MX2016007409A - Composiciones de acido ribonucleico de interferencia (ari) contra el componente del complemento y metodos para su uso. - Google Patents

Composiciones de acido ribonucleico de interferencia (ari) contra el componente del complemento y metodos para su uso.

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Publication number
MX2016007409A
MX2016007409A MX2016007409A MX2016007409A MX2016007409A MX 2016007409 A MX2016007409 A MX 2016007409A MX 2016007409 A MX2016007409 A MX 2016007409A MX 2016007409 A MX2016007409 A MX 2016007409A MX 2016007409 A MX2016007409 A MX 2016007409A
Authority
MX
Mexico
Prior art keywords
complement
methods
compositions
ribonucleic acid
ari
Prior art date
Application number
MX2016007409A
Other languages
English (en)
Other versions
MX382900B (es
Inventor
Bettencourt Brian
Borodovsky Anna
Original Assignee
Alnylam Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alnylam Pharmaceuticals Inc filed Critical Alnylam Pharmaceuticals Inc
Publication of MX2016007409A publication Critical patent/MX2016007409A/es
Publication of MX382900B publication Critical patent/MX382900B/es

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Abstract

La invención se refiere a composiciones de ARNi, por ejemplo, ácido ribonucleico de hebra doble ARNhd) que se dirigen al gen del factor B de complemento (CFB), al gen del componente de complemento C3 y al gen del componente de complemento c9 y a métodos para usar las composiciones de ARNi, por ejemplo, ARNhd, para inhibir la expresión de CFB, c9 y/o C3 y pasra tratar a sujetos que tienen una enfermedad asociada a un componente de complemento, por ejemplo, hemoglobinuria nocturna paraxistica y síndrome urémico hemolítico atípico.
MX2016007409A 2013-12-12 2014-12-12 COMPOSICIONES DE ÁCIDO RIBONUCLEICO DE INTERFERENCIA (ARNi) CONTRA EL COMPONENTE DEL COMPLEMENTO Y MÉTODOS PARA SU USO. MX382900B (es)

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