MX2016010037A - Nanosuspension de materiales naturales y metodo de preparacion del mismo. - Google Patents
Nanosuspension de materiales naturales y metodo de preparacion del mismo.Info
- Publication number
- MX2016010037A MX2016010037A MX2016010037A MX2016010037A MX2016010037A MX 2016010037 A MX2016010037 A MX 2016010037A MX 2016010037 A MX2016010037 A MX 2016010037A MX 2016010037 A MX2016010037 A MX 2016010037A MX 2016010037 A MX2016010037 A MX 2016010037A
- Authority
- MX
- Mexico
- Prior art keywords
- nanosuspension
- preparation
- natural materials
- natural material
- particle size
- Prior art date
Links
- 239000006070 nanosuspension Substances 0.000 title abstract 3
- 238000002360 preparation method Methods 0.000 title abstract 3
- 239000000463 material Substances 0.000 title 1
- 239000005445 natural material Substances 0.000 abstract 3
- 238000000034 method Methods 0.000 abstract 2
- 239000002245 particle Substances 0.000 abstract 2
- 239000006185 dispersion Substances 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 238000003801 milling Methods 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L29/00—Foods or foodstuffs containing additives; Preparation or treatment thereof
- A23L29/03—Organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/716—Glucans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/66—Microorganisms or materials therefrom
- A61K35/74—Bacteria
- A61K35/748—Cyanobacteria, i.e. blue-green bacteria or blue-green algae, e.g. spirulina
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/06—Fungi, e.g. yeasts
- A61K36/07—Basidiomycota, e.g. Cryptococcus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/63—Oleaceae (Olive family), e.g. jasmine, lilac or ash tree
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/24—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/145—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2200/00—Function of food ingredients
- A23V2200/20—Ingredients acting on or related to the structure
- A23V2200/25—Nanoparticles, nanostructures
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Mycology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- Medical Informatics (AREA)
- Botany (AREA)
- Alternative & Traditional Medicine (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Dispersion Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Immunology (AREA)
- Polymers & Plastics (AREA)
- Communicable Diseases (AREA)
- Dermatology (AREA)
- Inorganic Chemistry (AREA)
- Nutrition Science (AREA)
- Food Science & Technology (AREA)
- Oncology (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Plant Substances (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
La presente descripción se refiere a un método para la preparación de una nanosuspensión de al menos un material natural, en el que el método comprende las etapas de (a) proporcionar al menos un material natural que tiene un tamaño de partícula (D90) de menos de 320 µm; (b) dispersar dicho al menos un material natural de la etapa (a) en un disolvente; y (c) moler la dispersión de la etapa (b) a un tamaño de partícula (D90) inferior a 1000 nm. La nanosuspensión es útil para la preparación de un medicamento.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP14153705 | 2014-02-03 | ||
EP2014064449 | 2014-07-07 | ||
PCT/EP2015/052202 WO2015114164A1 (en) | 2014-02-03 | 2015-02-03 | Nanosuspension of natural materials and preparation method thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2016010037A true MX2016010037A (es) | 2017-10-26 |
Family
ID=52444306
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2016010037A MX2016010037A (es) | 2014-02-03 | 2015-02-03 | Nanosuspension de materiales naturales y metodo de preparacion del mismo. |
Country Status (22)
Country | Link |
---|---|
US (1) | US10213382B2 (es) |
EP (1) | EP3102185B1 (es) |
JP (2) | JP6751672B2 (es) |
KR (1) | KR20160118317A (es) |
CN (1) | CN106102719A (es) |
AU (1) | AU2015212726B2 (es) |
CA (1) | CA2938552C (es) |
CY (1) | CY1124656T1 (es) |
DK (1) | DK3102185T3 (es) |
ES (1) | ES2891151T3 (es) |
HR (1) | HRP20211513T1 (es) |
HU (1) | HUE056398T2 (es) |
LT (1) | LT3102185T (es) |
MX (1) | MX2016010037A (es) |
NZ (1) | NZ723631A (es) |
PL (1) | PL3102185T3 (es) |
RS (1) | RS62381B1 (es) |
RU (1) | RU2695325C1 (es) |
SA (1) | SA516371597B1 (es) |
SI (1) | SI3102185T1 (es) |
WO (1) | WO2015114164A1 (es) |
ZA (1) | ZA201604743B (es) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US10213382B2 (en) * | 2014-02-03 | 2019-02-26 | Apurano Pharmaceuticals Gmbh | Nanosuspension of natural materials and preparation method thereof |
CN107864621A (zh) * | 2015-08-04 | 2018-03-30 | 阿普拉诺生命科学有限责任公司 | 包含天然材料之颗粒和提取物的纳米混悬液 |
JP6664770B1 (ja) * | 2018-03-27 | 2020-03-13 | 株式会社Mizkan Holdings | 植物含有固体脂組成物、その製造方法及び外観・食味の改善方法 |
CA3104875A1 (en) * | 2018-07-10 | 2020-01-16 | Applied Lifesciences And Systems Poultry, Inc. | Systems and methods of preparing and delivering gels |
CN109432018A (zh) * | 2018-12-25 | 2019-03-08 | 中国人民解放军第四军医大学 | 难溶性药物的纳米混悬液及其制备方法和应用 |
KR102116022B1 (ko) * | 2019-07-16 | 2020-05-27 | (주)코이즈 | 고농도의 산소를 함유하는 미세소구체가 포함된 화장료 조성물 및 이의 제조방법 |
PL3883547T3 (pl) * | 2020-01-06 | 2023-06-05 | Cannaxan Gmbh | Wytwarzanie i zastosowanie nanopreparatu konopi indyjskich |
CN115998703B (zh) * | 2022-12-14 | 2024-09-06 | 迪沙药业集团有限公司 | 一种地榆组合物及其制备方法 |
US11832614B1 (en) | 2023-04-28 | 2023-12-05 | King Faisal University | Method of inhibiting mycotoxin growth using Arthrospira platensis nanoparticles |
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DE4137540A1 (de) | 1991-11-14 | 1993-05-19 | Steigerwald Arzneimittelwerk | Verwendung von praeparaten der curcuma-pflanzen |
JPH05221852A (ja) * | 1992-02-18 | 1993-08-31 | L T T Kenkyusho:Kk | 制ガン剤の新規製剤調製方法 |
ZA9711731B (en) * | 1996-12-31 | 1998-07-01 | Monsanto Co | Aqueous glycerol formulations of somatotropin |
US20050107582A1 (en) | 2003-07-30 | 2005-05-19 | Alfred Wong | Method for the preparation of phytosterols from tall oil pitch |
US20120042886A1 (en) * | 1998-03-11 | 2012-02-23 | Hanna Piskorz | Method of producing a nicotine medicament and a medicament made by the method |
DE19832304A1 (de) * | 1998-07-17 | 2000-01-20 | Reiner Weichert | Verfahren und Vorrichtung zur Ultrafein-Mahlung von festen Materialien |
US6375986B1 (en) | 2000-09-21 | 2002-04-23 | Elan Pharma International Ltd. | Solid dose nanoparticulate compositions comprising a synergistic combination of a polymeric surface stabilizer and dioctyl sodium sulfosuccinate |
WO2001001962A1 (en) | 1999-07-05 | 2001-01-11 | Idea Ag. | A method for the improvement of transport across adaptable semi-permeable barriers |
CN100391439C (zh) | 2001-04-27 | 2008-06-04 | 味之素株式会社 | 免疫增强剂 |
JP4752233B2 (ja) * | 2001-04-27 | 2011-08-17 | 味の素株式会社 | 免疫賦活剤 |
DE60207878T2 (de) * | 2001-09-28 | 2006-08-17 | Glycomed Sciences Ltd., Turramurra | Lösungsmittelextraktionsverfahren |
CN1416847A (zh) * | 2001-11-07 | 2003-05-14 | 焦柏忠 | 纳米级西洋参制品及其制作方法 |
IL146737A (en) * | 2001-11-26 | 2010-02-17 | Lycored Natural Prod Ind Ltd | Method for protecting lycopene dispersed in tomato fibers |
EP2255821A1 (de) * | 2002-02-28 | 2010-12-01 | Heitland & Petre International GmbH | Mikro-/Nanopartikel aus lipidhaltigen marinen Organismen für Pharmazie und Kosmetik |
EP1511468A1 (en) * | 2002-06-10 | 2005-03-09 | Elan Pharma International Limited | Nanoparticulate sterol formulations and sterol combinations |
US20120156309A1 (en) * | 2007-09-19 | 2012-06-21 | Eckert C Edward | Using Aqueous Oxygenation to Improve Animal Health & Wellness |
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KR20080003322A (ko) | 2005-02-24 | 2008-01-07 | 엘란 파마 인터내셔널 리미티드 | 도세탁셀 및 이의 유사체의 나노입자 배합물 |
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KR101160801B1 (ko) * | 2010-05-27 | 2012-06-29 | 서용일 | 고형 보조 첨가제 |
JP5801802B2 (ja) | 2010-06-08 | 2015-10-28 | カルピス株式会社 | 脂質代謝改善剤 |
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US10213382B2 (en) * | 2014-02-03 | 2019-02-26 | Apurano Pharmaceuticals Gmbh | Nanosuspension of natural materials and preparation method thereof |
US20150283070A1 (en) * | 2014-04-08 | 2015-10-08 | Sansa Corporation (Barbados) Inc. | Nicotine Formulations and Methods of Making the Same |
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2015
- 2015-02-03 US US15/116,434 patent/US10213382B2/en active Active
- 2015-02-03 ES ES15702278T patent/ES2891151T3/es active Active
- 2015-02-03 LT LTEPPCT/EP2015/052202T patent/LT3102185T/lt unknown
- 2015-02-03 RS RS20211145A patent/RS62381B1/sr unknown
- 2015-02-03 SI SI201531706T patent/SI3102185T1/sl unknown
- 2015-02-03 CN CN201580006784.1A patent/CN106102719A/zh active Pending
- 2015-02-03 CA CA2938552A patent/CA2938552C/en active Active
- 2015-02-03 HU HUE15702278A patent/HUE056398T2/hu unknown
- 2015-02-03 RU RU2016135693A patent/RU2695325C1/ru active
- 2015-02-03 AU AU2015212726A patent/AU2015212726B2/en active Active
- 2015-02-03 WO PCT/EP2015/052202 patent/WO2015114164A1/en active Application Filing
- 2015-02-03 NZ NZ723631A patent/NZ723631A/en unknown
- 2015-02-03 DK DK15702278.1T patent/DK3102185T3/da active
- 2015-02-03 HR HRP20211513TT patent/HRP20211513T1/hr unknown
- 2015-02-03 JP JP2016567161A patent/JP6751672B2/ja active Active
- 2015-02-03 PL PL15702278T patent/PL3102185T3/pl unknown
- 2015-02-03 EP EP15702278.1A patent/EP3102185B1/en active Active
- 2015-02-03 KR KR1020167024353A patent/KR20160118317A/ko not_active Application Discontinuation
- 2015-02-03 MX MX2016010037A patent/MX2016010037A/es active IP Right Grant
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2016
- 2016-07-11 ZA ZA2016/04743A patent/ZA201604743B/en unknown
- 2016-08-02 SA SA516371597A patent/SA516371597B1/ar unknown
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2018
- 2018-06-05 JP JP2018108078A patent/JP2018172394A/ja not_active Withdrawn
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2021
- 2021-10-05 CY CY20211100862T patent/CY1124656T1/el unknown
Also Published As
Publication number | Publication date |
---|---|
JP2017505814A (ja) | 2017-02-23 |
JP6751672B2 (ja) | 2020-09-09 |
HRP20211513T1 (hr) | 2021-12-24 |
LT3102185T (lt) | 2022-01-10 |
DK3102185T3 (da) | 2021-10-04 |
RU2695325C1 (ru) | 2019-07-23 |
NZ723631A (en) | 2017-08-25 |
PL3102185T3 (pl) | 2021-12-27 |
US10213382B2 (en) | 2019-02-26 |
EP3102185A1 (en) | 2016-12-14 |
RS62381B1 (sr) | 2021-10-29 |
KR20160118317A (ko) | 2016-10-11 |
JP2018172394A (ja) | 2018-11-08 |
ES2891151T3 (es) | 2022-01-26 |
ZA201604743B (en) | 2017-09-27 |
CA2938552A1 (en) | 2015-08-06 |
WO2015114164A1 (en) | 2015-08-06 |
CN106102719A (zh) | 2016-11-09 |
EP3102185B1 (en) | 2021-07-14 |
AU2015212726B2 (en) | 2018-02-01 |
CA2938552C (en) | 2021-07-13 |
SI3102185T1 (sl) | 2022-01-31 |
HUE056398T2 (hu) | 2022-02-28 |
CY1124656T1 (el) | 2022-07-22 |
AU2015212726A1 (en) | 2016-09-15 |
US20160346201A1 (en) | 2016-12-01 |
SA516371597B1 (ar) | 2020-04-29 |
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