MX2015015476A - Un metodo para medir sustancias relacionadas con el cancer mediante espectroscopia raman. - Google Patents

Un metodo para medir sustancias relacionadas con el cancer mediante espectroscopia raman.

Info

Publication number
MX2015015476A
MX2015015476A MX2015015476A MX2015015476A MX2015015476A MX 2015015476 A MX2015015476 A MX 2015015476A MX 2015015476 A MX2015015476 A MX 2015015476A MX 2015015476 A MX2015015476 A MX 2015015476A MX 2015015476 A MX2015015476 A MX 2015015476A
Authority
MX
Mexico
Prior art keywords
cancer
related substance
raman
quantification method
biochip
Prior art date
Application number
MX2015015476A
Other languages
English (en)
Inventor
Hiroaki Ito
Yuki Hasegawa
Katsuyuki Hasegawa
Original Assignee
Mytech Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=51867292&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MX2015015476(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Mytech Co Ltd filed Critical Mytech Co Ltd
Publication of MX2015015476A publication Critical patent/MX2015015476A/es

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/65—Raman scattering
    • G01N21/658—Raman scattering enhancement Raman, e.g. surface plasmons
    • C—CHEMISTRY; METALLURGY
    • C01—INORGANIC CHEMISTRY
    • C01G—COMPOUNDS CONTAINING METALS NOT COVERED BY SUBCLASSES C01D OR C01F
    • C01G5/00—Compounds of silver
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366—Apparatus specially adapted for solid-phase testing
    • G01N33/54373—Apparatus specially adapted for solid-phase testing involving physiochemical end-point determination, e.g. wave-guides, FETS, gratings
    • G01N33/5438—Electrodes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/551—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being inorganic
    • G01N33/553—Metal or metal coated
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57484—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites
    • G01N33/57496—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites involving intracellular compounds
    • C—CHEMISTRY; METALLURGY
    • C01—INORGANIC CHEMISTRY
    • C01P—INDEXING SCHEME RELATING TO STRUCTURAL AND PHYSICAL ASPECTS OF SOLID INORGANIC COMPOUNDS
    • C01P2002/00—Crystal-structural characteristics
    • C01P2002/60—Compounds characterised by their crystallite size

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Cell Biology (AREA)
  • General Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Inorganic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Hospice & Palliative Care (AREA)
  • Oncology (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

La invención se refiere a un método para medir sustancias relacionadas con el cáncer incluyendo el ADN libre derivado de células cancerosas por medio de espectroscopía de Raman; el método de medición se caracteriza porque involucra pasos para preparar un biochip que tiene una región de mesocristal de óxidos de plata que contienen un peróxido de plata, agregar una solución de suero sanguíneo o de muestra biológica mediante goteo en la región de mesocristal de dicho biochip, atrapar de manera selectiva las sustancias relacionadas con el cáncer que tienen una carga positiva en la muestra, irradiar la sustancia relacionada con el cáncer atrapada con una luz láser excitante y detectar una dispersión Raman mejorada por superficie de la misma, en donde se evaluan las enfermedades de cáncer con base en la intensidad de la Dispersión Raman Mejorada por Superficie (SERS); en las bandas especificas al carbono D y G en el espectro de dispersión de Raman, un espectro de pico característico de la sustancia relacionada con el cáncer puede detectarse en la proximidad de la característica del grupo metilo 2900 cm-1.
MX2015015476A 2013-05-08 2014-05-08 Un metodo para medir sustancias relacionadas con el cancer mediante espectroscopia raman. MX2015015476A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2013098608 2013-05-08
PCT/JP2014/062318 WO2014181816A1 (ja) 2013-05-08 2014-05-08 癌関連物質のラマン定量方法

Publications (1)

Publication Number Publication Date
MX2015015476A true MX2015015476A (es) 2016-07-07

Family

ID=51867292

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2015015476A MX2015015476A (es) 2013-05-08 2014-05-08 Un metodo para medir sustancias relacionadas con el cancer mediante espectroscopia raman.

Country Status (16)

Country Link
US (2) US10365222B2 (es)
EP (2) EP2995935B1 (es)
JP (5) JP6294614B2 (es)
KR (1) KR102162706B1 (es)
CN (2) CN105452850B (es)
AU (1) AU2014263556A1 (es)
BR (1) BR112015028026A2 (es)
CA (1) CA2911744C (es)
CL (1) CL2015003261A1 (es)
EA (1) EA037886B1 (es)
IL (1) IL242470B (es)
MX (1) MX2015015476A (es)
MY (1) MY174717A (es)
PH (2) PH12015502537A1 (es)
SG (1) SG11201509034XA (es)
WO (2) WO2014181816A1 (es)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6294614B2 (ja) * 2013-05-08 2018-03-14 有限会社マイテック 癌関連物質の定量方法
JP6312393B2 (ja) * 2013-09-25 2018-04-18 有限会社マイテック 多能性幹細胞の判別方法
JP2015182923A (ja) * 2014-03-25 2015-10-22 有限会社マイテック 過酸化銀を含む銀酸化物メソ結晶及びその製造方法
CA2948353C (en) 2014-05-08 2021-12-14 Mytech Co., Ltd. A plasmonic chip and a diagnostic method for observation of a fluorescence image and raman spectroscopy of cancer-related substance on the plasmonic chips
US10874333B2 (en) * 2015-09-15 2020-12-29 Massachusetts Institute Of Technology Systems and methods for diagnosis of middle ear conditions and detection of analytes in the tympanic membrane
US20170354950A1 (en) * 2016-06-14 2017-12-14 Mytech Co., Ltd. Silver oxide meso crystal containing silver peroxide and manufacturing method therefor
GB201704128D0 (en) * 2017-03-15 2017-04-26 Univ Swansea Method and apparatus for use in diagnosis and monitoring of colorectal cancer
KR102086583B1 (ko) * 2018-03-20 2020-03-09 (주)광림정공 바이오센서 칩 및 암 진단 시스템
JP2021156576A (ja) * 2018-06-21 2021-10-07 有限会社マイテック 疾病関連タンパク結合体を標的とする自家蛍光によるリキッド・バイオプシィ法
RU2723160C1 (ru) * 2019-08-15 2020-06-09 Федеральное государственное бюджетное образовательное учреждение высшего образования "Московский государственный университет имени М.В. Ломоносова" (МГУ) Способ обнаружения и определения днк с заданной последовательностью методом спектроскопии гигантского комбинационного рассеяния
KR20210131078A (ko) 2020-04-23 2021-11-02 동아대학교 산학협력단 생체 조직 내 탄소 나노물질의 정량 방법
CN112461810A (zh) * 2020-11-19 2021-03-09 河南科技大学第一附属医院 一种基于sers技术的格列齐特药片的检测方法
KR20220134419A (ko) 2021-03-26 2022-10-05 삼성전자주식회사 카이롭티컬 분광 플랫폼, 및 이를 이용한 라만 데이터 획득 방법
CN115078331B (zh) * 2021-09-07 2024-03-29 武汉大学 一种光谱学和人工智能交互的血清分析方法及其应用
JP2023074685A (ja) * 2021-11-18 2023-05-30 浜松ホトニクス株式会社 被検体分析方法
KR102559438B1 (ko) * 2022-08-18 2023-07-26 주식회사 엑소퍼트 엑소좀 sers 신호를 이용한 인공지능 기반의 다중암 동시 진단 시스템 및 그 방법

Family Cites Families (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS57128845A (en) * 1981-02-04 1982-08-10 Fuji Photo Film Co Ltd Measuring method for concentration of silver in solution
US5255067A (en) * 1990-11-30 1993-10-19 Eic Laboratories, Inc. Substrate and apparatus for surface enhanced Raman spectroscopy
US6143529A (en) 1996-08-14 2000-11-07 Exact Laboratories, Inc. Methods for improving sensitivity and specificity of screening assays
JP4128753B2 (ja) * 2001-03-14 2008-07-30 独立行政法人産業技術総合研究所 分子センサ
AU2003230799A1 (en) * 2002-04-05 2003-10-27 Massachusetts Institute Of Technology Systems and methods for spectroscopy of biological tissue
US20040259101A1 (en) 2003-06-20 2004-12-23 Shuber Anthony P. Methods for disease screening
US20050148098A1 (en) 2003-12-30 2005-07-07 Xing Su Methods for using raman spectroscopy to obtain a protein profile of a biological sample
EP1817042A2 (en) * 2004-11-15 2007-08-15 Board of Regents, The University of Texas System Glycerin based synthesis of silver nanoparticles and nanowires
JP2008529487A (ja) * 2005-02-07 2008-08-07 トポターゲット ユーケー リミテッド Ｈｄａｃ耐性細胞株に選択的細胞傷害性を有する薬剤のアッセイ
JP2006349463A (ja) * 2005-06-15 2006-12-28 Canon Inc 表面増強ラマン分光分析用治具及びその製造方法
JPWO2008090930A1 (ja) 2007-01-23 2010-05-20 オリンパス株式会社 癌の診断方法
KR20080090930A (ko) 2007-04-06 2008-10-09 삼성테크윈 주식회사 반도체 패키지용 기판 및 그 제조방법
KR100892629B1 (ko) * 2007-06-29 2009-04-08 한국과학기술원 표면 증강 라만 분광용 광 센서
JP2009014491A (ja) 2007-07-04 2009-01-22 Canon Inc 標的物質検出用素子および標的物質検出装置
WO2009090915A1 (ja) * 2008-01-17 2009-07-23 Nichia Corporation 導電性材料の製造方法、その方法により得られた導電性材料、その導電性材料を含む電子機器、発光装置、発光装置製造方法
JP4873510B2 (ja) * 2008-07-01 2012-02-08 学校法人日本大学 標的遺伝子特異的ヒストン修飾制御剤
EP2352999A4 (en) * 2008-10-15 2012-12-26 Univ Cornell EXTENDED ON-CHIP-SERS-BASED BIOMOLECULAR PROOF PROCEDURE BASED ON ELECTRO-KINETIC ACTIVE MICROWAVES
KR20120022754A (ko) * 2009-03-04 2012-03-12 유키 하세가와 표면 증강 라먼 산란 활성 측정 기판
US8269257B2 (en) * 2009-07-29 2012-09-18 Massachusetts Institute Of Technology Nanowire synthesis
KR101059896B1 (ko) 2009-10-12 2011-08-29 한국과학기술원 표면증강 라만산란을 이용한 생화학 물질의 검출 방법
JP5835584B2 (ja) * 2010-06-15 2015-12-24 日産化学工業株式会社 表面増強ラマン散乱用金属粒子及び分子センシング
KR101832206B1 (ko) * 2010-09-06 2018-02-26 유겐가이샤 마이테크 금속 착체 양자 결정의 제조 방법
US9006458B2 (en) * 2010-10-12 2015-04-14 Agency For Science, Technology And Research Surface Enhanced Raman Spectroscopy (SERS) compounds and methods of their preparation
JP6196159B2 (ja) * 2011-10-31 2017-09-13 有限会社マイテック 金属錯体量子結晶及びそれを用いる生化学物質の表面増強ラマン散乱（ｓｅｒｓ）分析法
JP6054030B2 (ja) * 2011-12-23 2016-12-27 有限会社マイテック 金属錯体量子結晶の作成方法
CN102608102A (zh) * 2012-03-24 2012-07-25 南京师范大学 一种基于表面增强拉曼光谱的人乳腺癌细胞mcf-7的特异性检测方法
CN102721680B (zh) * 2012-06-18 2014-12-03 复旦大学 一种高灵敏检测t-DNA的SERS液相芯片方法
JP6294614B2 (ja) * 2013-05-08 2018-03-14 有限会社マイテック 癌関連物質の定量方法

Also Published As

Publication number Publication date
JP6457935B2 (ja) 2019-01-23
CA2911744A1 (en) 2014-11-13
JP2014238384A (ja) 2014-12-18
KR20160019419A (ko) 2016-02-19
PH12015502537B1 (en) 2016-02-22
SG11201509034XA (en) 2016-01-28
CN107202786B (zh) 2019-10-25
WO2014181814A1 (ja) 2014-11-13
US20160187344A1 (en) 2016-06-30
MY174717A (en) 2020-05-10
KR102162706B1 (ko) 2020-10-07
CN105452850A (zh) 2016-03-30
EP2995935A1 (en) 2016-03-16
JP6529015B2 (ja) 2019-06-12
JPWO2014181816A1 (ja) 2017-02-23
CN107202786A (zh) 2017-09-26
JP6294621B2 (ja) 2018-03-14
PH12015502537A1 (en) 2016-02-22
BR112015028026A2 (pt) 2017-07-25
EP2995935A4 (en) 2017-03-15
IL242470B (en) 2020-09-30
JP2014238382A (ja) 2014-12-18
CN105452850B (zh) 2018-12-28
US9535069B2 (en) 2017-01-03
JPWO2014181814A1 (ja) 2017-02-23
US10365222B2 (en) 2019-07-30
EP3054285A1 (en) 2016-08-10
JP6294614B2 (ja) 2018-03-14
JP2017223678A (ja) 2017-12-21
EP2995935B1 (en) 2020-09-23
EA037886B1 (ru) 2021-06-01
US20170248523A1 (en) 2017-08-31
PH12019502307A1 (en) 2021-02-15
EP3054285A4 (en) 2017-09-06
CA2911744C (en) 2021-04-27
CL2015003261A1 (es) 2016-05-27
AU2014263556A1 (en) 2015-11-26
EA201592123A1 (ru) 2016-06-30
WO2014181816A1 (ja) 2014-11-13

Similar Documents

Publication Publication Date Title
PH12019502307A1 (en) Raman quantification method of cancer-related substance
WO2012070893A3 (ko) 코어 물질과 쉘 물질 사이에 나노갭이 형성된 단일 나노입자 및 이의 제조방법
EP3080585A4 (en) Biosensors for biological or chemical analysis and methods of manufacturing the same
NZ728582A (en) Instrument for analyzing biological samples and reagents
MY176182A (en) Biosensor based on measurements of the clustering dynamics of magnetic particles
HK1208071A1 (en) Multi-application approach for photometric determination of an analyte in a fluid sample on an automated analyzer
WO2011116006A3 (en) A rapid method to measure cyanide in biological samples
EP3800253A3 (en) Prostate cancer detection kit or device, and detection method
NZ726748A (en) A method of observing an auto fluorescence image of a cancer related substance through a fluorescence microscope
WO2013015810A3 (en) Surface enhanced raman spectroscopy employing a nanorod in a surface indentation
EP2557413A3 (en) Blood analysis apparatus and blood analysis method
GB201113138D0 (en) Method, system and device for detecting insects and other pests
MY181697A (en) Tracer and method of identifying tracer in product
WO2012149410A3 (en) Methods of collecting and analyzing samples
MX2014012406A (es) Tecnicas de analisis espectral para monitoreo de fluidos.
MX2015013310A (es) Metodo y reactivo para determinar metabolitos de la vitamina d.
EP3736571A4 (en) METHOD, REAGENT AND CHIP FOR MEASURING THE ANALYTE CONCENTRATION IN A BIOLOGICAL SAMPLE
IN2015DN01608A (es)
WO2011144900A3 (en) Transdermal device
EA201500377A1 (ru) Способ обнаружения анализируемого вещества и определение его концентрации с использованием намагничиваемых гранул
EP2809768A4 (en) METHOD AND DEVICE FOR FAST, HIGHLY SENSITIVE ANALYSIS OF SMALL VOLUME SAMPLES OF BIOLOGICAL MATERIALS
HUE040627T2 (hu) Gyorsteszt testfolyadékokban található humán papilloma vírusok elleni antitestek kvalitatív és/vagy kvantitatív analízisére és a gyorsteszt megvalósítására alkalmas berendezés
CL2014002976A1 (es) Metodo de analisis de una muestra biologica de un sujeto con cancer utilizando biomarcadores tnf, ripk1, cxl10, ccl5, nfkbia, herc5, cdyl, stk39 y mapk14 para la terapia inhibitoria con iap.
MX341439B (es) Metodos para analizar sustancias que contienen uno o mas compuestos de organoazufre utilizando un elemento computacional integrado.
MX2014012099A (es) Tecnicas de analisis espectral basadas en monitoreo espectral de una matriz.