MX2016006657A - Antagonistas de gastrina (por ejemplo, yf476, netazepido) para el tratamiento y prevencion de osteoporosis. - Google Patents
Antagonistas de gastrina (por ejemplo, yf476, netazepido) para el tratamiento y prevencion de osteoporosis.Info
- Publication number
- MX2016006657A MX2016006657A MX2016006657A MX2016006657A MX2016006657A MX 2016006657 A MX2016006657 A MX 2016006657A MX 2016006657 A MX2016006657 A MX 2016006657A MX 2016006657 A MX2016006657 A MX 2016006657A MX 2016006657 A MX2016006657 A MX 2016006657A
- Authority
- MX
- Mexico
- Prior art keywords
- gastrin
- prevention
- treatment
- netazepide
- osteoporosis
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
- A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
Landscapes
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Physical Education & Sports Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Rheumatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Las modalidades proporcionadas se basan en algunos aspectos en la demostración en la presente de un papel para la gastrina en la regulación del envejecimiento del eje de los intestinos-ovarios, y en los efectos de dirigir la actividad de la gastrina en la reversión de la pérdida ósea mediada por la gastrina; se proporcionan métodos, composiciones y agentes, incluyendo antagonistas de gastrina, por ejemplo antagonista del receptor CCK2 (en particular YF476), para el tratamiento, la mejora y la prevención de enfermedades y condiciones óseas; los métodos para el tratamiento de una enfermedad o condición ósea asociada con hipergastrinemia en un sujeto en necesidad del mismo, pueden comprender la administración al sujeto de al menos una dosis de una cantidad terapéuticamente eficaz de un agente dirigido al receptor de gastrina, tratando así la enfermedad o condición ósea asociada con la hipergastrinemia.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201361907980P | 2013-11-22 | 2013-11-22 | |
PCT/US2014/066832 WO2015077572A1 (en) | 2013-11-22 | 2014-11-21 | Gastrin antagonists (eg yf476, netazepide) for treatment and prevention of osteoporosis |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2016006657A true MX2016006657A (es) | 2016-10-12 |
Family
ID=52118000
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2016006657A MX2016006657A (es) | 2013-11-22 | 2014-11-21 | Antagonistas de gastrina (por ejemplo, yf476, netazepido) para el tratamiento y prevencion de osteoporosis. |
Country Status (14)
Country | Link |
---|---|
US (1) | US10709714B2 (es) |
EP (1) | EP3071206B1 (es) |
JP (1) | JP6502939B2 (es) |
KR (1) | KR102254957B1 (es) |
CN (1) | CN106163527A (es) |
AU (1) | AU2014352875B2 (es) |
BR (1) | BR112016011727A2 (es) |
CA (1) | CA2929858C (es) |
DK (1) | DK3071206T3 (es) |
ES (1) | ES2870538T3 (es) |
MX (1) | MX2016006657A (es) |
PL (1) | PL3071206T3 (es) |
RU (1) | RU2693484C1 (es) |
WO (1) | WO2015077572A1 (es) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US10881667B2 (en) | 2018-10-30 | 2021-01-05 | City University Of Hong Kong | Method and composition for treating epilepsy |
US11285161B2 (en) | 2019-04-26 | 2022-03-29 | City University Of Hong Kong | Method and composition for treating mental disorder and pain associated with nerve damage |
CN110935005A (zh) * | 2019-11-19 | 2020-03-31 | 宁波大学 | 一种丙谷二肽的新用途 |
CN115770266B (zh) * | 2023-01-30 | 2023-05-09 | 云南中医药大学 | 一种用于治疗绝经后骨质疏松的药物组合物 |
Family Cites Families (95)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1989005812A1 (en) * | 1987-12-22 | 1989-06-29 | Yoshitomi Pharmaceutical Industries, Ltd. | Thienodiazepine compounds and their medicinal use |
DE69017302T3 (de) | 1989-08-04 | 1999-08-05 | Merck Sharp & Dohme | Zentrale Cholecystokinin-Antagonisten zur Behandlung von psychiatrischen Krankheiten. |
US5399565A (en) | 1990-07-17 | 1995-03-21 | Eli Lilly And Company | Pyrazolidinone CCK and gastrin antagonists and pharmaceutical formulations therof |
CA2099672A1 (en) | 1990-12-25 | 1992-06-26 | Masato Satoh | Benzodiazepine derivatives |
JPH06509095A (ja) | 1991-07-12 | 1994-10-13 | ワーナー−ランバート・コンパニー | パニック発作の治療に有用なコレシストキニン拮抗薬 |
JP3239364B2 (ja) | 1991-10-11 | 2001-12-17 | ウェルファイド株式会社 | 骨粗鬆症治療薬およびジアゼピン化合物 |
AU3247593A (en) | 1991-12-20 | 1993-07-28 | Warner-Lambert Company | Therapeutic combinations useful in the treatment of gastroesophageal reflux disease |
IL104853A (en) | 1992-02-27 | 1997-11-20 | Yamanouchi Pharma Co Ltd | Benzodiazepine derivatives, their preparation and pharmaceutical compositions containing them |
TW281669B (es) | 1993-02-17 | 1996-07-21 | Chugai Pharmaceutical Co Ltd | |
GB2282595A (en) | 1993-08-25 | 1995-04-12 | Yamanouchi Pharma Co Ltd | Benzodiazepine derivatives |
IT1261255B (it) | 1993-09-09 | 1996-05-09 | Rotta Research Lab | Derivati acidi poliamidici ad attivita' antigastrinica, procedimento per la loro preparazione e loro uso farmaceutico. |
WO1997021731A1 (en) | 1995-12-11 | 1997-06-19 | New England Medical Center Hospitals, Inc. | Assay for and uses of peptide hormone receptor ligands |
US5750353A (en) | 1995-12-11 | 1998-05-12 | New England Medical Center Hospitals, Inc. | Assay for non-peptide agonists to peptide hormone receptors |
US5922883A (en) | 1996-04-03 | 1999-07-13 | Merck & Co., Inc. | Inhibitors of farnesyl-protein transferase |
ES2227833T3 (es) | 1997-05-12 | 2005-04-01 | Aphton Corporation | Composiciones inmunogenicas para el receptor cck-b/gastrina y metodos para el tratamiento de tumores. |
US20040001842A1 (en) | 1997-05-12 | 2004-01-01 | Dov Michaeli | Immunogenic compositions to the CCK-B/gastrin receptor and methods for the treatment of tumors |
EP1076561B1 (en) | 1998-05-15 | 2005-03-30 | Aphton Corporation | Combination therapy for the treatment of tumors |
US6232320B1 (en) | 1998-06-04 | 2001-05-15 | Abbott Laboratories | Cell adhesion-inhibiting antiinflammatory compounds |
PL345906A1 (en) | 1998-06-04 | 2002-01-14 | Abbott Lab | Cell adhesion-inhibiting antinflammatory compounds |
US6541669B1 (en) | 1998-06-08 | 2003-04-01 | Theravance, Inc. | β2-adrenergic receptor agonists |
JP4058243B2 (ja) | 1999-01-29 | 2008-03-05 | 中外製薬株式会社 | 軟骨形成促進剤およびインドリン−2−オン誘導体 |
WO2000075145A1 (en) | 1999-06-03 | 2000-12-14 | Abbott Laboratories | Cell adhesion-inhibiting antiinflammatory compounds |
US20030191279A1 (en) | 1999-08-27 | 2003-10-09 | Goldstein Steven Wayne | Urea derivatives useful as anticancer agents |
US6844367B1 (en) | 1999-09-17 | 2005-01-18 | Millennium Pharmaceuticals, Inc. | Benzamides and related inhibitors of factor Xa |
CZ20021548A3 (cs) | 1999-11-05 | 2002-10-16 | Societe De Conseils De Recherches Et D'application | Nové heterocyklické sloučeniny a jejich pouľití jako léků |
WO2001035899A2 (en) | 1999-11-19 | 2001-05-25 | Axxima Pharmaceuticals Ag | Inhibitors of helicobacter pylori induced gastrointestinal diseases |
WO2001077685A2 (en) | 2000-04-10 | 2001-10-18 | The General Hospital Corporation | Diagnosis and treatment of gastrointestinal disease |
AU2001273040A1 (en) | 2000-06-27 | 2002-01-08 | Du Pont Pharmaceuticals Company | Factor xa inhibitors |
CA2441228A1 (en) | 2001-03-23 | 2002-10-03 | Aphton Corporation | Combination treatment of pancreatic cancer |
EP1391211A1 (en) | 2001-04-27 | 2004-02-25 | Chugai Seiyaku Kabushiki Kaisha | Chondrogenesis promoters |
US20090191232A1 (en) | 2001-05-04 | 2009-07-30 | Gevas Philip C | Combination therapy for the treatment of tumors |
EP1391203A4 (en) | 2001-05-11 | 2005-09-14 | Astellas Pharma Inc | ANTITUMORAL AGENTS |
AUPR738301A0 (en) | 2001-08-30 | 2001-09-20 | Starpharma Limited | Chemotherapeutic agents |
US20060003993A1 (en) | 2001-11-13 | 2006-01-05 | James Black Foundation Limited | Benzotriazepnes as gastrin and cholecystokinin receptor ligands |
US20040127492A1 (en) | 2002-02-19 | 2004-07-01 | Pharmacia Corporation | Cyclic pyrazoles for the inhibition of mitogen activated protein kinase-activated protein kinase-2 |
DE10207037A1 (de) | 2002-02-20 | 2003-08-28 | Bayer Cropscience Gmbh | 2-Amino-4-bicyclyamino-6H-1,3.5-triazine, Verfahren zu deren Herstellung und deren Verwendung als Herbizide und Pflanzenwachstumsregulatoren |
UA79804C2 (en) | 2002-07-03 | 2007-07-25 | Janssen Pharmaceutica Nv | Cck-1 receptor modulators |
US20030049698A1 (en) | 2002-10-08 | 2003-03-13 | Wang Timothy C. | Diagnosis and treatment of gastrointestinal disease |
CA2520546A1 (en) | 2003-03-28 | 2005-02-10 | Janssen Pharmaceutica, N.V. | Benzo[1,2,5]thiadiazole compounds |
GB0310865D0 (en) | 2003-05-12 | 2003-06-18 | Black James Foundation | Gastrin and cholecystokinin receptor ligands |
WO2004101533A1 (en) | 2003-05-12 | 2004-11-25 | Janssen Pharmaceutica, N.V. | 1, 3, 4-benzotriazepin-2-one salts and their use as cck receptor ligands |
US20050042283A1 (en) | 2003-07-11 | 2005-02-24 | University Of Massachusetts | Histamine and CCK2/gastrin receptor blockade in the treatment of acid-peptic disease and cancer |
NZ545030A (en) | 2003-08-08 | 2009-08-28 | Janssen Pharmaceutica Nv | 2-(Quinoxalin-5-ylsulfonylamino) -benzamide compounds as CCK2 modulators |
US20070293482A1 (en) | 2004-03-19 | 2007-12-20 | Novartis Pharmaceuticals Corporation | Process for Preparing Benzodiazepines |
US7429604B2 (en) | 2004-06-15 | 2008-09-30 | Bristol Myers Squibb Company | Six-membered heterocycles useful as serine protease inhibitors |
US7947833B2 (en) | 2004-08-04 | 2011-05-24 | Janssen Pharmaceutica Nv | Preparation of quinoxaline compounds |
BRPI0516027A (pt) | 2004-09-24 | 2008-08-19 | Janssen Pharmaceutica Nv | compostos de sulfonamida |
EP1817333A4 (en) | 2004-10-12 | 2008-12-31 | Janssen Pharmaceutica Nv | CHOLECYSTOKININ-1 RECEPTOR MATERIALS OF DOGS AND THEIR USE |
AU2005302669A1 (en) | 2004-10-27 | 2006-05-11 | Neurogen Corporation | Diaryl ureas as CB1 antagonists |
EP1807390A4 (en) | 2004-11-04 | 2008-07-02 | Neurogen Corp | ARYL ALKYL UREA AS CB1 ANTAGONISTS |
GB0425196D0 (en) | 2004-11-15 | 2004-12-15 | Black James Foundation | Gastrin and cholecystokinin receptor ligands |
US20090291977A1 (en) | 2004-12-17 | 2009-11-26 | Madoka Jinno | Chromane Derivatives Useful As Acid Pump Antagonists |
SI1839662T1 (sl) | 2005-01-19 | 2010-07-30 | Zeria Pharm Co Ltd | Antitumorsko sredstvo |
AR053713A1 (es) | 2005-04-20 | 2007-05-16 | Xenon Pharmaceuticals Inc | Compuestos heterociclicos y sus usos como agentes terapeuticos |
JP5197361B2 (ja) | 2005-06-06 | 2013-05-15 | ザ ボード オブ トラスティーズ オブ ザ ユニヴァーシティー オブ イリノイ | 睡眠障害を処置するための組成物および方法 |
ATE442140T1 (de) | 2005-06-14 | 2009-09-15 | Raqualia Pharma Inc | Chroman-substituierte benzimidazolderivate als säurepumpenantagonisten |
EP1747800B1 (en) | 2005-07-29 | 2009-03-18 | Rottapharm S.p.A. | Combination of itriglumide and proton pump inhibitors in the treatment of gastrointestinal and related disorders |
WO2007026218A2 (en) | 2005-09-01 | 2007-03-08 | Pfizer Japan Inc. | Chromane substituted 2-alkyl imidazopyridine derivatives and use thereof as acid pump antagonists |
WO2007031860A1 (en) | 2005-09-15 | 2007-03-22 | Pfizer Japan Inc. | Indane substituted benzimidazoles and their use as acid pump inhibitors |
WO2007072142A2 (en) | 2005-12-19 | 2007-06-28 | Pfizer Japan Inc. | Benzimidazole-5-carboxamide derivatives |
ATE471319T1 (de) | 2005-12-19 | 2010-07-15 | Raqualia Pharma Inc | Chromansubstituierte benzimidazole und ihre verwendung als säurepumpenhemmer |
JP2009530262A (ja) | 2006-03-17 | 2009-08-27 | ラクオリア創薬株式会社 | クロマン誘導体 |
WO2007115670A1 (en) | 2006-04-12 | 2007-10-18 | Merck Patent Gmbh | N-oxides of heterocyclic substituted bisarylureas for treating kinase-mediated diseases |
FR2901472B1 (fr) | 2006-05-24 | 2010-08-13 | Oreal | Procede de defrisage des fibres keratiniques avec un moyen de chauffage et des agents denaturants |
FR2901473B1 (fr) | 2006-05-24 | 2010-08-13 | Oreal | Procede de defrisage des fibres keratiniques avec un moyen de chauffage et une amide |
ATE512969T1 (de) | 2006-09-21 | 2011-07-15 | Raqualia Pharma Inc | Benzimidazolderivate als selektive säurepumpenhemmer |
WO2008046082A2 (en) | 2006-10-12 | 2008-04-17 | Xenon Pharmaceuticals Inc. | Use of heterocyclic compounds as therapeutic agents |
WO2008059373A1 (es) | 2006-11-17 | 2008-05-22 | Raqualia Pharma Inc. | Vacuna contra la malaria, basada en la subunidad 200l de la proteína msp1 de plasmodium vivax. |
JP2008222557A (ja) | 2007-03-08 | 2008-09-25 | Kotobuki Seiyaku Kk | ピロロ[3,2−d]ピリミジン誘導体及びこれを有効成分とする医薬組成物 |
WO2008114123A1 (en) | 2007-03-21 | 2008-09-25 | Raqualia Pharma Inc. | Spiro benzimidazole derivatives as acid pump inhibitors |
WO2008124518A1 (en) | 2007-04-03 | 2008-10-16 | Janssen Pharmaceutica N.V. | Oxo-dihydroisoindole sulfonamide compounds as modulators of the cck2 receptor |
WO2008124524A2 (en) | 2007-04-03 | 2008-10-16 | Janssen Pharmaceutica N.V. | Aryl sulfonamide compounds as modulators of the cck2 receptor |
CN101687815A (zh) | 2007-06-26 | 2010-03-31 | 塞诺菲-安万特股份有限公司 | 苯并咪唑和氮杂苯并咪唑的区域选择性铜催化合成 |
RU2379043C2 (ru) * | 2007-08-02 | 2010-01-20 | Закрытое акционерное общество "Биологические исследования и системы" | Фармацевтическая композиция для профилактики и лечения остеопороза у женщин в период менопаузы |
WO2009020768A1 (en) | 2007-08-07 | 2009-02-12 | President And Fellows Of Harvard College | Targeting the oncoprotein nucleophosmin |
TW201011009A (en) | 2008-09-15 | 2010-03-16 | Priaxon Ag | Novel pyrrolidin-2-ones |
WO2010036316A1 (en) | 2008-09-24 | 2010-04-01 | Yangbo Feng | Urea and carbamate compounds and analogs as kinase inhibitors |
CN102333763A (zh) | 2009-03-31 | 2012-01-25 | 善利亚新药工业股份有限公司 | 1,5-苯二氮䓬衍生物的制备方法 |
US8648080B2 (en) | 2009-07-09 | 2014-02-11 | Raqualia Pharma Inc. | Acid pump antagonist for the treatment of diseases involved in abnormal gastrointestinal motility |
US20130029967A1 (en) | 2009-09-24 | 2013-01-31 | Centro Nacional De Investigaciones Oncologicas (Cnio) | Fused Imidazo [3,2 - D] Pyrazines as P13 Kinase Inhibitors |
EP3070077B1 (en) | 2009-10-06 | 2018-11-28 | Millennium Pharmaceuticals, Inc. | Heterocyclic compounds useful as pdk1 inhibitors |
AU2010319298B2 (en) | 2009-11-13 | 2015-11-05 | Plastipak Packaging, Inc. | Oxygen scavengers, compositions comprising the scavengers, and articles made from the compositions |
WO2011063164A2 (en) | 2009-11-18 | 2011-05-26 | Steady Sleep Rx Co., Inc. | Sustained release cannabinoid medicaments |
US8927561B2 (en) | 2010-04-23 | 2015-01-06 | Kineta, Inc. | Pyrimidinedione anti-viral compounds |
WO2012021837A2 (en) | 2010-08-12 | 2012-02-16 | Senomyx, Inc. | Method of improving stability of sweet enhancer and composition containing stabilized sweet enhancer |
US20120231083A1 (en) | 2010-11-18 | 2012-09-13 | The Board Of Trustees Of The University Of Illinois | Sustained release cannabinoid medicaments |
WO2012068516A2 (en) | 2010-11-18 | 2012-05-24 | Pier Pharmaceuticals | Low dose cannabinoid medicaments |
DK2835131T3 (en) | 2010-12-14 | 2017-12-04 | Electrophoretics Ltd | Casein kinase 1 delta inhibitors (CK1 delta) |
WO2013017479A1 (en) | 2011-07-29 | 2013-02-07 | Cellzome Limited | Pyrazolo[4,3-c]pyridine derivatives as jak inhibitors |
WO2013017480A1 (en) | 2011-07-29 | 2013-02-07 | Cellzome Limited | Pyrazolo[4,3-c]pyridine derivatives as jak inhibitors |
JP6210996B2 (ja) | 2011-11-07 | 2017-10-11 | マサチューセッツ インスティテュート オブ テクノロジー | Z選択的オレフィンメタセシスのためのタングステンオキソアルキリデン錯体 |
US10080805B2 (en) | 2012-02-24 | 2018-09-25 | Purdue Research Foundation | Cholecystokinin B receptor targeting for imaging and therapy |
WO2013158928A2 (en) | 2012-04-18 | 2013-10-24 | Elcelyx Therapeutics, Inc. | Chemosensory receptor ligand-based therapies |
TWI610916B (zh) | 2012-08-03 | 2018-01-11 | 廣東東陽光藥業有限公司 | 作爲丙型肝炎抑制劑的橋環化合物及其在藥物中的應用 |
US8952009B2 (en) | 2012-08-06 | 2015-02-10 | Amgen Inc. | Chroman derivatives as TRPM8 inhibitors |
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2014
- 2014-11-21 PL PL14815149T patent/PL3071206T3/pl unknown
- 2014-11-21 RU RU2016124538A patent/RU2693484C1/ru active
- 2014-11-21 AU AU2014352875A patent/AU2014352875B2/en active Active
- 2014-11-21 BR BR112016011727A patent/BR112016011727A2/pt not_active Application Discontinuation
- 2014-11-21 KR KR1020167015759A patent/KR102254957B1/ko active IP Right Grant
- 2014-11-21 US US14/550,233 patent/US10709714B2/en active Active
- 2014-11-21 JP JP2016533607A patent/JP6502939B2/ja active Active
- 2014-11-21 MX MX2016006657A patent/MX2016006657A/es unknown
- 2014-11-21 CA CA2929858A patent/CA2929858C/en active Active
- 2014-11-21 WO PCT/US2014/066832 patent/WO2015077572A1/en active Application Filing
- 2014-11-21 EP EP14815149.1A patent/EP3071206B1/en active Active
- 2014-11-21 CN CN201480073822.0A patent/CN106163527A/zh active Pending
- 2014-11-21 ES ES14815149T patent/ES2870538T3/es active Active
- 2014-11-21 DK DK14815149.1T patent/DK3071206T3/da active
Also Published As
Publication number | Publication date |
---|---|
BR112016011727A2 (pt) | 2017-08-08 |
KR102254957B1 (ko) | 2021-05-25 |
US10709714B2 (en) | 2020-07-14 |
RU2693484C1 (ru) | 2019-07-03 |
WO2015077572A1 (en) | 2015-05-28 |
AU2014352875A1 (en) | 2016-05-26 |
CA2929858C (en) | 2022-03-29 |
DK3071206T3 (da) | 2021-05-25 |
CN106163527A (zh) | 2016-11-23 |
EP3071206B1 (en) | 2021-02-17 |
KR20160088891A (ko) | 2016-07-26 |
PL3071206T3 (pl) | 2022-01-17 |
JP2016538295A (ja) | 2016-12-08 |
EP3071206A1 (en) | 2016-09-28 |
CA2929858A1 (en) | 2015-05-28 |
AU2014352875B2 (en) | 2019-10-24 |
US20150148339A1 (en) | 2015-05-28 |
JP6502939B2 (ja) | 2019-04-17 |
AU2014352875A8 (en) | 2016-06-30 |
ES2870538T3 (es) | 2021-10-27 |
RU2016124538A (ru) | 2017-12-27 |
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