MX2014014361A - Anticuerpos anti-egfr y usos de los mismos. - Google Patents
Anticuerpos anti-egfr y usos de los mismos.Info
- Publication number
- MX2014014361A MX2014014361A MX2014014361A MX2014014361A MX2014014361A MX 2014014361 A MX2014014361 A MX 2014014361A MX 2014014361 A MX2014014361 A MX 2014014361A MX 2014014361 A MX2014014361 A MX 2014014361A MX 2014014361 A MX2014014361 A MX 2014014361A
- Authority
- MX
- Mexico
- Prior art keywords
- antibodies
- egfr
- bind
- certain embodiments
- present
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
- A61K2039/507—Comprising a combination of two or more separate antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
Abstract
La presente invención proporciona anticuerpos que se unen a EGFR y métodos de uso de los mismos. De acuerdo con ciertas realizaciones de la invención, los anticuerpos son anticuerpos completamente humanos que se unen a EGFR con una afinidad elevada. En ciertas realizaciones, los anticuerpos de la presente invención son capaces de inhibir el crecimiento de células tumorales que expresan niveles elevados de EGFR y/o inducir citotoxicidad mediada por células dependiente de anticuerpos (ADCC) de tales células. Los anticuerpos de la invención son útiles para el tratamiento de diferentes cánceres así como de otros trastornos relacionados con EGFR.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201261663984P | 2012-06-25 | 2012-06-25 | |
US201361821000P | 2013-05-08 | 2013-05-08 | |
PCT/US2013/047476 WO2014004427A2 (en) | 2012-06-25 | 2013-06-25 | Anti-egfr antibodies and uses thereof |
Publications (2)
Publication Number | Publication Date |
---|---|
MX2014014361A true MX2014014361A (es) | 2015-02-05 |
MX356329B MX356329B (es) | 2018-05-24 |
Family
ID=48782632
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2014014361A MX356329B (es) | 2012-06-25 | 2013-06-25 | Anticuerpos anti-egfr y usos de los mismos. |
Country Status (24)
Country | Link |
---|---|
US (3) | US9132192B2 (es) |
EP (1) | EP2864357B1 (es) |
JP (1) | JP6486268B2 (es) |
KR (1) | KR20150023387A (es) |
CN (1) | CN104411722B (es) |
AR (1) | AR091545A1 (es) |
AU (2) | AU2013280610B2 (es) |
BR (1) | BR112014029099A2 (es) |
CA (1) | CA2876697C (es) |
CL (1) | CL2014003465A1 (es) |
CO (1) | CO7160093A2 (es) |
EA (1) | EA030421B1 (es) |
ES (1) | ES2816645T3 (es) |
HK (1) | HK1206040A1 (es) |
IL (1) | IL235392B (es) |
MX (1) | MX356329B (es) |
MY (2) | MY181086A (es) |
NZ (1) | NZ701633A (es) |
PH (1) | PH12014502437B1 (es) |
SG (3) | SG10201610590UA (es) |
TW (2) | TWI641619B (es) |
UY (1) | UY34876A (es) |
WO (1) | WO2014004427A2 (es) |
ZA (1) | ZA201407927B (es) |
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US9273143B2 (en) * | 2011-09-30 | 2016-03-01 | Regeneron Pharmaceuticals, Inc. | Methods and compositions comprising a combination of an anti-ErbB3 antibody and an anti-EGFR antibody |
MX357391B (es) | 2011-09-30 | 2018-07-06 | Regeneron Pharma | Anticuerpos anti-erbb3 y usos de los mismos. |
WO2014151649A1 (en) * | 2013-03-15 | 2014-09-25 | Alper Biotech, Llc | Monoclonal antibodies to egfr, and uses therefor |
US10844127B2 (en) | 2014-02-28 | 2020-11-24 | Merus N.V. | Antibodies that bind EGFR and ErbB3 |
BR122018009619B1 (pt) | 2014-05-16 | 2024-01-02 | Ablynx N.V | Domínios variáveis de imunoglobulina aperfeiçoados |
RU2746738C2 (ru) | 2014-05-16 | 2021-04-20 | Аблинкс Нв | Улучшенные вариабельные домены иммуноглобулина |
TW202340452A (zh) | 2015-08-04 | 2023-10-16 | 美商再生元醫藥公司 | 補充牛磺酸之細胞培養基及用法 |
CN105017424B (zh) * | 2015-08-31 | 2021-02-09 | 北京泱深生物信息技术有限公司 | 一种egfr抗体可变区及其应用 |
MX2018004988A (es) | 2015-10-23 | 2018-11-09 | Merus Nv | Moleculas de union que inhibe el crecimiento de cancer. |
CN108602890A (zh) | 2015-12-11 | 2018-09-28 | 瑞泽恩制药公司 | 用于减少或预防对egfr和/或erbb3阻滞剂具有抗性的肿瘤生长的方法 |
WO2018039499A1 (en) | 2016-08-24 | 2018-03-01 | Regeneron Pharmaceuticals, Inc. | Host cell protein modification |
BR112019020508A2 (pt) | 2017-03-31 | 2020-08-04 | Merus N.V. | anticorpos biespecíficos de ligação a erbb-2 e erbb3 para utilização no tratamento de células que possuem um gene de fusão nrg1 |
TW201934570A (zh) | 2017-07-06 | 2019-09-01 | 美商雷傑納榮製藥公司 | 供製備糖蛋白之細胞培養方法 |
JP2020530028A (ja) | 2017-08-09 | 2020-10-15 | メルス ナムローゼ フェンノートシャップ | EGFR及びcMETに結合する抗体 |
WO2019114793A1 (zh) * | 2017-12-13 | 2019-06-20 | 凯惠科技发展(上海)有限公司 | 一种egfr抗体及其制备方法和应用 |
MX2020006639A (es) | 2017-12-22 | 2020-09-14 | Regeneron Pharma | Sistema y metodo para caracterizar las impurezas de un producto farmaceutico. |
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TW202311746A (zh) | 2018-02-02 | 2023-03-16 | 美商再生元醫藥公司 | 用於表徵蛋白質二聚合之系統及方法 |
MX2020008988A (es) | 2018-02-28 | 2020-09-28 | Regeneron Pharma | Sistemas y metodos para la identificacion de contaminantes virales. |
EP3765498A1 (en) * | 2018-03-14 | 2021-01-20 | F. Hoffmann-La Roche AG | Method for affinity maturation of antibodies |
EP4317959A3 (en) | 2018-03-19 | 2024-03-27 | Regeneron Pharmaceuticals, Inc. | Microchip capillary electrophoresis assays and reagents |
TW202016125A (zh) | 2018-05-10 | 2020-05-01 | 美商再生元醫藥公司 | 用於定量及調節蛋白質黏度之系統與方法 |
CN108680746A (zh) * | 2018-06-05 | 2018-10-19 | 中国科学院合肥物质科学研究院 | 一种控制肺癌细胞活力的分子靶标及其应用 |
MX2021002279A (es) | 2018-08-27 | 2021-05-27 | Regeneron Pharma | Uso de espectroscopia raman en la purificacion corriente abajo. |
CN112601963A (zh) | 2018-08-30 | 2021-04-02 | 瑞泽恩制药公司 | 用于表征蛋白质复合物的方法 |
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BR112021018442A2 (pt) * | 2019-03-22 | 2022-01-11 | Regeneron Pharma | Anticorpos multiespecíficos egfr x cd28 |
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US11835527B2 (en) | 2020-01-21 | 2023-12-05 | Regeneron Pharmaceuticals, Inc. | Deglycosylation methods for electrophoresis of glycosylated proteins |
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TW202314240A (zh) | 2021-06-01 | 2023-04-01 | 美商再生元醫藥公司 | 微晶片毛細管電泳分析及試劑 |
TW202326138A (zh) | 2021-09-08 | 2023-07-01 | 美商再生元醫藥公司 | 用於定量抗體及其他含Fc蛋白之高通量及基於質譜之方法 |
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US20230116199A1 (en) | 2021-10-07 | 2023-04-13 | Regeneron Pharmaceuticals, Inc. | Systems and methods of ph modeling and control |
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IL85035A0 (en) | 1987-01-08 | 1988-06-30 | Int Genetic Eng | Polynucleotide molecule,a chimeric antibody with specificity for human b cell surface antigen,a process for the preparation and methods utilizing the same |
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2013
- 2013-06-20 TW TW102121841A patent/TWI641619B/zh not_active IP Right Cessation
- 2013-06-20 TW TW107129255A patent/TW201843172A/zh unknown
- 2013-06-25 MY MYPI2017704291A patent/MY181086A/en unknown
- 2013-06-25 AU AU2013280610A patent/AU2013280610B2/en active Active
- 2013-06-25 EP EP13735519.4A patent/EP2864357B1/en active Active
- 2013-06-25 CN CN201380033859.6A patent/CN104411722B/zh not_active Expired - Fee Related
- 2013-06-25 EA EA201590085A patent/EA030421B1/ru not_active IP Right Cessation
- 2013-06-25 JP JP2015518639A patent/JP6486268B2/ja active Active
- 2013-06-25 WO PCT/US2013/047476 patent/WO2014004427A2/en active Application Filing
- 2013-06-25 UY UY34876A patent/UY34876A/es unknown
- 2013-06-25 US US13/925,923 patent/US9132192B2/en active Active
- 2013-06-25 MX MX2014014361A patent/MX356329B/es active IP Right Grant
- 2013-06-25 SG SG10201610590UA patent/SG10201610590UA/en unknown
- 2013-06-25 AR ARP130102231 patent/AR091545A1/es unknown
- 2013-06-25 BR BR112014029099A patent/BR112014029099A2/pt not_active Application Discontinuation
- 2013-06-25 SG SG11201407163XA patent/SG11201407163XA/en unknown
- 2013-06-25 CA CA2876697A patent/CA2876697C/en active Active
- 2013-06-25 KR KR20147035064A patent/KR20150023387A/ko not_active Application Discontinuation
- 2013-06-25 MY MYPI2014003097A patent/MY164604A/en unknown
- 2013-06-25 ES ES13735519T patent/ES2816645T3/es active Active
- 2013-06-25 NZ NZ701633A patent/NZ701633A/en not_active IP Right Cessation
- 2013-06-25 SG SG10201804151QA patent/SG10201804151QA/en unknown
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2014
- 2014-10-29 IL IL235392A patent/IL235392B/en active IP Right Grant
- 2014-10-30 PH PH12014502437A patent/PH12014502437B1/en unknown
- 2014-10-30 ZA ZA2014/07927A patent/ZA201407927B/en unknown
- 2014-12-19 CL CL2014003465A patent/CL2014003465A1/es unknown
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2015
- 2015-07-13 HK HK15106655.6A patent/HK1206040A1/xx unknown
- 2015-08-06 US US14/820,324 patent/US9789184B2/en active Active
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2017
- 2017-09-11 US US15/700,665 patent/US20180036405A1/en not_active Abandoned
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2018
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