgacgccgtgaagggcaaatgcgtgctgttcccctatggcggctgccagggaaatggaaacaagttctactccgagaaagaatgccgcgagtactgtggcgtgccaggcgacggggatgaggaactgctgcggaaatcctgtgtcgagtgcccaccgtgcccagcaccacctgtggcaggaccgtcagtcttcctcttccccccaaaacccaaggacaccctcatgatctcccggacccctgaggtcacgtgcgtggtggtggacgtgagccacgaagaccccgaggtccagttcaactggtacgtggacggcatggaggtgcataatgccaagacaaagccacgggaggagcagttcaacagcacgttccgtgtggtcagcgtcctcaccgtcgtgcaccaggactggctgaacggcaaggagtacaagtgcaaggtctccaacaaaggcctcccagcccccatcgagaaaaccatctccaaaaccaaagggcagccccgagaaccacaggtgtacaccctgcccccatcccgggaggagatgaccaagaaccaggtcagcctgacctgcctggtcaaaggcttctaccccagcgacatcgccgtggagtgggagagcaatgggcagccggagaacaactacaagaccacacctcccatgctggactccgacggctccttcttcctctacagcaagctcaccgtggacaagagcaggtggcagcaggggaacgtcttctcatgctccgtgatgcatgaggctctgcacaaccactacacacagaagagcctctccctgtctccgggtaaa
avlpqeeegsgggqlvtevtkkedscqlgysagpcmgmtsryfyngtsmacetfqyggcmgngnnfvtekeclqtcrtvaacnlpivrgpcrafiqlwafdavkgkcvlfpyggcqgngnkfysekecreycgvpgdgdeellrkccvecppcpappvagpsvflfppkpkdtlmisrtpevtcvvvdvshedpevqfnwyvdgmevhnaktkpreeqfnstfrvvsvltvvhqdwlngkeykckvsnkglpapiektisktkgqprepqvytlppsreemtknqvsltclvkgfypsdiavewesngqpennykttppmldsdgsfflyskltvdksrwqqgnvfscsvmhealhnhytqkslslspgk
gctgtgctgcctcaggaagaggaaggctctggcggaggccagctcgtgaccgaagtgaccaagaaagaggactcctgccagctgggctactctgccggcccttgtatgggcatgacctcccggtacttctacaacggcacctccatggcctgcgagacattccagtacggcggctgcatgggcaacggcaacaactttgtgacagagaaagagtgcctgcagacctgcagaaccgtggccgcctgtaacctgcctatcgtgcggggaccctgtcgggcctttatccagctgtgggccttcgacgccgtgaagggcaaatgcgtgctgttcccctatggcggctgccagggaaatggaaacaagttctactccgagaaagaatgccgcgagtactgtggcgtgccaggcgacggggatgaggaactgctgcggaaatgttgtgtcgagtgcccaccgtgcccagcaccacctgtggcaggaccgtcagtcttcctcttccccccaaaacccaaggacaccctcatgatctcccggacccctgaggtcacgtgcgtggtggtggacgtgagccacgaagaccccgaggtccagttcaactggtacgtggacggcatggaggtgcataatgccaagacaaagccacgggaggagcagttcaacagcacgttccgtgtggtcagcgtcctcaccgtcgtgcaccaggactggctgaacggcaaggagtacaagtgcaaggtctccaacaaaggcctcccagcccccatcgagaaaaccatctccaaaaccaaagggcagccccgagaaccacaggtgtacaccctgcccccatcccgggaggagatgaccaagaaccaggtcagcctgacctgcctggtcaaaggcttctaccccagcgacatcgccgtggagtgggagagcaatgggcagccggagaacaactacaagaccacacctcccatgctggactccgacggctccttcttcctctacagcaagctcaccgtggacaagagcaggtggcagcaggggaacgtcttctcatgctccgtgatgcatgaggctctgcacaaccactacacacagaagagcctctccctgtctccgggtaaa
avlpqeeegagggqlvtevtkkedscqlgysagpcmgmtsryfyngtsmacetfqyggcmgngnnfvtekeclqtcrtvaacnlpivrgpcrafiqlwafdavkgkcvlfpyggcqgngnkfysekecreycgvpgdgdeellrepkssdkthtcppcpapellggssvflfppkpkdtlmisrtpevtcvvvdvshedpevkfnwyvdgvevhnaktkpreeqynstyrvvsvltvlhqdwlngkeykckvsnkalpasiektiskakgqprepqvytlppsreemtknqvsltclvkgfypsdiavewesngqpennykttppvldsdgsfflyskltvdksrwqqgnvfscsvmhealhnhytqkslslspg
gctgtgctgcctcaggaagaggaaggcgcaggcggaggccagctcgtgaccgaagtgaccaagaaagaggactcctgccagctgggctactctgccggcccttgtatgggcatgacctcccggtacttctacaacggcacctccatggcctgcgagacattccagtacggcggctgcatgggcaacggcaacaactttgtgacagagaaagagtgcctgcagacctgcagaaccgtggccgcctgtaacctgcctatcgtgcggggaccctgtcgggcctttatccagctgtgggccttcgacgccgtgaagggcaaatgcgtgctgttcccctatggcggctgccagggaaatggaaacaagttctactccgagaaagaatgccgcgagtactgtggcgtgccaggcgacggggatgaggaactgctgcgggagcccaaatcttccgacaagacccatacctgtccaccttgccctgcccccgagctgctgggaggatcctctgtgttcctgttccccccaaagcccaaggacaccctgatgatctcccggacccctgaagtgacctgcgtggtggtggatgtgtcccacgaggatcccgaagtgaagttcaattggtacgtggacggcgtggaagtgcacaacgccaagaccaagcccagagaggaacagtacaactccacctaccgggtggtgtccgtgctgaccgtgctgcaccaggattggctgaacggcaaagagtacaagtgcaaggtgtccaacaaggccctgcctgcctccatcgaaaagaccatctccaaggccaagggccagccccgggaaccccaggtgtacacactgccccctagccgggaagagatgacaaagaaccaggtgtccctgacctgtctcgtgaagggattctacccctccgatatcgccgtggaatgggagtccaacggccagcctgagaacaactacaagaccaccccccctgtgctggactccgacggctcattcttcctgtactccaagctgacagtggacaagtcccggtggcagcagggcaacgtgttctcctgctccgtgatgcacgaggccctgcacaaccactacacccagaagtccctgtccctgagccccggc
edscqlgysagpcmgmtsryfyngtsmacetfqyggcmgngnnfvtekeclqtcrtvaacnlpivrgpcrafiqlwafdavkgkcvlfpyggcqgngnkfysekecreycgvpgdgdeellrepkssdkthtcppcpapellggssvflfppkpkdtlmisrtpevtcvvvdvshedpevkfnwyvdgvevhnaktkpreeqynstyrvvsvltvlhqdwlngkeykckvsnkalpasiektiskakgqprepqvytlppsreemtknqvsltclvkgfypsdiavewesngqpennykttppvldsdgsfflyskltvdksrwqqgnvfscsvmhealhnhytqkslslspg
gaggactcctgccagctgggctactctgccggcccttgtatgggcatgacctcccggtacttctacaacggcacctccatggcctgcgagacattccagtacggcggctgcatgggcaacggcaacaactttgtgacagagaaagagtgcctgcagacctgcagaaccgtggccgcctgtaacctgcctatcgtgcggggaccctgtcgggcctttatccagctgtgggccttcgacgccgtgaagggcaaatgcgtgctgttcccctatggcggctgccagggaaatggaaacaagttctactccgagaaagaatgccgcgagtactgtggcgtgccaggcgacggggatgaggaactgctgcgggagcccaaatcttccgacaagacccatacctgtccaccttgccctgcccccgagctgctgggaggatcctctgtgttcctgttccccccaaagcccaaggacaccctgatgatctcccggacccctgaagtgacctgcgtggtggtggatgtgtcccacgaggatcccgaagtgaagttcaattggtacgtggacggcgtggaagtgcacaacgccaagaccaagcccagagaggaacagtacaactccacctaccgggtggtgtccgtgctgaccgtgctgcaccaggattggctgaacggcaaagagtacaagtgcaaggtgtccaacaaggccctgcctgcctccatcgaaaagaccatctccaaggccaagggccagccccgggaaccccaggtgtacacactgccccctagccgggaagagatgacaaagaaccaggtgtccctgacctgtctcgtgaagggattctacccctccgatatcgccgtggaatgggagtccaacggccagcctgagaacaactacaagaccaccccccctgtgctggactccgacggctcattcttcctgtactccaagctgacagtggacaagtcccggtggcagcagggcaacgtgttctcctgctccgtgatgcacgaggccctgcacaaccactacacccagaagtccctgtccctgagccccggc
avlpqeeegsgggqlvtevtkkepkssdkthtcppcpapellggssvflfppkpkdtlmisrtpevtcvvvdvshedpevkfnwyvdgvevhnaktkpreeqynstyrvvsvltvlhqdwlngkeykckvsnkalpasiektiskakgqprepqvytlppsreemtknqvsltclvkgfypsdiavewesngqpennykttppvldsdgsfflyskltvdksrwqqgnvfscsvmhealhnhytqkslslspg
gctgtgctgcctcaggaagaggaaggctctggcggaggccagctcgtgaccgaagtgaccaagaaagagcccaaatcttccgacaagacccatacctgtccaccttgccctgcccccgagctgctgggaggatcctctgtgttcctgttccccccaaagcccaaggacaccctgatgatctcccggacccctgaagtgacctgcgtggtggtggatgtgtcccacgaggatcccgaagtgaagttcaattggtacgtggacggcgtggaagtgcacaacgccaagaccaagcccagagaggaacagtacaactccacctaccgggtggtgtccgtgctgaccgtgctgcaccaggattggctgaacggcaaagagtacaagtgcaaggtgtccaacaaggccctgcctgcctccatcgaaaagaccatctccaaggccaagggccagccccgggaaccccaggtgtacacactgccccctagccgggaagagatgacaaagaaccaggtgtccctgacctgtctcgtgaagggattctacccctccgatatcgccgtggaatgggagtccaacggccagcctgagaacaactacaagaccaccccccctgtgctggactccgacggctcattcttcctgtactccaagctgacagtggacaagtcccggtggcagcagggcaacgtgttctcctgctccgtgatgcacgaggccctgcacaaccactacacccagaagtccctgtccctgagccccggc
avlpqeeegsgggqlvtevtkkedscqlgysagpcmgmtsryfyngtsmacetfqyggcmgngnnfvtekeclqtcrtvaacnlpivrgpcrafiqlwafdavkgkcvlfpyggcqgngnkfysekecreycgvpgdgdeellggggsggggsepkssdkthtcppcpapellggssvflfppkpkdtlmisrtpevtcvvvdvshedpevkfnwyvdgvevhnaktkpreeqynstyrvvsvltvlhqdwlngkeykckvsnkalpasiektiskakgqprepqvytlppsreemtknqvsltclvkgfypsdiavewesngqpennykttppvldsdgsfflyskltvdksrwqqgnvfscsvmhealhnhytqkslslspg
gctgtgctgcctcaggaagaggaaggctctggcggaggccagctcgtgaccgaagtgaccaagaaagaggactcctgccagctgggctactctgccggcccttgtatgggcatgacctcccggtacttctacaacggcacctccatggcctgcgagacattccagtacggcggctgcatgggcaacggcaacaactttgtgacagagaaagagtgcctgcagacctgcagaaccgtggccgcctgtaacctgcctatcgtgcggggaccctgtcgggcctttatccagctgtgggccttcgacgccgtgaagggcaaatgcgtgctgttcccctatggcggctgccagggaaatggaaacaagttctactccgagaaagaatgccgcgagtactgtggcgtgccaggcgacggggatgaggaactgctgggaggtggtggatcaggtggcggaggatcagagcccaaatcttccgacaagacccatacctgtccaccttgccctgcccccgagctgctgggaggatcctctgtgttcctgttccccccaaagcccaaggacaccctgatgatctcccggacccctgaagtgacctgcgtggtggtggatgtgtcccacgaggatcccgaagtgaagttcaattggtacgtggacggcgtggaagtgcacaacgccaagaccaagcccagagaggaacagtacaactccacctaccgggtggtgtccgtgctgaccgtgctgcaccaggattggctgaacggcaaagagtacaagtgcaaggtgtccaacaaggccctgcctgcctccatcgaaaagaccatctccaaggccaagggccagccccgggaaccccaggtgtacacactgccccctagccgggaagagatgacaaagaaccaggtgtccctgacctgtctcgtgaagggattctacccctccgatatcgccgtggaatgggagtccaacggccagcctgagaacaactacaagaccaccccccctgtgctggactccgacggctcattcttcctgtactccaagctgacagtggacaagtcccggtggcagcagggcaacgtgttctcctgctccgtgatgcacgaggccctgcacaaccactacacccagaagtccctgtccctgagccccggc
avlpqeeegsgggqlvtevtkkedscqlgysagpcmgmtsryfyngtsmacetfqyggcmgngnnfvtekeclqtcrtvaacnlpivrgpcrafiqlwafdavkgkcvlfpyggcqgngnkfysekecreycgvpgdgdeellrcppcpapellggssvflfppkpkdtlmisrtpevtcvvvdvshedpevkfnwyvdgvevhnaktkpreeqynstyrvvsvltvlhqdwlngkeykckvsnkalpasiektiskakgqprepqvytlppsreemtknqvsltclvkgfypsdiavewesngqpennykttppvldsdgsfflyskltvdksrwqqgnvfscsvmhealhnhytqkslslspg
gctgtgctgcctcaggaagaggaaggctctggcggaggccagctcgtgaccgaagtgaccaagaaagaggactcctgccagctgggctactctgccggcccttgtatgggcatgacctcccggtacttctacaacggcacctccatggcctgcgagacattccagtacggcggctgcatgggcaacggcaacaactttgtgacagagaaagagtgcctgcagacctgcagaaccgtggccgcctgtaacctgcctatcgtgcggggaccctgtcgggcctttatccagctgtgggccttcgacgccgtgaagggcaaatgcgtgctgttcccctatggcggctgccagggaaatggaaacaagttctactccgagaaagaatgccgcgagtactgtggcgtgccaggcgacggggatgaggaactgctgcggtgtccaccttgccctgcccccgagctgctgggaggatcctctgtgttcctgttccccccaaagcccaaggacaccctgatgatctcccggacccctgaagtgacctgcgtggtggtggatgtgtcccacgaggatcccgaagtgaagttcaattggtacgtggacggcgtggaagtgcacaacgccaagaccaagcccagagaggaacagtacaactccacctaccgggtggtgtccgtgctgaccgtgctgcaccaggattggctgaacggcaaagagtacaagtgcaaggtgtccaacaaggccctgcctgcctccatcgaaaagaccatctccaaggccaagggccagccccgggaaccccaggtgtacacactgccccctagccgggaagagatgacaaagaaccaggtgtccctgacctgtctcgtgaagggattctacccctccgatatcgccgtggaatgggagtccaacggccagcctgagaacaactacaagaccaccccccctgtgctggactccgacggctcattcttcctgtactccaagctgacagtggacaagtcccggtggcagcagggcaacgtgttctcctgctccgtgatgcacgaggccctgcacaaccactacacccagaagtccctgtccctgagccccggc
avlpqeeegsgggqlvtevtkkedscqlgysagpcmgmtsryfyngtsmacetfqyggcmgngnnfvtekeclqtcrtvaacnlpivrgpcrafiqlwafdavkgkcvlfpyggcqgngnkfysekecreycgvssvflfppkpkdtlmisrtpevtcvvvdvshedpevkfnwyvdgvevhnaktkpreeqynstyrvvsvltvlhqdwlngkeykckvsnkalpasiektiskakgqprepqvytlppsreemtknqvsltclvkgfypsdiavewesngqpennykttppvldsdgsfflyskltvdksrwqqgnvfscsvmhealhnhytqkslslspg
gctgtgctgcctcaggaagaggaaggctctggcggaggccagctcgtgaccgaagtgaccaagaaagaggactcctgccagctgggctactctgccggcccttgtatgggcatgacctcccggtacttctacaacggcacctccatggcctgcgagacattccagtacggcggctgcatgggcaacggcaacaactttgtgacagagaaagagtgcctgcagacctgcagaaccgtggccgcctgtaacctgcctatcgtgcggggaccctgtcgggcctttatccagctgtgggccttcgacgccgtgaagggcaaatgcgtgctgttcccctatggcggctgccagggaaatggaaacaagttctactccgagaaagaatgccgcgagtactgtggcgtgtcctctgtgttcctgttccccccaaagcccaaggacaccctgatgatctcccggacccctgaagtgacctgcgtggtggtggatgtgtcccacgaggatcccgaagtgaagttcaattggtacgtggacggcgtggaagtgcacaacgccaagaccaagcccagagaggaacagtacaactccacctaccgggtggtgtccgtgctgaccgtgctgcaccaggattggctgaacggcaaagagtacaagtgcaaggtgtccaacaaggccctgcctgcctccatcgaaaagaccatctccaaggccaagggccagccccgggaaccccaggtgtacacactgccccctagccgggaagagatgacaaagaaccaggtgtccctgacctgtctcgtgaagggattctacccctccgatatcgccgtggaatgggagtccaacggccagcctgagaacaactacaagaccaccccccctgtgctggactccgacggctcattcttcctgtactccaagctgacagtggacaagtcccggtggcagcagggcaacgtgttctcctgctccgtgatgcacgaggccctgcacaaccactacacccagaagtccctgtccctgagccccggc
avlpqeeegsgggqlvtevtssedscqlgysagpcmgmtsryfyngtsmacetfqyggcmgngnnfvtekeclqtcrtvaacnlpivrgpcrafiqlwafdavkgkcvlfpyggcqgngnkfysekecreycgvpgdgdeellrepkssdkthtcppcpapellggssvflfppkpkdtlmisrtpevtcvvvdvshedpevkfnwyvdgvevhnaktkpreeqynstyrvvsvltvlhqdwlngkeykckvsnkalpasiektiskakgqprepqvytlppsreemtknqvsltclvkgfypsdiavewesngqpennykttppvldsdgsfflyskltvdksrwqqgnvfscsvmhealhnhytqkslslspg
gctgtgctgcctcaggaagaggaaggctctggcggaggccagctcgtgaccgaagtgacctcctccgaggactcctgccagctgggctactctgccggcccttgtatgggcatgacctcccggtacttctacaacggcacctccatggcctgcgagacattccagtacggcggctgcatgggcaacggcaacaactttgtgacagagaaagagtgcctgcagacctgcagaaccgtggccgcctgtaacctgcctatcgtgcggggaccctgtcgggcctttatccagctgtgggccttcgacgccgtgaagggcaaatgcgtgctgttcccctatggcggctgccagggaaatggaaacaagttctactccgagaaagaatgccgcgagtactgtggcgtgccaggcgacggggatgaggaactgctgcgggagcccaaatcttccgacaagacccatacctgtccaccttgccctgcccccgagctgctgggaggatcctctgtgttcctgttccccccaaagcccaaggacaccctgatgatctcccggacccctgaagtgacctgcgtggtggtggatgtgtcccacgaggatcccgaagtgaagttcaattggtacgtggacggcgtggaagtgcacaacgccaagaccaagcccagagaggaacagtacaactccacctaccgggtggtgtccgtgctgaccgtgctgcaccaggattggctgaacggcaaagagtacaagtgcaaggtgtccaacaaggccctgcctgcctccatcgaaaagaccatctccaaggccaagggccagccccgggaaccccaggtgtacacactgccccctagccgggaagagatgacaaagaaccaggtgtccctgacctgtctcgtgaagggattctacccctccgatatcgccgtggaatgggagtccaacggccagcctgagaacaactacaagaccaccccccctgtgctggactccgacggctcattcttcctgtactccaagctgacagtggacaagtcccggtggcagcagggcaacgtgttctcctgctccgtgatgcacgaggccctgcacaaccactacacccagaagtccctgtccctgagccccggc
avlpqeeegsgggqlvtevtkktvaacnlpivrgpcrafiqlwafdavkgkcvlfpyggcqgngnkfysekecreycgvpgdgdeellrepkssdkthtcppcpapellggssvflfppkpkdtlmisrtpevtcvvvdvshedpevkfnwyvdgvevhnaktkpreeqynstyrvvsvltvlhqdwlngkeykckvsnkalpasiektiskakgqprepqvytlppsreemtknqvsltclvkgfypsdiavewesngqpennykttppvldsdgsfflyskltvdksrwqqgnvfscsvmhealhnhytqkslslspg
gctgtgctgcctcaggaagaggaaggctctggcggaggccagctcgtgaccgaagtgaccaagaaaaccgtggccgcctgtaacctgcctatcgtgcggggaccctgtcgggcctttatccagctgtgggccttcgacgccgtgaagggcaaatgcgtgctgttcccctatggcggctgccagggaaatggaaacaagttctactccgagaaagaatgccgcgagtactgtggcgtgccaggcgacggggatgaggaactgctgcgggagcccaaatcttccgacaagacccatacctgtccaccttgccctgcccccgagctgctgggaggatcctctgtgttcctgttccccccaaagcccaaggacaccctgatgatctcccggacccctgaagtgacctgcgtggtggtggatgtgtcccacgaggatcccgaagtgaagttcaattggtacgtggacggcgtggaagtgcacaacgccaagaccaagcccagagaggaacagtacaactccacctaccgggtggtgtccgtgctgaccgtgctgcaccaggattggctgaacggcaaagagtacaagtgcaaggtgtccaacaaggccctgcctgcctccatcgaaaagaccatctccaaggccaagggccagccccgggaaccccaggtgtacacactgccccctagccgggaagagatgacaaagaaccaggtgtccctgacctgtctcgtgaagggattctacccctccgatatcgccgtggaatgggagtccaacggccagcctgagaacaactacaagaccaccccccctgtgctggactccgacggctcattcttcctgtactccaagctgacagtggacaagtcccggtggcagcagggcaacgtgttctcctgctccgtgatgcacgaggccctgcacaaccactacacccagaagtccctgtccctgagccccggc
avlpqeeegsgggqlvtevtkkedscqlgysagpcmgmtsryfyngtsmacetfqyggcmgngnnfvtekeclqtcrepkssdkthtcppcpapellggssvflfppkpkdtlmisrtpevtcvvvdvshedpevkfnwyvdgvevhnaktkpreeqynstyrvvsvltvlhqdwlngkeykckvsnkalpasiektiskakgqprepqvytlppsreemtknqvsltclvkgfypsdiavewesngqpennykttppvldsdgsfflyskltvdksrwqqgnvfscsvmhealhnhytqkslslspg
gctgtgctgcctcaggaagaggaaggctctggcggaggccagctcgtgaccgaagtgaccaagaaagaggactcctgccagctgggctactctgccggcccttgtatgggcatgacctcccggtacttctacaacggcacctccatggcctgcgagacattccagtacggcggctgcatgggcaacggcaacaactttgtgacagagaaagagtgcctgcagacctgcagagagcccaaatcttccgacaagacccatacctgtccaccttgccctgcccccgagctgctgggaggatcctctgtgttcctgttccccccaaagcccaaggacaccctgatgatctcccggacccctgaagtgacctgcgtggtggtggatgtgtcccacgaggatcccgaagtgaagttcaattggtacgtggacggcgtggaagtgcacaacgccaagaccaagcccagagaggaacagtacaactccacctaccgggtggtgtccgtgctgaccgtgctgcaccaggattggctgaacggcaaagagtacaagtgcaaggtgtccaacaaggccctgcctgcctccatcgaaaagaccatctccaaggccaagggccagccccgggaaccccaggtgtacacactgccccctagccgggaagagatgacaaagaaccaggtgtccctgacctgtctcgtgaagggattctacccctccgatatcgccgtggaatgggagtccaacggccagcctgagaacaactacaagaccaccccccctgtgctggactccgacggctcattcttcctgtactccaagctgacagtggacaagtcccggtggcagcagggcaacgtgttctcctgctccgtgatgcacgaggccctgcacaaccactacacccagaagtccctgtccctgagccccggc
avlpqesegsgteplitgtlkkedscqlnysegpclgmqeryyyngasmacetfqyggclgngnnfisekdclqtcrtiaacnlpivqgpcrafiklwafdaaqgkciqfhyggckgngnkfysekeckeycgvpgdgyeelirskivprdcgckpcictvpevssvfifppkpkdvltitltpkvtcvvvdiskddpevqfswfvddvevhtaqtqpreeqfnstfrsvselpimhqdwlngkefkcrvnsaafpapiektisktkgrpkapqvytipppkeqmakdkvsltcmitdffpeditvewqwngqpaenykntqpimdtdgsyfvysklnvqksnweagntftcsvlheglhnhhtekslshspgk
gcagtgctgccccaagagagtgaggggtcagggactgagccactaataactgggaccctcaagaaagaagactcctgccagctcaattactcagaaggcccctgcctagggatgcaagagaggtattactacaacggcgcttccatggcctgcgagacctttcaatatgggggttgcctaggcaacggcaacaacttcatctctgagaaggactgtctgcagacatgtcggaccatagcggcctgcaatctccccatagtccaaggcccctgccgagccttcataaagctctgggcatttgatgcagcacaagggaagtgcatccaattccactacgggggctgcaaaggcaacggcaacaaattctactctgagaaggaatgcaaagagtactgtggagtccctggtgatgggtacgaggaactaatacgcagtaaaatcgtgcctcgggactgcggctgcaagccctgcatctgcaccgtgcccgaggtgtcctccgtgttcatcttcccacccaagcccaaggacgtgctgaccatcaccctgacccccaaagtgacctgcgtggtggtggacatctccaaggacgaccccgaggtgcagttcagttggttcgtggacgacgtggaagtgcacaccgcccagacccagcccagagaggaacagttcaactccaccttcagatccgtgtccgagctgcccatcatgcaccaggactggctgaacggcaaagagttcaagtgcagagtgaactccgccgccttcccagcccccatcgaaaagaccatctccaagaccaagggcagacccaaggccccccaggtgtacaccatccccccacccaaagaacagatggccaaggacaaggtgtccctgacctgcatgatcaccgatttcttcccagaggacatcaccgtggaatggcagtggaacggccagcccgccgagaactacaagaacacccagcccatcatggacaccgacggctcctacttcgtgtactccaagctgaacgtgcagaagtccaactgggaggccggcaacaccttcacctgtagcgtgctgcacgagggcctgcacaaccaccacaccgagaagtccctgtcccactcccccggcaag
epkssdkthtcppcpapellggssvflfppkpkdtlmisrtpevtcvvvdvshedpevkfnwyvdgvevhnaktkpreeqynstyrvvsvltvlhqdwlngkeykckvsnkalpasiektiskakgqprepqvytlppsreemtknqvsltclvkgfypsdiavewesngqpennykttppvldsdgsfflyskltvdksrwqqgnvfscsvmhealhnhytqkslslspgkggggsggggsggggsavlpqeeegsgggqlvtevtkkedscqlgysagpcmgmtsryfyngtsmacetfqyggcmgngnnfvtekeclqtcrtvaacnlpivrgpcrafiqlwafdavkgkcvlfpyggcqgngnkfysekecreycgvpgdgdeellr
gagcccaaatcttccgacaagacccatacctgtccaccttgccctgcccccgagctgctgggaggatcctctgtgttcctgttccccccaaagcccaaggacaccctgatgatctcccggacccctgaagtgacctgcgtggtggtggatgtgtcccacgaggatcccgaagtgaagttcaattggtacgtggacggcgtggaagtgcacaacgccaagaccaagcccagagaggaacagtacaactccacctaccgggtggtgtccgtgctgaccgtgctgcaccaggattggctgaacggcaaagagtacaagtgcaaggtgtccaacaaggccctgcctgcctccatcgaaaagaccatctccaaggccaagggccagccccgggaaccccaggtgtacacactgccccctagccgggaagagatgacaaagaaccaggtgtccctgacctgtctcgtgaagggattctacccctccgatatcgccgtggaatgggagtccaacggccagcctgagaacaactacaagaccaccccccctgtgctggactccgacggctcattcttcctgtactccaagctgacagtggacaagtcccggtggcagcagggcaacgtgttctcctgctccgtgatgcacgaggccctgcacaaccactacacccagaagtccctgtccctgagccccggcaagggaggtggtggatcaggaggtggaggttccggtggcggaggatcagctgtgctgcctcaggaagaggaaggctctggcggaggccagctcgtgaccgaagtgaccaagaaagaggactcctgccagctgggctactctgccggcccttgtatgggcatgacctcccggtacttctacaacggcacctccatggcctgcgagacattccagtacggcggctgcatgggcaacggcaacaactttgtgacagagaaagagtgcctgcagacctgcagaaccgtggccgcctgtaacctgcctatcgtgcggggaccctgtcgggcctttatccagctgtgggccttcgacgccgtgaagggcaaatgcgtgctgttcccctatggcggctgccagggaaatggaaacaagttctactccgagaaagaatgccgcgagtactgtggcgtgccaggcgacggggatgaggaactgctgcgg
avlpq eeegsgggql vtevtkkeds cqlgysagpc
mgmtsryfyn gtsmacetfq yggcmgngnn fvtekeclqt crtvaacnlp ivrgpcrafi
qlwafdavkg kcvlfpyggc qgngnkfyse kecreycgvp gdgdeellrf sn
mrslgallll lsaclavsag pvptppdniq vqenfnisri ygkwynlaig stcpwlkkim
drmtvstlvl gegateaeis mtstrwrkgv ceetsgayek tdtdgkflyh kskwnitmes
yvvhtnydey aifltkkfsr hhgptitakl ygrapqlret llqdfrvvaq gvgipedsif
tmadrgecvp geqepepili prvrravlpq eeegsgggql vtevtkkeds cqlgysagpc
mgmtsryfyn gtsmacetfq yggcmgngnn fvtekeclqt crtvaacnlp ivrgpcrafi
qlwafdavkg kcvlfpyggc qgngnkfyse kecreycgvp gdgdeellrf sn
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Claims (10)
- 配列番号1を含むUTI融合タンパク質。
- 配列番号1を含む単離されたUTI融合タンパク質。
- 融合タンパク質が、Fcドメインが共有結合的に結合する二量体である請求項1又は2に記載の融合タンパク質。
- 請求項1、2又は3に記載のUTI融合タンパク質、及び医薬上許容される賦形剤を含む医薬組成物。
- 医薬としての請求項1、2又は3に記載のUTI融合タンパク質の使用。
- 有効量の請求項1、2又は3に記載のUTI融合タンパク質を、それを必要とする患者に投与することを含むUTI関連病態の治療方法。
- 配列番号1をエンコードするポリヌクレオチド配列を含む核酸。
- 請求項7に記載の核酸を含む発現ベクター。
- 請求項8に記載の発現ベクターを含む組み換え宿主細胞。
- 組み換え融合タンパク質が発現するように増殖培地に請求項9に記載の組み換え宿主細胞を置くこと、及び細胞又は増殖培地から融合タンパク質を単離することを含むUTI融合タンパク質の製造方法。
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JP2021050161A (ja) | 2019-09-25 | 2021-04-01 | 武田薬品工業株式会社 | 複素環化合物及びその用途 |
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