SG11201908971RA - Erbb-2 and erbb3 binding bispecific antibodies for use in the treatment f cells that have an nrg1 fusion gene - Google Patents

Erbb-2 and erbb3 binding bispecific antibodies for use in the treatment f cells that have an nrg1 fusion gene

Info

Publication number
SG11201908971RA
SG11201908971RA SG11201908971RA SG11201908971RA SG 11201908971R A SG11201908971R A SG 11201908971RA SG 11201908971R A SG11201908971R A SG 11201908971RA SG 11201908971R A SG11201908971R A SG 11201908971RA
Authority
SG
Singapore
Prior art keywords
international
yalelaan
utrecht
erbb
cells
Prior art date
Application number
Inventor
Mark Throsby
Cecilia Anna Wilhelmina Geuijen
David Andre Baptiste Maussang-Detaille
Ton Logtenberg
Original Assignee
Merus Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merus Nv filed Critical Merus Nv
Publication of SG11201908971RA publication Critical patent/SG11201908971RA/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/32—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • C07K16/468—Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype

Abstract

INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 04 October 2018 (04.10.2018) W I PO I PCT o °nolo ono! oni omoilimio oimIE (10) International Publication Number WO 2018/182422 Al (51) International Patent Classification: A61K 39/395 (2006.01) C07K 16/30 (2006.01) C07K 16/28 (2006.01) C07K 16/32 (2006.01) (21) International Application Number: PCT/NL2018/050206 (22) International Filing Date: 03 April 2018 (03.04.2018) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 17164292.9 31 March 2017 (31.03.2017) EP (71) Applicant: MERUS N.V. [NL/NL]; Yalelaan 62, 3584 CM Utrecht (NL). (72) Inventors: THROSEY, Mark; c/o Yalelaan 62, 3584 CM Utrecht (NL). GEUIJEN, Cecilia Ana Wilhelmina; c/o Yalelaan 62, 3584 CM Utrecht (NL). MAUSSANG-DE- TAILLE, David Andre Baptiste; c/o Yalelaan 62, 3584 CM Utrecht (NL). LOGTENBERG, Ton; c/o Yalelaan 62, 3584 CM Utrecht (NL). (74) Agent: JANSEN, C.M.; V.O., Carnegieplein 5, 2517 KJ Den Haag (NL). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Published: with international search report (Art. 21(3)) 00 1-1 (54) Title: ERBB-2 AND ERBB3 BINDING BISPECIFIC ANTIBODIES FOR USE IN THE TREATMENT F CELLS THAT HAVE 00 AN NRG1 FUSION GENE 0 (57) : The invention relates to the field of antibodies. In particular it relates to the field of therapeutic (human) antibodies \" for the treatment of ErbB-2/ErbB-3 positive cells. More in particular it relates to treating of cells comprising an NRG1 fusion gene 0 comprising at least a portion of the NRG1-gene fused to a sequence from a different chromosomal location.
SG11201908971R 2017-03-31 2018-04-03 Erbb-2 and erbb3 binding bispecific antibodies for use in the treatment f cells that have an nrg1 fusion gene SG11201908971RA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP17164292 2017-03-31
PCT/NL2018/050206 WO2018182422A1 (en) 2017-03-31 2018-04-03 Erbb-2 and erbb3 binding bispecific antibodies for use in the treatment f cells that have an nrg1 fusion gene

Publications (1)

Publication Number Publication Date
SG11201908971RA true SG11201908971RA (en) 2019-10-30

Family

ID=58488840

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11201908971R SG11201908971RA (en) 2017-03-31 2018-04-03 Erbb-2 and erbb3 binding bispecific antibodies for use in the treatment f cells that have an nrg1 fusion gene

Country Status (14)

Country Link
US (1) US11780925B2 (en)
EP (1) EP3600413A1 (en)
JP (1) JP2020511993A (en)
KR (1) KR20190140945A (en)
CN (1) CN110650752A (en)
AU (1) AU2018246873B2 (en)
BR (1) BR112019020508A2 (en)
CA (1) CA3058343A1 (en)
EA (1) EA201992063A1 (en)
IL (2) IL310223A (en)
MX (1) MX2019011660A (en)
PH (1) PH12019550202A1 (en)
SG (1) SG11201908971RA (en)
WO (1) WO2018182422A1 (en)

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EP4110472A1 (en) * 2020-02-28 2023-01-04 Regeneron Pharmaceuticals, Inc. Bispecific antigen binding molecules that bind her2, and methods of use thereof
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EP4304636A1 (en) * 2021-03-11 2024-01-17 Elevation Oncology, Inc. Dosage and administration of anti-erbb3 (her3) monoclonal antibodies to treat tumors associated with neuregulin 1 (nrg1) gene fusions
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AU2018246873B2 (en) 2021-05-06
EA201992063A1 (en) 2020-03-26
WO2018182422A8 (en) 2019-10-31
IL269656B1 (en) 2024-02-01
BR112019020508A2 (en) 2020-08-04
CA3058343A1 (en) 2018-10-04
US20200102393A1 (en) 2020-04-02
JP2020511993A (en) 2020-04-23
MX2019011660A (en) 2019-11-18
WO2018182422A1 (en) 2018-10-04
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