SG10201610590UA - Anti-egfr antibodies and uses thereof - Google Patents

Anti-egfr antibodies and uses thereof

Info

Publication number
SG10201610590UA
SG10201610590UA SG10201610590UA SG10201610590UA SG10201610590UA SG 10201610590U A SG10201610590U A SG 10201610590UA SG 10201610590U A SG10201610590U A SG 10201610590UA SG 10201610590U A SG10201610590U A SG 10201610590UA SG 10201610590U A SG10201610590U A SG 10201610590UA
Authority
SG
Singapore
Prior art keywords
egfr antibodies
egfr
antibodies
Prior art date
Application number
SG10201610590UA
Inventor
Christopher Daly
Gavin Thurston
Nicholas J Padadopoulos
Original Assignee
Regeneron Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Regeneron Pharma filed Critical Regeneron Pharma
Publication of SG10201610590UA publication Critical patent/SG10201610590UA/en

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39558Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/12Drugs for disorders of the urinary system of the kidneys
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2863Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/505Medicinal preparations containing antigens or antibodies comprising antibodies
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/505Medicinal preparations containing antigens or antibodies comprising antibodies
    • A61K2039/507Comprising a combination of two or more separate antibodies
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/20Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565Complementarity determining region [CDR]
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/732Antibody-dependent cellular cytotoxicity [ADCC]
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/90Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/90Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94Stability, e.g. half-life, pH, temperature or enzyme-resistance

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Endocrinology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Oncology (AREA)
  • Biomedical Technology (AREA)
  • Dermatology (AREA)
  • Pulmonology (AREA)
  • Nutrition Science (AREA)
  • Reproductive Health (AREA)
  • Urology & Nephrology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
SG10201610590UA 2012-06-25 2013-06-25 Anti-egfr antibodies and uses thereof SG10201610590UA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261663984P 2012-06-25 2012-06-25
US201361821000P 2013-05-08 2013-05-08

Publications (1)

Publication Number Publication Date
SG10201610590UA true SG10201610590UA (en) 2017-02-27

Family

ID=48782632

Family Applications (3)

Application Number Title Priority Date Filing Date
SG11201407163XA SG11201407163XA (en) 2012-06-25 2013-06-25 Anti-egfr antibodies and uses thereof
SG10201804151QA SG10201804151QA (en) 2012-06-25 2013-06-25 Anti-egfr antibodies and uses thereof
SG10201610590UA SG10201610590UA (en) 2012-06-25 2013-06-25 Anti-egfr antibodies and uses thereof

Family Applications Before (2)

Application Number Title Priority Date Filing Date
SG11201407163XA SG11201407163XA (en) 2012-06-25 2013-06-25 Anti-egfr antibodies and uses thereof
SG10201804151QA SG10201804151QA (en) 2012-06-25 2013-06-25 Anti-egfr antibodies and uses thereof

Country Status (24)

Country Link
US (3) US9132192B2 (en)
EP (1) EP2864357B1 (en)
JP (1) JP6486268B2 (en)
KR (1) KR20150023387A (en)
CN (1) CN104411722B (en)
AR (1) AR091545A1 (en)
AU (2) AU2013280610B2 (en)
BR (1) BR112014029099A2 (en)
CA (1) CA2876697C (en)
CL (1) CL2014003465A1 (en)
CO (1) CO7160093A2 (en)
EA (1) EA030421B1 (en)
ES (1) ES2816645T3 (en)
HK (1) HK1206040A1 (en)
IL (1) IL235392B (en)
MX (1) MX356329B (en)
MY (2) MY181086A (en)
NZ (1) NZ701633A (en)
PH (1) PH12014502437B1 (en)
SG (3) SG11201407163XA (en)
TW (2) TW201843172A (en)
UY (1) UY34876A (en)
WO (1) WO2014004427A2 (en)
ZA (1) ZA201407927B (en)

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Also Published As

Publication number Publication date
MY164604A (en) 2018-01-30
PH12014502437A1 (en) 2015-01-12
JP6486268B2 (en) 2019-03-20
CA2876697C (en) 2021-07-13
IL235392B (en) 2019-02-28
MX2014014361A (en) 2015-02-05
UY34876A (en) 2013-12-31
SG10201804151QA (en) 2018-07-30
CO7160093A2 (en) 2015-01-15
CA2876697A1 (en) 2014-01-03
WO2014004427A3 (en) 2014-03-27
MY181086A (en) 2020-12-17
ZA201407927B (en) 2015-11-25
CL2014003465A1 (en) 2015-02-27
KR20150023387A (en) 2015-03-05
CN104411722B (en) 2017-11-17
TW201402610A (en) 2014-01-16
AU2018204895A1 (en) 2018-07-26
EA201590085A1 (en) 2015-04-30
US20130344093A1 (en) 2013-12-26
US9132192B2 (en) 2015-09-15
TW201843172A (en) 2018-12-16
US9789184B2 (en) 2017-10-17
US20180036405A1 (en) 2018-02-08
BR112014029099A2 (en) 2017-07-18
AR091545A1 (en) 2015-02-11
WO2014004427A2 (en) 2014-01-03
HK1206040A1 (en) 2015-12-31
AU2013280610A1 (en) 2014-11-20
CN104411722A (en) 2015-03-11
WO2014004427A8 (en) 2014-12-18
EA030421B1 (en) 2018-08-31
NZ701633A (en) 2017-08-25
US20150337043A1 (en) 2015-11-26
AU2013280610B2 (en) 2018-04-26
TWI641619B (en) 2018-11-21
MX356329B (en) 2018-05-24
EP2864357B1 (en) 2020-07-01
SG11201407163XA (en) 2014-11-27
JP2015521629A (en) 2015-07-30
PH12014502437B1 (en) 2015-01-12
ES2816645T3 (en) 2021-04-05
EP2864357A2 (en) 2015-04-29

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